Induction of SHP2 deficiency in chondrocytes causes severe scoliosis and kyphosis in mice

Spine

Volumn 38, Issue 21, 2013, Pages

  Kim, Harry K W ^a,b   Aruwajoye, Olumide ^a   Sucato, Daniel ^a,b   Richards, B Stephens ^a,b   Feng, Gen Sheng ^c   Chen, Di ^d   King, Philip D ^e   Kamiya, Nobuhiro ^a,b  

^a TEXAS SCOTTISH RITE HOSPITAL FOR CHILDREN   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d RUSH UNIVERSITY   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Adolescent; Age specifi c gene disruption; Cartilage; Chondrocyte; Conditional knockout; Kyphosis; Lordosis; Loss of function; Mouse model; Ras mapk signal; Scoliosis; Shp2; Spine

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE SHP 2;

ADOLESCENT; ADOLESCENT IDIOPATHIC SCOLIOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; DISEASE SEVERITY; HISTOPATHOLOGY; KYPHOSIS; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOGRAPHY; THORACIC LORDOSIS; THORACOLUMBAR KYPHOSCOLIOSIS;

ANIMALS; CERVICAL VERTEBRAE; CHONDROCYTES; COLLAGEN TYPE II; FEMALE; GENE EXPRESSION REGULATION; KYPHOSIS; LORDOSIS; LUMBAR VERTEBRAE; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; SCOLIOSIS; SEVERITY OF ILLNESS INDEX; TAMOXIFEN; THORACIC VERTEBRAE; TIME FACTORS; X-RAY MICROTOMOGRAPHY;

EID: 84888644272     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3182a3d370     Document Type: Article

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