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Volumn 41, Issue 12, 2013, Pages 1973-1974

Prediction of human pharmacokinetics in 2013 and beyond

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2B6; DRUG METABOLITE; GLUCURONOSYLTRANSFERASE;

EID: 84888614834     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.055376     Document Type: Article
Times cited : (9)

References (17)
  • 1
    • 84888591764 scopus 로고    scopus 로고
    • Hetertropic activity of P450 3A by a positive allosteric modulator of metabotrophic glutamate receptor 5: In vitro to in vivo translation and potential impact on clinicality relevant drug-drug interactions
    • Blobaum AL, Bridges TM, Byers FW, Turlington M, Mattmann M, Morrison RD, Mackie J, Lavreysen H, Bartolome JM, MacDonald GJ, et al. (2013) Hetertropic activity of P450 3A by a positive allosteric modulator of metabotrophic glutamate receptor 5: In vitro to in vivo translation and potential impact on clinicality relevant drug-drug interactions. Drug Metab Dispos 41:2066-2075.
    • (2013) Drug Metab Dispos , vol.41 , pp. 2066-2075
    • Blobaum, A.L.1    Bridges, T.M.2    Byers, F.W.3    Turlington, M.4    Mattmann, M.5    Morrison, R.D.6    Mackie, J.7    Lavreysen, H.8    Bartolome, J.M.9    MacDonald, G.J.10
  • 2
    • 84888583720 scopus 로고    scopus 로고
    • Drug metabolites as cytochrome P450 inhibitors: A retrospective analysis and proposed algorithm for evaluation of the pharmacokinetic interaction potential of metabolites in drug discovery and development
    • Callegari E, Kalgutkar AS, Leung LY, Obach RS, Plowchalk DR, and Tse S (2013) Drug metabolites as cytochrome P450 inhibitors: a retrospective analysis and proposed algorithm for evaluation of the pharmacokinetic interaction potential of metabolites in drug discovery and development. Drug Metab Dispos 41:2047-2055.
    • (2013) Drug Metab Dispos , vol.41 , pp. 2047-2055
    • Callegari, E.1    Kalgutkar, A.S.2    Leung, L.Y.3    Obach, R.S.4    Plowchalk, D.R.5    Tse, S.6
  • 3
    • 84888599070 scopus 로고    scopus 로고
    • Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac
    • Chan T, Yu H, Moore A, Khetani S, and Tweedie DJ (2013) Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac. Drug Metab Dispos 41:2024-2032.
    • (2013) Drug Metab Dispos , vol.41 , pp. 2024-2032
    • Chan, T.1    Yu, H.2    Moore, A.3    Khetani, S.4    Tweedie, D.J.5
  • 4
    • 84888632710 scopus 로고    scopus 로고
    • A perspective on the prediction of drug disposition attributes in drug research and development
    • Di L, Feng B, Goosen TC, Lai Y, Steyn SJ, Varma MV, and Obach RS (2013a) A perspective on the prediction of drug disposition attributes in drug research and development. Drug Metab Dispos 41:1975-1993.
    • (2013) Drug Metab Dispos , vol.41 , pp. 1975-1993
    • Di, L.1    Feng, B.2    Goosen, T.C.3    Lai, Y.4    Steyn, S.J.5    Varma, M.V.6    Obach, R.S.7
  • 6
    • 77149125562 scopus 로고    scopus 로고
    • Metabolites in Safety Testing: "MIST" for the clinical pharmacologist
    • Frederick CB and Obach RS (2012) Metabolites in Safety Testing: "MIST" for the clinical pharmacologist. Clin Pharmacol Therap 87:345-350.
    • (2012) Clin Pharmacol Therap , vol.87 , pp. 345-350
    • Frederick, C.B.1    Obach, R.S.2
  • 8
    • 84888597252 scopus 로고    scopus 로고
    • Utility of in vitro systems and preclinical data for the prediction of human intestinal first-pass metabolism during drug discovery and development
    • Karlsson FH, Bouchene S, Hilgendorf C, Dolgos H, and Peters SA (2013) Utility of in vitro systems and preclinical data for the prediction of human intestinal first-pass metabolism during drug discovery and development. Drug Metab Dispos 41:2033-2046.
