Plasma klotho levels were inversely associated with subclinical carotid atherosclerosis in HIV-infected patients receiving combined antiretroviral therapy

AIDS Research and Human Retroviruses

Volumn 29, Issue 12, 2013, Pages 1575-1581

  Jeong, Su Jin ^a   Song, Je Eun ^a   Kim, Sun Bean ^a   Kim, Hye Won ^a   Ku, Nam Su ^a   Han, Sang Hoon ^a   Choi, Jun Yong ^a   Song, Young Goo ^a   Cha, Bong Soo ^a   Kim, June Myung ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; GLUCOSE; KLOTHO PROTEIN; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; STAVUDINE; ZIDOVUDINE;

ADULT; ARTERIAL WALL THICKNESS; ARTICLE; CAROTID ARTERY; CAROTID ATHEROSCLEROSIS; CONTROLLED STUDY; DIET RESTRICTION; DISEASE ASSOCIATION; ENZYME BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY;

ADULT; ANTI-HIV AGENTS; CAROTID ARTERY DISEASES; DRUG THERAPY, COMBINATION; FEMALE; GLUCURONIDASE; HIV INFECTIONS; HUMANS; LIMIT OF DETECTION; MALE; PROSPECTIVE STUDIES;

EID: 84888325705     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2013.0048     Document Type: Article

References (35)

1. Palella FJ, Delaney KM, Moorman AC, et al.: Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998;338(13):853-860.
2. Mocroft A, Brettle R, Kirk O, et al.: Changes in the cause of death among HIV positive subjects across Europe: Results from the EuroSIDA study. AIDS 2002;16(12):1663-1671.
3. Mochan A, Modi M, and Modi G: Stroke in black South African HIV-positive patients: A prospective analysis. Stroke 2003;34(1):10-15.
4. Brannagan TH: Retroviral-associated vasculitis of the nervous system. Neurol Clin 1997;15(4):927-944.
5. Kuro-o M, Matsumura Y, Aizawa H, et al.: Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997;390(6655):45-51.
6. Saito Y, Yamagishi T, Nakamura T, et al.: Klotho protein protects against endothelial dysfunction. Biochem Biophys Res Commun 1998;248(2):324-329.
7. Urakawa I, Yamazaki Y, Shimada T, et al.: Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006;444(7120):770-774.
8. Saito Y, Nakamura T, Ohyama Y, et al.: In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem Biophys Res Commun 2000; 276(2):767-772.
9. Imura A, Tsuji Y, Murata M, et al.: Alpha-Klotho as a regulator of calcium homeostasis. Science 2007;316(5831):1615-1618.
10. Kurosu H, Yamamoto M, Clark JD, et al.: Suppression of aging in mice by the hormone klotho. Science 2005; 309(5742):1829-1833.
11. Imura A, Iwano A, Tohyama O, et al.: Secreted klotho protein in sera and CSF: Implication for post-translational cleavage in release of klotho protein from cell membrane. FEBS Lett 2004;565(1-3):143-147.
12. Yamazaki Y, Imura A, Urakawa I, et al.: Establishment of sandwich ELISA for soluble alpha-klotho measurement: Age-dependent change of soluble alpha-klotho levels in healthy subjects. Biochem Biophys Res Commun 2010; 398(3):513-518.
13. Semba RD, Cappola AR, Sun K, et al.: Plasma klotho and cardiovascular disease in adults. J Am Geriatr Soc 2011; 59(9):1596-1601.
14. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, and Turner RC: Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28(7):412-419.
15. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, and Roth D: A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999;130(6):461-470.
16. Stein JH, Korcarz CE, Hurst RT, et al.: Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: A consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr 2008;21(2): 93-111.
17. Cho YL, Kim DJ, Kim HD, et al.: Reference values of carotid artery intima-media thickness and association with atherosclerotic risk factors in healthy subjects in Korea. Korean J Intern Med 2003;64(3):275-283.
18. Pignoli P, Tremoli E, Poli A, Oreste P, and Paoletti R: Intimal plus medial thickness of the arterial wall: A direct mea-surement with ultrasound imaging. Circulation 1986;74(6): 1399-1406.
19. Yanase T, Nasu S, Mukuta Y, et al.: Evaluation of a new carotid intima-media thickness measurement by B-mode ultrasonography using an innovative measurement software, intimascope. Am J Hypertens 2006;19(12):1206-1212.
20. Stein JH, Korcarz CE, and Post WS: Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: Summary and discussion of the American Society of Echocardiography consensus statement. Prev Cardiol 2009;12(1):34-38.
21. Ito S, Kinoshita S, Shiraishi N, et al.: Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel klotho family protein. Mech Dev 2000;98(1-2):115-119.
22. Guaraldi G, Stentarelli C, Zona S, et al.: Lipodystrophy and anti-retroviral therapy as predictors of sub-clinical atherosclerosis in human immunodeficiency virus infected subjects. Atherosclerosis 2010;208(1):222-227.
23. Grinspoon S and Carr A: Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N Engl J Med 2005;352(1):48-62.
24. Armutcu F, Ataymen M, Atmaca H, and Gurel A: Oxidative stress markers, C-reactive protein and heat shock protein 70 levels in subjects with metabolic syndrome. Clin Chem Lab Med 2008;46(6):785-790.
25. Ohta J, Rakugi H, Ishikawa K, et al.: Klotho gene delivery suppresses oxidative stress in vivo. Geriatr Gerontol Int 2007;7(3):293-299.
26. White CR, Brock TA, Chang LY, et al.: Superoxide and peroxynitrite in atherosclerosis. Proc Natl Acad Sci USA 1994;91(3):1044-1048.
27. Moncada S and Martin JF: Evolution of nitric oxide. Lancet (London, England) 1993;341(8859):1511.
28. Hodis HN, Mack WJ, LaBree L, et al.: The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med 1998;128(4):262-269.
29. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, and Wolfson SK: Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999;340(1):14-22.
30. Chambless LE, Heiss G, Folsom AR, et al.: Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: The Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. Am J Epidemiol 1997;146(6):483-494.
31. Lorenz MW, von Kegler S, Steinmetz H, Markus HS, and Sitzer M: Carotid intima-media thickening indicates a higher vascular risk across a wide age range: Prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke 2006;37(1):87-92.
32. Lakatta EG, Wang M, and Najjar S: Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels. Med Clin North Am 2009;93(3):583-604.
33. Schillaci G, De Socio GV, Pirro M, et al.: Impact of treatment with protease inhibitors on aortic stiffness in adult patients with human immunodeficiency virus infection. Arterioscler Thromb Vasc Biol 2005;25(11):2381-2385.
34. van Leuven SI, Sankatsing R, Vermeulen JN, Kastelein JJ, Reiss P, and Stroes ES: Atherosclerotic vascular disease in HIV: It is not just antiretroviral therapy that hurts the heart! Curr Opin HIV AIDS 2007;2(4):324-331.
35. Kaplan RC, Kingsley LA, Gange SJ, et al.: Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men. AIDS 2008;22(13):1615-1624.