메뉴 건너뛰기




Volumn 1, Issue 1, 2012, Pages 2-18

Dual-targeting for the elimination of cancer cells with increased selectivity

Author keywords

Cancer therapy; Drug conjugates; Dual targeting; Effector cell; Macrophage; NK cell; Triplebody

Indexed keywords


EID: 84888330224     PISSN: 20734468     EISSN: None     Source Type: Journal    
DOI: 10.3390/antib1010002     Document Type: Review
Times cited : (14)

References (52)
  • 1
    • 27144449009 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of cancer
    • Adams, G.P.; Weiner, L.M. Monoclonal antibody therapy of cancer. Nat. Biotechnol. 2005, 23, 1147–1157.
    • (2005) Nat. Biotechnol , vol.23 , pp. 1147-1157
    • Adams, G.P.1    Weiner, L.M.2
  • 3
    • 62349132009 scopus 로고    scopus 로고
    • Monoclonal antibodies for cancer immunotherapy
    • Weiner, L.M.; Dhodapkar, M.V.; Ferrone, S. Monoclonal antibodies for cancer immunotherapy. Lancet 2009, 373, 1033–1040.
    • (2009) Lancet , vol.373 , pp. 1033-1040
    • Weiner, L.M.1    Dhodapkar, M.V.2    Ferrone, S.3
  • 5
    • 33744540096 scopus 로고    scopus 로고
    • Antitumor antibodies in the treatment of cancer: Fc receptors link opsonic antibody with cellular immunity
    • Clynes, R. Antitumor antibodies in the treatment of cancer: Fc receptors link opsonic antibody with cellular immunity. Hematol. Oncol. Clin. North Am. 2006, 20, 585–612.
    • (2006) Hematol. Oncol. Clin. North Am , vol.20 , pp. 585-612
    • Clynes, R.1
  • 8
    • 42949157368 scopus 로고    scopus 로고
    • Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer
    • Musolino, A.; Naldi, N.; Bortesi, B.; Pezzuolo, D.; Capelletti, M.; Missale, G.; Laccabue, D.; Zerbini, A.; Camisa, R.; Bisagni, G.; et al. Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer. J. Clin. Oncol. 2008, 26, 1789–1796.
    • (2008) J. Clin. Oncol , vol.26 , pp. 1789-1796
    • Musolino, A.1    Naldi, N.2    Bortesi, B.3    Pezzuolo, D.4    Capelletti, M.5    Missale, G.6    Laccabue, D.7    Zerbini, A.8    Camisa, R.9    Bisagni, G.10
  • 9
    • 34548509226 scopus 로고    scopus 로고
    • FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab
    • Zhang, W.; Gordon, M.; Schultheis, A.M.; Yang, D.Y.; Nagashima, F.; Azuma, M.; Chang, H.M.; Borucka, E.; Lurje, G.; Sherrod, A.E.; et al. FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. J. Clin. Oncol. 2007, 25, 3712–3718.
    • (2007) J. Clin. Oncol , vol.25 , pp. 3712-3718
    • Zhang, W.1    Gordon, M.2    Schultheis, A.M.3    Yang, D.Y.4    Nagashima, F.5    Azuma, M.6    Chang, H.M.7    Borucka, E.8    Lurje, G.9    Sherrod, A.E.10
  • 11
    • 77955782190 scopus 로고    scopus 로고
    • A recombinant trispecific single-chain Fv derivative directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting
    • Kugler, M.; Stein, C.; Kellner, C.; Mentz, K.; Saul, D.; Schwenkert, M.; Schubert, I.; Singer, H.; Oduncu, F.; Stockmeyer, B.; et al. A recombinant trispecific single-chain Fv derivative directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting. Br. J. Haematol. 2010, 150, 574–586.
