Parg deficiency confers radio-sensitization through enhanced cell death in mouse ES cells exposed to various forms of ionizing radiation

Biochemical and Biophysical Research Communications

Volumn 435, Issue 1, 2013, Pages 100-106

  Shirai, Hidenori ^a   Fujimori, Hiroaki ^a   Gunji, Akemi ^a   Maeda, Daisuke ^a   Hirai, Takahisa ^a,b   Poetsch, Anna R ^a   Harada, Hiromi ^a   Yoshida, Tomoko ^a,c   Sasai, Keisuke ^b   Okayasu, Ryuichi ^d   Masutani, Mitsuko ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KEIO UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

H2AX; AIF; Carbon ion irradiation; DDR; DNA repair; DSB; ES; FACS; Ionizing radiation; LET; NAD; P H3; PAR; Parg; Parp 1; Sensitization; SSB

Indexed keywords

CARBON; GLYCOSIDASE; HISTONE H2AX; HISTONE H2AX GAMMA; IRON; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; POLY(ADP RIBOSE)GLYCOHYDROLASE; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; EMBRYO; EMBRYONIC STEM CELL; GAMMA IRRADIATION; HISTONE PHOSPHORYLATION; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; RADIOSENSITIZATION;

ANIMALS; APOPTOSIS; CARBON; CELL SURVIVAL; CELLS, CULTURED; DNA BREAKS, DOUBLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, RADIATION; EMBRYONIC STEM CELLS; FLOW CYTOMETRY; GAMMA RAYS; GLYCOSIDE HYDROLASES; HEAVY IONS; HISTONES; IMMUNOBLOTTING; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; RADIATION, IONIZING; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84878208360     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.04.048     Document Type: Article

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