-
1
-
-
79954508175
-
Molecular predictors of response to chemotherapy in colorectal cancer
-
Dienstmann R, Vilar E, Tabernero J. Molecular predictors of response to chemotherapy in colorectal cancer. Cancer J. 2011;17(2):114-126.
-
(2011)
Cancer J
, vol.17
, Issue.2
, pp. 114-126
-
-
Dienstmann, R.1
Vilar, E.2
Tabernero, J.3
-
2
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61(5):759-767.
-
(1990)
Cell
, vol.61
, Issue.5
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
3
-
-
77449130761
-
Microsatellite instability in colorectal cancer
-
Boland CR, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology. 2010;138(6):2073-2087. e3.
-
(2010)
Gastroenterology
, vol.138
, Issue.6
, pp. 2073-2087
-
-
Boland, C.R.1
Goel, A.2
-
4
-
-
0033587747
-
CpG island methylator phenotype in colorectal cancer
-
Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A. 1999;96(15):8681-8686.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.15
, pp. 8681-8686
-
-
Toyota, M.1
Ahuja, N.2
Ohe-Toyota, M.3
Herman, J.G.4
Baylin, S.B.5
Issa, J.P.6
-
5
-
-
2342504508
-
Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers
-
Goel A, Arnold CN, Niedzwiecki D, et al. Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. Cancer Res. 2004;64(9):3014-3021.
-
(2004)
Cancer Res
, vol.64
, Issue.9
, pp. 3014-3021
-
-
Goel, A.1
Arnold, C.N.2
Niedzwiecki, D.3
-
6
-
-
7244232602
-
Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers
-
Goel A, Arnold CN, Tassone P, et al. Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers. Int J Cancer. 2004;112(5):754-759.
-
(2004)
Int J Cancer
, vol.112
, Issue.5
, pp. 754-759
-
-
Goel, A.1
Arnold, C.N.2
Tassone, P.3
-
7
-
-
36549059251
-
Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer
-
Shin SK, Nagasaka T, Jung BH, et al. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology. 2007;133(6):1849-1857.
-
(2007)
Gastroenterology
, vol.133
, Issue.6
, pp. 1849-1857
-
-
Shin, S.K.1
Nagasaka, T.2
Jung, B.H.3
-
8
-
-
84155165379
-
A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers
-
Silver A, Sengupta N, Propper D, et al. A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers. Int J Cancer. 2012;130(5):1082-1092.
-
(2012)
Int J Cancer
, vol.130
, Issue.5
, pp. 1082-1092
-
-
Silver, A.1
Sengupta, N.2
Propper, D.3
-
9
-
-
0026762968
-
Expectancy or primary chemotherapy in patients with advanced asymptomatic colorectal cancer: A randomized trial
-
Nordic Gastrointestinal Tumor Adjuvant Therapy Group
-
Nordic Gastrointestinal Tumor Adjuvant Therapy Group. Expectancy or primary chemotherapy in patients with advanced asymptomatic colorectal cancer: a randomized trial. J Clin Oncol. 1992;10(6):904-911.
-
(1992)
J Clin Oncol
, vol.10
, Issue.6
, pp. 904-911
-
-
-
10
-
-
0027461840
-
Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer
-
Scheithauer W, Rosen H, Kornek GV, Sebesta C, Depisch D. Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer. BMJ. 1993;306(6880):752-755.
-
(1993)
BMJ
, vol.306
, Issue.6880
, pp. 752-755
-
-
Scheithauer, W.1
Rosen, H.2
Kornek, G.V.3
Sebesta, C.4
Depisch, D.5
-
11
-
-
1342290189
-
FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
-
Tournigand C, Andre T, Achille E, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol. 2004;22(2):229-237.
-
(2004)
J Clin Oncol
, vol.22
, Issue.2
, pp. 229-237
-
-
Tournigand, C.1
Andre, T.2
Achille, E.3
-
12
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350(23):2335-2342.
-
(2004)
N Engl J Med
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
13
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 2004;351(4):337-345.