    • (2010) Br. J. Haematol , vol.150 , pp. 574-586
    • Kugler, M.1    Stein, C.2    Kellner, C.3    Mentz, K.4    Saul, D.5    Schwenkert, M.6    Schubert, I.7    Singer, H.8    Oduncu, F.9    Stockmeyer, B.10
  • 12
    • 84856776294 scopus 로고    scopus 로고
    • A recombinant triplebody with specificity for CD19 and HLA-DR mediates preferential binding to antigen double-positive cells by dual-targeting
    • Schubert, I.; Kellner, C.; Stein, C.; Kugler, M.; Schwenkert, M.; Saul, D.; Berens, C.; Oduncu, F.; Stockmeyer, B.; Mackensen, A.; et al. A recombinant triplebody with specificity for CD19 and HLA-DR mediates preferential binding to antigen double-positive cells by dual-targeting. mAbs 2012, 4, 45–56.
    • (2012) mAbs , vol.4 , pp. 45-56
    • Schubert, I.1    Kellner, C.2    Stein, C.3    Kugler, M.4    Schwenkert, M.5    Saul, D.6    Berens, C.7    Oduncu, F.8    Stockmeyer, B.9    Mackensen, A.10
  • 13
    • 78651404837 scopus 로고    scopus 로고
    • A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting
    • Schubert, I.; Kellner, C.; Stein, C.; Kugler, M.; Schwenkert, M.; Saul, D.; Mentz, K.; Singer, H.; Stockmeyer, B.; Hillen, W.; et al. A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting. MAbs 2011, 3, 21–30.
    • (2011) MAbs , vol.3 , pp. 21-30
    • Schubert, I.1    Kellner, C.2    Stein, C.3    Kugler, M.4    Schwenkert, M.5    Saul, D.6    Mentz, K.7    Singer, H.8    Stockmeyer, B.9    Hillen, W.10
  • 14
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • Topp, M.S.; Kufer, P.; Gokbuget, N.; Goebeler, M.; Klinger, M.; Neumann, S.; Horst, H.A.; Raff, T.; Viardot, A.; Schmid, M.; et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J. Clin. Oncol. 2011, 29, 2493–2498.
    • (2011) J. Clin. Oncol , vol.29 , pp. 2493-2498
    • Topp, M.S.1    Kufer, P.2    Gokbuget, N.3    Goebeler, M.4    Klinger, M.5    Neumann, S.6    Horst, H.A.7    Raff, T.8    Viardot, A.9    Schmid, M.10
  • 15
    • 67449119748 scopus 로고    scopus 로고
    • Treatment with anti-CD19 BiTE antibody bli¬natumomab (MT103/MEDI-538) is able to eliminate minimal residual disease (MRD) in patients with B-precursor acute lmphoblastic leukemia (ALL): First results of an ongoing phase II study (ASH Annual Meeting Abstract)
    • G.N
    • Topp, M,G.N.; Kufer, P.; Zugmaier, G.; Degenhard, E.; Neumann, S.; Horst, H.A.; Viardot, A.; Schmid, M.; Ottmann, O.G.; Schmidt, M.; et al. Treatment with anti-CD19 BiTE antibody bli¬natumomab (MT103/MEDI-538) is able to eliminate minimal residual disease (MRD) in patients with B-precursor acute lmphoblastic leukemia (ALL): First results of an ongoing phase II study (ASH Annual Meeting Abstract). Blood 2008, 112, 1926.
    • (2008) Blood , vol.112 , pp. 1926
    • Topp, M1    Kufer, P.2    Zugmaier, G.3    Degenhard, E.4    Neumann, S.5    Horst, H.A.6    Viardot, A.7    Schmid, M.8    Ottmann, O.G.9    Schmidt, M.10
  • 16
    • 77953228970 scopus 로고    scopus 로고
    • Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen
    • Bluemel, C.; Hausmann, S.; Fluhr, P.; Sriskandarajah, M.; Stallcup, W.B.; Baeuerle, P.A.; Kufer, P. Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen. Cancer Immunol. Immunother. 2010, 59, 1197–1209.
    • (2010) Cancer Immunol. Immunother , vol.59 , pp. 1197-1209
    • Bluemel, C.1    Hausmann, S.2    Fluhr, P.3    Sriskandarajah, M.4    Stallcup, W.B.5    Baeuerle, P.A.6    Kufer, P.7
  • 17
    • 15944388634 scopus 로고    scopus 로고
    • Engineered single chain antibody fragments for radioimmunotherapy
    • Huhalov, A.; Chester, K.A. Engineered single chain antibody fragments for radioimmunotherapy. Q. J. Nucl. Med. Mol. Imaging. 2004, 48, 279–288.
