Aging as accelerated accumulation of somatic variants: Whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

Twin Research and Human Genetics

Volumn 16, Issue 6, 2013, Pages 1026-1032

  Ye, Kai ^a,b   Beekman, Marian ^a   Lameijer, Eric Wubbo ^a   Zhang, Yanju ^a   Moed, Matthijs H ^a   Van Den Akker, Erik B ^a,c   Deelen, Joris ^a,b   Houwing Duistermaat, Jeanine J ^a   Kremer, Dennis ^a   Anvar, Seyed Yahya ^a   Laros, Jeroen F J ^a   Jones, David ^d   Raine, Keiran ^d   Blackburne, Ben ^e   Potluri, Shobha ^f   Long, Quan ^g   Guryev, Victor ^h   Van Der Breggen, Ruud ^a   Westendorp, Rudi G J ^a   'T Hoen, Peter A C ^a   Den Dunnen, Johan ^a   Van Ommen, Gert Jan B ^a   Willemsen, Gonneke ⁱ   Pitts, Steven J ^f   Cox, David R ^f   Ning, Zemin ^d   Boomsma, Dorret I ⁱ   Slagboom, P Eline ^a,b   more..

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Netherlands Consortium for Healthy Ageing   (Netherlands)

^c DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

^f PFIZER INC   (United States)

^g GREGOR MENDEL INSTITUTE OF MOLECULAR PLANT BIOLOGY   (Austria)

^h HUBRECHT INSTITUTE   (Netherlands)

ⁱ VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Aging; Human genome; Next gen sequencing; Somatic mutations; Twin discordances

Indexed keywords

ADULT; AGED; AGING; AMINO ACID SUBSTITUTION; ARTICLE; COPY NUMBER VARIATION; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTRON; MONOZYGOTIC TWINS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOMATIC MUTATION; TWIN DISCORDANCE;

ADULT; AGED, 80 AND OVER; AGING; BLOOD CELLS; FEMALE; GENOME, HUMAN; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALE; MIDDLE AGED; MUTATION; TWINS, MONOZYGOTIC;

EID: 84888861117     PISSN: 18324274     EISSN: None     Source Type: Journal    
DOI: 10.1017/thg.2013.73     Document Type: Article

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