Effects of immunization against androstenedione or bone morphogenetic protein 15 (BMP15) on reproductive performance in sheep

Journal of Animal Science

Volumn 91, Issue 12, 2013, Pages 5946-5953

  Juengel, J L ^a   Proctor, L E ^a   Wearne, K ^a   Olliver, D ^a   Hudson, N L ^b   Jensen, D ^a   Davis, G H ^a   Johnstone, P D ^a   McNatty, K P ^b  

^a INVERMAY AGRICULTURAL CENTRE   (New Zealand)

^b VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

Author keywords

Androstenedione immunization; Bone morphogenetic protein 15 immunization; Reproductive performance; Sheep

Indexed keywords

OVIS ARIES;

ANDROSTENEDIONE; BONE MORPHOGENETIC PROTEIN 15; VACCINE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIRTH; BIRTH WEIGHT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; IMMUNOLOGY; LITTER SIZE; METHODOLOGY; OVULATION INDUCTION; PHYSIOLOGY; PREGNANCY; RANDOMIZED CONTROLLED TRIAL; SHEEP; WEANING;

ANDROSTENEDIONE; ANIMALS; BIRTH WEIGHT; BONE MORPHOGENETIC PROTEIN 15; FEMALE; LITTER SIZE; OVULATION INDUCTION; PARTURITION; PREGNANCY; SHEEP; VACCINES; WEANING;

EID: 84888142768     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2012-6085     Document Type: Article

References (37)

