Association analysis of the major histocompatibility complex, class II, DQ β1 gene, HLA-DQB1, with narcolepsy in Han Chinese patients from Taiwan

Sleep Medicine

Volumn 14, Issue 12, 2013, Pages 1393-1397

  Chen, Yun Hsiang ^a   Huang, Yu Shu ^b   Chien, Wei Hsien ^c   Chen, Chia Hsiang ^b  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

Association; Cataplexy; Genetics; Human leukocyte antigen (HLA); Narcolepsy; Pathogenesis

Indexed keywords

HLA DQB1 ANTIGEN;

ALLELE; ARTICLE; CATAPLEXY; CHINESE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE; GENETIC ASSOCIATION; GENOTYPE; HLA DQB1 GENE; HOMOZYGOTE; HUMAN; INTERNATIONAL CLASSIFICATION OF SLEEP DISORDERS; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; NARCOLEPSY; NUCLEIC ACID HYBRIDIZATION; PRIORITY JOURNAL; TAIWAN;

ASSOCIATION; CATAPLEXY; GENETICS; HUMAN LEUKOCYTE ANTIGEN (HLA); NARCOLEPSY; PATHOGENESIS;

ASIAN CONTINENTAL ANCESTRY GROUP; CATAPLEXY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HLA-DQ BETA-CHAINS; HUMAN GROWTH HORMONE; HUMANS; MALE; NARCOLEPSY; RISK FACTORS; TAIWAN;

EID: 84888137470     PISSN: 13899457     EISSN: 18785506     Source Type: Journal    
DOI: 10.1016/j.sleep.2013.06.017     Document Type: Article

References (37)

