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Volumn 54, Issue 5, 2013, Pages 480-488

Clinical significance of determining plasma homocysteine: Case-control study on arterial and venous thrombotic patients

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

EID: 84888413707     PISSN: 03539504     EISSN: 13328166     Source Type: Journal    
DOI: 10.3325/cmj.2013.54.480     Document Type: Article
Times cited : (10)

References (48)
  • 1
    • 79957624262 scopus 로고    scopus 로고
    • New antithrombotics: The impact on global health care
    • Medline:21529897 doi:10.1016/j.thromres.2011.03.022
    • Mahan CE, Fanikos J. New antithrombotics: The impact on global health care. Thromb Res. 2011;127:518-24. Medline:21529897 doi:10.1016/j.thromres.2011.03.022
    • (2011) Thromb Res. , vol.127 , pp. 518-524
    • Mahan, C.E.1    Fanikos, J.2
  • 2
    • 77951217314 scopus 로고    scopus 로고
    • Fibrinolytic parameters, lipid status and Lp(a) lipoprotein in ischemic stroke patients
    • Medline:20229676
    • Vuckovic B, Deric M, Iilic T, Canak V, Kojic-Damjanov S, Zarkov M, et al. Fibrinolytic parameters, lipid status and Lp(a) lipoprotein in ischemic stroke patients. Srp Arh Celok Lek. 2010;138 Suppl 1:12-7. Medline:20229676
    • (2010) Srp Arh Celok Lek. , vol.138 , Issue.SUPPL. 1 , pp. 12-17
    • Vuckovic, B.1    Deric, M.2    Iilic, T.3    Canak, V.4    Kojic-Damjanov, S.5    Zarkov, M.6
  • 3
    • 78649344437 scopus 로고    scopus 로고
    • Venous thrombosis in elderly: incidence, risk factors and risk groups
    • Medline:20629943 doi:10.1111/j.1538- 7836.2010.03986.x
    • E nghers MJ, vanHylckama AV, Rosendaal FR. Venous thrombosis in elderly: incidence, risk factors and risk groups. J Thromb Haemost. 2010;8:2105-10. Medline:20629943 doi:10.1111/j.1538- 7836.2010.03986.x
    • (2010) J Thromb Haemost. , vol.8 , pp. 2105-2110
    • Enghers, M.J.1    vanHylckama, A.V.2    Rosendaal, F.R.3
  • 5
    • 84888407698 scopus 로고    scopus 로고
    • Hyperhomocysteinemia as risk factor of occlusive vascular diseases with estimation of laboratory methods for homocysteine determination [in Serbian]
    • PhD thesis. School of Medicine, Novi Sad University
    • Milosevic-Tosic M. Hyperhomocysteinemia as risk factor of occlusive vascular diseases with estimation of laboratory methods for homocysteine determination [in Serbian]. PhD thesis. School of Medicine, Novi Sad University; 2010.
    • (2010)
    • Milosevic-Tosic, M.1
  • 6
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis
    • Medline:5792556
    • McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969;56:111- 28. Medline:5792556
    • (1969) Am J Pathol. , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 8
    • 0031982698 scopus 로고    scopus 로고
    • Variability and determinants of total homocysteine concentrations in plasma in an elderly population
    • Medline:9550566
    • Clarke R, Woodhouse P, Ulvik A, Frost C, Sherliker P, Refsum H, et al. Variability and determinants of total homocysteine concentrations in plasma in an elderly population. Clin Chem. 1998;44:102-7. Medline:9550566
    • (1998) Clin Chem. , vol.44 , pp. 102-107
    • Clarke, R.1    Woodhouse, P.2    Ulvik, A.3    Frost, C.4    Sherliker, P.5    Refsum, H.6
  • 9
    • 80051695692 scopus 로고    scopus 로고
    • Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta analysis of genetic studies and randomized trials
    • Medline:21803414 doi:10.1016/S0140- 6736(11)60872-6
    • H olmes MV, Newcombe P, Hubacek JA, Sofat R, Ricketts SL, Cooper J, et al. Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta analysis of genetic studies and randomized trials. Lancet. 2011;378:584-94. Medline:21803414 doi:10.1016/S0140- 6736(11)60872-6
    • (2011) Lancet. , vol.378 , pp. 584-594
    • Holmes, M.V.1    Newcombe, P.2    Hubacek, J.A.3    Sofat, R.4    Ricketts, S.L.5    Cooper, J.6
  • 11
    • 33748349409 scopus 로고    scopus 로고
    • Significance of hyperhomocysteinemia
    • H errman W. Significance of hyperhomocysteinemia. Clin Lab Med. 2006;52:367-74.
