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Volumn 19, Issue 6, 2013, Pages 437-445

Salmonella enterica serovar typhimurium virulence-resistance plasmids derived from the pslt carrying nonconventional class 1 integrons with dfra12 gene in their variable region and sul3 in the 3′ conserved segment

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CONTROLLED STUDY; GENE CASSETTE; GENETIC VARIABILITY; GENOMIC ISLAND; GENOTYPE; HUMAN; INTEGRON; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; SOUTHERN BLOTTING; SWINE;

EID: 84888388744     PISSN: 10766294     EISSN: 19318448     Source Type: Journal    
DOI: 10.1089/mdr.2012.0226     Document Type: Article
Times cited : (8)

References (45)
  • 1
    • 50149101408 scopus 로고    scopus 로고
    • Real-time PCRs and fingerprinting assays for the detection and characterization of Salmonella Genomic Island-1 encoding multidrug resistance: Application to 445 European isolates of Salmonella, Escherichia coli, Shigella and Proteus
    • Amar, C.F., C. Arnold, A. Bankier, P.H. Dear, B. Guerra, K.L. Hopkins, E. Liebana, D.J. Mevius, and E.J. Threlfall. 2008. Real-time PCRs and fingerprinting assays for the detection and characterization of Salmonella Genomic Island-1 encoding multidrug resistance: application to 445 European isolates of Salmonella, Escherichia coli, Shigella, and Proteus. Microb. Drug Resist. 14:79-92.
    • (2008) Microb. Drug Resist. , vol.14 , pp. 79-92
    • Amar, C.F.1    Arnold, C.2    Bankier, A.3    Dear, P.H.4    Guerra, B.5    Hopkins, K.L.6    Liebana, E.7    Mevius, D.J.8    Threlfall, E.J.9
  • 2
    • 0017614807 scopus 로고
    • Bacteriophage-typing designations of Salmonella Typhimurium
    • Anderson, E.S., L.R. Ward, M.J. Saxe, and J.D.H. de Sa. 1977. Bacteriophage-typing designations of Salmonella Typhimurium. J. Hyg. 78:297-300.
    • (1977) J. Hyg. , vol.78 , pp. 297-300
    • Anderson, E.S.1    Ward, L.R.2    Saxe, M.J.3    De Sa, J.D.H.4
  • 3
    • 34247134023 scopus 로고    scopus 로고
    • Dissemination of sul3-containing elements linked to class 1 integrons with an unusual 3' conserved sequence region among Salmonella isolates
    • Antunes, P., J. Machado, and L. Peixe. 2007. Dissemination of sul3-containing elements linked to class 1 integrons with an unusual 3' conserved sequence region among Salmonella isolates. Antimicrob. Agents Chemother. 51:1545-1548.
    • (2007) Antimicrob. Agents Chemother , vol.51 , pp. 1545-1548
    • Antunes, P.1    MacHado, J.2    Peixe, L.3
  • 4
    • 2942666034 scopus 로고    scopus 로고
    • From pieces to patterns: Evolutionary engineering in bacterial pathogens
    • Baquero, F. 2004. From pieces to patterns: evolutionary engineering in bacterial pathogens. Nat. Rev. Microbiol. 2: 510-518.
    • (2004) Nat. Rev. Microbiol , vol.2 , pp. 510-518
    • Baquero, F.1
  • 5
    • 0028924342 scopus 로고
    • A general method for detecting and sizing large plasmids
    • Barton, B.M., G.P. Harding, and A.J. Zuccarelli. 1995. A general method for detecting and sizing large plasmids. Anal. Biochem. 226:235-240.
