Toxicological profile of small airway epithelial cells exposed to gold nanoparticles

Experimental Biology and Medicine

Volumn 238, Issue 12, 2013, Pages 1355-1361

  Ng, Cheng Teng ^a,b   Li, Jasmine Jia'En ^a,b   Gurung, Resham Lal ^a   Hande, Manoor Prakash ^a   Ong, Choon Nam ^b   Bay, Boon Huat ^a   Yung, Lin Yue Lanry ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

cytotoxicity and genotoxicity; DNA damage; Gold nanoparticles; lung; metallothionein (MT); oxidative stress

Indexed keywords

GOLD NANOPARTICLE; LIPID HYDROPEROXIDE; LIPID PEROXIDE; METALLOTHIONEIN; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL ULTRASTRUCTURE; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROBLAST; OXIDATIVE STRESS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ROENTGEN SPECTROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

CYTOTOXICITY AND GENOTOXICITY; DNA DAMAGE; GOLD NANOPARTICLES; LUNG; METALLOTHIONEIN (MT); OXIDATIVE STRESS;

CELL LINE; CELL SURVIVAL; COMET ASSAY; EPITHELIAL CELLS; FIBROBLASTS; GOLD; HUMANS; LUNG; METAL NANOPARTICLES; METALLOTHIONEIN; MICROSCOPY, ELECTRON, TRANSMISSION; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84888398445     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370213505964     Document Type: Article

References (57)

