Severe renal impairment is associated with symptomatic intracerebral hemorrhage after thrombolysis for ischemic stroke

Stroke

Volumn 44, Issue 11, 2013, Pages 3217-3219

  Tütüncü, Serdar ^a   Ziegler, Annerose M ^a   Scheitz, Jan F ^a   Slowinski, Torsten ^a   Rocco, Andrea ^a   Endres, Matthias ^a   Nolte, Christian H ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Acute renal failure; Cerebral hemorrhage; Stroke; Thrombolytic therapy

Indexed keywords

ALTEPLASE; CREATININE;

AGED; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CHRONIC KIDNEY DISEASE; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FIBRINOLYTIC THERAPY; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSION; INTERNATIONAL CLASSIFICATION OF DISEASES; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY;

ACUTE RENAL FAILURE; CEREBRAL HEMORRHAGE; STROKE; THROMBOLYTIC THERAPY;

ACUTE KIDNEY INJURY; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; FEMALE; FIBRINOLYTIC AGENTS; GLOMERULAR FILTRATION RATE; HUMANS; MALE; RECOMBINANT PROTEINS; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; RISK; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84888225127     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.002859     Document Type: Article

References (14)

1. Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet. 1998;352:1245-1251.
2. Lindley RI, Wardlaw JM, Sandercock PA, Rimdusid P, Lewis SC, Signorini DF, et al. Frequency and risk factors for spontaneous hemorrhagic transformation of cerebral infarction. J Stroke Cerebrovasc Dis. 2004;13:235-246.
3. Strbian D, Engelter S, Michel P, Meretoja A, Sekoranja L, Ahlhelm FJ, et al. Symptomatic intracranial hemorrhage after stroke thrombolysis: the SEDAN score. Ann Neurol. 2012;71:634-641.
4. Mazya M, Egido JA, Ford GA, Lees KR, Mikulik R, Toni D, et al; SITS Investigators. Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score. Stroke. 2012;43:1524-1531.
5. Jalal DI, Chonchol M, Targher G. Disorders of hemostasis associated with chronic kidney disease. Semin Thromb Hemost. 2010;36:34-40.
6. Menon BK, Saver JL, Prabhakaran S, Reeves M, Liang L, Olson DM, et al. Risk score for intracranial hemorrhage in patients with acute ischemic stroke treated with intravenous tissue-type plasminogen activator. Stroke. 2012;43:2293-2299.
7. Gerischer LM, Fiebach JB, Scheitz JF, Audebert HJ, Endres M, Nolte CH. Magnetic resonance imaging-based versus computed tomography-based thrombolysis in acute ischemic stroke: comparison of safety and efficacy within a cohort study. Cerebrovasc Dis. 2013;35:250-256.
8. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF III, Feldman HI, et al; CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604-612.
9. Piccini JP, Stevens SR, Chang Y, Singer DE, Lokhnygina Y, Go AS, et al. Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R (2) CHADS (2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts. Circulation. 2013;127:224-232.
10. Neumann-Haefelin T, Hoelig S, Berkefeld J, Fiehler J, Gass A, Humpich M, et al; MR Stroke Group. Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke. Stroke. 2006;37:2463-2466.
11. Lyrer PA, Fluri F, Gisler D, Papa S, Hatz F, Engelter ST. Renal function and outcome among stroke patients treated with IV thrombolysis. Neurology. 2008;71:1548-1550.
12. Agrawal V, Rai B, Fellows J, McCullough PA. In-hospital outcomes with thrombolytic therapy in patients with renal dysfunction presenting with acute ischaemic stroke. Nephrol Dial Transplant. 2010;25:1150-1157.
13. Power A, Epstein D, Cohen D, Bathula R, Devine J, Kar A, et al. Renal impairment reduces the efficacy of thrombolytic therapy in acute ischemic stroke. Cerebrovasc Dis. 2013;35:45-52.
14. Naganuma M, Koga M, Shiokawa Y, Nakagawara J, Furui E, Kimura K, et al. Reduced estimated glomerular filtration rate is associated with stroke outcome after intravenous rt-PA: the Stroke Acute Management with Urgent Risk-Factor Assessment and Improvement (SAMURAI) rt-PA registry. Cerebrovasc Dis. 2011;31:123-129.