-
(2004)
N Engl J Med
, vol.351
, Issue.4
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
14
-
-
84860208741
-
Vascular endothelial growth factors (VEGF) and VEGF receptor expression as predictive biomarkers for benefit with bevacizumab in metastatic colorectal cancer (mCRC): Analysis of the phase III MAX study
-
Weickhardt AJ, Williams D, Lee C, et al. Vascular endothelial growth factors (VEGF) and VEGF receptor expression as predictive biomarkers for benefit with bevacizumab in metastatic colorectal cancer (mCRC): analysis of the phase III MAX study. J Clin Oncol. 2011;29 Suppl:3531.
-
(2011)
J Clin Oncol
, Issue.29 SUPPL
, pp. 3531
-
-
Weickhardt, A.J.1
Williams, D.2
Lee, C.3
-
15
-
-
79957793636
-
Bevacizumab-induced hypertension: Pathogenesis and management
-
Syrigos KN, Karapanagiotou E, Boura P, Manegold C, Harrington K. Bevacizumab-induced hypertension: pathogenesis and management. BioDrugs. 2011;25(3):159-169.
-
(2011)
BioDrugs
, vol.25
, Issue.3
, pp. 159-169
-
-
Syrigos, K.N.1
Karapanagiotou, E.2
Boura, P.3
Manegold, C.4
Harrington, K.5
-
17
-
-
0035256698
-
Untangling the ErbB signalling network
-
Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2001;2(2):127-137.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, Issue.2
, pp. 127-137
-
-
Yarden, Y.1
Sliwkowski, M.X.2
-
18
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Kohne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009;360(14):1408-1417.
-
(2009)
N Engl J Med
, vol.360
, Issue.14
, pp. 1408-1417
-
-
van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
-
19
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
-
Van Cutsem E, Peeters M, Siena S, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol. 2007;25(13):1658-1664.
-
(2007)
J Clin Oncol
, vol.25
, Issue.13
, pp. 1658-1664
-
-
van Cutsem, E.1
Peeters, M.2
Siena, S.3
-
20
-
-
20144381957
-
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
-
Chung KY, Shia J, Kemeny NE, et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol. 2005;23(9):1803-1810.
-
(2005)
J Clin Oncol
, vol.23
, Issue.9
, pp. 1803-1810
-
-
Chung, K.Y.1
Shia, J.2
Kemeny, N.E.3
-
21
-
-
17844362179
-
Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: A cohort study
-
Moroni M, Veronese S, Benvenuti S, et al. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol. 2005;6(5):279-286.
-
(2005)
Lancet Oncol
, vol.6
, Issue.5
, pp. 279-286
-
-
Moroni, M.1
Veronese, S.2
Benvenuti, S.3
-
22
-
-
41549097718
-
EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients
-
Cappuzzo F, Finocchiaro G, Rossi E, et al. EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients. Ann Oncol. 2008;19(4):717-723.
-
(2008)
Ann Oncol
, vol.19
, Issue.4
, pp. 717-723
-
-
Cappuzzo, F.1
Finocchiaro, G.2
Rossi, E.3
-
23
-
-
34548258303
-
Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab
-
Sartore-Bianchi A, Moroni M, Veronese S, et al. Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab. J Clin Oncol. 2007;25(22): 3238-3245.
-
(2007)
J Clin Oncol
, vol.25
, Issue.22
, pp. 3238-3245
-
-
Sartore-Bianchi, A.1
Moroni, M.2
Veronese, S.3
-
24
-
-
84857366043
-
Standardisation of EGFR FISH in colorectal cancer: Results of an international interlaboratory reproducibility ring study
-
Sartore-Bianchi A, Fieuws S, Veronese S, et al. Standardisation of EGFR FISH in colorectal cancer: results of an international interlaboratory reproducibility ring study. J Clin Pathol. 2012;65(3):218-223.
-
(2012)
J Clin Pathol
, vol.65
, Issue.3
, pp. 218-223
-
-
Sartore-Bianchi, A.1
Fieuws, S.2
Veronese, S.3
-
25
-
-
70049091759
-
Epidermal growth factor receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: A fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis
-
Scartozzi M, Bearzi I, Mandolesi A, et al. Epidermal growth factor receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis. BMC Cancer. 2009;9:303.
