Partial genetic deficiency in tissue kallikrein impairs adaptation to high potassium intake in humans

Kidney International

Volumn 84, Issue 6, 2013, Pages 1271-1277

  Monteiro, Joana S ^a   Blanchard, Anne ^b,c,d   Curis, Emmanuel ^b,c   Chambrey, Régine ^b,d   Jeunemaitre, Xavier ^b,d   Azizi, Michel ^b,c,d  

^a University of Porto   (Portugal)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^d INSERM   (France)

Author keywords

kallikrein; polymorphism; potassium metabolism

Indexed keywords

ALDOSTERONE; KALLIKREIN;

ADULT; ALDOSTERONE BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; KALLIKREIN GENE; KIDNEY METABOLISM; KIDNEY TUBULE ABSORPTION; MALE; NORMAL HUMAN; POTASSIUM BLOOD LEVEL; POTASSIUM EXCRETION; POTASSIUM INTAKE; POTASSIUM METABOLISM; PRIORITY JOURNAL; TISSUE LEVEL;

ADAPTATION, PHYSIOLOGICAL; ADULT; ALDOSTERONE; CROSS-OVER STUDIES; DIET, SODIUM-RESTRICTED; FUROSEMIDE; HEALTHY VOLUNTEERS; HETEROZYGOTE; HOMOZYGOTE; HUMANS; INFUSIONS, INTRAVENOUS; KIDNEY; MALE; PHENOTYPE; POTASSIUM, DIETARY; SODIUM CHLORIDE, DIETARY; SODIUM POTASSIUM CHLORIDE SYMPORTER INHIBITORS; TIME FACTORS; TISSUE KALLIKREINS;

EID: 84888646411     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2013.224     Document Type: Article

References (25)

1. Youn JH, McDonough AA. Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol 2009; 71: 381-401.
2. Wang W. Regulation of renal K transport by dietary K intake. Annu Rev Physiol 2004; 66: 547-569.
3. Wang WH, Giebisch G. Regulation of potassium (K) handling in the renal collecting duct. Pflugers Arch 2009; 458: 157-168.
4. McDonough AA, Thompson CB, Youn JH. Skeletal muscle regulates extracellular potassium. Am J Physiol Renal Physiol 2002; 282: F967-F974.
5. Giebisch G. Renal potassium transport: Mechanisms and regulation. Am J Physiol 1998; 274: F817-F833.
6. Frindt G, Palmer LG. K+ secretion in the rat kidney: Na+ channeldependent and -independent mechanisms. Am J Physiol Renal Physiol 2009; 297: F389-F396.
7. Frindt G, Palmer LG. Effects of dietary K on cell-surface expression of renal ion channels and transporters. Am J Physiol Renal Physiol 2010; 299: F890-F897.
8. Ahn KY, Park KY, Kim KK et al. Chronic hypokalemia enhances expression of the H(+)-K(+)-ATPase alpha 2-subunit gene in renal medulla. Am J Physiol 1996; 271: F314-F321.
9. Greenlee MM, Lynch IJ, Gumz ML et al. Mineralocorticoids stimulate the activity and expression of renal H+, K+-ATPases. J Am Soc Nephrol 2011; 22: 49-58.
10. Meneton P, Schultheis PJ, Greeb J et al. Increased sensitivity to K+ deprivation in colonic H, K-ATPase-deficient mice. J Clin Invest 1998; 101: 536-542.
11. Palmer LG, Antonian L, Frindt G. Regulation of apical K and Na channels and Na/K pumps in rat cortical collecting tubule by dietary K. J Gen Physiol 1994; 104: 693-710.
12. Zhang Y, Lin DH, Wang ZJ et al. K restriction inhibits protein phosphatase 2B (PP2B) and suppression of PP2B decreases ROMK channel activity in the CCD. Am J Physiol Cell Physiol 2008; 294: C765-C773.
13. El Moghrabi S, Houillier P, Picard N et al. Tissue kallikrein permits early renal adaptation to potassium load. Proc Natl Acad Sci USA 2010; 107: 13526-13531.
14. Patel AB, Chao J, Palmer LG. Tissue kallikrein activation of the epithelial Na channel. Am J Physiol Renal Physiol 2012; 303: F540-F550.
15. Picard N, Eladari D, El Moghrabi S et al. Defective ENaC processing and function in tissue kallikrein-deficient mice. J Biol Chem 2008; 283: 4602-4611.
16. Chambrey R, Picard N. Role of tissue kallikrein in regulation of tubule function. Curr Opin Nephrol Hypertens 2011; 20: 523-528.
17. Carretero O, Scicli AG. The Renal Kallikrein-Kinin System as a Regulator of Cardiovascular and Renal Function. Raven Press: New York, 1995.
18. Slim R, Torremocha F, Moreau T et al. Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity. J Am Soc Nephrol 2002; 13: 968-976.
19. Song CK, Martinez JA, Kailasam MT et al. Renal kallikrein excretion: Role of ethnicity, gender, environment, and genetic risk of hypertension. J Hum Hypertens 2000; 14: 461-468.
20. Hunt SC, Hasstedt SJ, Wu LL et al. A gene-environment interaction between inferred kallikrein genotype and potassium. Hypertension 1993; 22: 161-168.
21. Azizi M, Boutouyrie P, Bissery A et al. Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans. J Clin Invest 2005; 115: 780-787.
22. Blanchard A, Azizi M, Peyrard S et al. Partial human genetic deficiency in tissue kallikrein activity and renal calcium handling. Clin J Am Soc Nephrol 2007; 2: 320-325.
23. Kamenicky P, Blanchard A, Frank M et al. Body fluid expansion in acromegaly is related to enhanced epithelial sodium channel (ENaC) activity. J Clin Endocrinol Metab 2011; 96: 2127-2135.
24. Bourgeois L, Brillard-Bourdet M, Deperthes D et al. Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2. J Biol Chem 1997; 272: 29590-29595.
25. R Development Core Team. A Language and Environment for Statistical Computing. R Foundation for Statistical Computing: Vienna, Austria, 2011. Médicale