메뉴 건너뛰기




Volumn 2013, Issue , 2013, Pages

Subtoxic levels of apigenin inhibit expression and secretion of VEGF by uveal melanoma cells via suppression of ERK1/2 and PI3K/AKT pathways

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APIGENIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; VASCULOTROPIN;

EID: 84888598216     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/817674     Document Type: Article
Times cited : (21)

References (38)
  • 1
    • 26844447940 scopus 로고    scopus 로고
    • Population-based incidence of uveal melanoma in various races and ethnic groups
    • DOI 10.1016/j.ajo.2005.05.034, PII S0002939405006136
    • Hu D. N., Yu G. P., McCormick S. A., Schneider S., Finger P. T., Population-based incidence of uveal melanoma in various races and ethnic groups. American Journal of Ophthalmology 2005 140 4 612 617 2-s2.0-26844447940 10.1016/j.ajo.2005.05.034 (Pubitemid 41455300)
    • (2005) American Journal of Ophthalmology , vol.140 , Issue.4
    • Hu, D.-N.1    Yu, G.-P.2    McCormick, S.A.3    Schneider, S.4    Finger, P.T.5
  • 2
    • 0142200859 scopus 로고    scopus 로고
    • Very Long-Term Prognosis of Patients with Malignant Uveal Melanoma
    • DOI 10.1167/iovs.03-0538
    • Kujala E., Mäkitie T., Kivelä T., Very long-term prognosis of patients with malignant uveal melanoma. Investigative Ophthalmology and Visual Science 2003 44 11 4651 4659 2-s2.0-0142200859 10.1167/iovs.03-0538 (Pubitemid 37315273)
    • (2003) Investigative Ophthalmology and Visual Science , vol.44 , Issue.11 , pp. 4651-4659
    • Kujala, E.1    Makitie, T.2    Kivela, T.3
  • 3
    • 67349216128 scopus 로고    scopus 로고
    • Effectiveness of treatments for metastatic uveal melanoma
    • 2-s2.0-67349216128 10.1016/j.ajo.2009.01.023
    • Augsburger J. J., Corrêa Z. M., Shaikh A. H., Effectiveness of treatments for metastatic uveal melanoma. American Journal of Ophthalmology 2009 148 1 119 127 2-s2.0-67349216128 10.1016/j.ajo.2009.01.023
    • (2009) American Journal of Ophthalmology , vol.148 , Issue.1 , pp. 119-127
    • Augsburger, J.J.1    Corrêa, Z.M.2    Shaikh, A.H.3
  • 4
    • 4344692045 scopus 로고    scopus 로고
    • Constitutive and inducible expression and regulation of vascular endothelial growth factor
    • DOI 10.1016/j.cytogfr.2004.04.003, PII S1359610104000413
    • Xie K., Wei D., Shi Q., Huang S., Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine and Growth Factor Reviews 2004 15 5 297 324 2-s2.0-4344692045 10.1016/j.cytogfr.2004.04.003 (Pubitemid 39140697)
    • (2004) Cytokine and Growth Factor Reviews , vol.15 , Issue.5 , pp. 297-324
    • Xie, K.1    Wei, D.2    Shi, Q.3    Huang, S.4
  • 5
    • 14044271973 scopus 로고    scopus 로고
    • Transcriptional regulation of vascular endothelial growth factor in cancer
    • DOI 10.1016/j.cytogfr.2005.01.005
    • Loureiro R. M. B., D'Amore P. A., Transcriptional regulation of vascular endothelial growth factor in cancer. Cytokine and Growth Factor Reviews 2005 16 1 77 89 2-s2.0-14044271973 10.1016/j.cytogfr.2005.01.005 (Pubitemid 40279118)
    • (2005) Cytokine and Growth Factor Reviews , vol.16 , Issue.1 , pp. 77-89
    • Loureiro, R.M.B.1    D'Amore, P.A.2
  • 6
    • 84883345017 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression and inhibition in uveal melanoma cell lines
    • article 336 10.3332/ecancer.2013.336
    • Logan P., Burnier J., Burnier M. N. Jr., Vascular endothelial growth factor expression and inhibition in uveal melanoma cell lines. Ecancermedicalscience 2013 7 article 336 10.3332/ecancer.2013.336
    • (2013) Ecancermedicalscience , vol.7
    • Logan, P.1    Burnier, J.2    Burnier Jr., M.N.3
