Silencing of poly(ADP-ribose) glycohydrolase sensitizes lung cancer cells to radiation through the abrogation of DNA damage checkpoint

Biochemical and Biophysical Research Communications

Volumn 441, Issue 4, 2013, Pages 793-798

  Nakadate, Yusuke ^a,b   Kodera, Yasuo ^a   Kitamura, Yuka ^a   Tachibana, Taro ^b   Tamura, Tomohide ^a   Koizumi, Fumiaki ^a  

^a NATIONAL CANCER CENTER HOSPITAL   (Japan)

^b Osaka City University   (Japan)

Author keywords

Checkpoint; DNA damage; Lung cancer; PARG; Radiation; Sensitization

Indexed keywords

GLYCOSIDASE; POLY(ADP RIBOSE) GLYCOHYDROLASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; DNA DAMAGE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LUNG CANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS; RADIATION EXPOSURE; RADIOSENSITIVITY;

BASE EXCISION REPAIR; BER; CHECKPOINT; DNA DAMAGE; DOUBLE-STRAND BREAK; DSB; LUNG CANCER; NAD; NICOTINE ADENINE DINUCLEOTIDE; NON-SMALL CELL LUNG CANCER; NSCLC; PAR; PARG; PARP; POLY(ADP-RIBOSE); POLY(ADP-RIBOSE) GLYCOHYDROLASE; POLY(ADP-RIBOSE) POLYMERASE; RADIATION; SCLC; SENSITIZATION; SINGLE-STRAND BREAK; SMALL CELL LUNG CANCER; SSB; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 1; XRCC1;

CELL LINE, TUMOR; DNA DAMAGE; G2 PHASE CELL CYCLE CHECKPOINTS; GENE SILENCING; GLYCOSIDE HYDROLASES; HUMANS; LUNG NEOPLASMS; RADIATION TOLERANCE; RNA, SMALL INTERFERING;

EID: 84888853891     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.10.134     Document Type: Article

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