    • (1995) Anal. Biochem. , vol.226 , pp. 235-240
    • Barton, B.M.1    Harding, G.P.2    Zuccarelli, A.J.3
  • 6
    • 80052634359 scopus 로고    scopus 로고
    • Antimicrobial resistance and virulence determinants in European Salmonella Genomic Island 1 positive Salmonella enterica isolates from different origins
    • on behalf of the Med-Vet-Net WP21 Project Group
    • Beutlich, J., S. Jahn, B. Malorny, E. Hauser, S. Hü hn, A. Schroeter, M.R. Rodicio, B. Appel, J. Threlfall, D. Mevius, R. Helmuth, and B. Guerra, on behalf of the Med-Vet-Net WP21 Project Group. 2011. Antimicrobial resistance and virulence determinants in European Salmonella Genomic Island 1 positive Salmonella enterica isolates from different origins. Appl. Environ. Microbiol. 77:5655-5664.
    • (2011) Appl. Environ. Microbiol , vol.77 , pp. 5655-5664
    • Beutlich, J.1    Jahn, S.2    Malorny, B.3    Hauser, E.4    Hü Hn, S.5    Schroeter, A.6    Rodicio, M.R.7    Appel, B.8    Threlfall, J.9    Mevius, D.10    Helmuth, R.11    Guerra, B.12
  • 7
    • 0034801311 scopus 로고    scopus 로고
    • Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona
    • Boyd, D., G.A. Peters, A. Cloeckaert, K.S. Boumedine, E. Chaslus-Dancla, H. Imberechts, and M.R. Mulvey. 2001. Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona. J. Bacteriol. 183:5725-5732.
    • (2001) J. Bacteriol , vol.183 , pp. 5725-5732
    • Boyd, D.1    Peters, G.A.2    Cloeckaert, A.3    Boumedine, K.S.4    Chaslus-Dancla, E.5    Imberechts, H.6    Mulvey, M.R.7
  • 8
    • 84888373977 scopus 로고    scopus 로고
    • Bundesinstitut Fü R Risikobewertung
    • September 14 2012 (Online.)
    • Bundesinstitut fü r Risikobewertung. 2010. Deutsche Antibiotika-Resistenzsituation in der Lebensmittelkette-DARLink. www.bfr.bund.de/cm/350/deutsche-antibiotika-re sistenzsituation-in-der- lebensmittel kette-darlink.pdf September 14 2012 (Online.)
    • (2010) Deutsche Antibiotika-Resistenzsituation in der Lebensmittelkette-DARLink
  • 10
    • 33746396988 scopus 로고    scopus 로고
    • Evolution of the virulence plasmids of non-typhoid Salmonella and its association with antimicrobial resistance
    • Chu, C., and C.H. Chiu. 2006. Evolution of the virulence plasmids of non-typhoid Salmonella and its association with antimicrobial resistance. Microbes Infect. 8:1931-1936.
    • (2006) Microbes Infect. , vol.8 , pp. 1931-1936
    • Chu, C.1    Chiu, C.H.2
  • 11
    • 0032924519 scopus 로고    scopus 로고
    • Comparative physical and genetic maps of the virulence plasmids of Salmonella enterica serovars Typhimurium, Enteritidis, Choleraesuis and Dublin
    • Chu, C., S.F. Hong, C. Tsai, W.S. Lin, T.P. Liu, and J.T. Ou. 1999. Comparative physical and genetic maps of the virulence plasmids of Salmonella enterica serovars Typhimurium, Enteritidis, Choleraesuis, and Dublin. Infect. Immun. 67:2611-2614.
    • (1999) Infect. Immun. , vol.67 , pp. 2611-2614
    • Chu, C.1    Hong, S.F.2    Tsai, C.3    Lin, W.S.4    Liu, T.P.5    Ou, J.T.6
  • 12
    • 84888330309 scopus 로고    scopus 로고
    • Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically
    • Clinical and Laboratory Standards Institute CLSI, Wayne, PA
    • Clinical and Laboratory Standards Institute. 2009. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard, 8th ed. (M07-A8), Vol. 29, No. 2, CLSI, Wayne, PA.
    • (2009) Approved Standard, 8th Ed. (M07-A8) , vol.29 , Issue.2
  • 13
    • 84888349172 scopus 로고    scopus 로고
    • Clinical and Laboratory Standards Institute. Performance standards for antimicro bial susceptibility testing; 21st informational supplement (M100-S21) CLSI, Wayne, PA
    • Clinical and Laboratory Standards Institute. 2011. Performance standards for antimicro bial susceptibility testing; 21st informational supplement (M100-S21), Vol. 31, No. 1, CLSI, Wayne, PA.
