Aluminum hydroxide nanoparticles show a stronger vaccine adjuvant activity than traditional aluminum hydroxide microparticles

Journal of Controlled Release

Volumn 173, Issue 1, 2014, Pages 148-157

  Li, Xinran ^a   Aldayel, Abdulaziz M ^a   Cui, Zhengrong ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Antibody responses; Local inflammation; Microparticles; Nanoparticles; Vaccine

Indexed keywords

ANTIBODY RESPONSE; ANTIGEN PRESENTING CELLS; BACILLUS ANTHRACIS; EFFECTIVE APPROACHES; LOCAL INFLAMMATION; MICRO-PARTICLES; PROTECTIVE ANTIGENS; VACCINE ADJUVANTS;

ANTIBODIES; ANTIGENS; NANOPARTICLES; PATHOLOGY; VACCINES;

SYNTHESIS (CHEMICAL);

ALUMINUM HYDROXIDE; ALUMINUM HYDROXIDE MICROPARTICLE; ALUMINUM HYDROXIDE NANOPARTICLE; ANTIGEN; IMMUNOLOGICAL ADJUVANT; OVALBUMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN PRESENTING CELL; ARTICLE; BACILLUS ANTHRACIS; CONTROLLED STUDY; DRUG SYNTHESIS; FEMALE; IMMUNE RESPONSE; MOUSE; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; ZETA POTENTIAL;

ANTIBODY RESPONSES; LOCAL INFLAMMATION; MICROPARTICLES; NANOPARTICLES; VACCINE;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM HYDROXIDE; ANIMALS; ANTHRAX; ANTHRAX VACCINES; ANTIBODY FORMATION; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; CELL LINE; CELLS, CULTURED; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NANOPARTICLES; OVALBUMIN; PARTICLE SIZE; VACCINES;

EID: 84888221477     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.10.032     Document Type: Article

References (36)