    • (2004) Q. J. Nucl. Med. Mol. Imaging , vol.48 , pp. 279-288
    • Huhalov, A.1    Chester, K.A.2
  • 19
    • 0028467948 scopus 로고
    • Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligand
    • Raghavan, M.; Chen, M.Y.; Gastinel, L.N.; Bjorkman, P.J. Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligand. Immunity 1994, 1, 303–315.
    • (1994) Immunity , vol.1 , pp. 303-315
    • Raghavan, M.1    Chen, M.Y.2    Gastinel, L.N.3    Bjorkman, P.J.4
  • 20
    • 33846031141 scopus 로고    scopus 로고
    • PEGylation and multimerization of the anti-p185HER-2 single chain Fv fragment 4D5: Effects on tumor targeting
    • Kubetzko, S.; Balic, E.; Waibel, R.; Zangemeister-Wittke, U.; Pluckthun, A. PEGylation and multimerization of the anti-p185HER-2 single chain Fv fragment 4D5: Effects on tumor targeting. J. Biol. Chem. 2006, 281, 35186–35201.
    • (2006) J. Biol. Chem , vol.281 , pp. 35186-35201
    • Kubetzko, S.1    Balic, E.2    Waibel, R.3    Zangemeister-Wittke, U.4    Pluckthun, A.5
  • 21
    • 0034671764 scopus 로고    scopus 로고
    • Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives
    • Schoonjans, R.; Willems, A.; Schoonooghe, S.; Fiers, W.; Grooten, J.; Mertens, N. Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives. J. Immunol. 2000, 165, 7050–7057.
    • (2000) J. Immunol , vol.165 , pp. 7050-7057
    • Schoonjans, R.1    Willems, A.2    Schoonooghe, S.3    Fiers, W.4    Grooten, J.5    Mertens, N.6
  • 22
    • 34250361507 scopus 로고    scopus 로고
    • Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin
    • Muller, D.; Karle, A.; Meissburger, B.; Hofig, I.; Stork, R.; Kontermann, R.E. Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin. J. Biol. Chem. 2007, 282, 12650–12660.
    • (2007) J. Biol. Chem , vol.282 , pp. 12650-12660
    • Muller, D.1    Karle, A.2    Meissburger, B.3    Hofig, I.4    Stork, R.5    Kontermann, R.E.6
  • 23
    • 82755197856 scopus 로고    scopus 로고
    • Strategies for extended serum half-life of protein therapeutics
    • Kontermann, R.E. Strategies for extended serum half-life of protein therapeutics. Curr. Opin. Biotechnol. 2011, 22, 868–876.
    • (2011) Curr. Opin. Biotechnol , vol.22 , pp. 868-876
    • Kontermann, R.E.1
  • 24
    • 0028277821 scopus 로고
    • Antigen forks: bispecific reagents that inhibit cell growth by binding selected pairs of tumor antigens
    • Ring, D.B.; Hsieh-Ma, S.T.; Shi, T.; Reeder, J. Antigen forks: bispecific reagents that inhibit cell growth by binding selected pairs of tumor antigens. Cancer Immunol. Immunother. 1994, 39, 41–48.
    • (1994) Cancer Immunol. Immunother , vol.39 , pp. 41-48
    • Ring, D.B.1    Hsieh-Ma, S.T.2    Shi, T.3    Reeder, J.4
  • 25
    • 79959766443 scopus 로고    scopus 로고
    • The Bs20x22 anti-CD20-CD22 bispecific antibody has more lymphomacidal activity than do the parent antibodies alone
    • Tuscano, J.M.; Ma, Y.; Martin, S.M.; Kato, J.; O'Donnell, R.T. The Bs20x22 anti-CD20-CD22 bispecific antibody has more lymphomacidal activity than do the parent antibodies alone. Cancer Immunol. Immunother. 2011, 60, 771–780.