    • (2006) Clin Lab Med. , vol.52 , pp. 367-374
    • Herrman, W.1
  • 12
    • 0037300574 scopus 로고    scopus 로고
    • Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and double blind placebo-controlled trial
    • Medline:12535752 doi:10.1016/S0021- 9150(02)00372-6
    • Christ-Crain M, Meier C, Guglielmetti M, Huber PR, Riesen W, Staub JJ, et al. Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and double blind placebo-controlled trial. Atherosclerosis. 2003;166:379-86. Medline:12535752 doi:10.1016/S0021- 9150(02)00372-6
    • (2003) Atherosclerosis. , vol.166 , pp. 379-386
    • Christ-Crain, M.1    Meier, C.2    Guglielmetti, M.3    Huber, P.R.4    Riesen, W.5    Staub, J.J.6
  • 13
    • 0032743831 scopus 로고    scopus 로고
    • International Hcy group. Determination of homocysteine reference intervals: Data from the European Automated FPIA study
    • Michel G, Staub U, Schroeder G, Shih J; International Hcy group. Determination of homocysteine reference intervals: Data from the European Automated FPIA study. Clin Lab. 1999;45:651-6.
    • (1999) Clin Lab. , vol.45 , pp. 651-656
    • Michel, G.1    Staub, U.2    Schroeder, G.3    Shih, J.4
  • 14
    • 0033882025 scopus 로고    scopus 로고
    • Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs
    • Medline:10926922
    • Klee GG. Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs. vitamin B12 and folate. Clin Chem. 2000;46:1277-83. Medline:10926922
    • (2000) vitamin B12 and folate. Clin Chem. , vol.46 , pp. 1277-1283
    • Klee, G.G.1
  • 15
    • 78649640615 scopus 로고    scopus 로고
    • FV Leiden mutation and deep venous thrombosis in Vojvodina: a case-control study
    • doi:10.2478/v10011-010-0050-7
    • Salatic I, Kiralj K, Mitic G, Veselinovic I, Vapa D. FV Leiden mutation and deep venous thrombosis in Vojvodina: a case-control study. J Med Biochem. 2011;30:51-4. doi:10.2478/v10011-010-0050-7
    • (2011) J Med Biochem. , vol.30 , pp. 51-54
    • Salatic, I.1    Kiralj, K.2    Mitic, G.3    Veselinovic, I.4    Vapa, D.5
  • 16
    • 84868573713 scopus 로고    scopus 로고
    • C677T methylenetetrahydrofolate reductase gene polymorphism as a risk factor involved in venous thromboembolism: a population based case-control study
    • Medline:22992862
    • Yin G, Yan L, Zhang Z, Chen K, Jin X. C677T methylenetetrahydrofolate reductase gene polymorphism as a risk factor involved in venous thromboembolism: a population based case-control study. Mol Med Rep. 2012;6:1271-5. Medline:22992862
    • (2012) Mol Med Rep. , vol.6 , pp. 1271-1275
    • Yin, G.1    Yan, L.2    Zhang, Z.3    Chen, K.4    Jin, X.5
  • 17
    • 0028845307 scopus 로고
    • Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men
    • Medline:7475822 doi:10.1016/S0140-6736(95)92407-8
    • Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet. 1995;346:1395-8. Medline:7475822 doi:10.1016/S0140-6736(95)92407-8
    • (1995) Lancet. , vol.346 , pp. 1395-1398
    • Perry, I.J.1    Refsum, H.2    Morris, R.W.3    Ebrahim, S.B.4    Ueland, P.M.5    Shaper, A.G.6
  • 18
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes
    • Medline:7563456 doi:10.1001/ jama.1995.03530130055028
    • Boushey CJ, Beresford SAA, Omen GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes. JAMA. 1995;274:1049-57. Medline:7563456 doi:10.1001/ jama.1995.03530130055028
