Does methotrexate administration for ectopic pregnancy after in vitro fertilization impact ovarian reserve or ovarian responsiveness?

Fertility and Sterility

Volumn 100, Issue 6, 2013, Pages 1590-1593

  Boots, Christina E ^a,b   Gustofson, Robert L ^c   Feinberg, Eve C ^b,d  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^c Rinehart Center for Reproductive Medicine   (United States)

^d Fertility Centers of Illinois   (United States)

Author keywords

ectopic pregnancy; in vitro fertilization; Methotrexate; ovarian reserve; ovarian responsiveness

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; ESTRADIOL; FOLLITROPIN; GONADOTROPIN DERIVATIVE; METHOTREXATE; ABORTIVE AGENT;

ADULT; ARTICLE; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; ECTOPIC PREGNANCY; EMBRYO DEVELOPMENT; EMBRYO TRANSFER; ENDOMETRIOSIS; ESTRADIOL BLOOD LEVEL; FEMALE; FEMALE FERTILITY; FEMALE INFERTILITY; FERTILIZATION; FERTILIZATION IN VITRO; GESTATIONAL AGE; GESTATIONAL SAC; GROUPS BY AGE; HUMAN; MAJOR CLINICAL STUDY; MALE INFERTILITY; MULTIPLE CYCLE TREATMENT; OOCYTE; OUTCOME ASSESSMENT; OVARIAN RESERVE; OVARIAN RESPONSIVENESS; OVARY FOLLICLE; OVARY FUNCTION; OVARY HYPERSTIMULATION; OVARY INSUFFICIENCY; PREGNANCY RATE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SINGLE DRUG DOSE; THERAPY EFFECT; TRANSVAGINAL ECHOGRAPHY; UTERINE TUBE DISEASE; VITRIFICATION; COMORBIDITY; DRUG EFFECTS; INFERTILITY, FEMALE; OVULATION; PREGNANCY; PREGNANCY, ECTOPIC; PREVALENCE; RISK FACTOR; TREATMENT OUTCOME; UNITED STATES;

ABORTIFACIENT AGENTS, NONSTEROIDAL; ADULT; CHICAGO; COHORT STUDIES; COMORBIDITY; FEMALE; HUMANS; INFERTILITY, FEMALE; METHOTREXATE; OVULATION; PREGNANCY; PREGNANCY RATE; PREGNANCY, ECTOPIC; PREVALENCE; RETROSPECTIVE STUDIES; RISK FACTORS; TREATMENT OUTCOME;

EID: 84888430852     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2013.08.007     Document Type: Article

References (19)

1. S.K. Van Den Eeden, J. Shan, C. Bruce, and M. Glasser Ectopic pregnancy rate and treatment utilization in a large managed care organization Obstet Gynecol 105 2005 1052
2. B.J. Van Voorhis Outcomes from assisted reproductive technology Obstet Gynecol 107 2006 183
3. S.B. Zane, B.A. Kieke Jr., J.S. Kendrick, and C. Bruce Surveillance in a time of changing health care practices: estimating ectopic pregnancy incidence in the United States Matern Child Health J 6 2002 227
4. American Society for Reproductive Medicine, and Society for Assisted Reproductive Technology Assisted reproductive technology in the United States: 1999 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry Fertil Steril 78 2002 918
5. S.A. Carson, and J.E. Buster Ectopic pregnancy N Engl J Med 329 1993 1174 1181
6. G.H. Lipscomb, M.L. McCord, T.G. Stovall, G. Huff, S.G. Portera, and F.W. Ling Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies N Engl J Med 341 1999 1974 1978
7. T.G. Stovall, F.W. Ling, L.A. Gray, S.A. Carson, and J.E. Buster Methotrexate treatment of unruptured ectopic pregnancy: a report of 100 cases Obstet Gynecol 77 1991 749 753
8. K.T. Barnhart, G. Gosman, R. Ashby, and M. Sammel The medical management of ectopic pregnancy: a meta-analysis comparing "single dose" and "multidose" regimens Obstet Gynecol 101 2003 778
9. T.G. Stovall, F.W. Ling, and J.E. Buster Reproductive performance after methotrexate treatment of ectopic pregnancy Am J Obstet Gynecol 162 1990 1620 1623
10. Z. Blumenfeld How to preserve fertility in young women exposed to chemotherapy? The role of GnRH agonist cotreatment in addition to cryopreservation of embryo, oocytes, or ovaries Oncologist 12 2007 1044
11. T.G. Stovall, F.W. Ling, and L.A. Gray Single-dose methotrexate for treatment of ectopic pregnancy Obstet Gynecol 77 1991 754 757
12. J.E. Buster, and S. Krotz Reproductive performance after ectopic pregnancy Sem Reprod Med 25 2007 131
13. K.A. Keefe, J.S. Wald, D.P. Goldstein, M. Bernstein, and R.S. Berkowitz Reproductive outcome after methotrexate treatment of tubal pregnancies J Reprod Med 43 1998 28
14. R. Orvieto, J. Kruchkovich, E. Zohav, and J. Rabinson Does methotrexate treatment for ectopic pregnancy influence the patient's performance during a subsequent in vitro fertilization/embryo transfer cycle? Fertil Steril 88 2007 1685 1686
15. B. Oriol, A. Barrio, A. Pacheco, J. Serna, J.L. Zuzuarregui, and J.A. Garcia-Velasco Systemic methotrexate to treat ectopic pregnancy does not affect ovarian reserve Fertil Steril 90 2008 1579 1582
16. M. Provansal, A. Agostini, O. Lacroix, S. Gerbeau, J.M. Grillo, and M. Gamerre Ultrasound monitoring in patients undergoing in-vitro fertilization after methotrexate treatment for ectopic pregnancy Ultrasound Obstet Gynecol 34 2009 715 719
17. J.F. McLaren, R.O. Burney, A.A. Milki, L.M. Westphal, M.H. Dahan, and R.B. Lathi Effect of methotrexate exposure on subsequent fertility in women undergoing controlled ovarian stimulation Fertil Steril 92 2009 515 519
18. S. Charache, P.T. Condit, and S.R. Humphreys Studies on the folic acid vitamins, and the persistence of amethopterin in mammalian tissues Cancer 13 1960 236 240
19. R. Svirsky, U. Rozovski, Z. Vaknin, M. Pansky, D. Schneider, and R. Halperin The safety of conception occurring shortly after methotrexate treatment of an ectopic pregnancy Reprod Toxicol 27 2009 85 87