  • 9
    • 79952760563 scopus 로고    scopus 로고
    • VEGF as a biomarker for metastatic uveal melanoma in humans
    • 2-s2.0-79952760563 10.3109/02713683.2010.534573
    • Barak V., Pe'er J., Kalickman I., Frenkel S., VEGF as a biomarker for metastatic uveal melanoma in humans. Current Eye Research 2011 36 4 386 390 2-s2.0-79952760563 10.3109/02713683.2010.534573
    • (2011) Current Eye Research , vol.36 , Issue.4 , pp. 386-390
    • Barak, V.1    Pe'Er, J.2    Kalickman, I.3    Frenkel, S.4
  • 10
    • 77953189137 scopus 로고    scopus 로고
    • Apigenin: A promising molecule for cancer prevention
    • 2-s2.0-77953189137 10.1007/s11095-010-0089-7
    • Shukla S., Gupta S., Apigenin: a promising molecule for cancer prevention. Pharmaceutical Research 2010 27 6 962 978 2-s2.0-77953189137 10.1007/s11095-010-0089-7
    • (2010) Pharmaceutical Research , vol.27 , Issue.6 , pp. 962-978
    • Shukla, S.1    Gupta, S.2
  • 11
    • 34248226610 scopus 로고    scopus 로고
    • Apigenin and cancer chemoprevention: Progress, potential and promise (review)
    • 2-s2.0-34248226610
    • Patel D., Shukla S., Gupta S., Apigenin and cancer chemoprevention: progress, potential and promise (review). International Journal of Oncology 2007 30 1 233 245 2-s2.0-34248226610
    • (2007) International Journal of Oncology , vol.30 , Issue.1 , pp. 233-245
    • Patel, D.1    Shukla, S.2    Gupta, S.3
  • 12
    • 14644432362 scopus 로고    scopus 로고
    • Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
    • DOI 10.1096/fj.04-2175com
    • Fang J., Xia C., Cao Z., Zheng J. Z., Reed E., Jiang B. H., Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB Journal 2005 19 3 342 353 2-s2.0-14644432362 10.1096/fj.04-2175com (Pubitemid 40316522)
    • (2005) FASEB Journal , vol.19 , Issue.3 , pp. 342-353
    • Fang, J.1    Xia, C.2    Cao, Z.3    Zheng, J.Z.4    Reed, E.5    Jiang, B.-H.6
  • 13
    • 34047132303 scopus 로고    scopus 로고
    • Apigenin inhibits tumor angiogenesis through decreasing HIF-1α and VEGF expression
    • DOI 10.1093/carcin/bgl205
    • Fang J., Zhou Q., Liu L. Z., Xia C., Hu X., Shi X., Jiang B. H., Apigenin inhibits tumor angiogenesis through decreasing HIF-1 and VEGF expression. Carcinogenesis 2007 28 4 858 864 2-s2.0-34047132303 10.1093/carcin/bgl205 (Pubitemid 46523341)
    • (2007) Carcinogenesis , vol.28 , Issue.4 , pp. 858-864
    • Fang, J.1    Zhou, Q.2    Liu, L.-Z.3    Xia, C.4    Hu, X.5    Shi, X.6    Jiang, B.-H.7
  • 14
    • 50249087534 scopus 로고    scopus 로고
    • Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells
    • 2-s2.0-50249087534 10.1002/mc.20421
    • Mirzoeva S., Nam D. K., Chiu K., Franzen C. A., Bergan R. C., Pelling J. C., Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells. Molecular Carcinogenesis 2008 47 9 686 700 2-s2.0-50249087534 10.1002/mc.20421
    • (2008) Molecular Carcinogenesis , vol.47 , Issue.9 , pp. 686-700
    • Mirzoeva, S.1    Nam, D.K.2    Chiu, K.3    Franzen, C.A.4    Bergan, R.C.5    Pelling, J.C.6
  • 15
    • 2442424073 scopus 로고    scopus 로고
    • Suppression of Constitutive and Tumor Necrosis Factor α-Induced Nuclear Factor (NF)-κB Activation and Induction of Apoptosis by Apigenin in Human Prostate Carcinoma PC-3 Cells: Correlation with Down-Regulation of NF-κB-Responsive Genes
    • DOI 10.1158/1078-0432.CCR-03-0586
    • Shukla S., Gupta S., Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes. Clinical Cancer Research 2004 10 9 3169 3178 2-s2.0-2442424073 10.1158/1078-0432.CCR-03-0586 (Pubitemid 38619698)
    • (2004) Clinical Cancer Research , vol.10 , Issue.9 , pp. 3169-3178
    • Shukla, S.1    Gupta, S.2
  • 16