-
(2009)
BMC Cancer
, vol.9
, pp. 303
-
-
Scartozzi, M.1
Bearzi, I.2
Mandolesi, A.3
-
26
-
-
84857965566
-
Amphiregulin and epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases
-
Kuramochi H, Nakajima G, Kaneko Y, et al. Amphiregulin and epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases. BMC Cancer. 2012;12:88.
-
(2012)
BMC Cancer
, vol.12
, pp. 88
-
-
Kuramochi, H.1
Nakajima, G.2
Kaneko, Y.3
-
27
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
Khambata-Ford S, Garrett CR, Meropol NJ, et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol. 2007;25(22):3230-3237.
-
(2007)
J Clin Oncol
, vol.25
, Issue.22
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
-
28
-
-
73349098041
-
Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab
-
Jacobs B, De Roock W, Piessevaux H, et al. Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab. J Clin Oncol. 2009;27(30):5068-5074.
-
(2009)
J Clin Oncol
, vol.27
, Issue.30
, pp. 5068-5074
-
-
Jacobs, B.1
de Roock, W.2
Piessevaux, H.3
-
29
-
-
77949887855
-
Pharmacogenomic and pharmacoproteomic studies of cetuximab in metastatic colorectal cancer: Biomarker analysis of a phase I dose-escalation study
-
Tabernero J, Cervantes A, Rivera F, et al. Pharmacogenomic and pharmacoproteomic studies of cetuximab in metastatic colorectal cancer: biomarker analysis of a phase I dose-escalation study. J Clin Oncol. 2010;28(7):1181-1189.
-
(2010)
J Clin Oncol
, vol.28
, Issue.7
, pp. 1181-1189
-
-
Tabernero, J.1
Cervantes, A.2
Rivera, F.3
-
30
-
-
72449204284
-
High epiregulin (EREG) gene expression plus K-ras wild-type (WT) status as predictors of cetuximab benefit in the treatment of advanced colorectal cancer (ACRC): Results from the NCIC CTG CO.17 - a phase III trial of cetuximab versus best supportive care (BSC
-
Jonker DJ, Karapetis CS, Harbison CT, et al. High epiregulin (EREG) gene expression plus K-ras wild-type (WT) status as predictors of cetuximab benefit in the treatment of advanced colorectal cancer (ACRC): results from the NCIC CTG CO.17 - a phase III trial of cetuximab versus best supportive care (BSC). J Clin Oncol. 2009;27 Suppl 15;4016.
-
(2009)
J Clin Oncol
, Issue.15-27 SUPPL
, pp. 4016
-
-
Jonker, D.J.1
Karapetis, C.S.2
Harbison, C.T.3
-
31
-
-
33947594129
-
Hyperactive Ras in developmental disorders and cancer
-
Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer. 2007;7(4):295-308.
-
(2007)
Nat Rev Cancer
, vol.7
, Issue.4
, pp. 295-308
-
-
Schubbert, S.1
Shannon, K.2
Bollag, G.3
-
32
-
-
0023256456
-
Prevalence of ras gene mutations in human colorectal cancers
-
Bos JL, Fearon ER, Hamilton SR, et al. Prevalence of ras gene mutations in human colorectal cancers. Nature. 1987;327(6120):293-297.
-
(1987)
Nature
, vol.327
, Issue.6120
, pp. 293-297
-
-
Bos, J.L.1
Fearon, E.R.2
Hamilton, S.R.3
-
33
-
-
0024376173
-
Ras Oncogenes in human cancer: A review
-
Bos JL. Ras Oncogenes in human cancer: a review. Cancer Res. 1989;49(17):4682-4689.
-
(1989)
Cancer Res
, vol.49
, Issue.17
, pp. 4682-4689
-
-
Bos, J.L.1
-
34
-
-
79952702311
-
KRAS mutation analysis: A comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients
-
Knijn N, Mekenkamp LJ, Klomp M, et al. KRAS mutation analysis: a comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients. Br J Cancer. 2011;104(6):1020-1026.
