Microbubble type and distribution dependence of focused ultrasound-induced blood-brain barrier opening

Ultrasound in Medicine and Biology

Volumn 40, Issue 1, 2014, Pages 130-137

  Wang, Shutao ^a   Samiotaki, Gesthimani ^a   Olumolade, Oluyemi ^a   Feshitan, Jameel A ^a   Konofagou, Elisa E ^a,b  

^a Columbia University ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Blood brain barrier opening; Focused ultrasound; Microbubble distribution; Microbubble type

Indexed keywords

BLOOD; CAVITATION; MAGNETIC RESONANCE IMAGING; MAMMALS; POLYDISPERSITY;

ACOUSTIC PRESSURES; BLOOD-BRAIN BARRIER; FOCUSED ULTRASOUND; IMAGE-BASED ANALYSIS; INERTIAL CAVITATION; MICRO-BUBBLE; PULSE REPETITION FREQUENCIES; ULTRASOUND CONTRAST AGENT;

ULTRASONICS;

DIAGNOSTIC AGENT; GADODIAMIDE; INHOUSE PREPARED POLYDISPERSE MICROBUBBLE; PERFLUTREN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MONITORING; BLOOD BRAIN BARRIER; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG SCREENING; ECHOGRAPHY; EXTRAVASATION; FOCUSED ULTRASOUND; HISTOLOGY; IMAGE ANALYSIS; MICROBUBBLE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

BLOOD-BRAIN BARRIER OPENING; FOCUSED ULTRASOUND; MICROBUBBLE DISTRIBUTION; MICROBUBBLE TYPE;

ANIMALS; BLOOD-BRAIN BARRIER; ELECTROPORATION; FLUOROCARBONS; HIGH-ENERGY SHOCK WAVES; MICE; MICE, INBRED C57BL; MICROBUBBLES; PERMEABILITY; RADIATION DOSAGE; SONICATION;

EID: 84888439313     PISSN: 03015629     EISSN: 1879291X     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2013.09.015     Document Type: Article

References (27)