1. Warheit DB,Sayes CM,Reed KL,Swain KA.Health effects related to nanoparticle exposures: environmental, health and safety considerations for assessing hazards and risks.Pharmacol Ther. 2008;120:35-42.
2. Griffitt RJ,Hyndman K,Denslow ND,Barber DS.Comparison of molecular and histological changes in zebrafish gills exposed to metallic nanoparticles.Toxicol Sci. 2009;107:404-15.
3. United States Environmental Protection Agency. See http://www.epa.gov/nanoscience/ (last checked 17 January 2013).
4. Powell MC,Kanarek MS.Nanomaterial health effects-part 1: background and current knowledge.WMJ. 2006;105:16-20.
5. Powell MC,Kanarek MS.Nanomaterial health effects-Part 2: uncertainties and recommendations for the future.WMJ. 2006;105:18-23.
6. Sandhu KK,McIntosh CM,Simard JM,Smith SW,Rotello VM.Gold nanoparticle-mediated transfection of mammalian cells.Bioconjug Chem. 2002;13:3-6.
7. Dreaden EC,Mackey MA,Huang X,Kang B,El-Sayed MA.Beating cancer in multiple ways using nanogold.Chem Soc Rev. 2011;40:3391-404.
8. Nowack B,Bucheli T.Occurrence, behavior and effects of nanoparticles in the environment.Environ Pollut. 2007;150:5-22.
9. Singh N,Manshian B,Jenkins GJ,Griffiths SM,Williams PM,Maffeis TG,Wright CJ,Doak SH.NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials.Biomaterials. 2009;30:3891-914.
10. Khlebtsov N,Dykman L.Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies.Chem Soc Rev. 2011;40:1647-71.
11. Muller J,Huaux F,Fonseca A,Nagy JB,Moreau N,Delos M,Raymundo-Piñero E,Béguin F,Kirsch-Volders M,Fenoglio I,Fubini B,Lison D.Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: toxicological aspects.Chem Res Toxicol. 2008;21:1698-705.
12. van der Zande M,Junker R,Walboomers XF,Jansen JA.Carbon nanotubes in animal models: a systematic review on toxic potential.Tissue Eng Part B Rev. 2011;17:57-69.
13. Li JJ,Hartono D,Ong CN,Bay BH,Yung LY.Autophagy and oxidative stress associated with gold nanoparticles.Biomaterials. 2010;31:5996-6003.
14. Han SG,Newsome B,Hennig B.Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells.Toxicology. 2013;306:1-8.
15. Skocaj M,Filipic M,Petkovic J,Novak S.Titanium dioxide in our everyday life; is it safe?.Radiol Oncol. 2011;45:227-47.
16. Hext PM,Tomenson JA,Thompson P.Titanium dioxide: inhalation toxicology and epidemiology.Ann Occup Hyg. 2005;49:461-72.
17. Maynard AD,Warheit DB,Philbert MA.The new toxicology of sophisticated materials: nanotoxicology and beyond.Toxicol Sci. 2011;120:S109-29.
18. Johnston HJ,Hutchison G,Christensen FM,Peters S,Hankin S,Stone V.A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity.Crit Rev Toxicol. 2010;40:328-46.
19. Srinivas A,Rao PJ,Selvam G,Murthy PB,Reddy PN.Acute inhalation toxicity of cerium oxide nanoparticles in rats.Toxicol Lett. 2011;205:105-15.
20. Chompoosor A,Saha K,Ghosh PS,Macarthy DJ,Miranda OR,Zhu ZJ,Arcaro KF,Rotello VM.The role of surface functionality on acute cytotoxicity, ROS generation and DNA damage by cationic gold nanoparticles.Small. 2010;6:2246-49.
21. Pan Y,Leifert A,Ruau D,Neuss S,Bornemann J,Schmid G,Brandau W,Simon U,Jahnen-Dechent W.Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage.Small. 2009;5:2067-76.
22. Borm PJ,Kreyling W.Toxicological hazards of inhaled nanoparticles-potential implications for drug delivery.J Nanosci Nanotechnol. 2004;4:521-31.
23. Vallee BL.The function of metallothionein.Neurochem Int. 1995;27:23-33.
24. Cherian MG,Jayasurya A,Bay BH.Metallothioneins in human tumors and potential roles in carcinogenesis.Mutat Res. 2003;533:201-9.
25. Saito S,Kojima Y.Relative gold-binding capacity of metallothionein: studies in renal cytosols of gold-injected rats.Res Commun Mol Pathol Pharmacol. 1996;92:119-26.
26. Li JJ,Zou L,Hartono D,Ong CN,Bay BH,Yung LY.Gold nanoparticles induce oxidative damage in lung fibroblasts in vitro.Adv Mater. 2008;20:138-42.
27. Li JJ,Lo SL,Ng CT,Gurung RL,Hartono D,Hande MP,Ong CN,Bay BH,Yung LY.Genomic instability of gold nanoparticle treated human lung fibroblast cells.Biomaterials. 2011;32:5515-23.
28. Mididoddi S,McGuirt JP,Sens MA,Todd JH,Sens DA.Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney.Toxicol Lett. 1996;85:17-27.
29. Potter TM,Neun BW,Stern ST.Assay to detect lipid peroxidation upon exposure to nanoparticles.Methods Mol Biol. 2011;697:181-9.
30. Olive PL,Banath JP,Durand RE.Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay.1990. Radiat Res. 2012;178:AV35-42.