    • (2011) , vol.31 , Issue.1
  • 14
    • 77957874402 scopus 로고    scopus 로고
    • European Committee on Antimicrobial Susceptibility Testing Version 1.3, January 2011 Online
    • European Committee on Antimicrobial Susceptibility Testing. 2011. Breakpoint tables for interpretation of MICs and zone diameters. Version 1.3, January 2011. www.eu cast.org/fileadmin/src/media/PDFs/EUCAST-files/Disk-test- documents/EU CAST-breakpoints-v1.3-pdf.pdf (Online.)
    • (2011) Breakpoint Tables for Interpretation of MICs and Zone Diameters
  • 15
    • 0000527903 scopus 로고
    • Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans
    • U. S. A.
    • Figurski, D.H., and D.R. Helinski. 1979. Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. Proc. Natl. Acad. Sci. U. S. A. 76:1648-1652.
    • (1979) Proc. Natl. Acad. Sci. , vol.76 , pp. 1648-1652
    • Figurski, D.H.1    Helinski, D.R.2
  • 17
    • 79951519386 scopus 로고    scopus 로고
    • IncA/C plasmids mediate antimicrobial resistance linked to virulence genes in the Spanish clone of the emerging Salmonella enterica serotype 4,[5],12:I
    • Garc?́a, P., B. Guerra, M. Bances, M.C. Mendoza, and M.R. Rodicio. 2011. IncA/C plasmids mediate antimicrobial resistance linked to virulence genes in the Spanish clone of the emerging Salmonella enterica serotype 4,[5],12:i:-. J. Antimicrob. Chemother. 66:543-549.
    • (2011) J. Antimicrob. Chemother , vol.66 , pp. 543-549
    • Garća, P.1    Guerra, B.2    Bances, M.3    Mendoza, M.C.4    Rodicio, M.R.5
  • 19
    • 0035086083 scopus 로고    scopus 로고
    • Multidrug resistance is mediated by large plasmids carrying a class 1 integron in the emergent Salmonella en terica serotype [4,5,12:I:-]
    • Guerra, B., S.M. Soto, J.M. Argü elles, and M.C. Mendoza. 2001. Multidrug resistance is mediated by large plasmids carrying a class 1 integron in the emergent Salmonella en terica serotype [4,5,12:i:-]. Antimicrob. Agents Chemother. 45:1305-1308.
    • (2001) Antimicrob. Agents Chemother , vol.45 , pp. 1305-1308
    • Guerra, B.1    Soto, S.M.2    Argü Elles, J.M.3    Mendoza, M.C.4
  • 20
    • 0036720596 scopus 로고    scopus 로고
    • Characterization of a self-transferable plasmid from Salmonella enterica serotype Typhimurium clinical isolates carry ing two integron-borne gene cassettes together with virulence and drug resistance genes
    • Guerra, B., S. Soto, R. Helmuth, and M.C. Mendoza. 2002. Characterization of a self-transferable plasmid from Salmonella enterica serotype Typhimurium clinical isolates carry ing two integron-borne gene cassettes together with virulence and drug resistance genes. Antimicrob. Agents Chemother. 46:2977-2981.
    • (2002) Antimicrob. Agents Chemother , vol.46 , pp. 2977-2981
    • Guerra, B.1    Soto, S.2    Helmuth, R.3    Mendoza, M.C.4
  • 21
    • 0038101656 scopus 로고    scopus 로고
    • Multiple resistance mechanisms in fluoroquinoloneresistant Salmonella isolates from Germany
    • Guerra, B., B. Malorny, A. Schroeter, and R. Helmuth. 2003. Multiple resistance mechanisms in fluoroquinoloneresistant Salmonella isolates from Germany. Antimicrob. Agents Chemother. 47:2059.