    • 80051534217 scopus 로고    scopus 로고
    • Apigenin prevents development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumors in sprague-dawley rats
    • 2-s2.0-80051534217 10.1158/1940-6207.CAPR-10-0382
    • Mafuvadze B., Benakanakere I., López Pérez F. R., Besch-Williford C., Ellersieck M. R., Hyder S. M., Apigenin prevents development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene- induced mammary tumors in sprague-dawley rats. Cancer Prevention Research 2011 4 8 1316 1324 2-s2.0-80051534217 10.1158/1940-6207.CAPR-10-0382
    • (2011) Cancer Prevention Research , vol.4 , Issue.8 , pp. 1316-1324
    • Mafuvadze, B.1    Benakanakere, I.2    López Pérez, F.R.3    Besch-Williford, C.4    Ellersieck, M.R.5    Hyder, S.M.6
  • 17
    • 84862679196 scopus 로고    scopus 로고
    • Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model
    • 2-s2.0-82355170167 10.1007/s11095-011-0625-0
    • Shukla S., MacLennan G. T., Fu P., Gupta S., Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model. Pharmaceutical Research 2012 29 6 1506 1517 2-s2.0-82355170167 10.1007/s11095-011-0625-0
    • (2012) Pharmaceutical Research , vol.29 , Issue.6 , pp. 1506-1517
    • Shukla, S.1    Maclennan, G.T.2    Fu, P.3    Gupta, S.4
  • 18
    • 79957639518 scopus 로고    scopus 로고
    • A mechanism of apigenin-induced apoptosis is potentially related to anti-angiogenesis and anti-migration in human hepatocellular carcinoma cells
    • 2-s2.0-79957639518 10.1016/j.fct.2011.04.015
    • Kim B. R., Jeon Y. K., Nam M. J., A mechanism of apigenin-induced apoptosis is potentially related to anti-angiogenesis and anti-migration in human hepatocellular carcinoma cells. Food and Chemical Toxicology 2011 49 7 1626 1632 2-s2.0-79957639518 10.1016/j.fct.2011.04.015
    • (2011) Food and Chemical Toxicology , vol.49 , Issue.7 , pp. 1626-1632
    • Kim, B.R.1    Jeon, Y.K.2    Nam, M.J.3
  • 19
    • 79954598113 scopus 로고    scopus 로고
    • Apigenin down-regulates the hypoxia response genes: HIF-1 , GLUT-1, and VEGF in human pancreatic cancer cells
    • 2-s2.0-79954598113 10.1016/j.jss.2010.10.041
    • Melstrom L. G., Salabat M. R., Ding X. Z., Strouch M. J., Grippo P. J., Mirzoeva S., Pelling J. C., Bentrem D. J., Apigenin down-regulates the hypoxia response genes: HIF-1 GLUT-1, and VEGF in human pancreatic cancer cells. Journal of Surgical Research 2011 167 2 173 181 2-s2.0-79954598113 10.1016/j.jss.2010. 10.041
    • (2011) Journal of Surgical Research , vol.167 , Issue.2 , pp. 173-181
    • Melstrom, L.G.1    Salabat, M.R.2    Ding, X.Z.3    Strouch, M.J.4    Grippo, P.J.5    Mirzoeva, S.6    Pelling, J.C.7    Bentrem, D.J.8
  • 20
    • 56249133327 scopus 로고    scopus 로고
    • Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids
    • 2-s2.0-56249133327 10.1080/01635580802100851
    • Luo H., Jiang B. H., King S. M., Chen Y. C., Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids. Nutrition and Cancer 2008 60 6 800 809 2-s2.0-56249133327 10.1080/01635580802100851
    • (2008) Nutrition and Cancer , vol.60 , Issue.6 , pp. 800-809
    • Luo, H.1    Jiang, B.H.2    King, S.M.3    Chen, Y.C.4
  • 21
    • 23944521126 scopus 로고    scopus 로고
    • Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: Implication of chemoprevention of lung cancer
    • DOI 10.1124/mol.105.011254
    • Liu L. Z., Fang J., Zhou Q., Hu X., Shi X., Jiang B. H., Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer. Molecular Pharmacology 2005 68 3 635 643 2-s2.0-23944521126 10.1124/mol.105. 011254 (Pubitemid 41206017)
    • (2005) Molecular Pharmacology , vol.68 , Issue.3 , pp. 635-643
    • Liu, L.-Z.1    Fang, J.2    Zhou, Q.3    Hu, X.4    Shi, X.5    Jiang, B.-H.6