31. Karin M,Eddy RL,Henry WM,Haley LL,Byers MG,Shows TB.Human metallothionein genes are clustered on chromosome 16.Proc Natl Acad Sci U S A. 1984;81:5494-8.
32. Vasak M,Hasler DW.Metallothioneins: new functional and structural insights.Curr Opin Chem Biol. 2000;4:177-83.
33. Stennard FA,Holloway AF,Hamilton J,West AK.Characterisation of six additional human metallothionein genes.Biochim Biophys Acta. 1994;1218:357-65.
34. West AK,Stallings R,Hildebrand CE,Chiu R,Karin M,Richards RI.Human metallothionein genes: structure of the functional locus at 16q13.Genomics. 1990;8:513-18.
35. Khan JA,Pillai B,Das TK,Singh Y,Maiti S.Molecular effects of uptake of gold nanoparticles in HeLa cells.Chembiochem. 2007;8:1237-40.
36. Chithrani DB.Intracellular uptake, transport, and processing of gold nanostructures.Mol Membr Biol. 2010;27:299-311.
37. Wang SH,Lee CW,Chiou A,Wei PK.Size-dependent endocytosis of gold nanoparticles studied by three-dimensional mapping of plasmonic scattering images.J Nanobiotechnol. 2010;8:33-33.
38. Zhang Q,Hitchins VM,Schrand AM,Hussain SM,Goering PL.Uptake of gold nanoparticles in murine macrophage cells without cytotoxicity or production of pro-inflammatory mediators.Nanotoxicology. 2011;5:284-95.
39. Shukla RK,Sharma V,Pandey AK,Singh S,Sultana S,Dhawan A.ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells.Toxicol In Vitro. 2011;25:231-41.
40. Kim S,Choi JE,Choi J,Chung KH,Park K,Yi J,Ryu DY.Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells.Toxicol In Vitro. 2009;23:1076-84.
41. Gosens I,Post JA,de la Fonteyne LJ,Jansen EH,Geus JW,Cassee FR,de Jong WH.Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation.Part Fibre Toxicol. 2010;7:37-37.
42. Wong BA,Nash DG,Moss OR.Generation of nanoparticles agglomerates and their dispersion in lung serum simulant or water.J Phys Conf Ser. 2009;151:012036-012036.
43. Ryter SW,Kim HP,Hoetzel A,Park JW,Nakahira K,Wang X,Choi AM.Mechanisms of cell death in oxidative stress.Antioxid Redox Signal. 2007;9:49-89.
44. Schins RP,Knaapen AM.Genotoxicity of poorly soluble particles.Inhal Toxicol. 2007;19:189-98.
45. Jin CY,Zhu BS,Wang XF,Lu QH.Cytotoxicity of titanium dioxide nanoparticles in mouse fibroblast cells.Chem Res Toxicol. 2008;21:1871-7.
46. Reeves JF,Davies SJ,Dodd NJ,Jha AN.Hydroxyl radicals (*OH) are associated with titanium dioxide (TiO(2)) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells.Mutat Res. 2008;640:113-22.
47. Lu S,Duffin R,Poland C,Daly P,Murphy F,Drost E,Macnee W,Stone V,Donaldson K.Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation.Environ Health Perspect. 2009;117:241-7.
48. Yang H,Liu C,Yang D,Zhang H,Xi Z.Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition.J Appl Toxicol. 2009;29:69-78.
49. Johnston HJ,Hutchison GR,Christensen FM,Aschberger K,Stone V.The biological mechanisms and physicochemical characteristics responsible for driving fullerene toxicity.Toxicol Sci. 2010;114:162-82.
50. Naqvi S,Samim M,Abdin M,Ahmed FJ,Maitra A,Prashant C,Dinda AK.Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress.Int J Nanomed. 2010;5:983-9.
51. Petkovic J,Zegura B,Stevanovic M,Drnovsek N,Uskokovic D,Novak S,Filipič M.DNA damage and alterations in expression of DNA damage responsive genes induced by TiO(2) nanoparticles in human hepatoma HepG2 cells.Nanotoxicology. 2011;5:341-53.
52. Guo YY,Zhang J,Zheng YF,Yang J,Zhu XQ.Cytotoxic and genotoxic effects of multi-wall carbon nanotubes on human umbilical vein endothelial cells in vitro.Mutat Res. 2011;721:184-91.
53. Lee K,Lee H,Lee KW,Park TG.Optical imaging of intracellular reactive oxygen species for the assessment of the cytotoxicity of nanoparticles.Biomaterials. 2011;32:2556-65.
54. Tanaka S,Niioka T.Cytoprotective effects of metallothionein induced by metals against oxidative stress induced by hydrogen peroxide.Biomed Res Trace Elem. 2001;12:353-4.
55. Li J,Liu Y,Ru B.Effect of metallothionein on cell viability and its interactions with cadmium and zinc in HEK293 cells.Cell Biol Int. 2005;29:843-8.
56. Xu J,Wang G,Wang Y,Liu Q,Xu W,Tan Y,Cai L.Diabetes- and angiotensin II-induced cardiac endoplasmic reticulum stress and cell death: metallothionein protection.J Cell Mol Med. 2009;13:1499-512.
57. Hussain S,Slikker W,Ali SF.Role of metallothionein and other antioxidants in scavenging superoxide radicals and their possible role in neuroprotection.Neurochem Int. 1996;29:145-52.