    • (2013) Drug Metab Dispos , vol.41 , pp. 2033-2046
    • Karlsson, F.H.1    Bouchene, S.2    Hilgendorf, C.3    Dolgos, H.4    Peters, S.A.5
  • 9
    • 84888615911 scopus 로고    scopus 로고
    • In vitro P-gp efflux ratio can predict the in vivo brain penetration regardless of BDDCS class
    • Kikuchi R, de Morais SM, and Kalvass JC (2013) In vitro P-gp efflux ratio can predict the in vivo brain penetration regardless of BDDCS class. Drug Metab Dispos 41:2012-2017.
    • (2013) Drug Metab Dispos , vol.41 , pp. 2012-2017
    • Kikuchi, R.1    De Morais, S.M.2    Kalvass, J.C.3
  • 10
    • 84888580865 scopus 로고    scopus 로고
    • Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: Implications for prediction of multiple time-dependent inhibitor systems
    • Lutz JD, Vandenbrink BM, Babu NK, Nelson WL, Kunze KL, and Isoherranen N (2013) Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for prediction of multiple time-dependent inhibitor systems. Drug Metab Dispos 41:2056-2065.
    • (2013) Drug Metab Dispos , vol.41 , pp. 2056-2065
    • Lutz, J.D.1    Vandenbrink, B.M.2    Babu, N.K.3    Nelson, W.L.4    Kunze, K.L.5    Isoherranen, N.6
  • 11
    • 84858673980 scopus 로고    scopus 로고
    • Simultaneous assessment of uptake and metabolism in rat hepatocytes: A comprehensive mechanistic model
    • Ménochet K, Kenworthy KE, Houston JB, and Galetin A (2012) Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model. J Pharmacol Exp Ther 341:2-15.
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 2-15
    • Ménochet, K.1    Kenworthy, K.E.2    Houston, J.B.3    Galetin, A.4
  • 12
    • 46449096570 scopus 로고    scopus 로고
    • Rate-limiting steps in hepatic drug clearance: Comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir
    • Parker AJ and Houston JB (2008) Rate-limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir. Drug Metab Dispos 36:1375-1384.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1375-1384
    • Parker, A.J.1    Houston, J.B.2
  • 13
    • 84888624560 scopus 로고    scopus 로고
    • Impact of physiologically-based pharmacokinetic modelling and simulation in drug development
    • Shardlow C, Generaux G, Patel A, Tai G, Tran T, and Bloomer J (2013) Impact of physiologically-based pharmacokinetic modelling and simulation in drug development. Drug Metab Dispos 41:1994-2003.
    • (2013) Drug Metab Dispos , vol.41 , pp. 1994-2003
    • Shardlow, C.1    Generaux, G.2    Patel, A.3    Tai, G.4    Tran, T.5    Bloomer, J.6
  • 14
    • 17644380257 scopus 로고    scopus 로고
    • Predicting drug disposition via application of BCS: Transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system
    • Wu CY and Benet LZ (2005) Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res 22:11-23.
    • (2005) Pharm Res , vol.22 , pp. 11-23
    • Wu, C.Y.1    Benet, L.Z.2
  • 15
    • 84888613878 scopus 로고    scopus 로고
    • CYP2B6 pharmacogenetics-based in vitro-in-vivo extrapolation (VIVE) of efavirenz clearance by PBPK modelling
    • Xu C, Quinney SK, Guo Y, Hall SD, Yi L, and Desta Z (2013) CYP2B6 pharmacogenetics-based in vitro-in-vivo extrapolation (VIVE) of efavirenz clearance by PBPK modelling. Drug Metab Dispos 41:2004-2011.
    • (2013) Drug Metab Dispos , vol.41 , pp. 2004-2011
    • Xu, C.1    Quinney, S.K.2    Guo, Y.3    Hall, S.D.4    Yi, L.5    Desta, Z.6
  • 16
    • 80053161024 scopus 로고    scopus 로고
    • Kinetic characterization of rat hepatic uptake of 16 actively transported drugs
    • Yabe Y, Galetin A, and Houston JB (2011) Kinetic characterization of rat hepatic uptake of 16 actively transported drugs. Drug Metab Dispos 39:1808-1814.
    • (2011) Drug Metab Dispos , vol.39 , pp. 1808-1814
    • Yabe, Y.1    Galetin, A.2    Houston, J.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.