-
(2011)
Br J Cancer
, vol.104
, Issue.6
, pp. 1020-1026
-
-
Knijn, N.1
Mekenkamp, L.J.2
Klomp, M.3
-
35
-
-
58749102224
-
High concordance of KRAS status between primary colorectal tumors and related metastatic sites: Implications for clinical practice
-
Santini D, Loupakis F, Vincenzi B, et al. High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice. Oncologist. 2008;13(12): 1270-1275.
-
(2008)
Oncologist
, vol.13
, Issue.12
, pp. 1270-1275
-
-
Santini, D.1
Loupakis, F.2
Vincenzi, B.3
-
36
-
-
51649084560
-
Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer
-
Artale S, Sartore-Bianchi A, Veronese SM, et al. Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer. J Clin Oncol. 2008;26(25):4217-4219.
-
(2008)
J Clin Oncol
, vol.26
, Issue.25
, pp. 4217-4219
-
-
Artale, S.1
Sartore-Bianchi, A.2
Veronese, S.M.3
-
37
-
-
78149250536
-
Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
-
Douillard JY, Siena S, Cassidy J, et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol. 2010;28(31):4697-4705.
-
(2010)
J Clin Oncol
, vol.28
, Issue.31
, pp. 4697-4705
-
-
Douillard, J.Y.1
Siena, S.2
Cassidy, J.3
-
38
-
-
78149239651
-
Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer
-
Peeters M, Price TJ, Cervantes A, et al. Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. J Clin Oncol. 2010;28(31):4706-4713.
-
(2010)
J Clin Oncol
, vol.28
, Issue.31
, pp. 4706-4713
-
-
Peeters, M.1
Price, T.J.2
Cervantes, A.3
-
39
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008;26(10):1626-1634.
-
(2008)
J Clin Oncol
, vol.26
, Issue.10
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
40
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med. 2008;359(17):1757-1765.
-
(2008)
N Engl J Med
, vol.359
, Issue.17
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
41
-
-
65349189958
-
American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
-
Allegra CJ, Jessup JM, Somerfield MR, et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J Clin Oncol. 2009;27(12):2091-2096.
-
(2009)
J Clin Oncol
, vol.27
, Issue.12
, pp. 2091-2096
-
-
Allegra, C.J.1
Jessup, J.M.2
Somerfield, M.R.3
-
42
-
-
79956310674
-
Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: The OPUS study
-
Bokemeyer C, Bondarenko I, Hartmann JT, et al. Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol. 2011;22(7): 1535-1546.
-
(2011)
Ann Oncol
, vol.22
, Issue.7
, pp. 1535-1546
-
-
Bokemeyer, C.1
Bondarenko, I.2
Hartmann, J.T.3
-
43
-
-
79956298812
-
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
-
Van Cutsem E, Kohne CH, Lang I, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol. 2011;29(15):2011-2019.
-
(2011)
J Clin Oncol
, vol.29
, Issue.15
, pp. 2011-2019
-
-
van Cutsem, E.1
Kohne, C.H.2
Lang, I.3
-
44
-
-
84862026304
-
Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials
-
Bokemeyer C, Van Cutsem E, Rougier P, et al. Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials. Eur J Cancer. 2012;48(10):1466-1475.
-
(2012)
Eur J Cancer
, vol.48
, Issue.10
, pp. 1466-1475
-
-
Bokemeyer, C.1
van Cutsem, E.2
Rougier, P.3
-
45
-
-
79959337678
-
Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
-
Maughan TS, Adams RA, Smith CG, et al. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet. 2010;377(9783):2103-2114.
-
(2010)
Lancet
, vol.377
, Issue.9783
, pp. 2103-2114
-
-
Maughan, T.S.1
Adams, R.A.2
Smith, C.G.3
-
46
-
-
79952153189
-
Randomized phase III study of 5-fluorouracil/folinate/oxaliplatin given continuously or intermittently with or without cetuximab, as first-line treatment of metastatic colorectal cancer: The NORDIC VII study (NCT00145314), by the Nordic Colorectal Cancer Biomodulation Group
-
Tveit K, Guren T, Glimelius B, et al. Randomized phase III study of 5-fluorouracil/folinate/oxaliplatin given continuously or intermittently with or without cetuximab, as first-line treatment of metastatic colorectal cancer: The NORDIC VII study (NCT00145314), by the Nordic Colorectal Cancer Biomodulation Group. Ann Oncol. 2010;21 Suppl 8:viii9.
