Increased lysosomal proteolysis counteracts protein accumulation in the proximal tubule during focal segmental glomerulosclerosis

Kidney International

Volumn 84, Issue 5, 2013, Pages 902-910

  Nielsen, Rikke ^a   Mollet, Geraldine ^b,c   Esquivel, Ernie L ^b,c,d   Weyer, Kathrin ^a   Nielsen, Pia K ^a   Antignac, Corinne ^b,c   Christensen, Erik I ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

endocytosis; enzymes; lysosome; proteinuria

Indexed keywords

ACID PHOSPHATASE; ALPHA MANNOSIDASE; ALPHA N ACETYLGLUCOSAMINIDASE; BETA GLUCOSIDASE; CUBILIN; DEOXYRIBONUCLEASE II; LYSOSOME ENZYME; MEGALIN; MESSENGER RNA; PHOSPHOLIPASE A2; PODOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CUBILIN GENE; ENZYME DEGRADATION; FOCAL GLOMERULOSCLEROSIS; IMMUNOHISTOCHEMISTRY; KIDNEY PROXIMAL TUBULE; LYSOSOMAL ENZYME GENE; LYSOSOME STORAGE DISEASE; MEGALIN GENE; MOUSE; NONHUMAN; NPHS2 GENE; PODOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; PROTEINURIA; SIGNAL TRANSDUCTION;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOCYTOSIS; FIBROSIS; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; INFLAMMATION MEDIATORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY TUBULES, PROXIMAL; LIGANDS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-2; LYSOSOMES; MEMBRANE PROTEINS; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; PEPTIDE HYDROLASES; PODOCYTES; PROTEINURIA; PROTEOLYSIS; RECEPTORS, CELL SURFACE; RNA, MESSENGER; TIME FACTORS; UP-REGULATION;

EID: 84888317388     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2013.218     Document Type: Article

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