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 2059
    • Guerra, B.1    Malorny, B.2    Schroeter, A.3    Helmuth, R.4
  • 22
    • 3042736050 scopus 로고    scopus 로고
    • Characterization and localization of drug resistance determinants in multidrug-resistant, integroncarrying Salmonella enterica serotype Typhimurium strains
    • Guerra, B., E. Junker, A. Miko, R. Helmuth, and M.C. Mendoza. 2004. Characterization and localization of drug resistance determinants in multidrug-resistant, integroncarrying Salmonella enterica serotype Typhimurium strains. Microb. Drug Resist. 10:83-91.
    • (2004) Microb. Drug Resist. , vol.10 , pp. 83-91
    • Guerra, B.1    Junker, E.2    Miko, A.3    Helmuth, R.4    Mendoza, M.C.5
  • 23
    • 0028926269 scopus 로고
    • Salmonella Typhimurium DT193: Differentiation of an epidemic phage type by antibiogram, plasmid profile, plasmid fingerprint and Salmonella plasmid virulence (spv) gene probe
    • Hampton, M.D., E.J. Threlfall, J.A. Frost, L.R. Ward, and B. Rowe. 1995. Salmonella Typhimurium DT193: differentiation of an epidemic phage type by antibiogram, plasmid profile, plasmid fingerprint and Salmonella plasmid virulence (spv) gene probe. J. Appl. Bacteriol. 78:402-408.
    • (1995) J. Appl. Bacteriol , vol.78 , pp. 402-408
    • Hampton, M.D.1    Threlfall, E.J.2    Frost, J.A.3    Ward, L.R.4    Rowe, B.5
  • 24
    • 0021922141 scopus 로고
    • Epidemiology of virulence-associated plasmids and outer membrane protein patterns within seven common Salmonella serotypes
    • Helmuth, R., R. Stephan, C. Bunge, B. Hoog, A. Steinbeck, and E. Bulling. 1985. Epidemiology of virulence-associated plasmids and outer membrane protein patterns within seven common Salmonella serotypes. Infect. Immun. 48:175-182.
    • (1985) Infect. Immun. , vol.48 , pp. 175-182
    • Helmuth, R.1    Stephan, R.2    Bunge, C.3    Hoog, B.4    Steinbeck, A.5    Bulling, E.6
  • 25
    • 30344448873 scopus 로고    scopus 로고
    • Molecular epidemiology of emergent multidrug-resistant Salmonella enterica serotype Typhimurium strains carrying the virulence resistance plasmid pUOStVR2
    • Herrero, A., M.R. Rodicio, M.A. González-Hevia, and M.C. Mendoza. 2006. Molecular epidemiology of emergent multidrug-resistant Salmonella enterica serotype Typhimurium strains carrying the virulence resistance plasmid pUOStVR2. J. Antimicrob. Chemother. 57:39-45.
    • (2006) J. Antimicrob. Chemother , vol.57 , pp. 39-45
    • Herrero, A.1    Rodicio, M.R.2    González-Hevia, M.A.3    Mendoza, M.C.4
  • 26
    • 39849099228 scopus 로고    scopus 로고
    • Salmonella Enterica Serotype Typhimurium Carrying Hybrid Virulence-resistance Plasmids (PUO-StVR): A New Multidrugresistant Group Endemic in Spain
    • Herrero, A., M.R. Rodicio, M.A. Echeita, and M.C. Mendoza. 2008a. Salmonella enterica serotype Typhimurium carrying hybrid virulence-resistance plasmids (pUO-StVR): a new multidrugresistant group endemic in Spain. Int. J. Med. Microbiol. 298:253-261.
    • (2008) Int. J. Med. Microbiol , vol.298 , pp. 253-261
    • Herrero, A.1    Rodicio, M.R.2    Echeita, M.A.3    Mendoza, M.C.4
  • 27
    • 57049160548 scopus 로고    scopus 로고
    • Characterization of pUO-StVR2, a virulenceresistance plasmid evolved from the pSLT virulence plasmid of Salmonella enterica serovar Typhimurium
    • Herrero, A., M.C. Mendoza, R. Rodicio, and M.R. Rodicio. 2008b. Characterization of pUO-StVR2, a virulenceresistance plasmid evolved from the pSLT virulence plasmid of Salmonella enterica serovar Typhimurium. Antimicrob. Agents Chemother. 52:4514-4517.