    • (1995) JAMA. , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.A.2    Omen, G.S.3    Motulsky, A.G.4
  • 19
    • 0037164375 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: evidence on causality from meta-analysis
    • Medline:12446535 doi:10.1136/ bmj.325.7374.1202
    • Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from meta-analysis. BMJ. 2002;325:1202-6. Medline:12446535 doi:10.1136/ bmj.325.7374.1202
    • (2002) BMJ. , vol.325 , pp. 1202-1206
    • Wald, D.S.1    Law, M.2    Morris, J.K.3
  • 20
    • 33645796222 scopus 로고    scopus 로고
    • NORVIT Trial Investigators. Homocysteine lowering and cardiovascular events after acute myocardial infarction
    • Medline:16531614 doi:10.1056/NEJMoa055227
    • Bonaa KH, Njolstad I, Ueland PM; NORVIT Trial Investigators. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med. 2006;354:1578-88. Medline:16531614 doi:10.1056/NEJMoa055227
    • (2006) N Engl J Med. , vol.354 , pp. 1578-1588
    • Bonaa, K.H.1    Njolstad, I.2    Ueland, P.M.3
  • 22
    • 0037345584 scopus 로고    scopus 로고
    • Hyperhomocysteinemia: a million ways to lose control
    • Medline:12639825 doi:10.1161/01.ATV.0000063607.56590.7F
    • Faraci FM. Hyperhomocysteinemia: a million ways to lose control. Arterioscler Thromb Vasc Biol. 2003;23:371-3. Medline:12639825 doi:10.1161/01.ATV.0000063607.56590.7F
    • (2003) Arterioscler Thromb Vasc Biol. , vol.23 , pp. 371-373
    • Faraci, F.M.1
  • 23
    • 0033620779 scopus 로고    scopus 로고
    • Homocysteine and vascular disease
    • Medline:10437885 doi:10.1016/S0140- 6736(98)11058-9
    • H ankey GJ, Eikelboom JW. Homocysteine and vascular disease. Lancet. 1999;354:407-13. Medline:10437885 doi:10.1016/S0140- 6736(98)11058-9
    • (1999) Lancet. , vol.354 , pp. 407-413
    • Hankey, G.J.1    Eikelboom, J.W.2
  • 24
    • 0034827634 scopus 로고    scopus 로고
    • Defects as important factors for moderate hyperhomocysteinemia
    • Medline:11592436 doi:10.1515/CCLM.2001.115
    • Geisel J, Zimbelmann I, Schorr H, Knapp JP, Bodis M, Hubner U, et al. Defects as important factors for moderate hyperhomocysteinemia. Clin Chem Lab Med. 2001;39:698-704. Medline:11592436 doi:10.1515/CCLM.2001.115
    • (2001) Clin Chem Lab Med. , vol.39 , pp. 698-704
    • Geisel, J.1    Zimbelmann, I.2    Schorr, H.3    Knapp, J.P.4    Bodis, M.5    Hubner, U.6
  • 25
    • 0026633925 scopus 로고
    • Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease
    • Medline:1503807 doi:10.1146/annurev.nu.12.070192.001431
    • Kang SS, Wong PW, Malinow MR. Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr. 1992;12:279- 98. Medline:1503807 doi:10.1146/annurev.nu.12.070192.001431
    • (1992) Annu Rev Nutr. , vol.12 , pp. 279-298
    • Kang, S.S.1    Wong, P.W.2    Malinow, M.R.3
  • 26
    • 0033547641 scopus 로고    scopus 로고
    • An alternative view of homocysteine
    • Medline:10636386 doi:10.1016/S0140- 6736(99)03383-8
    • D udman NP. An alternative view of homocysteine. Lancet. 1999;354:2072-4. Medline:10636386 doi:10.1016/S0140- 6736(99)03383-8
    • (1999) Lancet. , vol.354 , pp. 2072-2074
    • Dudman, N.P.1
  • 27
    • 0004285329 scopus 로고    scopus 로고
    • Homocysteine in health and disease
    • Cambridge: Cambridge University Press
    • Lentz SR. Homocysteine in health and disease. Cambridge: Cambridge University Press; 2001.
