Measurement of interscapular brown adipose tissue of mice in differentially housed temperatures by chemical-shift-encoded water-fat MRI

Journal of Magnetic Resonance Imaging

Volumn 38, Issue 6, 2013, Pages 1425-1433

  Smith Jr , Daniel L ^a   Yang, Yongbin ^a   Hu, Houchun H ^b   Zhai, Guihua ^c   Nagy, Tim R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c University of Alabama   (United States)

Author keywords

body composition; brown adipose tissue; fat signal fraction; thermogenesis; water fat MRI; white adipose tissue

Indexed keywords

FAT; WATER;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; BODY COMPOSITION; BODY WEIGHT; BROWN ADIPOSE TISSUE; CHEMICAL SHIFT ENCODED WATER FAT MAGNETIC RESONANCE IMAGING; CONTROLLED STUDY; ENVIRONMENTAL TEMPERATURE; FAT MASS; FAT SIGNAL FRACTION; FOOD INTAKE; INTERSCAPULAR BROWN ADIPOSE TISSUE; LEAN BODY WEIGHT; MAGNET; MALE; MEASUREMENT; MOUSE; NONHUMAN; NONSHIVERING THERMOGENESIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RESPIRATORY GATED IMAGING;

BODY COMPOSITION; BROWN ADIPOSE TISSUE; FAT-SIGNAL FRACTION; THERMOGENESIS; WATER-FAT MRI; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE, BROWN; ANIMALS; BODY TEMPERATURE; BODY WATER; EATING; ECOSYSTEM; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED C57BL; REPRODUCIBILITY OF RESULTS; SCAPULA; SENSITIVITY AND SPECIFICITY; THERMOGENESIS;

EID: 84888204767     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.24138     Document Type: Article

References (38)