1. D.T. O'Hagan, M.L. MacKichan, and M. Singh Recent developments in adjuvants for vaccines against infectious diseases Biomol. Eng. 18 2001 69 85 (Pubitemid 32889607)
2. I.Z. Romero Mendez, Y. Shi, H. HogenEsch, and S.L. Hem Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants Vaccine 25 2007 825 833 (Pubitemid 44856127)
3. S.L. Hem, and H. Hogenesch Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation Expert Rev. Vaccine 6 2007 685 698 (Pubitemid 47607846)
4. B. Hansen, A. Sokolovska, H. HogenEsch, and S.L. Hem Relationship between the strength of antigen adsorption to an aluminum-containing adjuvant and the immune response Vaccine 25 2007 6618 6624 (Pubitemid 47211514)
5. I. Berthold, M.L. Pombo, L. Wagner, and J.L. Arciniega Immunogenicity in mice of anthrax recombinant protective antigen in the presence of aluminum adjuvants Vaccine 23 2005 1993 1999 (Pubitemid 40289072)
6. H. HogenEsch Mechanisms of stimulation of the immune response by aluminum adjuvants Vaccine 20 Suppl. 3 2002 S34 S39
7. L.S. Jones, L.J. Peek, J. Power, A. Markham, B. Yazzie, and C.R. Middaugh Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens J. Biol. Chem. 280 2005 13406 13414 (Pubitemid 40517228)
8. J.W. Mannhalter, H.O. Neychev, G.J. Zlabinger, R. Ahmad, and M.M. Eibl Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation Clin. Exp. Immunol. 61 1985 143 151 (Pubitemid 15029859)
9. M. Ulanova, A. Tarkowski, M. Hahn-Zoric, and L.A. Hanson The common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism Infect. Immun. 69 2001 1151 1159 (Pubitemid 32109584)
10. S.C. Eisenbarth, O.R. Colegio, W. O'Connor, F.S. Sutterwala, and R.A. Flavell Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants Nature 453 2008 1122 1126 (Pubitemid 351871731)
11. R.K. Gupta Aluminum compounds as vaccine adjuvants Adv. Drug Deliv. Rev. 32 1998 155 172 (Pubitemid 28267407)
12. I. Gutierro, R.M. Hernandez, M. Igartua, A.R. Gascon, and J.L. Pedraz Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres Vaccine 21 2002 67 77 (Pubitemid 35351352)
13. M. Kalkanidis, G.A. Pietersz, S.D. Xiang, P.L. Mottram, B. Crimeen-Irwin, K. Ardipradja, and M. Plebanski Methods for nano-particle based vaccine formulation and evaluation of their immunogenicity Methods 40 2006 20 29 (Pubitemid 44415495)
14. J. Wendorf, J. Chesko, J. Kazzaz, M. Ugozzoli, M. Vajdy, D. O'Hagan, and M. Singh A comparison of anionic nanoparticles and microparticles as vaccine delivery systems Hum. Vaccine 4 2008 44 49 (Pubitemid 351785260)
15. T. Fifis, A. Gamvrellis, B. Crimeen-Irwin, G.A. Pietersz, J. Li, P.L. Mottram, I.F. McKenzie, and M. Plebanski Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors J. Immunol. 173 2004 3148 3154 (Pubitemid 39142021)
16. X.R. Li, B.R. Sloat, N. Yanasarn, and Z.R. Cui Relationship between the size of nanoparticles and their adjuvant activity: data from a study with an improved experimental design Eur. J. Pharm. Biopharm. 78 2011 107 116
17. A.A. Lugade, J.P. Moran, S.A. Gerber, R.C. Rose, J.G. Frelinger, and E.M. Lord Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor J. Immunol. 174 2005 7516 7523 (Pubitemid 40806254)
18. Z.H. Shen, G. Reznikoff, G. Dranoff, and K.L. Rock Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules J. Immunol. 158 1997 2723 2730 (Pubitemid 127470530)
19. B.R. Sloat, M.A. Sandoval, A.M. Hau, Y. He, and Z. Cui Strong antibody responses induced by protein antigens conjugated onto the surface of lecithin-based nanoparticles J. Control. Release 141 2010 93 100
20. A.Y. Hao, Y.Y. Geng, Q. Xu, Z.Y. Lu, and L. Yu Study of different effects on foaming process of biodegradable PLA/starch composites in supercritical/compressed carbon dioxide J. Appl. Polym. Sci. 109 2008 2679 2686
21. M.B. Lutz, N. Kukutsch, A.L. Ogilvie, S. Rossner, F. Koch, N. Romani, and G. Schuler An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow J. Immunol. Methods 223 1999 77 92 (Pubitemid 29096240)
22. M.M. Tomayko, and C.P. Reynolds Determination of subcutaneous tumor size in athymic (nude) mice Cancer Chemother. Pharmacol. 24 1989 148 154 (Pubitemid 19163397)
23. J. Lim, Y. Kim, W. Lee, M. Kim, E.J. Lee, C.S. Kang, and K. Han Fresh-frozen, optimal cutting temperature (OCT) compound-embedded bone marrow aspirates: a reliable resource for morphological, immunohistochemical and molecular examinations Int. J. Lab. Hematol. 32 2010 e34 e39
24. W. Stumm, L. Sigg, and B. Sulzberger Chemistry of the Solid-Water Interface: Processes at the Mineral-Water and Particle-Water Interface in Natural Systems 1992 Wiley New York
25. S. Lowell, and S. Lowell Characterization of Porous Solids and Powders: Surface Area, Pore Size, and Density 2004 Kluwer Academic Publishers Dordrecht; Boston
26. A.R. Bumb, C.A.S., M. Bernardo, P.J. Dobson, P. Choyke, and M.W. Brechbiel Multi-modal Superparamagnetic Nanoprobe: Harnessing Magnetic, Nuclear, and Optical Power for Diagnostic Imaging Applications NSTI-Nanotech 3 2010
27. S. Iyer, H. HogenEsch, and S.L. Hem Effect of the degree of phosphate substitution in aluminum hydroxide adjuvant on the adsorption of phosphorylated proteins Pharm. Dev. Technol. 8 2003 81 86 (Pubitemid 36337481)
28. L.D. Falo Jr., M. Kovacsovics-Bankowski, K. Thompson, and K.L. Rock Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity Nat. Med. 1 1995 649 653
29. K.A. Bradley, J. Mogridge, M. Mourez, R.J. Collier, and J.A. Young Identification of the cellular receptor for anthrax toxin Nature 414 2001 225 229 (Pubitemid 33051239)
30. B.R. Sloat, and Z. Cui Evaluation of the immune response induced by a nasal anthrax vaccine based on the protective antigen protein in anaesthetized and non-anaesthetized mice J. Pharm. Pharmacol. 58 2006 439 447
31. H.L. Davis, R. Weeratna, T.J. Waldschmidt, L. Tygrett, J. Schorr, and A.M. Krieg CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen J. Immunol. 160 1998 870 876 (Pubitemid 28049329)
32. G.L. Morefield, A. Sokolovska, D. Jiang, H. HogenEsch, J.P. Robinson, and S.L. Hem Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro Vaccine 23 2005 1588 1595 (Pubitemid 40203396)
33. V. Kanchan, and A.K. Panda Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response Biomaterials 28 2007 5344 5357 (Pubitemid 47532191)
34. S.D. Xiang, A. Scholzen, G. Minigo, C. David, V. Apostolopoulos, P.L. Mottram, and M. Plebanski Pathogen recognition and development of particulate vaccines: does size matter? Methods 40 2006 1 9 (Pubitemid 44415493)
35. N. Goto, H. Kato, J. Maeyama, K. Eto, and S. Yoshihara Studies on the toxicities of aluminium hydroxide and calcium phosphate as immunological adjuvants for vaccines Vaccine 11 1993 914 918 (Pubitemid 23218797)
36. N. Goto, H. Kato, J. Maeyama, M. Shibano, T. Saito, J. Yamaguchi, and S. Yoshihara Local tissue irritating effects and adjuvant activities of calcium phosphate and aluminium hydroxide with different physical properties Vaccine 15 1997 1364 1371 (Pubitemid 27397815)