    • (2011) Cancer Immunol. Immunother , vol.60 , pp. 771-780
    • Tuscano, J.M.1    Ma, Y.2    Martin, S.M.3    Kato, J.4    O'Donnell, R.T.5
  • 27
    • 84860332847 scopus 로고    scopus 로고
    • Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas
    • Epub ahead of print
    • Gupta, P.; Goldenberg, D.M.; Rossi, E.A.; Cardillo, T.M.; Byrd, J.C.; Muthusamy, N.; Furman, R.R.; Chang, C.H. Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas. Blood 2012, Epub ahead of print.
    • (2012) Blood
    • Gupta, P.1    Goldenberg, D.M.2    Rossi, E.A.3    Cardillo, T.M.4    Byrd, J.C.5    Muthusamy, N.6    Furman, R.R.7    Chang, C.H.8
  • 29
    • 79955675632 scopus 로고    scopus 로고
    • A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity
    • Dong, J.; Sereno, A.; Aivazian, D.; Langley, E.; Miller, B.R.; Snyder, W.B.; Chan, E.; Cantele, M.; Morena, R.; Joseph, I.B.; et al. A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity. MAbs 2011, 3, 273–288.
    • (2011) MAbs , vol.3 , pp. 273-288
    • Dong, J.1    Sereno, A.2    Aivazian, D.3    Langley, E.4    Miller, B.R.5    Snyder, W.B.6    Chan, E.7    Cantele, M.8    Morena, R.9    Joseph, I.B.10
  • 30
    • 84859409756 scopus 로고    scopus 로고
    • Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3
    • McDonagh, C.F.; Huhalov, A.; Harms, B.D.; Adams, S.; Paragas, V.; Oyama, S.; Zhang, B.; Luus, L.; Overland, R.; Nguyen, S.; et al. Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3. Mol. Cancer Ther. 2012, 11, 582–593.
    • (2012) Mol. Cancer Ther , vol.11 , pp. 582-593
    • McDonagh, C.F.1    Huhalov, A.2    Harms, B.D.3    Adams, S.4    Paragas, V.5    Oyama, S.6    Zhang, B.7    Luus, L.8    Overland, R.9    Nguyen, S.10
  • 31
    • 0032737901 scopus 로고    scopus 로고
    • Acquired antagonistic activity of a bispecific diabody directed against two different epitopes on vascular endothelial growth factor receptor 2
    • Lu, D.; Kotanides, H.; Jimenez, X.; Zhou, Q.; Persaud, K.; Bohlen, P.; Witte, L.; Zhu, Z. Acquired antagonistic activity of a bispecific diabody directed against two different epitopes on vascular endothelial growth factor receptor 2. J. Immunol. Methods 1999, 230, 159–171.
    • (1999) J. Immunol. Methods , vol.230 , pp. 159-171
    • Lu, D.1    Kotanides, H.2    Jimenez, X.3    Zhou, Q.4    Persaud, K.5    Bohlen, P.6    Witte, L.7    Zhu, Z.8
  • 32
    • 15944419554 scopus 로고    scopus 로고
    • A recombinant, fully human, bispecific antibody neutralizes the biological activities mediated by both vascular endothelial growth factor receptors 2 and 3
    • Jimenez, X.; Lu, D.; Brennan, L.; Persaud, K.; Liu, M.; Miao, H.; Witte, L.; Zhu, Z. A recombinant, fully human, bispecific antibody neutralizes the biological activities mediated by both vascular endothelial growth factor receptors 2 and 3. Mol. Cancer Ther. 2005, 4, 427–434.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 427-434
    • Jimenez, X.1    Lu, D.2    Brennan, L.3    Persaud, K.4    Liu, M.5    Miao, H.6    Witte, L.7    Zhu, Z.8
  • 33
    • 78651399650 scopus 로고    scopus 로고
    • A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor
    • Emanuel, S.L.; Engle, L.J.; Chao, G.; Zhu, R.R.; Cao, C.; Lin, Z.; Yamniuk, A.P.; Hosbach, J.; Brown, J.; Fitzpatrick, E.; et al. A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor. MAbs 2011, 3, 38–48.