1. Cannon B, Nedergaard J,. Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84: 277-359.
2. Himms-Hagen J,. Obesity may be due to a malfunctioning of brown fat. Can Med Assoc J 1979; 121: 1361-1364.
3. Hany TF, Gharehpapagh E, Kamel EM, Buck A, Himms-Hagen J, von Schulthess GK,. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med Mol Imaging 2002; 29: 1393-1398.
4. Nedergaard J, Bengtsson T, Cannon B,. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2007; 293: E444-E452.
5. Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009; 360: 1518-1525.
6. Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360: 1509-1517.
7. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009; 360: 1500-1508.
8. Saito M, Okamatsu-Ogura Y, Matsushita M, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009; 58: 1526-1531.
9. Zingaretti MC, Crosta F, Vitali A, et al. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 2009; 23: 3113-3120.
10. Heaton JM,. The distribution of brown adipose tissue in the human. J Anat 1972; 112: 35-39.
11. Nnodim JO,. The occurrence of brown adipose in man inhabiting the tropics. Z Mikrosk Anat Forsch 1990; 104: 721-728.
12. Tanuma Y, Tamamoto M, Ito T, Yokochi C,. The occurrence of brown adipose tissue in perirenal fat in Japanese. Arch Histol Jpn 1975; 38: 43-70.
13. Tanuma Y, Ohata M, Ito T, Yokochi C,. Possible function of human brown adipose tissue as suggested by observation on perirenal brown fats from necropsy cases of variable age groups. Arch Histol Jpn 1976; 39: 117-145.
14. Aherne W, Hull D,. Brown adipose tissue and heat production in the newborn infant. J Pathol Bacteriol 1966; 91: 223-234.
15. Hu HH, Smith DL Jr, Nayak KS, Goran MI, Nagy TR,. Identification of brown adipose tissue in mice with fat-water IDEAL-MRI. J Magn Reson Imaging 2010; 31: 1195-1202.
16. Baba S, Engles JM, Huso DL, Ishimori T, Wahl RL,. Comparison of uptake of multiple clinical radiotracers into brown adipose tissue under cold-stimulated and nonstimulated conditions. J Nucl Med 2007; 48: 1715-1723.
17. Overton JM,. Phenotyping small animals as models for the human metabolic syndrome: thermoneutrality matters. Int J Obes (Lond) 2010; 34 (Suppl 2): S53-S58.
18. Tinsley FC, Taicher GZ, Heiman ML,. Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis. Obes Res 2004; 12: 150-160.
19. Jones AS, Johnson MS, Nagy TR,. Validation of quantitative magnetic resonance for the determination of body composition of mice. Int J Body Comp Res 2009; 7: 67-72.
20. Reeder SB, Pineda AR, Wen Z, et al. Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL): application with fast spin-echo imaging. Magn Reson Med 2005; 54: 636-644.
21. Hu HH, Kim HW, Nayak KS, Goran MI,. Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans. Obesity (Silver Spring) 2010; 18: 841-847.
22. Ren J, Dimitrov I, Sherry AD, Malloy CR,. Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. J Lipid Res 2008; 49: 2055-2062.
23. Hamilton G, Smith DL Jr, Bydder M, Nayak KS, Hu HH,. MR properties of brown and white adipose tissues. J Magn Reson Imaging 2011; 34: 468-473.
24. Hu HH, Bornert P, Hernando D, et al. ISMRM workshop on fat-water separation: insights, applications and progress in MRI. Magn Reson Med 2012; 68: 378-388.
25. Huffman DM, Grizzle WE, Bamman MM, et al. SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res 2007; 67: 6612-6618.
26. Lunati E, Marzola P, Nicolato E, Fedrigo M, Villa M, Sbarbati A,. In vivo quantitative lipidic map of brown adipose tissue by chemical shift imaging at 4.7 Tesla. J Lipid Res 1999; 40: 1395-1400.
27. Feldmann HM, Golozoubova V, Cannon B, Nedergaard J,. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 2009; 9: 203-209.
28. Cannon B, Nedergaard J,. Nonshivering thermogenesis and its adequate measurement in metabolic studies. J Exp Biol 2011; 214: 242-253.
29. Chen YI, Cypess AM, Sass CA, et al. Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging. Obesity (Silver Spring) 2012; 20: 1519-1526.
30. Branca RT, Warren WS,. In vivo brown adipose tissue detection and characterization using water-lipid intermolecular zero-quantum coherences. Magn Reson Med 2011; 65: 313-319.
31. Hu HH, Tovar JP, Pavlova Z, Smith ML, Gilsanz V,. Unequivocal identification of brown adipose tissue in a human infant. J Magn Reson Imaging 2012; 35: 938-942.
32. Himms-Hagen J, Villemure C,. Number of mice per cage influences uncoupling protein content of brown adipose tissue. Proc Soc Exp Biol Med 1992; 200: 502-506.
33. Teague RJ, Kanarek R, Bray GA, Glick Z, Orthen-Gambill N,. Effect of diet on the weight of brown adipose tissue in rodents. Life Sci 1981; 29: 1531-1536.
34. Khanna A, Branca RT,. Detecting brown adipose tissue activity with BOLD MRI in mice. Magn Reson Med 2012; 68: 1285-1290.
35. Baba S, Jacene HA, Engles JM, Honda H, Wahl RL,. CT Hounsfield units of brown adipose tissue increase with activation: preclinical and clinical studies. J Nucl Med 2010; 51: 246-250.
36. Hu HH, Chung SA, Nayak KS, Jackson HA, Gilsanz V,. Differential computed tomographic attenuation of metabolically active and inactive adipose tissues: preliminary findings. J Comput Assist Tomogr 2011; 35: 65-71.
37. Huang B, Law MW, Khong PL,. Whole-body PET/CT scanning: estimation of radiation dose and cancer risk. Radiology 2009; 251: 166-174.
38. Hu HH, Tovar JP, Pavlova Z, Smith ML, Gilsanz V,. Unequivocal identification of brown adipose tissue in a human infant. J Magn Reson Imaging 2012; 35: 938-942.