1. Alifakiotis, T. 1986. Increasing ovulation rate and lambing percentage by active immunization against androstenedione in dairy sheep breeds. Theriogenology 25:681-688.
2. Amer, P. R. 2000. Trait economic weights for genetic improvement with SIL. Proc. New Zeal. Soc. Anim. Prod. 60:189-191.
3. Boland, M. P., C. D. Nancarrow, J. D. Murray, R. J. Scaramuzzi, R. Sutton, R. M. Hoskinson, and I. G. Hazelton. 1986. Fertilization and early embryonic development in androstenedione-immunized Merino ewes. J. Reprod. Fertil. 78:423-431.
4. Borg, R. C., D. R. Notter, L. A. Kuehn, and R. W. Kott. 2007. Breeding objectives for Targhee sheep. J. Anim. Sci. 85:2815-2829.
5. Cameron, A. W., C. M. Oldham, I. J. Fairnie, E. J. Keogh, and D. R. Lindsay. 1988. The number of spermatozoa, the number of ovulations per ewe, and immunization against androstenedione affect fertility and prolificacy of sheep. J. Reprod. Fertil. 84:43-50.
6. Crawford, J. L., D. A. Heath, K. L. Reader, L. D. Quirke, N. L. Hudson, J. L. Juengel, and K. P. McNatty. 2011. Oocytes in sheep homozygous for a mutation in bone morphogenetic protein receptor 1b express lower mRNA levels of bone morphogenetic protein 15 but not growth differentiation factor 9. Reproduction 142:53-61.
7. Croker, K. P., R. I. Cox, M. A. Johns, T. J. Johnson, D. Roberts, M. Salerian, and F. Sunderman. 1988. Potential for Fecundin to influence the reproductive performance of merino ewes in Western Australia. Aust. J. Biol. Sci. 41:47-55.
8. Davis, G. H., K. G. Dodds, J. C. McEwan, and P. F. Fennessy. 1993. Liveweight, fleece weight and prolificacy of Romney ewes carrying the inverdale prolificacy gene (FecXI) located on the X-chromosome. Livest. Prod. Sci. 34:83-91.
9. Davis, G. H., S. M. Galloway, A. O'Connell, P. A. Farquhar, K. P. McNatty, and J. L. Juengel. 2008. Hyper-prolific ewes carrying copies of three major genes: A model for studying genes controlling ovulation rate. Biol. Reprod. 78:110. (Abstr.)
10. Demmers, K. J., B. Smaill, G. H. Davis, K. G. Dodds, and J. L. Juengel. 2011. Heterozygous Inverdale ewes show increased ovulation rate sensitivity to pre-mating nutrition. Reprod. Fertil. Dev. 23:866-875.
11. Feary, E. S., J. L. Juengel, P. Smith, M. C. French, A. R. O'Connell, S. B. Lawrence, S. M. Galloway, G. H. Davis, and K. P. Mc-Natty. 2007. Patterns of expression of messenger RNAs encoding GDF9, BMP15, TGFBR1, BMPR1b, and BMPR2 during follicular development and characterization of ovarian follicular populations in ewes carrying the Woodlands FecX2W mutation. Biol. Reprod. 77:990-998.
12. Galloway, S. M., K. P. McNatty, L. M. Cambridge, M. P. Laitinen, J. L. Juengel, T. S. Jokiranta, R. J. McLaren, K. Luiro, K. G. Dodds, G. W. Montgomery, A. E. Beattie, G. H. Davis, and O. Ritvos. 2000. Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. Nat. Genet. 25:279-283.
13. Garcia-Herreros, M., P. Bermejo-Alvarez, D. Rizos, A. Gutierrez-Adan, A. G. Fahey, and P. Lonergan. 2010. Intrafollicular testosterone concentration and sex ratio in individually cultured bovine embryos. Reprod. Fertil. Dev. 22:533-538.
14. Grant, V. J., R. J. Irwin, N. T. Standley, A. N. Shelling, and L. W. Chamley. 2008. Sex of bovine embryos may be related to mothers' preovulatory follicular testosterone. Biol. Reprod. 78:812-815.
15. Hayashi, K., A. R. O'Connell, J. L. Juengel, K. P. McNatty, G. H. Davis, F. W. Bazer, and T. E. Spencer. 2008. Postnatal uterine development in Inverdale ewe lambs. Reproduction 135:357-365.
16. Hussein, T. S., J. G. Thompson, and R. B. Gilchrist. 2006. Oocytesecreted factors enhance oocyte developmental competence. Dev. Biol. 296:514-521.
17. Juengel, J. L., D. A. Heath, L. D. Quirke, and K. P. McNatty. 2006. Oestrogen receptor alpha and beta, androgen receptor and progesterone receptor mRNA and protein localisation within the developing ovary and in small growing follicles of sheep. Reproduction 131:81-92.
18. Juengel, J. L., N. L. Hudson, D. A. Heath, P. Smith, K. L. Reader, S. B. Lawrence, A. R. O'Connell, M. P. Laitinen, M. Cranfield, N. P. Groome, O. Ritvos, and K. P. McNatty. 2002. Growth differentiation factor 9 and bone morphogenetic protein 15 are essential for ovarian follicular development in sheep. Biol. Reprod. 67:1777-1789.
