Hepatoprotective and antioxidant activity of Canscora Perfoliata Lam (Gentianaceae) against CCL4 induced hepatotoxicity in rats

International Journal of Research in Ayurveda and Pharmacy

Volumn 3, Issue 6, 2012, Pages 822-826

  Thangakrishnakumari, S ^a   Nishanthini, A ^b   Muthukumarasamy, S ^a   Mohan, V R ^b  

^a Sri KGS Arts College   (India)

^b V O CHIDAMBARAM COLLEGE   (India)

Author keywords

Antioxidant; Bilirubin; CCl4; Hepatoprotective activity; MDA

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALKALINE PHOSPHATASE; ALKALOID DERIVATIVE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BILIRUBIN GLUCURONIDE; CANSCORA PERFOLIATA EXTRACT; CARBON TETRACHLORIDE; CATALASE; COUMARIN; FLAVONOID; GLOBULIN; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLYCOSIDE; MALONALDEHYDE; PHENOL DERIVATIVE; PLANT EXTRACT; SAPONIN DERIVATIVE; STEROID; SUPEROXIDE DISMUTASE; TANNIN DERIVATIVE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CANSCORA PERFOLIATA; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME ASSAY; GENTIANACEAE; HYPOPROTEINEMIA; LIPID PEROXIDATION; LIVER PROTECTION; LIVER TOXICITY; NONHUMAN; PHYTOCHEMISTRY; PROTEIN METABOLISM; PROTEIN SYNTHESIS; RAT;

EID: 84888308779     PISSN: 22774343     EISSN: 22293566     Source Type: Journal    
DOI: 10.7897/2277-4343.03628     Document Type: Article

References (29)

1. Ahsan R, Monirul Islam KM, Musaddik A, Hague E. Hepatoprotective activity of methanol extract of some medicinal plants against carbon tetrachloride induced hepatotoxicity in albino rats. Glob J Pharmacol 2009; 3: 116-122.
2. Nazemma TH, Brindha V. Antihepatotoxic and antioxidant defense potential of Mimosa pudica. Int J Drug Discov 2009; 1: 1-14.
3. Manokaran S, Jaswanth A, Sengottuvelu S, Nandhakumar J, Duraisamy R, Karthikeyan, D. et al., Hepatoprotective activity of Aerva lanata Linn against paracetamol induced hepatotoxicity in rats. Research J Pharm and Tech 2008; 1: 398-400.
4. Rachehh MA, Yadav PN, Cokani RH, Jain SM. Antiinflammatory activity of Benincasa hispid fruit. Int J Phar Biosci 2011; 2: 98-106.
5. Muthukumarasamy S, Mohan VR, Kumaresan S, Chelladurai V. Herbal remedies of Palliyar tribe of Grizzled Giant Squirrel Wildlife Sanctuary, Srivilliputhur, Western Ghats, Tamil Nadu for poisonous bites. J Econ Taxon Bot 2003; 27: 761-764.
6. Das KK, Das SN, Das Gupta S. The influence of ascorbic acid against nickel-induced hepatic lipid peroxidation in rats. J Basic Clin. Physiol. Pharmacol 2001; 12: 187-195. http://dx.doi.org/10.1515/JBCPP.2001.12.3.187 PMid:11762690
7. Premila Abraham P, Wilfred G, Ramakrishna B. Decreased activity of hepatic alkaline protease in rats with carbon tetrachlorideinduced liver cirrhosis. Indian J Exp Biol 1999; 37: 1234-1244.
8. Brinda P, Sasikala P, Purushothaman KK: Pharmacognostic studies on Merugan kizhangu. Bulletin in Medical Ethnobotanical Research 1981; 3:84-96.
9. Anonymous: Phytochemical investigation of certain medicinal plants used in Ayurveda. Central Council for Research in Ayurveda and Siddha, New Delhi. 1990.
10. Lala PK: Lab manuals of Pharmacognosy CSI Publishers and Distributers, Kolkata. 1993.
11. OECD, (Organisation for Economic co-operation and Development). OECD guidelines for the testing of chemicals/Section 4: Health Effects Test No. 423; Acute oral Toxicity- Acute Toxic Class method. OECD. Paris. 2002.
12. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin's phenol reagent. Journal of Biological Chemistry 1951; 193: 265-275. PMid:14907713
13. Reitman S, Frankel SA. Colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. American Journal of Clinical Pathology 1957; 28: 56-63. PMid:13458125
14. King EJ, Armstrong AR. Determination of serum and bile phosphatase activity. Cannadian Medical Association Journal 1934; 31: 56-63.
15. Balistrei WR, Shaw LM. Liver function In: Fundamental of Clinical Chemistry, (Ed) Tietz N.W. 3rd edition. W.B. Saunders Company, Philadelphia, 1987. p. 729-761.
16. Okhawa H, Ohishi N, Yagi K. Assay of lipid peroxidases in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 1979; 95: 351-358. http://dx.doi.org/10.1016/0003-2697(79)90738-3
17. Mishra HP, Fridowich I. The role of superoxide dismutase anion in antioxidation of epinephrine and sample assay in superoxide dismutase. Journal of Biological Chemistry 1972; 241: 3170.
18. Aebi H. Catalase, in Methods of enzymatic analysis. Bergmayer H.U. (Ed) chemie, 2nd edn. Weinheim: F.R.G; 1974. 673-684.
19. Colowick SP, Kaplan NO, Packer L. Methods in Enzymology. Academic press, London; 1984. p.121-125.
20. Pagila DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical medicine 1967; 70: 158-169.
21. Goldberg DM, Spooner RJ. Glutathione Reductase, In: Methods in Enzymatic Analysis, VCH Weinhem, Germany 1983; 258-265. PMid:6312299
22. Larrey D. Drug induced liver diseases. J Hepatol 2003; 32: 77-88. http://dx.doi.org/10.1016/S0168-8278(00)80417-1
23. Watkins PB, Seeff LB, Drug-induced liver injury: summary of a single topic clinical research committee. Hepatology 2006; 43:618- 631. http://dx.doi.org/10.1002/hep.21095 PMid:16496329
24. Recknagel RO. A new direction in the study of carbon tetrachloride hepatotoxicity. Life Sci 1983 ; 33: 401-408. http://dx.doi.org/10.1016/0024-3205(83)90787-7
25. Suky TMB, Parthipan B, Kingston C, Mohan, VR, Tresina Soris, P. Hepatoprotecive and antioxidant effect of Balanites aegyptiaca (L.) Del against CCl4 induced hepatotoxicity in rats. Int J Pharmaceu Sci Res 2011; 2: 887-892.
26. Graw A, Cowan RA, O'Reilly DSJ, Stevant MJ, Stephard J. Clinical biochemistry- an illustrated color text. Is ted. New York: Churchill Livingstone; 1999. p 51-53.
27. Olaleye M, Afolabi C, Adebayo A, Ogunboye A, Akindahunsi A. Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats. Food Chem Toxicol 2010; 48: 2200-2205 http://dx.doi.org/10.1016/j.fct.2010.05.047 PMid:20553784
28. Curtis SJ, Moritz M, Snodgrass PJ. Serum enzymes derived from liver cell fractions and the response to carbon tetrachloride intoxication in rats. Gastroenterology 1972; 62:84-92. PMid:5059436
29. Chance B, Green Stein DS, Roughton RJW. The mechanism of catalase action 1-steady state analysis. Arch Biochem Biophys.1952; 37: 301- 339. http://dx.doi.org/10.1016/0003- 9861(52)90194-X