Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity

Journal of the American Society of Nephrology

Volumn 13, Issue 4, 2002, Pages 968-976

  Slim, Rola ^a   Torremocha, Florence ^a   Moreau, Thierry ^a   Pizard, Anne ^a   Hunt, Steven C ^a   Vuagnat, Albert ^a   Williams, Gordon H ^a   Gauthier, Francis ^a   Jeunemaitre, Xavier ^a   Alhenc Gelas, François ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

KININOGEN; RECOMBINANT HORMONE; RECOMBINANT KALLIKREIN; TISSUE KALLIKREIN; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL TONE; CONTROLLED STUDY; CRYSTALLOGRAPHY; EXON; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENETIC POLYMORPHISM; HORMONE ACTION; HORMONE SYNTHESIS; HUMAN; HYPERTENSION; KALLIKREIN KININ SYSTEM; KIDNEY DISEASE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; VASCULAR DISEASE;

EID: 0036212197     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. The renal kallikrein-kinin system as a regulator of cardiovascular and renal function
2. Cardiovascular abnormalities with normal blood pressure in tissue kallikrein deficient mice
3. Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors
4. Renin-angiotensin system modulates renal bradykinin production
5. Familial aggregation of urinary kallikrein concentration in childhood: Relation to blood pressure, race and urinary electrolytes
6. A gene for high urinary kallikrein may protect against hypertension in Utah kindreds
7. Urinary kallikrein excretion in hypertensive man: Relationships to sodium intake and sodium-retaining steroids
8. Cosegregation of blood pressure with a kallikrein gene family polymorphism
9. Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4
10. Structure and chromosomal localization of the human renal kallikrein gene
11. Human glandular kallikrein genes: Genetic and physical mapping of the hKLK1 locus using a highly polymorphic microsatellite PCR marker
12. DNA polymorphisms in the 5′-flanking region of the human tissue kallikrein gene
13. No effect of TaqI polymorphism at the human renal kallikrein (KLK1) locus on normal blood pressure level or variability
14. Analyses of mutations in the human renal kallikrein (hKLK1) gene and their possible relevance to blood pressure regulation and risk of myocardial infarction
15. A general approach to single-nucleotide polymorphism discovery
16. HYPERGENE: A clinical and genetic database for genetic analysis in human hypertension
17. Haplotypes of angiotensinogen in essential hypertension
18. Treatment of mild to moderate hypertension with or without the converting enzyme inhibitor enalapril: Results of a six-month double-blind trial
19. Altered adrenal sensitivity to angiotensin II in low-renin essential hypertension
20. Aldosterone stimulation by angiotensin II: Influence of gender, plasma renin, and familial resemblance
21. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
22. Mutagenically separated PCR (MS-PCR): A highly specific one step procedure for easy mutation detection
23. Measurement of urinary kallikrein activity: Species differences in kinin production
24. Urinary kallikrein: Assay validation and physiological variability
25. Hydrolysis of somatostatin by human tissue kallikrein after the amino acid pair Phe-Phe
26. Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2
27. Kallistatin: A novel human serine proteinase inhibitor: Molecular cloning, tissue distribution, and expression in Escherichia coli
28. Direct immunometric assay of active renin in human plasma
29. A direct determination of plasma aldosterone
30. Expression of functional human C1 inhibitor in Cos cells
31. Purification of human urinary prokallikrein: Identification of the site of activation by the metalloproteinase thermolysin
32. Role of serine 214 and tyrosine 171, components of the S2 subsite of α-lytic protease, in catalysis
33. The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes
34. Expression and characterization of human tissue kallikrein variants
35. Substrate specificity of tissue kallikreins: Importance of an extended interaction site
36. Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments
37. Crystal structure of recombinant human tissue kallikrein at 2.0 Å resolution
38. MOLMOL: A program for display and analysis of macromolecular structures
39. Identification and structure of the rat true tissue kallikrein gene expressed in the kidney
40. Mouse glandular kallikrein genes: Identification, structure, and expression of the renal kallikrein gene
41. The radioimmunoassay of human urinary kallikrein and comparisons with kallikrein activity measurements
42. Response of the renal kallikrein-kinin system, intravascular volume, and renal hemodynamics to sodium restriction and diuretic treatment in essential hypertension
43. Decreased flow-dependent dilatation in carotid arteries of tissue kallikrein-knockout mice