Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention

BMC Pediatrics

Volumn 13, Issue 1, 2013, Pages

  Roth, Christian L ^a   Hinney, Anke ^b   Schur, Ellen A ^c   Elfers, Clinton T ^a   Reinehr, Thomas ^d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^d UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

Dopamine receptor polymorphisms; Lifestyle intervention; Obesity; Weight reduction

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR;

ADOLESCENT; ALLELE; ARTICLE; BEHAVIOR THERAPY; BODY MASS; BODY WEIGHT; CASE CONTROL STUDY; CHILD; CHILDHOOD OBESITY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DNA POLYMORPHISM; EXERCISE; EXON; EXPLORATORY RESEARCH; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; KINESIOTHERAPY; LEAN BODY WEIGHT; LIFESTYLE MODIFICATION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; NUTRITION EDUCATION; SCHOOL CHILD; SKINFOLD THICKNESS; VARIABLE NUMBER OF TANDEM REPEAT; WEIGHT REDUCTION;

ADOLESCENT; ADULT; ALLELES; BODY MASS INDEX; CASE-CONTROL STUDIES; CHILD; FEMALE; GENOTYPE; HUMANS; LONGITUDINAL STUDIES; MALE; MINISATELLITE REPEATS; OBESITY; OVERWEIGHT; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; WEIGHT LOSS;

EID: 84888267320     PISSN: None     EISSN: 14712431     Source Type: Journal    
DOI: 10.1186/1471-2431-13-197     Document Type: Article

References (53)