    • (2011) MAbs , vol.3 , pp. 38-48
    • Emanuel, S.L.1    Engle, L.J.2    Chao, G.3    Zhu, R.R.4    Cao, C.5    Lin, Z.6    Yamniuk, A.P.7    Hosbach, J.8    Brown, J.9    Fitzpatrick, E.10
  • 35
    • 77953369554 scopus 로고    scopus 로고
    • A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo
    • Mabry, R.; Gilbertson, D.G.; Frank, A.; Vu, T.; Ardourel, D.; Ostrander, C.; Stevens, B.; Julien, S.; Franke, S.; Meengs, B.; et al. A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo. MAbs 2010, 2, 20–34.
    • (2010) MAbs , vol.2 , pp. 20-34
    • Mabry, R.1    Gilbertson, D.G.2    Frank, A.3    Vu, T.4    Ardourel, D.5    Ostrander, C.6    Stevens, B.7    Julien, S.8    Franke, S.9    Meengs, B.10
  • 36
    • 77951520735 scopus 로고    scopus 로고
    • Molecular construction and optimization of anti-human IL-1alpha/beta dual variable domain immunoglobulin (DVD-Ig) molecules
    • Wu, C.; Ying, H.; Bose, S.; Miller, R.; Medina, L.; Santora, L.; Ghayur, T. Molecular construction and optimization of anti-human IL-1alpha/beta dual variable domain immunoglobulin (DVD-Ig) molecules. MAbs 2009, 1, 339–347.
    • (2009) MAbs , vol.1 , pp. 339-347
    • Wu, C.1    Ying, H.2    Bose, S.3    Miller, R.4    Medina, L.5    Santora, L.6    Ghayur, T.7
  • 38
    • 0033390142 scopus 로고    scopus 로고
    • Development of a trispecific antibody conjugate that directs two distinct tumor-associated antigens to CD64 on myeloid effector cells
    • Somasundaram, C.; Sundarapandiyan, K.; Keler, T.; Deo, Y.M.; Graziano, R.F. Development of a trispecific antibody conjugate that directs two distinct tumor-associated antigens to CD64 on myeloid effector cells. Hum. Antibodies 1999, 9, 47–54.
    • (1999) Hum. Antibodies , vol.9 , pp. 47-54
    • Somasundaram, C.1    Sundarapandiyan, K.2    Keler, T.3    Deo, Y.M.4    Graziano, R.F.5
  • 39
    • 70349653790 scopus 로고    scopus 로고
    • A novel reduced immunogenicity bispecific targeted toxin simultaneously recognizing human epidermal growth factor and interleukin-4 receptors in a mouse model of metastatic breast carcinoma
    • Oh, S.; Stish, B.J.; Sachdev, D.; Chen, H.; Dudek, A.Z.; Vallera, D.A. A novel reduced immunogenicity bispecific targeted toxin simultaneously recognizing human epidermal growth factor and interleukin-4 receptors in a mouse model of metastatic breast carcinoma. Clin. Cancer Res. 2009, 15, 6137–6147.
    • (2009) Clin. Cancer Res , vol.15 , pp. 6137-6147
    • Oh, S.1    Stish, B.J.2    Sachdev, D.3    Chen, H.4    Dudek, A.Z.5    Vallera, D.A.6
  • 40
    • 77953403241 scopus 로고    scopus 로고
    • A new drug delivery method of bispecific ligand-directed toxins, which reduces toxicity and promotes efficacy in a model of orthotopic pancreatic cancer
    • Oh, S.; Stish, B.J.; Vickers, S.M.; Buchsbaum, D.J.; Saluja, A.K.; Vallera, D.A. A new drug delivery method of bispecific ligand-directed toxins, which reduces toxicity and promotes efficacy in a model of orthotopic pancreatic cancer. Pancreas 2010, 39, 913–922.