1. Arvanitis C.D., Livingstone M.S., Vykhodtseva N., McDannold N. Controlled ultrasound-induced blood-brain barrier disruption usingpassive acoustic emissions monitoring. PloS One 2012, 7:e45783.
2. Baseri B., Choi J.J., Tung Y.S., Konofagou E.E. Multi-modality safety assessment of blood-brain barrier opening using focused ultrasound and definity microbubbles: a short-term study. Ultrasound Med Biol 2010, 36:1445-1459.
3. Cheung K., Couture O., Bevan P.D., Cherin E., Williams R., Burns P.N., Foster F.S. Invitro characterization of the subharmonic ultrasound signal from Definity microbubbles at high frequencies. Phys Med Biol 2008, 53:1209-1223.
4. Choi J.J., Pernot M., Small S.A., Konofagou E.E. Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice. Ultrasound Med Biol 2007, 33:95-104.
5. Choi J.J., Wang S., Brown T.R., Small S.A., Duff K.E., Konofagou E.E. Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound. Ultrason Imaging 2008, 30:189-200.
6. Elias WJ, Huss D, Khaled MA, Monteith SJ, Frysinger R, Loomba J, Druzgal J, Wylie S, Voss T, Harrison M, Wooten F, Wintermark MD. MR Guided focused ultrasound lesioning for the treatment of essential tremor: A new paradigm for noninvasive lesioning and neuromodulation. In: Congress of Neurological Surgeons 2011 Annual Meeting, Washington, DC,2011.
7. Feshitan J.A., Chen C.C., Kwan J.J., Borden M.A. Microbubble size isolation by differential centrifugation. JColloid Interface Sc 2009, 329:316-324.
8. Goertz D.E., de Jong N., van der Steen A.F. Attenuation and size distribution measurements of Definity and manipulated Definity populations. Ultrasound Med Biol 2007, 33:1376-1388.
9. Helfield B.L., Huo X., Williams R., Goertz D.E. The effect of preactivation vial temperature on the acoustic properties of Definity. Ultrasound Med Biol 2012, 38:1298-1305.
10. Hynynen K., McDannold N., Vykhodtseva N., Jolesz F.A. Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology 2001, 220:640-646.
11. Lipsman N., Schwartz M.L., Huang Y., Lee L., Sankar T., Chapman M., Hynynen K., Lozano A.M. MR-guided focused ultrasound thalamotomy for essential tremor: A proof-of-concept study. Lancet Neurol 2013, 12:462-468.
12. Luan Y., Faez T., Gelderblom E., Skachkov I., Geers B., Lentacker I., vander Steen T., Versluis M., de Jong N. Acoustical properties of individual liposome-loaded microbubbles. Ultrasound Med Biol 2012, 38:2174-2185.
13. Marquet F., Tung Y.S., Teichert T., Ferrera V.P., Konofagou E.E. Noninvasive, transient and selective blood-brain barrier opening in non-human primates invivo. PloS One 2011, 6:e22598.
14. McDannold N., Arvanitis C.D., Vykhodtseva N., Livingstone M.S. Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: Safety and efficacy evaluation in rhesus macaques. Cancer Res 2012, 72:3652-3663.
15. McDannold N., Vykhodtseva N., Hynynen K. Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption. Ultrasound Med Biol 2008, 34:930-937.
16. Pardridge W.M. The blood-brain barrier: Bottleneck in brain drug development. NeuroRx 2005, 2:3-14.
17. Parker G., Buckley D. Tracer kinetic modelling for T1-weighted dynamic contrast-enhanced MRI. Dynamic contrast-enhanced magnetic resonance imaging in oncology 2005, 81-92. Springer, Berlin/Heidelberg. A. Jackson, D. Buckley, G. Parker (Eds.).
18. Samiotaki G., Vlachos F., Tung Y.S., Konofagou E.E. Aquantitative pressure and microbubble-size dependence study of focused ultrasound-induced blood-brain barrier opening reversibility invivo using MRI. Magn Reson Med 2012, 67:769-777.
19. Sirsi S., Borden M. Microbubble compositions, properties and biomedical applications. Bubble Sci Eng Technol 2009, 1:3-17.
20. Tung Y.S., Marquet F., Teichert T., Ferrera V., Konofagou E.E. Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates. Appl Phys Lett 2011, 98:163704.
21. Tung YS, Olumolade OO, Wang S, Wu SY, Konofagou EE. Physical mechanism of non-inertial cavitation induced blood-brain barrier opening using focused ultrasound and microbubbles. In: Proceedings, 12th International Symposium on Therapeutic Ultrasound, Heidelberg, Germany,2012.
22. Tung Y.S., Choi J.J., Baseri B., Konofagou E.E. Identifying the inertial cavitation threshold and skull effects in a vessel phantom using focused ultrasound and microbubbles. Ultrasound Med Biol 2010, 36:840-852.
23. Tung Y.S., Vlachos F., Choi J.J., Deffieux T., Selert K., Konofagou E.E. Invivo transcranial cavitation threshold detection during ultrasound-induced blood-brain barrier opening in mice. Phys Med Biol 2010, 55:6141-6155.
24. Tung Y.S., Vlachos F., Feshitan J.A., Borden M.A., Konofagou E.E. The mechanism of interaction between focused ultrasound and microbubbles in blood-brain barrier opening in mice. JAcoust Soc Am 2011, 130:3059-3067.
25. Vlachos F., Tung Y.S., Konofagou E.E. Permeability assessment of the focused ultrasound-induced blood-brain barrier opening using dynamic contrast-enhanced MRI. Phys Med Biol 2010, 55:5451-5466.
26. Vlachos F., Tung Y.S., Konofagou E. Permeability dependence study of the focused ultrasound-induced blood-brain barrier opening at distinct pressures and microbubble diameters using DCE-MRI. Magn Reson Med 2011, 66:821-830.
27. Wiedemair W., Tukovic Z., Jasak H., Poulikakos D., Kurtcuoglu V. On ultrasound-induced microbubble oscillation in a capillary blood vessel and its implications for the blood-brain barrier. Phys Med Biol 2012, 57:1019-1045.