    • (2008) Antimicrob. Agents Chemother , vol.52 , pp. 4514-4517
    • Herrero, A.1    Mendoza, M.C.2    Rodicio, R.3    Rodicio, M.R.4
  • 28
    • 70349684486 scopus 로고    scopus 로고
    • Detection of Salmonella enterica serovar Typhimurium with pUO-StVR2-like virulence-resistance hybrid plasmids in the United Kingdom
    • Herrero, A., M.C. Mendoza, E.J. Threlfall, and M.R. Rodicio. 2009. Detection of Salmonella enterica serovar Typhimurium with pUO-StVR2-like virulence-resistance hybrid plasmids in the United Kingdom. Eur. J. Clin. Microbiol. Infect. Dis. 28:1087-1093.
    • (2009) Eur. J. Clin. Microbiol. Infect. Dis. , vol.28 , pp. 1087-1093
    • Herrero, A.1    Mendoza, M.C.2    Threlfall, E.J.3    Rodicio, M.R.4
  • 29
    • 0019931520 scopus 로고
    • Association of adhesive, invasive, and virulent phenotypes of Salmonella Typhimurium with autonomous 60-megadalton plasmids
    • Jones, G.W., D.K. Rabert, D.M. Svinarich, and H.J. Whit-field. 1982. Association of adhesive, invasive, and virulent phenotypes of Salmonella Typhimurium with autonomous 60-megadalton plasmids. Infect. Immun. 38:476-486.
    • (1982) Infect. Immun. , vol.38 , pp. 476-486
    • Jones, G.W.1    Rabert, D.K.2    Svinarich, D.M.3    Whit-Field, H.J.4
  • 30
    • 0019433725 scopus 로고
    • Rapid procedure for detection and isolation of large and small plasmids
    • Kado, C.I., and S.T. Liu. 1981. Rapid procedure for detection and isolation of large and small plasmids. J. Bacteriol. 145:1365-1373.
    • (1981) J. Bacteriol , vol.145 , pp. 1365-1373
    • Kado, C.I.1    Liu, S.T.2
  • 32
    • 0028837276 scopus 로고
    • PCR mapping of integrons reveals several novel combinations of resistance genes
    • Lévesque, C., L. Piche, C. Larose, and P.H. Roy. 1995. PCR mapping of integrons reveals several novel combinations of resistance genes. Antimicrob. Agents Chemother. 39:185-191.
    • (1995) Antimicrob. Agents Chemother , vol.39 , pp. 185-191
    • Lévesque, C.1    Piche, L.2    Larose, C.3    Roy, P.H.4
  • 33
    • 0036782279 scopus 로고    scopus 로고
    • Interactions among strategies associated with bacterial infection: Pathogenicity, epidemicity, and antibiotic resistance
    • Mart?́nez, J.L., and F. Baquero. 2002. Interactions among strategies associated with bacterial infection: pathogenicity, epidemicity, and antibiotic resistance. Clin. Microbiol. Rev. 15:647-679.
    • (2002) Clin. Microbiol. Rev. , vol.15 , pp. 647-679
    • Mart́nez, J.L.1    Baquero, F.2
  • 35
    • 78650412681 scopus 로고    scopus 로고
    • PUO-SeVR1 is an emergent virulence-resistance complex plasmid of Salmonella enterica serovar Enteritidis
    • Rodr?́guez, I., B. Guerra, M.C. Mendoza, and M.R. Rodicio. 2011. pUO-SeVR1 is an emergent virulence-resistance complex plasmid of Salmonella enterica serovar Enteritidis. J. Antimicrob. Chemother. 66:218-220.