    • (2001)
    • Lentz, S.R.1
  • 28
    • 84865860702 scopus 로고    scopus 로고
    • Interference in mevalonate pathway ameliorates homocysteine-induced endothelium dysfunction
    • Medline:22796672 doi:10.1016/j. ejphar.2012.07.014
    • Zhang B, Qiu L, Fu M, Hu S. Interference in mevalonate pathway ameliorates homocysteine-induced endothelium dysfunction. Eur J Pharmacol. 2012;692:61-8. Medline:22796672 doi:10.1016/j. ejphar.2012.07.014
    • (2012) Eur J Pharmacol. , vol.692 , pp. 61-68
    • Zhang, B.1    Qiu, L.2    Fu, M.3    Hu, S.4
  • 29
    • 80051863310 scopus 로고    scopus 로고
    • Channeling the homocysteine chapel
    • Medline:21852445 doi:10.1182/blood-2011-06- 361360
    • Sibinga NES. Channeling the homocysteine chapel. Blood. 2011;118:1717-9. Medline:21852445 doi:10.1182/blood-2011-06- 361360
    • (2011) Blood. , vol.118 , pp. 1717-1719
    • Sibinga, N.E.S.1
  • 30
    • 84888393682 scopus 로고    scopus 로고
    • Association of inflammation biomarkers with homocysteine & lipid profile in obese young adults
    • Malleshappa K, Rajasekhar P, Jayalakshmi L. Association of inflammation biomarkers with homocysteine & lipid profile in obese young adults. Natl J Basic Med Sci. 2012;2:189-93.
    • (2012) Natl J Basic Med Sci. , vol.2 , pp. 189-193
    • Malleshappa, K.1    Rajasekhar, P.2    Jayalakshmi, L.3
  • 31
    • 0032499024 scopus 로고    scopus 로고
    • Homocysteine and atherothrombosis
    • Medline:9535670 doi:10.1056/NEJM199804093381507
    • Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998;338:1042-50. Medline:9535670 doi:10.1056/NEJM199804093381507
    • (1998) N Engl J Med. , vol.338 , pp. 1042-1050
    • Welch, G.N.1    Loscalzo, J.2
  • 32
    • 0035107609 scopus 로고    scopus 로고
    • Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model
    • Medline:11254667 doi:10.1172/JCI10588
    • H ofmann MA, Lalla E, Lu Y, Ryu Gleason M, Wolf BM, Tanji N, et al. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest. 2001;107:675-83. Medline:11254667 doi:10.1172/JCI10588
    • (2001) J Clin Invest. , vol.107 , pp. 675-683
    • Hofmann, M.A.1    Lalla, E.2    Lu, Y.3    Ryu Gleason, M.4    Wolf, B.M.5    Tanji, N.6
  • 33
    • 0034065732 scopus 로고    scopus 로고
    • Simultaneously increased TxA(2) activity in isolated arterioles and platelets of rats with hyperhomocysteinemia
    • Medline:10807734 doi:10.1161/01. ATV.20.5.1203
    • U ngvari Z, Sarkadi-Nagy E, Bagi Z, Szollar L, Koller A. Simultaneously increased TxA(2) activity in isolated arterioles and platelets of rats with hyperhomocysteinemia. Arterioscler Thromb Vasc Biol. 2000;20:1203-8. Medline:10807734 doi:10.1161/01. ATV.20.5.1203
    • (2000) Arterioscler Thromb Vasc Biol. , vol.20 , pp. 1203-1208
    • Ungvari, Z.1    Sarkadi-Nagy, E.2    Bagi, Z.3    Szollar, L.4    Koller, A.5
  • 34
    • 79959841027 scopus 로고    scopus 로고
    • Plasma homocysteine levels, methilene tetrahidrofolate reductase polymorphisms, and the risk of thromboembolism in children
    • Medline:21602719 doi:10.1097/MPH.0b013e318219324f
    • N ahar A, Sabo C, Chitlur M, Ravindrainath Y, Lusher J, Rajpurkar M. Plasma homocysteine levels, methilene tetrahidrofolate reductase polymorphisms, and the risk of thromboembolism in children. J Pediatr Hematol Oncol. 2011;33:330-3 Medline:21602719. doi:10.1097/MPH.0b013e318219324f
    • (2011) J Pediatr Hematol Oncol. , vol.33 , pp. 330-333
    • Nahar, A.1    Sabo, C.2    Chitlur, M.3    Ravindrainath, Y.4    Lusher, J.5    Rajpurkar, M.6
  • 35
    • 0037163849 scopus 로고    scopus 로고
    • THFR Studies Collaboration Group. MTHFR 677C?T polymorphism and risk of coronary heart disease: a metaanalysis