    • (2010) Pancreas , vol.39 , pp. 913-922
    • Oh, S.1    Stish, B.J.2    Vickers, S.M.3    Buchsbaum, D.J.4    Saluja, A.K.5    Vallera, D.A.6
  • 41
    • 67549102111 scopus 로고    scopus 로고
    • Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy
    • Vallera, D.A.; Chen, H.; Sicheneder, A.R.; Panoskaltsis-Mortari, A.; Taras, E.P. Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy. Leuk. Res. 2009, 33, 1233–1242.
    • (2009) Leuk. Res , vol.33 , pp. 1233-1242
    • Vallera, D.A.1    Chen, H.2    Sicheneder, A.R.3    Panoskaltsis-Mortari, A.4    Taras, E.P.5
  • 43
    • 84858249264 scopus 로고    scopus 로고
    • 1st ed.; Springer-Verlag Berlin: Heidelberg, Germany
    • Kontermann, R.E. Bispecific Antibodies, 1st ed.; Springer-Verlag Berlin: Heidelberg, Germany, 2011; p. 373.
    • (2011) Bispecific Antibodies , pp. 373
    • Kontermann, R.E.1
  • 46
    • 28844456971 scopus 로고    scopus 로고
    • Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia
    • Taussig, D.C.; Pearce, D.J.; Simpson, C.; Rohatiner, A.Z.; Lister, T.A.; Kelly, G.; Luongo, J.L.; Danet-Desnoyers, G.A.; Bonnet, D. Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood 2005, 106, 4086–4092.
    • (2005) Blood , vol.106 , pp. 4086-4092
    • Taussig, D.C.1    Pearce, D.J.2    Simpson, C.3    Rohatiner, A.Z.4    Lister, T.A.5    Kelly, G.6    Luongo, J.L.7    Danet-Desnoyers, G.A.8    Bonnet, D.9
  • 47
  • 48
    • 60749090900 scopus 로고    scopus 로고
    • Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework
    • Kugler, M.; Stein, C.; Schwenkert, M.; Saul, D.; Vockentanz, L.; Huber, T.; Wetzel, S.K.; Scholz, O.; Pluckthun, A.; Honegger, A.; et al. Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework. Protein Eng. Des. Sel. 2009, 22, 135–147.
    • (2009) Protein Eng. Des. Sel , vol.22 , pp. 135-147
    • Kugler, M.1    Stein, C.2    Schwenkert, M.3    Saul, D.4    Vockentanz, L.5    Huber, T.6    Wetzel, S.K.7    Scholz, O.8    Pluckthun, A.9    Honegger, A.10
  • 49
    • 27244440324 scopus 로고    scopus 로고
    • Molecular genetics of acute lymphoblastic leukemia
    • Armstrong, S.A.; Look, A.T. Molecular genetics of acute lymphoblastic leukemia. J. Clin. Oncol. 2005, 23, 6306–6315.
    • (2005) J. Clin. Oncol , vol.23 , pp. 6306-6315
    • Armstrong, S.A.1    Look, A.T.2
  • 50
    • 0036049687 scopus 로고    scopus 로고
    • Antigen expression patterns reflecting genotype of acute leukemias
    • Hrusak, O.; Porwit-MacDonald, A. Antigen expression patterns reflecting genotype of acute leukemias. Leukemia 2002, 16, 1233–1258.
    • (2002) Leukemia , vol.16 , pp. 1233-1258
    • Hrusak, O.1    Porwit-MacDonald, A.2
  • 52
    • 84863724580 scopus 로고    scopus 로고
    • A deimmunized bispecific ligand-directed Toxin that shows an impressive anti-pancreatic cancer effect in a systemic nude mouse orthotopic model
    • Epub ahead of print
    • Oh, S.; Todhunter, D.A.; Panoskaltsis-Mortari, A.; Buchsbaum, D.J.; Toma, S.; Vallera, D.A. A deimmunized bispecific ligand-directed Toxin that shows an impressive anti-pancreatic cancer effect in a systemic nude mouse orthotopic model. Pancreas 2012, Epub ahead of print.
    • (2012) Pancreas
    • Oh, S.1    Todhunter, D.A.2    Panoskaltsis-Mortari, A.3    Buchsbaum, D.J.4    Toma, S.5    Vallera, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.