  • 22
    • 0027197111 scopus 로고
    • Studies of human uveal melanocytes in vitro: Isolation, purification and cultivation of human uveal melanocytes
    • Hu D. N., McCormick S. A., Ritch R., Pelton-Henrion K., Studies of human uveal melanocytes in vitro: isolation, purification and cultivation of human uveal melanocytes. Investigative Ophthalmology and Visual Science 1993 34 7 2210 2219 2-s2.0-0027197111 (Pubitemid 23191247)
    • (1993) Investigative Ophthalmology and Visual Science , vol.34 , Issue.7 , pp. 2210-2219
    • Hu, D.-N.1    McCormick, S.A.2    Ritch, R.3    Pelton-Henrion, K.4
  • 23
    • 0034565169 scopus 로고    scopus 로고
    • Regulation of growth and melanogenesis of uveal melanocytes
    • 2-s2.0-0034565169
    • Hu D. N., Regulation of growth and melanogenesis of uveal melanocytes. Pigment Cell Research 2000 13 8 81 86 2-s2.0-0034565169
    • (2000) Pigment Cell Research , vol.13 , Issue.8 , pp. 81-86
    • Hu, D.N.1
  • 24
    • 0034769544 scopus 로고    scopus 로고
    • A functional study on prostanoid receptors involved in cultured human iridal melanocyte stimulation
    • DOI 10.1006/exer.2001.1011
    • Hu D. N., McCormick S. A., Woodward D. F., A functional study on prostanoid receptors involved in cultured human iridal melanocyte stimulation. Experimental Eye Research 2001 73 1 93 100 2-s2.0-0034769544 10.1006/exer.2001.1011 (Pubitemid 32977968)
    • (2001) Experimental Eye Research , vol.73 , Issue.1 , pp. 93-100
    • Hu, D.-N.1    Mccormick, S.A.2    Woodward, D.F.3
  • 25
    • 65449154005 scopus 로고    scopus 로고
    • Comparison of eumelanin and pheomelanin content between cultured uveal melanoma cells and normal uveal melanocytes
    • 2-s2.0-65449154005 10.1097/CMR.0b013e328329ae49
    • Hu D. N., Wakamatsu K., Ito S., McCormick S. A., Comparison of eumelanin and pheomelanin content between cultured uveal melanoma cells and normal uveal melanocytes. Melanoma Research 2009 19 2 75 79 2-s2.0-65449154005 10.1097/CMR.0b013e328329ae49
    • (2009) Melanoma Research , vol.19 , Issue.2 , pp. 75-79
    • Hu, D.N.1    Wakamatsu, K.2    Ito, S.3    McCormick, S.A.4
  • 27
    • 0029950678 scopus 로고    scopus 로고
    • Expression of type VI collagen in uveal melanoma: Its role in pattern formation and tumor progression
    • Daniels K. J., Boldt H. C., Martin J. A., Gardner L. M., Meyer M., Folberg R., Expression of type VI collagen in uveal melanoma: its role in pattern formation and tumor progression. Laboratory Investigation 1996 75 1 55 66 2-s2.0-0029950678 (Pubitemid 26250273)
    • (1996) Laboratory Investigation , vol.75 , Issue.1 , pp. 55-66
    • Daniels, K.J.1    Boldt, H.C.2    Martin, J.A.3    Gardner, L.M.4    Meyer, M.5    Folberg, R.6
  • 30
    • 0036216639 scopus 로고    scopus 로고
    • Uveal melanomas express vascular endothelial growth factor and basic fibroblast growth factor and support endothelial cell growth
    • DOI 10.1136/bjo.86.4.440
    • Boyd S. R., Tan D. S. W., de Souza L., Neale M. H., Myatt N. E., Alexander R. A., Robb M., Hungerford J. L., Cree I. A., Uveal melanomas express vascular endothelial growth factor and basic fibroblast growth factor and support endothelial cell growth. British Journal of Ophthalmology 2002 86 4 440 447 2-s2.0-0036216639 10.1136/bjo.86.4.440 (Pubitemid 34293295)
    • (2002) British Journal of Ophthalmology , vol.86 , Issue.4 , pp. 440-447
    • Boyd, S.R.1    Tan, D.S.W.2    De Souza, L.3    Neale, M.H.4    Myatt, N.E.5    Alexander, R.A.6    Robb, M.7    Hungerford, J.L.8    Cree, I.A.9
  • 31
    • 0033921038 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in uveal melanoma and its correlation with metastasis
