Repression of farnesoid X receptor contributes to biliary injuries of liver grafts through disturbing cholangiocyte bile acid transport

American Journal of Transplantation

Volumn 13, Issue 12, 2013, Pages 3094-3102

  Cheng, L ^a,b   Tian, F ^a,c   Tang, L ^a   Chen, G ^c   Luo, Z ^a   Ren, J ^a   Wang, S ^c  

^a CHENGDU MILITARY GENERAL HOSPITAL   (China)

^b Dujiangyan aviation medical evaluating and training center of PLA Air Force   (China)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bile acid transporters; Bile duct injury; Biliary epithelial cells; Farnesoid X receptor; Liver transplantation

Indexed keywords

BILE ACID; FARNESOID X RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILE DUCT INJURY; BILIARY TRANSIT TIME; BIOACCUMULATION; CELL TYPE; CHOLANGIOCYTE; COLD ISCHEMIA; CONTROLLED STUDY; DISEASE SEVERITY; DNA BINDING; HEPATOBILIARY PARAMETERS; HUMAN; HUMAN CELL; HYPOXIA; LIPID TRANSPORT; LIVER GRAFT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

BILE ACID TRANSPORTERS; BILE DUCT INJURY; BILIARY EPITHELIAL CELLS; FARNESOID X RECEPTOR; LIVER TRANSPLANTATION;

ANIMALS; ANOXIA; APOPTOSIS; BILE ACIDS AND SALTS; BILE DUCTS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; ISCHEMIA; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84888346142     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12479     Document Type: Article

References (32)

1. Buis CI, Verdonk RC, Van der Jagt EJ, et al. Nonanastomotic biliary strictures after liver transplantation, part 1: Radiological features and risk factors for early vs. late presentation. Liver Transpl 2007; 13: 708-718.
2. Heidenhain C, Pratschke J, Puhl G, et al. Incidence of and risk factors for ischemic-type biliary lesions following orthotopic liver transplantation. Transpl Int 2010; 23: 14-22.
3. Sanchez-Urdazpal L, Gores GJ, Ward EM, et al. Ischemic-type biliary complications after orthotopic liver transplantation. Hepatology 1992; 16: 49-53.
4. +/- mice. Hepatology 2006; 43: 1022-1031.
5. Buis CI, Geuken E, Visser DS, et al. Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures. J Hepatol 2009; 50: 69-79.
6. Geuken E, Visser D, Kuipers F, et al. Rapid increase of bile salt secretion is associated with bile duct injury after human liver transplantation. J Hepatol 2004; 41: 1017-1025.
7. Chen G, Wang S, Bie P, Li X, Dong J., Endogenous bile salts are associated with bile duct injury in the rat liver transplantation model. Transplantation 2009; 87: 330-339.
8. Allen K, Jaeschke H, Copple BL., Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol 2011; 178: 175-186.
9. -/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes. J Hepatol 2005; 43: 1045-1054.
10. Cheng L, Zhao L, Li D, et al. Role of cholangiocyte bile acid transporters in large bile duct injury after rat liver transplantation. Transplantation 2010; 90: 127-134.
11. Fiorucci S, Rizzo G, Donini A, Distrutti E, Santucci L., Targeting farnesoid X receptor for liver and metabolic disorders. Trends Mol Med 2007; 13: 298-309.
12. Kim MS, Shigenaga J, Moser A, Feingold K, Grunfeld C., Repression of farnesoid X receptor during the acute phase response. J Biol Chem 2003; 278: 8988-8995.
13. Huls M, van den Heuvel JJ, Dijkman HB, Russel FG, Masereeuw R., ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney. Kidney Int 2006; 69: 2186-2193.
14. Fujino T, Murakami K, Ozawa I, et al. Hypoxia downregulates farnesoid X receptor via a hypoxia-inducible factor-independent but p38 mitogen-activated protein kinase-dependent pathway. FEBS J 2009; 276: 1319-1332.
15. Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA., The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. Am J Physiol Gastrointest Liver Physiol 2006; 290: G476-G485.
16. Boyer JL, Trauner M, Mennone A, et al. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol 2006; 290: G1124-G1130.
17. Chen F, Ma L, Dawson PA, et al. Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J Biol Chem 2003; 278: 19909-19916.
18. +-dependent bile acid transporter is associated with cholehepatic shunting in rats. Hepatology 2005; 41: 1037-1045.
19. Sun AQ, Salkar R, Sachchidanand Xu S, et al. A 14-amino acid sequence with a beta-turn structure is required for apical membrane sorting of the rat ileal bile acid transporter. J Biol Chem 2003; 278: 4000-4009.
20. Alrefai WA, Sarwar Z, Tyagi S, Saksena S, Dudeja PK, Gill RK., Cholesterol modulates human intestinal sodium-dependent bile acid transporter. Am J Physiol Gastrointest Liver Physiol 2005; 288: G978-G985.
21. Renner O, Harsch S, Strohmeyer A, Schimmel S, Stange EF., Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease. J Lipid Res 2008; 49: 2045-2054.
22. Seward DJ, Koh AS, Boyer JL, Ballatori N., Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter OSTalpha-OSTbeta. J Biol Chem 2003; 278: 27473-27482.
23. Pribylova-Hribova P, Kotsch K, Lodererova A, et al. TGF-beta1 mRNA upregulation influences chronic renal allograft dysfunction. Kidney Int 2006; 69: 1872-1879.
24. Zhao L, Yang R, Cheng L, Wang M, Jiang Y, Wang S., LPS-induced epithelial-mesenchymal transition of intrahepatic biliary epithelial cells. J Surg Res 2011; 171: 819-825.
25. Tian F, Cheng L, Li D, et al. Downregulation of mucins in graft bile ducts after liver transplantation in rats. Transplantation 2011; 92: 529-535.
26. Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA., FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. J Lipid Res 2006; 47: 201-214.
27. Scotti E, Gilardi F, Godio C, et al. Bile acids and their signaling pathways: eclectic regulators of diverse cellular functions. Cell Mol Life Sci 2007; 64: 2477-2491.
28. Xia X, Francis H, Glaser S, Alpini G, LeSage G., Bile acid interactions with cholangiocytes. World J Gastroenterol 2006; 12: 3553-3563.
29. Fiorucci S, Mencarelli A, Distrutti E, Palladino G, Cipriani S., Targetting farnesoid-X-receptor: from medicinal chemistry to disease treatment. Curr Med Chem 2009; 17: 139-159.
30. Gadaleta RM, Oldenburg B, Willemsen EC, et al. Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-kappaB signaling in the intestine. Biochim Biophys Acta 2011; 1812: 851-858.
31. Gadaleta RM, van Erpecum KJ, Oldenburg B, et al. Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 2011; 60: 463-472.
32. Renga B, Migliorati M, Mencarelli A, Fiorucci S., Reciprocal regulation of the bile acid-activated receptor FXR and the interferon-gamma-STAT-1 pathway in macrophages. Biochim Biophys Acta 2009; 1792: 564-573.