Proteinuria: Tubular handling of albumin - Degradation or salvation?

Nature Reviews Nephrology

Volumn 9, Issue 12, 2013, Pages 700-702

  Christensen, Erik I ^a   Birn, Henrik ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CUBILIN; FC RECEPTOR;

ALBUMIN BLOOD LEVEL; ALBUMINURIA; ARTICLE; DISSOCIATION; GLOMERULAR FILTRATION BARRIER; GLOMERULUS; GLOMERULUS FILTRATION; HUMAN; KIDNEY DISEASE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; TRANSCYTOSIS; TRANSGENIC MOUSE;

ALBUMINURIA; ANIMALS; HUMANS; KIDNEY TUBULES, PROXIMAL; MODELS, BIOLOGICAL; SERUM ALBUMIN; TRANSCYTOSIS;

EID: 84888859855     PISSN: 17595061     EISSN: 1759507X     Source Type: Journal    
DOI: 10.1038/nrneph.2013.212     Document Type: Article

References (10)

1. Christensen, E. I., Nielsen, R. & Birn, H. in Seldin and Giebisch's The Kidney: Physiology and Pathophysiology (eds Alpern, R. J., Moe, O. W. & Caplan, M.) 2453-2471 (Elsevier, 2013)
2. Russo, L. M. et al. The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: Retrieval is disrupted in nephrotic states. Kidney Int. 71, 504-513 (2007) (Pubitemid 46398675)
3. Gekle, M. Renal tubule albumin transport. Annu. Rev. Physiol. 67, 573-594 (2005) (Pubitemid 40404502)
4. Tenten, V. et al. Albumin is recycled from the primary urine by tubular transcytosis. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2013010018
5. van Roeyen, C. R. et al. Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D. Kidney Int. 80, 1292-1305 (2011)
6. Haymann, J. P. et al. Characterization and localization of the neonatal Fc receptor in adult human kidney. J. Am. Soc. Nephrol. 11, 632-639 (2000)
7. Sarav, M. et al. Renal FcRn reclaims albumin but facilitates elimination of IgG. J. Am. Soc. Nephrol. 20, 1941-1952 (2009)
8. Nielsen, J. T. & Christensen, E. I. Basolateral endocytosis of protein in isolated perfused proximal tubules. Kidney Int. 27, 39-45 (1985) (Pubitemid 15130683)
9. Weyer, K. et al. Mouse model of proximal tubule endocytic dysfunction. Nephrol. Dial. Transplant. 26, 3446-3451 (2011)
10. Wani, M. A. et al. Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. Proc. Natl Acad. Sci. USA 103, 5084-5089 (2006)