    • Medline:12387655 doi:10.1001/ jama.288.16.2023
    • Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG; MTHFR Studies Collaboration Group. MTHFR 677C?T polymorphism and risk of coronary heart disease: a metaanalysis. JAMA. 2002;288:2023-31. Medline:12387655 doi:10.1001/ jama.288.16.2023
    • (2002) JAMA. , vol.288 , pp. 2023-2031
    • Klerk, M.1    Verhoef, P.2    Clarke, R.3    Blom, H.J.4    Kok, F.J.5    Schouten, E.G.6
  • 36
    • 79955565728 scopus 로고    scopus 로고
    • Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients
    • Medline:21482964 doi:10.1161/ CIRCULATIONAHA.110.000588
    • Bostom AG, Carpenter MA, Kusek JW, Levey AS, Hunsicker L, Pfeffer MA, et al. Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients. Circulation. 2011;123:1763-70. Medline:21482964 doi:10.1161/ CIRCULATIONAHA.110.000588
    • (2011) Circulation. , vol.123 , pp. 1763-1770
    • Bostom, A.G.1    Carpenter, M.A.2    Kusek, J.W.3    Levey, A.S.4    Hunsicker, L.5    Pfeffer, M.A.6
  • 37
    • 0030027668 scopus 로고    scopus 로고
    • Relation between folate status, a common mutation in methylentetrahydro-folate reductase, and plasma homocysteine concentrations
    • Medline:8616944 doi:10.1161/01.CIR.93.1.7
    • Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, et al. Relation between folate status, a common mutation in methylentetrahydro-folate reductase, and plasma homocysteine concentrations. Circulation. 1996;93:7-9. Medline:8616944 doi:10.1161/01.CIR.93.1.7
    • (1996) Circulation. , vol.93 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3    Ellison, R.C.4    Eckfeldt, J.H.5    Rosenberg, I.H.6
  • 38
    • 18144447640 scopus 로고    scopus 로고
    • The effect of a common methyleneterahydrofolate reductase mutation on the levels of homocysteine, folate, vitamin B 12 and on the risk of premature atherosclerosis
    • Medline:9863549 doi:10.1016/S0021-9150(98)00156-7
    • Verhoeff BJ, Trip MD, Prins MH, Kastelein JJP, Reitsma PH. The effect of a common methyleneterahydrofolate reductase mutation on the levels of homocysteine, folate, vitamin B 12 and on the risk of premature atherosclerosis. Atherosclerosis. 1998;141:161-6. Medline:9863549 doi:10.1016/S0021-9150(98)00156-7
    • (1998) Atherosclerosis. , vol.141 , pp. 161-166
    • Verhoeff, B.J.1    Trip, M.D.2    Prins, M.H.3    Kastelein, J.J.P.4    Reitsma, P.H.5
  • 39
    • 80051696421 scopus 로고    scopus 로고
    • Folate and cardiovascular disease: one size does not fit all
    • Medline:21803413 doi:10.1016/S0140-6736(11)61057-X
    • Rimm EB, Stampfer MJ. Folate and cardiovascular disease: one size does not fit all. Lancet. 2011;378:544-6. Medline:21803413 doi:10.1016/S0140-6736(11)61057-X
    • (2011) Lancet. , vol.378 , pp. 544-546
    • Rimm, E.B.1    Stampfer, M.J.2
  • 40
    • 79960947136 scopus 로고    scopus 로고
    • High consumption of O-3 polyunsaturated fatty acids decrease plasma homocysteine: A meta-analysis of randomized, placebo-controlled trials
    • Medline:21501950 doi:10.1016/j. nut.2010.12.011
    • H uang T, Zheng J, Chen Y, Yang B, Wanhlqvist ML, Li D. High consumption of O-3 polyunsaturated fatty acids decrease plasma homocysteine: A meta-analysis of randomized, placebo-controlled trials. Nutrition. 2011;27:863-7. Medline:21501950 doi:10.1016/j. nut.2010.12.011
    • (2011) Nutrition. , vol.27 , pp. 863-867
    • Huang, T.1    Zheng, J.2    Chen, Y.3    Yang, B.4    Wanhlqvist, M.L.5    Li, D.6
  • 41
    • 35148844597 scopus 로고    scopus 로고
    • The association between betaine and choline intakes and the plasma concentrations of homocysteine in women