    • DOI 10.1136/bjo.84.7.750
    • Sheidow T. G., Hooper P. L., Crukley C., Young J., Heathcote J. G., Expression of vascular endothelial growth factor in uveal melanoma and its correlation with metastasis. British Journal of Ophthalmology 2000 84 7 750 756 2-s2.0-0033921038 10.1136/bjo.84.7.750 (Pubitemid 30438555)
    • (2000) British Journal of Ophthalmology , vol.84 , Issue.7 , pp. 750-756
    • Sheidow, T.G.1    Hooper, P.L.2    Crukley, C.3    Young, J.4    Heathcote, J.G.5
  • 33
    • 0036221217 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is elevated in ocular fluids of eyes harbouring uveal melanoma: Identification of a potential therapeutic window
    • DOI 10.1136/bjo.86.4.448
    • Boyd S. R., Tan D., Bunce C., Gittos A., Neale M. H., Hungerford J. L., Charnock-Jones S., Cree I. A., Vascular endothelial growth factor is elevated in ocular fluids of eyes harbouring uveal melanoma: identification of a potential therapeutic window. British Journal of Ophthalmology 2002 86 4 448 452 2-s2.0-0036221217 10.1136/bjo.86.4.448 (Pubitemid 34293296)
    • (2002) British Journal of Ophthalmology , vol.86 , Issue.4 , pp. 448-452
    • Boyd, S.R.1    Tan, D.2    Bunce, C.3    Gittos, A.4    Neale, M.H.5    Hungerford, J.L.6    Charnock-Jones, S.7    Cree, I.A.8
  • 34
    • 33646907501 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells
    • DOI 10.1074/jbc.M600228200
    • Calipel A., Mouriaux F., Glotin A. L., Malecaze F., Faussat A. M., Mascarelli F., Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells. Journal of Biological Chemistry 2006 281 14 9238 9250 2-s2.0-33646907501 10.1074/jbc.M600228200 (Pubitemid 43864639)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.14 , pp. 9238-9250
    • Calipel, A.1    Mouriaux, F.2    Glotin, A.-L.3    Malecaze, F.4    Faussat, A.-M.5    Mascarelli, F.6
  • 36
    • 77949545648 scopus 로고    scopus 로고
    • Evaluation of the mTOR pathway in ocular (uvea and conjunctiva) melanoma
    • 2-s2.0-77949545648 10.1097/CMR.0b013e32832ccd09
    • Pópulo H., Soares P., Rocha A. S., Silva P., Lopes J. M., Evaluation of the mTOR pathway in ocular (uvea and conjunctiva) melanoma. Melanoma Research 2010 20 2 107 117 2-s2.0-77949545648 10.1097/CMR. 0b013e32832ccd09
    • (2010) Melanoma Research , vol.20 , Issue.2 , pp. 107-117
    • Pópulo, H.1    Soares, P.2    Rocha, A.S.3    Silva, P.4    Lopes, J.M.5
  • 37
    • 23744472959 scopus 로고    scopus 로고
    • Immunohistochemical expression of phospho-Akt in uveal melanoma
    • DOI 10.1097/00008390-200508000-00003
    • Saraiva V. S., Caissie A. L., Segal L., Edelstein C., Burnier M. N. Jr., Immunohistochemical expression of phospho-Akt in uveal melanoma. Melanoma Research 2005 15 4 245 250 2-s2.0-23744472959 10.1097/00008390-200508000-00003 (Pubitemid 41127459)
    • (2005) Melanoma Research , vol.15 , Issue.4 , pp. 245-250
    • Saraiva, V.S.1    Caissie, A.L.2    Segal, L.3    Edelstein, C.4    Burnier Jr., M.N.5
  • 38
    • 64049119151 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met
    • 2-s2.0-64049119151 10.1167/iovs.08-2681
    • Yan D., Zhou X., Chen X., Hu D. N., Dong X. D., Wang J., Lu F., Tu L. L., Qu J., MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met. Investigative Ophthalmology and Visual Science 2009 50 4 1559 1565 2-s2.0-64049119151 10.1167/iovs.08-2681
    • (2009) Investigative Ophthalmology and Visual Science , vol.50 , Issue.4 , pp. 1559-1565
    • Yan, D.1    Zhou, X.2    Chen, X.3    Hu, D.N.4    Dong, X.D.5    Wang, J.6    Lu, F.7    Tu, L.L.8    Qu, J.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.