1. Doehring A, Kirchhof A, Lotsch J. Genetic diagnostics of functional variants of the human dopamine D2 receptor gene. Psychiatr Genet 2009, 19(5):259-268. 10.1097/YPG.0b013e32832d0941, 19512960.
2. Chen D, Liu F, Shang Q, Song X, Miao X, Wang Z. Association between polymorphisms of DRD2 and DRD4 and opioid dependence: evidence from the current studies. Am J Med Genet B Neuropsychiatr Genet 2011, 156B(6):661-670.
3. Mignini F, Napolioni V, Codazzo C, Carpi FM, Vitali M, Romeo M, Ceccanti M. DRD2/ANKK1 TaqIA and SLC6A3 VNTR polymorphisms in alcohol dependence: association and gene-gene interaction study in a population of Central Italy. Neurosci Lett 2012, 522(2):103-107. 10.1016/j.neulet.2012.06.008, 22698582.
4. Mehta S, Melhorn SJ, Smeraglio A, Tyagi V, Grabowski T, Schwartz MW, Schur EA. Regional brain response to visual food cues is a marker of satiety that predicts food choice. Am J Clin Nutr 2012, 96(5):989-999. 10.3945/ajcn.112.042341, 3471210, 22990034.
5. Nicola SM. The nucleus accumbens as part of a basal ganglia action selection circuit. Psychopharmacol (Berl) 2007, 191(3):521-550.
6. Del Parigi A, Gautier JF, Chen K, Salbe AD, Ravussin E, Reiman E, Tataranni PA. Neuroimaging and obesity: mapping the brain responses to hunger and satiation in humans using positron emission tomography. Ann N Y Acad Sci 2002, 967:389-397.
7. LaBar KS, Gitelman DR, Parrish TB, Kim YH, Nobre AC, Mesulam MM. Hunger selectively modulates corticolimbic activation to food stimuli in humans. Behav Neurosci 2001, 115(2):493-500.
8. Uher R, Treasure J, Heining M, Brammer MJ, Campbell IC. Cerebral processing of food-related stimuli: effects of fasting and gender. Behav Brain Res 2006, 169(1):111-119. 10.1016/j.bbr.2005.12.008, 16445991.
9. Stice E, Yokum S, Bohon C, Marti N, Smolen A. Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4. Neuroimage 2010, 50(4):1618-1625. 10.1016/j.neuroimage.2010.01.081, 20116437.
10. Comings DE, Blum K. Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog Brain Res 2000, 126:325-341.
11. Wang GJ, Volkow ND, Fowler JS. The role of dopamine in motivation for food in humans: implications for obesity. Expert Opin Ther Targets 2002, 6(5):601-609. 10.1517/14728222.6.5.601, 12387683.
12. DelParigi A, Chen K, Salbe AD, Hill JO, Wing RR, Reiman EM, Tataranni PA. Persistence of abnormal neural responses to a meal in postobese individuals. Int J Obes Relat Metab Disord 2004, 28(3):370-377. 10.1038/sj.ijo.0802558, 14676847.
13. Stoeckel LE, Kim J, Weller RE, Cox JE, Cook EW, Horwitz B. Effective connectivity of a reward network in obese women. Brain Res Bull 2009, 79(6):388-395. 10.1016/j.brainresbull.2009.05.016, 3441054, 19467298.
14. Davis C, Fox J. Sensitivity to reward and body mass index (BMI): evidence for a non-linear relationship. Appetite 2008, 50(1):43-49. 10.1016/j.appet.2007.05.007, 17614159.
15. Haltia LT, Rinne JO, Merisaari H, Maguire RP, Savontaus E, Helin S, Nagren K, Kaasinen V. Effects of intravenous glucose on dopaminergic function in the human brain in vivo. Synapse 2007, 61(9):748-756. 10.1002/syn.20418, 17568412.
16. Volkow ND, Wang GJ, Telang F, Fowler JS, Thanos PK, Logan J, Alexoff D, Ding YS, Wong C, Ma Y, et al. Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors. Neuroimage 2008, 42(4):1537-1543. 10.1016/j.neuroimage.2008.06.002, 2659013, 18598772.
17. Dubertret C, Gouya L, Hanoun N, Deybach JC, Ades J, Hamon M, Gorwood P. The 3′ region of the DRD2 gene is involved in genetic susceptibility to schizophrenia. Schizophr Res 2004, 67(1):75-85. 10.1016/S0920-9964(03)00220-2, 14741327.
18. Ritchie T, Noble EP. Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics. Neurochem Res 2003, 28(1):73-82. 10.1023/A:1021648128758, 12587665.
19. Davis C, Levitan RD, Yilmaz Z, Kaplan AS, Carter JC, Kennedy JL. Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes. Prog Neuropsychopharmacol Biol Psychiatry 2012, 38(2):328-335. 10.1016/j.pnpbp.2012.05.002, 22579533.