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 8
-
-
Tveit, K.1
Guren, T.2
Glimelius, B.3
-
47
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
Bokemeyer C, Bondarenko I, Makhson A, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol. 2009;27(5):663-671.
-
(2009)
J Clin Oncol
, vol.27
, Issue.5
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
-
48
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med. 2009;360(6): 563-572.
-
(2009)
N Engl J Med
, vol.360
, Issue.6
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
-
49
-
-
59949102930
-
A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
-
Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol. 2009;27(5):672-680.
-
(2009)
J Clin Oncol
, vol.27
, Issue.5
, pp. 672-680
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
-
50
-
-
44249111440
-
EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
-
Sobrero AF, Maurel J, Fehrenbacher L, et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol. 2008;26(14): 2311-2319.
-
(2008)
J Clin Oncol
, vol.26
, Issue.14
, pp. 2311-2319
-
-
Sobrero, A.F.1
Maurel, J.2
Fehrenbacher, L.3
-
51
-
-
77149166461
-
Analysis of KRAS mutations in patients with metastatic colorectal cancer receiving cetuximab in combination with irinotecan: Results from the EPIC trial
-
Langer C, Kopit J, Awad M, et al. Analysis of KRAS mutations in patients with metastatic colorectal cancer receiving cetuximab in combination with irinotecan: results from the EPIC trial. Ann Oncol. 2008;19 Suppl 8:viii133.
-
(2008)
Ann Oncol
, vol.19
, Issue.SUPPL. 8
-
-
Langer, C.1
Kopit, J.2
Awad, M.3
-
52
-
-
61449154484
-
KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: Practical application of patient selection
-
Jimeno A, Messersmith WA, Hirsch FR, Franklin WA, Eckhardt SG. KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection. J Clin Oncol. 2009;27(7):1130-1136.
-
(2009)
J Clin Oncol
, vol.27
, Issue.7
, pp. 1130-1136
-
-
Jimeno, A.1
Messersmith, W.A.2
Hirsch, F.R.3
Franklin, W.A.4
Eckhardt, S.G.5
-
53
-
-
79960435101
-
Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer
-
Molinari F, Felicioni L, Buscarino M, et al. Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer. Clin Cancer Res. 2011;17(14):4901-4914.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.14
, pp. 4901-4914
-
-
Molinari, F.1
Felicioni, L.2
Buscarino, M.3
-
54
-
-
0034548712
-
K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression
-
Guerrero S, Casanova I, Farre L, Mazo A, Capella G, Mangues R. K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression. Cancer Res. 2000;60(23): 6750-6756.
-
(2000)
Cancer Res
, vol.60
, Issue.23
, pp. 6750-6756
-
-
Guerrero, S.1
Casanova, I.2
Farre, L.3
Mazo, A.4
Capella, G.5
Mangues, R.6
-
55
-
-
78049341541
-
Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab
-
De Roock W, Jonker DJ, Di Nicolantonio F, et al. Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. JAMA. 2010;304(16):1812-1820.
-
(2010)
JAMA
, vol.304
, Issue.16
, pp. 1812-1820
-
-
de Roock, W.1
Jonker, D.J.2
Di Nicolantonio, F.3
-
56
-
-
84867117207
-
Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab
-
Tejpar S, Celik I, Schlichting M, Sartorius U, Bokemeyer C, Van Cutsem E. Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab. J Clin Oncol. 2012;30(29): 3570-3577.
-
(2012)
J Clin Oncol
, vol.30
, Issue.29
, pp. 3570-3577
-
-
Tejpar, S.1
Celik, I.2
Schlichting, M.3
Sartorius, U.4
Bokemeyer, C.5
van Cutsem, E.6
-
57
-
-
84875742535
-
Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: Assessment as prognostic and predictive biomarkers of response to panitumumab
-
Peeters M, Douillard JY, Van Cutsem E, et al. Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: assessment as prognostic and predictive biomarkers of response to panitumumab. J Clin Oncol. 20, 2013;31(6):759-765.