    • Medline:17921386
    • Chiuve SE, Goavannucci EL, Hankinson SE, Zeisel SH, Dougherty LW, Willett C, et al. The association between betaine and choline intakes and the plasma concentrations of homocysteine in women. Am J Clin Nutr. 2007;86:1073-81. Medline:17921386
    • (2007) Am J Clin Nutr. , vol.86 , pp. 1073-1081
    • Chiuve, S.E.1    Goavannucci, E.L.2    Hankinson, S.E.3    Zeisel, S.H.4    Dougherty, L.W.5    Willett, C.6
  • 42
    • 0037406381 scopus 로고    scopus 로고
    • Genetic determinants of the homocysteine level
    • Medline:12694331 doi:10.1046/j.1523-1755.63.s84.52.x
    • Sunder-Plassmann G, Fodinger M. Genetic determinants of the homocysteine level. Kidney Int Suppl. 2003;84:S141-4. Medline:12694331 doi:10.1046/j.1523-1755.63.s84.52.x
    • (2003) Kidney Int Suppl. , vol.84
    • Sunder-Plassmann, G.1    Fodinger, M.2
  • 43
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    • Medline:7647779 doi:10.1038/ng0595-111
    • Frosst P, Blom HJ, Miols R, Goyette P, Sheppard CA, Matthews RG, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111-3. Medline:7647779 doi:10.1038/ng0595-111
    • (1995) Nat Genet. , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Miols, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 44
    • 0037785270 scopus 로고    scopus 로고
    • Homocysteine: chemistry, metabolism and role in pathophysiological processes [in Serbian]
    • doi:10.2298/JMH0302127M
    • Mirkovic D, Majkic-Singh N, Ignjatovic S. Homocysteine: chemistry, metabolism and role in pathophysiological processes [in Serbian]. Jugoslav Med Biohem. 2003;22:127-40. doi:10.2298/JMH0302127M
    • (2003) Jugoslav Med Biohem. , vol.22 , pp. 127-140
    • Mirkovic, D.1    Majkic-Singh, N.2    Ignjatovic, S.3
  • 45
    • 0030027668 scopus 로고    scopus 로고
    • Relation between folate status, a common mutation in methylentetrahydro-folate reductase, and plasma homocysteine concentrations
    • Medline:8616944 doi:10.1161/01.CIR.93.1.7
    • Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, et al. Relation between folate status, a common mutation in methylentetrahydro-folate reductase, and plasma homocysteine concentrations. Circulation. 1996;93:7-9. Medline:8616944 doi:10.1161/01.CIR.93.1.7
    • (1996) Circulation. , vol.93 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3    Ellison, R.C.4    Eckfeldt, J.H.5    Rosenberg, I.H.6
  • 46
    • 18144447640 scopus 로고    scopus 로고
    • The effect of a common methyleneterahydrofolate reductase mutation on the levels of homocysteine, folate, vitamin B 12 and on the risk of premature atherosclerosis
    • Medline:9863549 doi:10.1016/S0021-9150(98)00156-7
    • Verhoeff BJ, Trip MD, Prins MH, Kastelein JJP, Reitsma PH. The effect of a common methyleneterahydrofolate reductase mutation on the levels of homocysteine, folate, vitamin B 12 and on the risk of premature atherosclerosis. Atherosclerosis. 1998;141:161-6. Medline:9863549 doi:10.1016/S0021-9150(98)00156-7
    • (1998) Atherosclerosis. , vol.141 , pp. 161-166
    • Verhoeff, B.J.1    Trip, M.D.2    Prins, M.H.3    Kastelein, J.J.P.4    Reitsma, P.H.5
  • 48
    • 33645777279 scopus 로고    scopus 로고
    • Homocysteine trials-clear outcomes for complex reasons
    • Medline:16531615 doi:10.1056/NEJMe068060
    • Loscalzo J. Homocysteine trials-clear outcomes for complex reasons. N Engl J Med. 2006;354:1629-32. Medline:16531615 doi:10.1056/NEJMe068060
    • (2006) N Engl J Med. , vol.354 , pp. 1629-1632
    • Loscalzo, J.1


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