19. Juengel, J. L., N. L. Hudson, L. Whiting, and K. P. McNatty. 2004. Effects of immunization against bone morphogenetic protein 15 and growth differentiation factor 9 on ovulation rate, fertilization, and pregnancy in ewes. Biol. Reprod. 70:557-561.
20. Juengel, J. L., L. D. Quirke, S. Lun, D. A. Heath, P. D. Johnstone, and K. P. McNatty. 2011. Effects of immunizing ewes against bone morphogenetic protein 15 on their responses to exogenous gonadotrophins to induce multiple ovulations. Reproduction 142:565-572.
21. Kerslake, J. I., J. M. Everett-Hincks, and A. Campbell. 2005. Lamb survival: A new examination of an old problem. Proc. N. Z. Soc. Anim. Prod. 65:13-18.
22. McNatty, K. P., S. M. Galloway, T. Wilson, P. Smith, N. L. Hudson, A. O'Connell, A. H. Bibby, D. A. Heath, G. H. Davis, J. P. Hanrahan, and J. L. Juengel. 2005. Physiological effects of major genes affecting ovulation rate in sheep. Genet. Sel. Evol. 37(Suppl. 1):S25-S38.
23. McNatty, K. P., N. L. Hudson, L. Whiting, K. L. Reader, S. Lun, A. Western, D. A. Heath, P. Smith, L. G. Moore, and J. L. Juengel. 2007. The effects of immunizing sheep with different BMP15 or GDF9 peptide sequences on ovarian follicular activity and ovulation rate. Biol. Reprod. 76:552-560.
24. McNatty, K. P., L. G. Moore, N. L. Hudson, L. D. Quirke, S. B. Lawrence, K. Reader, J. P. Hanrahan, P. Smith, N. P. Groome, M. Laitinen, O. Ritvos, and J. L. Juengel. 2004. The oocyte and its role in regulating ovulation rate: A new paradigm in reproductive biology. Reproduction 128:379-386.
25. Moor, R. M., C. Polge, and S. M. Willadsen. 1980. Effect of follicular steroids on the maturation and fertilization of mammalian oocytes. J. Embryol. Exp. Morphol. 56:319-335.
26. Morris, S., P. Kenyon, D. L. Burnham, and J. M. Everett-Hincks. 2003. The effect of sward height on twin and triplet lamb birth weights and survival rates to weaning. Proc. N.Z. Soc. Anim. Prod. 63:152-154.
27. Okada, A., Y. Ohta, S. Inoue, H. Hiroi, M. Muramatsu, and T. Iguchi. 2003. Expression of estrogen, progesterone and androgen receptors in the oviduct of developing, cycling and pre-implantation rats. J. Mol. Endocrinol. 30:301-315.
28. Osborn, J. C., R. M. Moor, and I. M. Crosby. 1986. Effect of alterations in follicular steroidogenesis on the nuclear and cytoplasmic maturation of ovine oocytes. J. Embryol. Exp. Morphol. 98:187-208.
29. Padmanabhan, V., H. N. Sarma, M. Savabieasfahani, T. L. Steckler, and A. Veiga-Lopez. 2010. Developmental reprogramming of reproductive and metabolic dysfunction in sheep: Native steDownloaded roids vs. Environmental steroid receptor modulators. Int. J. Androl. 33:394-404.
30. Peterson, S. W., P. Kenyon, and S. Morris. 2006. Do ewes with twin and triplet lambs produce different yields of milk and does the grazing behaviour of their lambs differ? Proc. N. Z. Soc. Anim. Prod. 66:444-449.
31. Scaramuzzi, R. J., D. T. Baird, B. K. Campbell, M. A. Driancourt, J. Dupont, J. E. Fortune, R. B. Gilchrist, G. B. Martin, K. P. McNatty, A. S. McNeilly, P. Monget, D. Monniaux, C. Vinoles, and R. Webb. 2011. Regulation of folliculogenesis and the determination of ovulation rate in ruminants. Reprod. Fertil. Dev. 23:444-467.
32. Scaramuzzi, R. J., B. K. Campbell, J. A. Downing, N. R. Kendall, M. Khalid, M. Munoz-Gutierrez, and A. Somchit. 2006. A review of the effects of supplementary nutrition in the ewe on the concentrations of reproductive and metabolic hormones and the mechanisms that regulate folliculogenesis and ovulation rate. Reprod. Nutr. Dev. 46:339-354.
33. Scaramuzzi, R. J., W. G. Davidson, and P. F. Van Look. 1977. Increasing ovulation rate in sheep by active immunisation against an ovarian steroid androstenedione. Nature 269:817-818.
34. Scaramuzzi, R. J., C. D. Nancarrow, J. D. Murray, and J. R. Walton. 1993. Reproductive wastage in the androstenedione-immune ewe. J. Reprod. Fertil. 98:617-624.
35. Smith, J. F., and C. A. Morris. 2006. Review of zearalenone studies with sheep in New Zealand. Proc. N. Z. Soc. Anim. Prod. 66:306-310.
36. Stubbings, L. A., and B. A. Maund. 1988. Effects on the fecundity of sheep of immunisation against androstenedione. Vet. Rec. 123:489-492.
37. Wilson, C. M., and M. J. McPhaul. 1996. A and B forms of the androgen receptor are expressed in a variety of human tissues. Mol. Cell. Endocrinol. 120:51-57.