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Volumn 122, Issue 22, 2013, Pages 3547-3548

Emergence of crenolanib for FLT3-mutant AML

Author keywords

[No Author keywords available]

Indexed keywords

CRENOLANIB; FLT3 LIGAND; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; QUIZARTINIB; RAS PROTEIN; SORAFENIB; STAT5 PROTEIN;

EID: 84888260780     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-10-528992     Document Type: Review
Times cited : (16)

References (10)
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    • Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia
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    • Zimmerman, E.I.1    Turner, D.C.2    Buaboonnam, J.3
  • 2
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    • FLT3 inhibition as therapy in acute myeloid leukemia: A record of trials and tribulations
    • Fathi AT, Chabner BA. FLT3 inhibition as therapy in acute myeloid leukemia: a record of trials and tribulations. Oncologist. 2011;16(8):1162-1174.
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  • 3
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996;10(12):1911-1918.
    • (1996) Leukemia. , vol.10 , Issue.12 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3
  • 5
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99(12):4326- 4335.
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    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 6
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Medical Research Council Adult Leukaemia Working Party
    • Gale RE, Green C, Allen C, et al; Medical Research Council Adult Leukaemia Working Party. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood. 2008;111(5):2776-2784.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3
  • 7
    • 0034554796 scopus 로고    scopus 로고
    • Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
    • Mizuki M, Fenski R, Halfter H, et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood. 2000;96(12):3907-3914.
    • (2000) Blood , vol.96 , Issue.12 , pp. 3907-3914
    • Mizuki, M.1    Fenski, R.2    Halfter, H.3
  • 8
    • 66149152278 scopus 로고    scopus 로고
    • FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro
    • von Bubnoff N, Engh RA, Aberg E, Sänger J, Peschel C, Duyster J. FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro. Cancer Res. 2009;69(7):3032-3041.
    • (2009) Cancer Res. , vol.69 , Issue.7 , pp. 3032-3041
    • Von Bubnoff, N.1    Engh, R.A.2    Aberg, E.3    Sänger, J.4    Peschel, C.5    Duyster, J.6
  • 9
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    • Crenolanib is a highly potent, selective, FLT3 TKI with activity against D835 mutations [abstract]
    • Abstract 1341
    • Galanis A, Rajkhowa T, Muralidhara C, Ramachandran A, Levis M. Crenolanib is a highly potent, selective, FLT3 TKI with activity against D835 mutations [abstract]. Blood. 2012;120. Abstract 1341.
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    • Galanis, A.1    Rajkhowa, T.2    Muralidhara, C.3    Ramachandran, A.4    Levis, M.5
  • 10
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    • Crenolanib (CP-868, 596) is a potent and selective type I FLT3 inhibitor that retains activity against AC220 resistancecausing FLT3 kinase domain mutations [abstract]
    • Abstract 141
    • Smith CC, Lasater E, McCreery M, et al. Crenolanib (CP-868, 596) is a potent and selective type I FLT3 inhibitor that retains activity against AC220 resistancecausing FLT3 kinase domain mutations [abstract]. Blood. 2012;120. Abstract 141.
    • (2012) Blood , vol.120
    • Smith, C.C.1    Lasater, E.2    McCreery, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.