Pathogen selection drives nonoverlapping associations between HLA loci

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 48, 2013, Pages 19645-19650

  Penman, Bridget S ^a   Ashby, Ben ^a   Buckee, Caroline O ^b   Gupta, Sunetra ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Human evolution; Infectious disease; Major histocompatibility complex; Mathematical model; Population genetics

Indexed keywords

HLA DRB1 ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR;

ADAPTIVE IMMUNITY; ARTICLE; BASIC REPRODUCTION NUMBER; COEVOLUTION; GENE CLUSTER; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENOTYPE; HAPLOTYPE; HEREDITY; HLA SYSTEM; HOMOZYGOTE; HOST PATHOGEN INTERACTION; IMMUNITY; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; POPULATION STRUCTURE; PRIORITY JOURNAL; T LYMPHOCYTE;

HUMAN EVOLUTION; INFECTIOUS DISEASE; MAJOR HISTOCOMPATIBILITY COMPLEX; MATHEMATICAL MODEL; POPULATION GENETICS;

ADAPTIVE IMMUNITY; ANIMALS; BIOLOGICAL EVOLUTION; ETHNIC GROUPS; GENETICS, POPULATION; HISTOCOMPATIBILITY ANTIGENS; HLA ANTIGENS; HOST-PATHOGEN INTERACTIONS; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, BIOLOGICAL; SELECTION, GENETIC;

EID: 84888372097     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1304218110     Document Type: Article

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