    • (2011) J. Antimicrob. Chemother , vol.66 , pp. 218-220
    • Rodŕguez, I.1    Guerra, B.2    Mendoza, M.C.3    Rodicio, M.R.4
  • 36
    • 0033186120 scopus 로고    scopus 로고
    • The virulence plasmids of Salmonella
    • Rotger, R., and J. Casadesú s. 1999. The virulence plasmids of Salmonella. Int. Microbiol. 2:177-184.
    • (1999) Int. Microbiol , vol.2 , pp. 177-184
    • Rotger, R.1    Casadesú, S.J.2
  • 37
    • 29144517791 scopus 로고    scopus 로고
    • Distribution and function of plasmids in Salmonella enterica
    • Rychlik, I., D. Gregorova, and H. Hradecka. 2006. Distribution and function of plasmids in Salmonella enterica. Vet. Microbiol. 112:1-10.
    • (2006) Vet. Microbiol , vol.112 , pp. 1-10
    • Rychlik, I.1    Gregorova, D.2    Hradecka, H.3
  • 38
    • 0004262043 scopus 로고
    • A Laboratory Manual. 2nd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
    • Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning. A Laboratory Manual. 2nd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
    • (1989) Molecular Cloning
    • Sambrook, J.1    Fritsch, E.F.2    Maniatis, T.3
  • 40
    • 0028365082 scopus 로고
    • Identification of a conjugative plasmid carrying antibiotic resistance and Salmonella plasmid virulence (spv) genes in epidemic strains of Salmonella Typhimurium phage type 193
    • Threlfall, E.J., M.D. Hampton, H. Chart, and B. Rowe. 1994. Identification of a conjugative plasmid carrying antibiotic resistance and Salmonella plasmid virulence (spv) genes in epidemic strains of Salmonella Typhimurium phage type 193. Lett. Appl. Microbiol. 18:82-85.
    • (1994) Lett. Appl. Microbiol , vol.18 , pp. 82-85
    • Threlfall, E.J.1    Hampton, M.D.2    Chart, H.3    Rowe, B.4
  • 41
    • 0036284848 scopus 로고    scopus 로고
    • Antimicrobial drug resistance in Salmonella: Problems and perspectives in food and water-borne infections
    • Threlfall, E.J. 2002. Antimicrobial drug resistance in Salmonella: problems and perspectives in food and water-borne infections. FEMS Microbiol. Rev. 26:141-148.
    • (2002) FEMS Microbiol. Rev. , vol.26 , pp. 141-148
    • Threlfall, E.J.1
  • 43
    • 19344375964 scopus 로고    scopus 로고
    • Distribution of classic" virulence factors among Salmonella spp
    • van Asten, A.J., and J.E. van Dijk. 2005. Distribution of "classic" virulence factors among Salmonella spp. FEMS Immunol. Med. Microbiol. 44:251-259.
    • (2005) FEMS Immunol. Med. Microbiol , vol.44 , pp. 251-259
    • Van Asten, A.J.1    Van Dijk, J.E.2
  • 44
    • 0024552512 scopus 로고
    • Sequence analysis of rsk, a portion of the 95-kilobase plasmid of Salmonella Typhimurium associated with resistance to the bactericidal activity of serum
    • Vandenbosch, J.L., D.K. Rabert, D.R. Kurlandsky, and G.W. Jones. 1989. Sequence analysis of rsk, a portion of the 95-kilobase plasmid of Salmonella Typhimurium associated with resistance to the bactericidal activity of serum. Infect. Immun. 57:850-857.
    • (1989) Infect. Immun. , vol.57 , pp. 850-857
    • Vandenbosch, J.L.1    Rabert, D.K.2    Kurlandsky, D.R.3    Jones, G.W.4
  • 45
    • 14744277633 scopus 로고    scopus 로고
    • Integrons and transposons on the Salmonella enterica serovar Typhimurium virulence plasmid
    • Villa, L., and A. Carattoli. 2005. Integrons and transposons on the Salmonella enterica serovar Typhimurium virulence plasmid. Antimicrob. Agents Chemother. 49:1194-1197.
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 1194-1197
    • Villa, L.1    Carattoli, A.2


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