-
(2013)
J Clin Oncol. 20
, vol.31
, Issue.6
, pp. 759-765
-
-
Peeters, M.1
Douillard, J.Y.2
van Cutsem, E.3
-
58
-
-
77949435827
-
Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
-
Bardelli A, Siena S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J Clin Oncol. 2010;28(7): 1254-1261.
-
(2010)
J Clin Oncol
, vol.28
, Issue.7
, pp. 1254-1261
-
-
Bardelli, A.1
Siena, S.2
-
59
-
-
52749099497
-
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
-
Linardou H, Dahabreh IJ, Kanaloupiti D, et al. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol. 2008;9(10):962-972.
-
(2008)
Lancet Oncol
, vol.9
, Issue.10
, pp. 962-972
-
-
Linardou, H.1
Dahabreh, I.J.2
Kanaloupiti, D.3
-
60
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
-
De Roock W, Claes B, Bernasconi D, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol. 2010;11(8): 753-762.
-
(2010)
Lancet Oncol
, vol.11
, Issue.8
, pp. 753-762
-
-
de Roock, W.1
Claes, B.2
Bernasconi, D.3
-
61
-
-
80054738165
-
Addition of panitumumab to irinotecan: Results of PICCOLO, a randomized controlled trial in advanced colorectal cancer (aCRC
-
Seymour MT, Brown SR, Richman S, Middleton GW, Maughan T, Olivier C. Addition of panitumumab to irinotecan: results of PICCOLO, a randomized controlled trial in advanced colorectal cancer (aCRC). J Clin Oncol. 2011;29 Suppl:3523.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
, pp. 3523
-
-
Seymour, M.T.1
Brown, S.R.2
Richman, S.3
Middleton, G.W.4
Maughan, T.5
Olivier, C.6
-
62
-
-
84855944905
-
Development of molecular biomarkers in individualized treatment of colorectal cancer
-
De Mattos-Arruda L, Dienstmann R, Tabernero J. Development of molecular biomarkers in individualized treatment of colorectal cancer. Clin Colorectal Cancer. 2011;10(4):279-289.
-
(2011)
Clin Colorectal Cancer
, vol.10
, Issue.4
, pp. 279-289
-
-
De Mattos-Arruda, L.1
Dienstmann, R.2
Tabernero, J.3
-
63
-
-
79952463028
-
Optimizing targeted therapeutic development: Analysis of a colorectal cancer patient population with the BRAF (V600E) mutation
-
Tie J, Gibbs P, Lipton L, et al. Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF (V600E) mutation. Int J Cancer. 2011;128(9):2075-2084.
-
(2011)
Int J Cancer
, vol.128
, Issue.9
, pp. 2075-2084
-
-
Tie, J.1
Gibbs, P.2
Lipton, L.3
-
64
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949-954.
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
65
-
-
79951763829
-
BRAF V600E confers resistance to cetuximab or panitumumab in metastatic colorectal cancer
-
Di Nicolantonio F, Martini M, Molinari F, et al. BRAF V600E confers resistance to cetuximab or panitumumab in metastatic colorectal cancer. Eur J Cancer Suppl. 2008;6(12):81.
-
(2008)
Eur J Cancer Suppl
, vol.6
, Issue.12
, pp. 81
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
-
66
-
-
84888118811
-
A phase IIB double-blind, randomized study evaluating the efficacy and safety of sorafenib (SOR) compared with placebo (PBO) when administered in combination with chemotherapy (modified FOLFOX6) for first-line treatment (tx) of patients (pts) with metastatic colorectal cancer (mCRC). The RESPECT Trial
-
Tabernero J, Konne C, O'Dwyer PJ, et al. A phase IIB double-blind, randomized study evaluating the efficacy and safety of sorafenib (SOR) compared with placebo (PBO) when administered in combination with chemotherapy (modified FOLFOX6) for first-line treatment (tx) of patients (pts) with metastatic colorectal cancer (mCRC). The RESPECT Trial. Eur J Cancer. 2011;47 Suppl 2:11.