1. Dauvilliers Y., Arnulf I., Mignot E. Narcolepsy with cataplexy. Lancet 2007, 369:499-511.
2. Longstreth W.T., Koepsell T.D., Ton T.G., Hendrickson A.F., van Belle G. The epidemiology of narcolepsy. Sleep 2007, 30:13-26.
3. Hublin C., Partinen M., Kaprio J., Koskenvuo M., Guilleminault C. Epidemiology of narcolepsy. Sleep 1994, 17(8 suppl):S7-S12.
4. Ohayon M.M., Priest R.G., Zulley J., Smirne S., Paiva T. Prevalence of narcolepsy symptomatology and diagnosis in the European general population. Neurology 2002, 58:1826-1833.
5. Nishino S., Okura M., Mignot E. Narcolepsy: genetic predisposition and neuropharmacological mechanisms. Sleep Med Rev 2000, 4:57-99.
6. Wijnans L., Lecomte C., de Vries C., Weibel D., Sammon C., Hviid A., et al. The incidence of narcolepsy in Europe: before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns. Vaccine 2012.
7. Partinen M., Saarenpaa-Heikkila O., Ilveskoski I., Hublin C., Linna M., Olsen P., et al. Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland. PloS One 2012, 7:e33723.
8. Nohynek H., Jokinen J., Partinen M., Vaarala O., Kirjavainen T., Sundman J., et al. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PloS One 2012, 7:e33536.
9. Han F., Lin L., Warby S.C., Faraco J., Li J., Dong S.X., et al. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol 2011, 70:410-417. [published online ahead of print August 22, 2011].
10. Mignot E., Tafti M., Dement W.C., Grumet F.C. Narcolepsy and immunity. Adv Neuroimmunol 1995, 5:23-37.
11. Overeem S., Black J.L., Lammers G.J. Narcolepsy: immunological aspects. Sleep Med Rev 2008, 12:95-107.
12. *0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans. Sleep 1994, 17:S60-S67.
13. Alaez C., Lin L., Flores A.H., Vazquez M., Munguia A., Mignot E., et al. Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggested. BMC Med Genet 2008, 9:79.
14. *0602 allele in narcolepsy and idiopathic hypersomnia patients seen at a sleep disorders outpatient unit in Sao Paulo. Rev Bras Psiquiatr 2009, 31:10-14.
15. *0601 modulate narcolepsy susceptibility in Koreans. Hum Immunol 2007, 68:59-68.
16. Mignot E., Lin L., Rogers W., Honda Y., Qiu X., Lin X., et al. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet 2001, 68:686-699.
17. Chabas D., Taheri S., Renier C., Mignot E. The genetics of narcolepsy. Annu Rev Genomics Hum Genet 2003, 4:459-483.
18. Mignot E., Lin X., Kalil J., George C., Singh S., Billiard M., et al. DQB1-0602 (DQw1) is not present in most non DR2 Caucasian narcoleptics. Sleep 1992, 15:415-422.
19. *0602 is associated with cataplexy in 509 narcoleptic patients. Sleep 1997, 20:1012-1020.
20. *0602 homozygosity increases relative risk for narcolepsy but not disease severity in two ethnic groups. US Modafinil in Narcolepsy Multicenter Study Group. Tissue Antigen 1998, 51:96-100.
21. Huang Y.S., Tafti M., Guilleminault C. Daytime sleepiness with and without cataplexy in Chinese-Taiwanese patients. Sleep Med 2006, 7:454-457.
22. Wing Y.K., Chen L., Fong S.Y., Ng M.H., Ho C.K., Cheng S.H., et al. Narcolepsy in Southern Chinese patients: clinical characteristics, HLA typing and seasonality of birth. J Neurol Neurosurg Psychiatry 2008, 79:1262-1267.
23. Han F., Lin L., Li J., Dong S.X., An P., Zhao L., et al. HLA-DQ association and allele competition in Chinese narcolepsy. Tissue Antigen 2012, 80:328-335.
24. Hollenbach J.A., Mack S.J., Thomson G., Gourraud P.A. Analytical methods for disease association studies with immunogenetic data. Methods Mol Biol 2012, 882:245-266.
25. Shiina T., Inoko H., Kulski J.K. An update of the HLA genomic region, locus information and disease associations: 2004. Tissue Antigen 2004, 64:631-649.
26. Beck S., Trowsdale J. Sequence organisation of the class II region of the human MHC. Immunol Rev 1999, 167:201-210.
27. Davis S.J., Ikemizu S., Evans E.J., Fugger L., Bakker T.R., van der Merwe P.A. The nature of molecular recognition by T cells. Nat Immunol 2003, 4:217-224.
28. Andre S., Tough D.F., Lacroix-Desmazes S., Kaveri S.V., Bayry J. Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications. Am J Pathol 2009, 174:1575-1587.
29. Romagnani S. Th1/Th2 cells. Inflamm Bowel Dis 1999, 5:285-294.
30. Jones E.Y., Fugger L., Strominger J.L., Siebold C. MHC class II proteins and disease: a structural perspective. Nat Rev Immunol 2006, 6:271-282.
31. Nishino S., Ripley B., Overeem S., Lammers G.J., Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000, 355:39-40.
32. Taheri S., Zeitzer J.M., Mignot E. The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu Rev Neurosci 2002, 25:283-313.
33. Peyron C., Faraco J., Rogers W., Ripley B., Overeem S., Charnay Y., et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 2000, 6:991-997.
34. Thannickal T.C., Moore R.Y., Nienhuis R., Ramanathan L., Gulyani S., Aldrich M., et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000, 27:469-474.
35. Blouin A.M., Thannickal T.C., Worley P.F., Baraban J.M., Reti I.M., Siegel J.M. Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy. Neurology 2005, 65:1189-1192. [published online ahead of print August 31, 2005].
36. *0602-positive narcoleptic subjects with cataplexy. Biol Psychiatry 2005, 58:504-509.
37. Hallmayer J., Faraco J., Lin L., Hesselson S., Winkelmann J., Kawashima M., et al. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet 2009, 41:708-711. [published online ahead of print May 3, 2009].