Glomerular expression of myxovirus resistance protein 1 in human mesangial cells: Possible activation of innate immunity in the pathogenesis of lupus nephritis

Nephrology

Volumn 18, Issue 12, 2013, Pages 833-837

  Watanabe, Shojiro ^a   Imaizumi, Tadaatsu ^b   Tsuruga, Kazushi ^a   Aizawa, Tomomi ^a   Ito, Tatsuya ^a   Matsumiya, Tomoh ^b   Yoshida, Hidemi ^b   Joh, Kensuke ^c   Ito, Etsuro ^a   Tanaka, Hiroshi ^a,d  

^a HIROSAKI UNIVERSITY HOSPITAL   (Japan)

^b HIROSAKI UNIVERSITY   (Japan)

^c Division of Pathology Sendai Shakaihoken Hospital   (Japan)

^d HIROSAKI UNIVERSITY   (Japan)

Author keywords

human myxovirus resistance protein 1; interferon ; lupus nephritis; mesangial cell

Indexed keywords

BETA INTERFERON; DOUBLE STRANDED RNA; MYXOVIRUS RESISTANCE PROTEIN; MYXOVIRUS RESISTANCE PROTEIN 1; POLYINOSINIC POLYCYTIDYLIC ACID; UNCLASSIFIED DRUG; MESSENGER RNA; MX1 PROTEIN, HUMAN;

ARTICLE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOREACTIVITY; INNATE IMMUNITY; LUPUS ERYTHEMATOSUS NEPHRITIS; MESANGIUM CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURPURA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL CULTURE; GENETICS; IMMUNOLOGY; LUPUS NEPHRITIS; METABOLISM;

CELLS, CULTURED; HUMANS; IMMUNITY, INNATE; LUPUS NEPHRITIS; MESANGIAL CELLS; MYXOVIRUS RESISTANCE PROTEINS; POLY I-C; RNA, MESSENGER;

EID: 84888857656     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/nep.12155     Document Type: Article

References (15)

1. Migliorini A, Anders HJ,. A novel pathogenetic concept-antiviral immunity in lupus nephritis. Nat. Rev. Nephrol. 2012; 8: 183-189.
2. Yap DYH, Lai KN,. Role of cytokines in the pathogenesis of systemic lupus erythematosus-from bench to bedside. Nephrology (Carlton) 2013; 18: 243-255.
3. Robson MG,. Toll-like receptors and renal disease. Nephron Exp. Nephrol. 2009; 113: e1-7.
4. Tanaka H, Imaizumi T,. Toll-like receptor 3 and retinoic acid-inducible gene-I implicated to the pathogenesis of autoimmune renal diseases. In:, Stanilova SA, (ed.). Genes and Autoimmunity-Intracellular Signaling and Microbiome Contribution. Rijeka: InTec Open Access Publisher, 2013; 59-74.
5. Flur K, Allam R, Zecher D, et al. Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5. Implications for viral infection-associated glomerulonephritis. Am. J. Pathol. 2009; 175: 2014-2022.
6. Haller O, Staeheli P, Kochs G,. Interferon-induced Mx proteins in antiviral host defense. Biochemie 2007; 89: 812-818.
7. Feng X, Wu H, Grossman JM, et al. Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis Rheum. 2006; 54: 2951-2962.
8. Imaizumi T, Tanaka H, Matsumiya T, et al. Retinoic acid-inducible gene-I is induced by double-stranded RNA and regulates the expression of CC chemokine ligand (CCL) 5 in human mesangial cells. Nephrol. Dial. Transplant. 2010; 25: 3534-3539.
9. Imaizumi T, Tanaka H, Mechti N, et al. Polyinosinic-polycytidylic acid induces the expression of interferon-stimulated gene 20 in mesangial cells. Nephron Exp. Nephrol. 2011; 119: e40-48.
10. Imaizumi T, Aizawa-Yashiro T, Tsuruga K, et al. Melanoma differentiation-associated gene 5 regulates the expression of a chemokine CXCL10 in human mesangial cells: Implications for chronic inflammatory renal diseases. Tohoku J. Exp. Med. 2012; 228: 17-26.
11. Dempoya J, Matsumiya T, Imaizumi T, et al. Double-stranded RNA induces biphasic STAT1 phosphorylation by both type I IFN-dependent and type I IFN-independent pathways. J. Virol. 2012; 86: 12760-12769.
12. Cappelletti C, Baggi F, Zolezzi F, et al. Type I interferon and toll-like receptor expression characterizes inflammatory myopathies. Neurology 2011; 76: 2079-2088.
13. Wang X, Magro CM,. Human myxovirus resistance protein 1 (MxA) as a useful marker in the differential diagnosis of subcutaneous lymphoma vs. lupus erythematosus orofundus. Eur. J. Dermatol. 2012; 22: 629-633.
14. Floege J, Burg M, Al Masri AN, Gröne HJ, von Wussow P,. Expression of interferon-inducible Mx-proteins in patients with IgA nephropathy or Henoch-Schönlein purpura. Am. J. Kidney Dis. 1999; 33: 434-440.
15. Suzuki K, Imaizumi T, Oki E, Tsugawa K, Ito E, Tanaka H,. Expression of retinoic acid-inducible gene-I in lupus nephritis. Nephrol. Dial. Transplant. 2007; 22: 2407-2409.