No independent association of serum phosphorus with risk for death or progression to end-stage renal disease in a large screen for chronic kidney disease

Kidney International

Volumn 84, Issue 5, 2013, Pages 989-997

  Mehrotra, Rajnish ^a   Peralta, Carmen A ^b   Chen, Shu Cheng ^c   Li, Suying ^c   Sachs, Michael ^a   Shah, Anuja ^d   Norris, Keith ^e   Saab, Georges ^f   Whaley Connell, Adam ^g   Kestenbaum, Bryan ^a   McCullough, Peter A ^h  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MINNEAPOLIS MEDICAL RESEARCH FOUNDATION   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^f METROHEALTH MEDICAL CENTER   (United States)

^g University of Missouri   (United States)

^h PROVIDENCE HOSPITAL   (United States)

Author keywords

barrier to care; cardiovascular disease; chronic kidney disease; end stage renal disease; mortality; phosphorus

Indexed keywords

PHOSPHATE;

ADULT; AGED; ARTICLE; CAUSE OF DEATH; CHRONIC KIDNEY DISEASE; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HIGH RISK PATIENT; HUMAN; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MASS SCREENING; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; RISK ASSESSMENT; SURVIVAL RATE; SURVIVAL TIME;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; DISEASE PROGRESSION; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; PHOSPHORUS; PROPORTIONAL HAZARDS MODELS; RENAL INSUFFICIENCY, CHRONIC; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS;

EID: 84888380229     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2013.145     Document Type: Article

References (36)

1. Go AS, Chertow GM, Fan D et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 2004; 351: 1296-1305.
2. Keith DS, Nichols GA, Gullion CM et al. Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med 2004; 164: 659-663.
3. Baigent C, Landray MJ, Reith C et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet 2011; 377: 2181-2192.
4. Holtkamp FA, de Zeeuw D, de Graeff PA et al. Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials. Eur Heart J 2011; 32: 1493-1499.
5. Block GA. Therapeutic interventions for chronic kidney disease-mineral and bone disorders: focus on mortality. Curr Opin Nephrol Hypertens 2011; 20: 376-381.
6. Jono S, McKee MD, Murry CE et al. Phosphate regulation of vascular smooth muscle cell calcification. Circ Res 2000; 87: E10-E17.
7. Reynolds JL, Joannides AJ, Skepper JN et al. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 2004; 15: 2857-2867.
8. Mathew S, Tustison KS, Sugatani T et al. The mechanism of phosphorus as a cardiovascular risk factor in CKD. J Am Soc Nephrol 2008; 19: 1092-1105.
9. Chiu YW, Adler SG, Budoff MJ et al. Coronary artery calcification and mortality in diabetic patients with proteinuria. Kidney Int 2010; 77: 1107-1114.
10. Block GA, Raggi P, Bellasi A et al. Mortality effect of coronary calcification and phosphate binder choice in incident hemodialysis patients. Kidney Int 2007; 71: 438-441.
11. Kalpakian MA, Mehrotra R. Vascular calcification and disordered mineral metabolism in dialysis patients. Semin Dial 2007; 20: 139-143.
12. Palmer SC, Hayen A, Macaskill P et al. Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis. JAMA 2011; 305: 1119-1127.
13. Tonelli M, Sacks F, Pfeffer M et al. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 2005; 112: 2627-2633.
14. Kestenbaum B, Sampson JN, Rudser KD et al. Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol 2005; 16: 520-528.
15. Kovesdy CP, Anderson JE, Kalantar-Zadeh K. Outcomes associated with serum phosphorus level in males with non-dialysis dependent chronic kidney disease. Clin Nephrol 2010; 73: 268-275.
16. Voormolen N, Noordzij M, Grootendorst DC et al. High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patients. Nephrol Dial Transplant 2007; 22: 2909-2916.
17. Schwarz S, Trivedi BK, Kalantar-Zadeh K et al. Association of disorders in mineral metabolism with progression of chronic kidney disease. Clin J Am Soc Nephrol 2006; 1: 825-831.
18. Norris KC, Greene T, Kopple J et al. Baseline predictors of renal disease progression in the African American Study of Hypertension and Kidney Disease. J Am Soc Nephrol 2006; 17: 2928-2936.
19. Menon V, Greene T, Pereira AA et al. Relationship of phosphorus and calcium-phosphorus product with mortality in CKD. Am J Kidney Dis 2005; 46: 455-463.
20. Gutierrez OM, Anderson C, Isakova T et al. Low socioeconomic status associates with higher serum phosphate irrespective of race. J Am Soc Nephrol 2010; 21: 1953-1960.
21. Brown WW, Peters RM, Ohmit SE et al. Early detection of kidney disease in community settings: the Kidney Early Evaluation Program (KEEP). Am J Kidney Dis 2003; 42: 22-35.
22. Moe SM, Chen NX. Mechanisms of vascular calcification in chronic kidney disease. J Am Soc Nephrol 2008; 19: 213-216.
23. Hruska KA, Mathew S, Lund R et al. Hyperphosphatemia of chronic kidney disease. Kidney Int 2008; 74: 148-157.
24. Davies MR, Lund RJ, Hruska KA. BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure. J Am Soc Nephrol 2003; 14: 1559-1567.
25. Terai K, Nara H, Takakura K et al. Vascular calcification and secondary hyperparathyroidism of severe chronic kidney disease and its relation to serum phosphate and calcium levels. Br J Pharmacol 2009; 156: 1267-1278.
26. Mehrotra R, Budoff M, Christenson P et al. Determinants of coronary artery calcification in diabetics with and without nephropathy. Kidney Int 2004; 66: 2022-2031.
27. Russo D, Palmiero G, De Blasio AP et al. Coronary artery calcification in patients with CRF not undergoing dialysis. Am J Kidney Dis 2004; 44: 1024-1030.
28. Shuto E, Taketani Y, Tanaka R et al. Dietary phosphorus acutely impairs endothelial function. J Am Soc Nephrol 2009; 20: 1504-1512.
29. Ibels LS, Alfrey AC, Haut L et al. Preservation of function in experimental renal disease by dietary restriction of phosphate. N Engl J Med 1978; 298: 122-126.
30. Ibels LS, Alfrey AC, Huffer WE et al. Calcification in end-stage kidneys. Am J Med 1981; 71: 33-37.
31. Haut LL, Alfrey AC, Guggenheim S et al. Renal toxicity of phosphate in rats. Kidney Int 1980; 17: 722-731.
32. Brown SA, Crowell WA, Barsanti JA et al. Beneficial effects of dietary mineral restriction in dogs with marked reduction of functional renal mass. J Am Soc Nephrol 1991; 1: 1169-1179.
33. Chiu YW, Adler S, Budoff M et al. Prevalence and prognostic significance of renal artery calcification in patients with diabetes and proteinuria. Clin J Am Soc Nephrol 2010; 5: 2093-2100.
34. Gutierrez OM, Isakova T, Enfield G et al. Impact of poverty on serum phosphate concentrations in the Third National Health and Nutrition Examination Survey. J Ren Nutr 2011; 21: 140-148.
35. Gutierrez OM, Katz R, Peralta CA et al. Associations of socioeconomic status and processed food intake with serum phosphorus concentration in community-living adults: the Multi-Ethnic Study of Atherosclerosis (MESA). J Ren Nutr 2012; 22: 480-489.
36. Levey AS, Stevens LA, Schmid CH et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-612.