20. Noain D, Avale ME, Wedemeyer C, Calvo D, Peper M, Rubinstein M. Identification of brain neurons expressing the dopamine D4 receptor gene using BAC transgenic mice. Eur J Neurosci 2006, 24(9):2429-2438. 10.1111/j.1460-9568.2006.05148.x, 17100831.
21. Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HH. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 1995, 65(3):1157-1165.
22. Stice E, Spoor S, Bohon C, Small DM. Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele. Science 2008, 322(5900):449-452. 10.1126/science.1161550, 2681095, 18927395.
23. Muller TD, Tschop MH, Jarick I, Ehrlich S, Scherag S, Herpertz-Dahlmann B, Zipfel S, Herzog W, de Zwaan M, Burghardt R, et al. Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa. J Psychiatr Res 2011, 45(5):706-711. 10.1016/j.jpsychires.2010.10.001, 21035823.
24. Kromeyer-Hauschild K, Wabitsch M, Geller F, et al. Percentiles of body mass index in children and adolescents evaluated from different regional German studies. Monatsschr Kinderheilkd 2001, 149:807-818.
25. Slaughter MH, Lohman TG, Boileau RA, Horswill CA, Stillman RJ, Van Loan MD, Bemben DA. Skinfold equations for estimation of body fatness in children and youth. Hum Biol 1988, 60(5):709-723.
26. Reinehr T, de Sousa G, Toschke AM, Andler W. Long-term follow-up of cardiovascular disease risk factors in children after an obesity intervention. Am J Clin Nutr 2006, 84(3):490-496.
27. Hinney A, Schneider J, Ziegler A, Lehmkuhl G, Poustka F, Schmidt MH, Mayer H, Siegfried W, Remschmidt H, Hebebrand J. No evidence for involvement of polymorphisms of the dopamine D4 receptor gene in anorexia nervosa, underweight, and obesity. Am J Med Genet 1999, 88(6):594-597. 10.1002/(SICI)1096-8628(19991215)88:6<594::AID-AJMG2>3.0.CO;2-F, 10581473.
28. Lunetta KL. Genetic association studies. Circulation 2008, 118(1):96-101. 10.1161/CIRCULATIONAHA.107.700401, 18591452.
29. Cole TJ. The LMS method for constructing normalized growth standards. Eur J Clin Nutr 1990, 44(1):45-60.
30. Ghahremani DG, Lee B, Robertson CL, Tabibnia G, Morgan AT, De Shetler N, Brown AK, Monterosso JR, Aron AR, Mandelkern MA, et al. Striatal dopamine D2/D3 receptors mediate response inhibition and related activity in frontostriatal neural circuitry in humans. J Neurosci 2012, 32(21):7316-7324. 10.1523/JNEUROSCI.4284-11.2012, 3517177, 22623677.
31. Rieger M, Gauggel S, Burmeister K. Inhibition of ongoing responses following frontal, nonfrontal, and basal ganglia lesions. Neuropsychology 2003, 17(2):272-282.
32. Aron AR, Durston S, Eagle DM, Logan GD, Stinear CM, Stuphorn V. Converging evidence for a fronto-basal-ganglia network for inhibitory control of action and cognition. J Neurosci 2007, 27(44):11860-11864. 10.1523/JNEUROSCI.3644-07.2007, 17978025.
33. Mostofsky SH, Simmonds DJ. Response inhibition and response selection: two sides of the same coin. J Cogn Neurosci 2008, 20(5):751-761. 10.1162/jocn.2008.20500, 18201122.
34. Chambers CD, Garavan H, Bellgrove MA. Insights into the neural basis of response inhibition from cognitive and clinical neuroscience. Neurosci Biobehav Rev 2009, 33(5):631-646. 10.1016/j.neubiorev.2008.08.016, 18835296.
35. Tabibnia G, Monterosso JR, Baicy K, Aron AR, Poldrack RA, Chakrapani S, Lee B, London ED. Different forms of self-control share a neurocognitive substrate. J Neurosci 2011, 31(13):4805-4810. 10.1523/JNEUROSCI.2859-10.2011, 3096483, 21451018.
36. Braet C, Claus L, Verbeken S, Van Vlierberghe L. Impulsivity in overweight children. Eur Child Adolesc Psychiatry 2007, 16(8):473-483. 10.1007/s00787-007-0623-2, 17876511.
37. Nederkoorn C, Jansen E, Mulkens S, Jansen A. Impulsivity predicts treatment outcome in obese children. Behav Res Ther 2007, 45(5):1071-1075. 10.1016/j.brat.2006.05.009, 16828053.
