Magnetic resonance imaging-based versus computed tomography-based thrombolysis in acute ischemic stroke: Comparison of safety and efficacy within a cohort study

Cerebrovascular Diseases

Volumn 35, Issue 3, 2013, Pages 250-256

  Gerischer, Lea Morrin ^a   Fiebach, Jochen B ^a   Scheitz, Jan F ^a   Audebert, Heinrich J ^a   Endres, Matthias ^a   Nolte, Christian H ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Computed tomography; Early mortality; Ischemic stroke; Magnetic resonance imaging; Symptomatic intracranial hemorrhage; Thrombolysis

Indexed keywords

ALTEPLASE; GLUCOSE;

AGED; ARTICLE; BLOOD CLOT LYSIS; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; COHORT ANALYSIS; COMORBIDITY; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY DISEASE; DISEASE SEVERITY; FEMALE; HEART FAILURE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MORTALITY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSERVATIONAL STUDY; PNEUMONIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANKIN SCALE; SAFETY; ARTERY EMBOLISM; ATRIAL FIBRILLATION; CAUSE OF DEATH; COMPARATIVE EFFECTIVENESS; COMPUTED TOMOGRAPHY SCANNER; FIBRINOLYTIC THERAPY; FOLLOW UP; FUNCTIONAL STATUS; GLUCOSE BLOOD LEVEL; LEG ARTERY EMBOLISM; NUCLEAR MAGNETIC RESONANCE SCANNER; OUTCOME ASSESSMENT; PATIENT SAFETY; RESPIRATORY FAILURE; SYMPTOMATIC INTRACRANIAL HEMORRHAGE; TIME TO TREATMENT; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; COHORT STUDIES; FEMALE; HUMANS; INTRACRANIAL HEMORRHAGES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; STROKE; THROMBOLYTIC THERAPY; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 84875671856     PISSN: 10159770     EISSN: 14219786     Source Type: Journal    
DOI: 10.1159/000347071     Document Type: Article

References (21)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group: Tissue plasminogen activator for acute isch-emic stroke. N Engl J Med 1995;333:1581-1587.
2. Hacke W, Kaste M, Bluhmki E, et al: Throm-bolysis with alteplase 3 to 4.5 h after acute ischemic stroke. N Engl J Med 2008; 359: 1317-1329.
3. Schellinger PD, Fiebach JB, Hacke W: Imag-ing-based decision making in thrombolytic therapy for ischemic stroke: present status. Stroke 2003; 34:575-583.
4. Lansberg MG, Albers GW, Wijman CA: Symptomatic intracerebral hemorrhage following thrombolytic therapy for acute isch-emic stroke: a review of the risk factors. Cere-brovasc Dis 2007; 24:1-10.
5. Tanne D, Kasner SE, Demchuk AM, et al: Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey. Circulation 2002; 105:1679-1685.
6. Köhrmann M, Schellinger PD: Acute stroke triage to intravenous thrombolysis and other therapies with advanced CT or MR Imaging: pro MR imaging. Radiology 2009; 251:627-633.
7. Fiebach JB, Schellinger PD, Gass A, et al: Stroke magnetic resonance imaging is accurate in hyperacute intracerebral hemorrhage-A multicenter study on the validitiy of stroke imaging. Stroke 2004; 35:502-506.
8. Sunshine JL, Tarr RW, Lanzieri CF, et al: Hy-peracute stroke: ultrafast MR imaging to triage patients prior to therapy. Radiology 1999; 212:325-332.
9. Jansen O, Schellinger P, Fiebach J, et al: Early recanalisation in acute ischaemic stroke saves tissue at risk defined by MRI. Lancet 1999; 353:2036-2037.
10. Wintermark M, Rowley HA, Lev MH: Acute stroke triage to intravenous thrombolysis and other therapies with advanced CT or MR imaging: pro CT. Radiology 2009; 251:619-626.
11. Sølling C, Hjort N, Ashkanian M, et al: Safety and efficacy of MRI-based selection for recombinant tissue plasminogen activator treatment: responder analysis of outcome in the 3-hour time window. Cerebrovasc Dis 2009; 27:223-229.
12. Köhrmann M, Jüttler E, Fiebach JB, et al: MRI versus CT-based thrombolysis treatment within and beyond the 3 h time window after stroke onset: a cohort study. Lancet Neurol 2006; 5:661-667.
13. Schellinger PD, Thomalla G, Fiehler J, et al: MRI-based and CT-based thrombolytic therapy in acute stroke within and beyond established time windows: an analysis of 1, 210 patients. Stroke 2007; 38:2640-2645.
14. Shobha N, Buchan AM, Hill MD, Canadian Alteplase for Stroke Effectiveness Study (CASES): Thrombolysis at 3-4.5 h after acute ischemic stroke onset-Evidence from the Canadian Alteplase for Stroke Effectiveness Study (CASES) registry. Cerebrovasc Dis 2011; 31:223-228.
15. Singer OC, Hamann GF, Misselwitz B, et al: Time trends in systemic thrombolysis in a large hospital-based stroke registry. Cerebro-vasc Dis 2012; 33:316-321.
16. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al: Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24:35-41.
17. Hotter B, Pittl S, Ebinger M, et al: Prospective study on the mismatch concept in acute stroke patients within the first 24 h after symptom onset-1000Plus study. BMC Neurology 2009; 9:60.
18. European Stroke Organisation (ESO) Executive Committee, ESO Writing Committee: Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 2008; 25:457-507.
19. Berger K, Weltermann B, Kolominsky-Rabas K, Meves S, Heuschmann P, Böhner J, et al: The reliability of stroke scales. The German version of NIHSS, ESS, Rankin scales. Fortschr Neurol Psychiatr 1999; 67:81-93.
20. Singer OC, Kurre W, Humpich MC, Lorenz MW, Kastrup A, Liebeskind DS, et al: Risk assessment of symptomatic intracerebral hemorrhage after thrombolysis using DWI-AS-PECTS. Stroke 2009; 40:2743-2748.
21. Häusler KG, Gerischer LM, Vatankhah B, et al: Impact of hospital admission during non-working hours on patient outcomes after thrombolysis for stroke. Stroke 2011; 42: 2521-2525.