38. van den Berg L, Pieterse K, Malik JA, Luman M, Willems van Dijk K, Oosterlaan J, Delemarre-van de Waal HA. Association between impulsivity, reward responsiveness and body mass index in children. Int J Obes (Lond) 2011, 35(10):1301-1307. 10.1038/ijo.2011.116, 21694699.
39. Guo G, North KE, Gorden-Larsen P, Bulik CM, Choi S. Body mass, DRD4, physical activity, sedentary behavior, and family socioeconomic status: the add health study. Obesity (Silver Spring) 2007, 15(5):1199-1206. 10.1038/oby.2007.640, 17495196.
40. Kaplan AS, Levitan RD, Yilmaz Z, Davis C, Tharmalingam S, Kennedy JL. A DRD4/BDNF gene-gene interaction associated with maximum BMI in women with bulimia nervosa. Int J Eat Disord 2008, 41(1):22-28. 10.1002/eat.20474, 17922530.
41. Sobik L, Hutchison K, Craighead L. Cue-elicited craving for food: a fresh approach to the study of binge eating. Appetite 2005, 44(3):253-261. 10.1016/j.appet.2004.12.001, 15876472.
42. McClernon FJ, Hutchison KE, Rose JE, Kozink RV. DRD4 VNTR polymorphism is associated with transient fMRI-BOLD responses to smoking cues. Psychopharmacol (Berl) 2007, 194(4):433-441.
43. Filbey FM, Ray L, Smolen A, Claus ED, Audette A, Hutchison KE. Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes. Alcohol Clin Exp Res 2008, 32(7):1113-1123. 10.1111/j.1530-0277.2008.00692.x, 2856650, 18540916.
44. Shao C, Li Y, Jiang K, Zhang D, Xu Y, Lin L, Wang Q, Zhao M, Jin L. Dopamine D4 receptor polymorphism modulates cue-elicited heroin craving in Chinese. Psychopharmacol (Berl) 2006, 186(2):185-190.
45. Thomas GN, Critchley JA, Tomlinson B, Cockram CS, Chan JC. Relationships between the taqI polymorphism of the dopamine D2 receptor and blood pressure in hyperglycaemic and normoglycaemic Chinese subjects. Clin Endocrinol (Oxf) 2001, 55(5):605-611. 10.1046/j.1365-2265.2001.01404.x, 11894971.
46. Fang YJ, Thomas GN, Xu ZL, Fang JQ, Critchley JA, Tomlinson B. An affected pedigree member analysis of linkage between the dopamine D2 receptor gene TaqI polymorphism and obesity and hypertension. Int J Cardiol 2005, 102(1):111-116. 10.1016/j.ijcard.2004.05.010, 15939106.
47. Chen AL, Blum K, Chen TJ, Giordano J, Downs BW, Han D, Barh D, Braverman ER. Correlation of the Taq1 dopamine D2 receptor gene and percent body fat in obese and screened control subjects: a preliminary report. Food Funct 2012, 3(1):40-48. 10.1039/c1fo10089k, 22051885.
48. Jenkinson CP, Hanson R, Cray K, Wiedrich C, Knowler WC, Bogardus C, Baier L. Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians. Int J Obes Relat Metab Disord 2000, 24(10):1233-1238. 10.1038/sj.ijo.0801381, 11093282.
49. Southon A, Walder K, Sanigorski AM, Zimmet P, Nicholson GC, Kotowicz MA, Collier G. The Taq IA and Ser311 Cys polymorphisms in the dopamine D2 receptor gene and obesity. Diabetes Nutr Metab 2003, 16(1):72-76.
50. Fuemmeler BF, Agurs-Collins TD, McClernon FJ, Kollins SH, Kail ME, Bergen AW, Ashley-Koch AE. Genes implicated in serotonergic and dopaminergic functioning predict BMI categories. Obesity (Silver Spring) 2008, 16(2):348-355. 10.1038/oby.2007.65, 2919156, 18239643.
51. Snijder MB, Visser M, Dekker JM, Seidell JC, Fuerst T, Tylavsky F, Cauley J, Lang T, Nevitt M, Harris TB. The prediction of visceral fat by dual-energy X-ray absorptiometry in the elderly: a comparison with computed tomography and anthropometry. Int J Obes Relat Metab Disord 2002, 26(7):984-993.
52. Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med 1997, 337(13):869-873. 10.1056/NEJM199709253371301, 9302300.
53. Esposito-Smythers C, Spirito A, Rizzo C, McGeary JE, Knopik VS. Associations of the DRD2 TaqIA polymorphism with impulsivity and substance use: preliminary results from a clinical sample of adolescents. Pharmacol Biochem Behav 2009, 93(3):306-312. 10.1016/j.pbb.2009.03.012, 2706288, 19344737.