-
(2011)
Eur J Cancer
, Issue.47 SUPPL 2
, pp. 11
-
-
Tabernero, J.1
Konne, C.2
O'Dwyer, P.J.3
-
67
-
-
78649723255
-
PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumours
-
Kopetz S, Desai J, Chan E, et al. PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumours. J Clin Oncol. 2010;28 Suppl 15:3534.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL. 15
, pp. 3534
-
-
Kopetz, S.1
Desai, J.2
Chan, E.3
-
68
-
-
76149102749
-
Early efficacy signal demonstrated in advanced melanoma in a phase I trial of the oncogenic BRAF-selective inhibitor PLX4032
-
Chapman P, Puzanov I, Sosman J. Early efficacy signal demonstrated in advanced melanoma in a phase I trial of the oncogenic BRAF-selective inhibitor PLX4032. Eur J Cancer Suppl. 2009;7(3):5.
-
(2009)
Eur J Cancer Suppl
, vol.7
, Issue.3
, pp. 5
-
-
Chapman, P.1
Puzanov, I.2
Sosman, J.3
-
69
-
-
62449302407
-
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
-
Sartore-Bianchi A, Martini M, Molinari F, et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res. 2009;69(5):1851-1857.
-
(2009)
Cancer Res
, vol.69
, Issue.5
, pp. 1851-1857
-
-
Sartore-Bianchi, A.1
Martini, M.2
Molinari, F.3
-
70
-
-
35348908314
-
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
-
Frattini M, Saletti P, Romagnani E, et al. PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer. 2007;97(8):1139-1145.
-
(2007)
Br J Cancer
, vol.97
, Issue.8
, pp. 1139-1145
-
-
Frattini, M.1
Saletti, P.2
Romagnani, E.3
-
71
-
-
40949135397
-
PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
-
Jhawer M, Goel S, Wilson AJ, et al. PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res. 2008;68(6): 1953-1961.
-
(2008)
Cancer Res
, vol.68
, Issue.6
, pp. 1953-1961
-
-
Jhawer, M.1
Goel, S.2
Wilson, A.J.3
-
72
-
-
66849140563
-
PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer
-
Loupakis F, Pollina L, Stasi I, et al. PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer. J Clin Oncol. 2009;27(16):2622-2629.
-
(2009)
J Clin Oncol
, vol.27
, Issue.16
, pp. 2622-2629
-
-
Loupakis, F.1
Pollina, L.2
Stasi, I.3
-
73
-
-
65649086786
-
PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer
-
Prenen H, De Schutter J, Jacobs B, et al. PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer. Clin Cancer Res. 2009;15(9):3184-3188.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.9
, pp. 3184-3188
-
-
Prenen, H.1
de Schutter, J.2
Jacobs, B.3
-
74
-
-
0141842714
-
Farnesyltransferase inhibitors: An overview of the results of preclinical and clinical investigations
-
Brunner TB, Hahn SM, Gupta AK, Muschel RJ, McKenna WG, Bernhard EJ. Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations. Cancer Res. 2003;63(18): 5656-5668.
-
(2003)
Cancer Res
, vol.63
, Issue.18
, pp. 5656-5668
-
-
Brunner, T.B.1
Hahn, S.M.2
Gupta, A.K.3
Muschel, R.J.4
McKenna, W.G.5
Bernhard, E.J.6
-
75
-
-
2342645506
-
Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
-
Van Cutsem E, van de Velde H, Karasek P, et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol. 2004;22(8):1430-1438.
-
(2004)
J Clin Oncol
, vol.22
, Issue.8
, pp. 1430-1438
-
-
van Cutsem, E.1
van de Velde, H.2
Karasek, P.3
-
76
-
-
31144453233
-
BRAF mutation predicts sensitivity to MEK inhibition
-
Solit DB, Garraway LA, Pratilas CA, et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature. 2006;439(7074):358-362.
-
(2006)
Nature
, vol.439
, Issue.7074
, pp. 358-362
-
-
Solit, D.B.1
Garraway, L.A.2
Pratilas, C.A.3
-
77
-
-
66249116702
-
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
-
Wee S, Jagani Z, Xiang KX, et al. PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Res. 2009;69(10):4286-4293.
-
(2009)
Cancer Res
, vol.69
, Issue.10
, pp. 4286-4293
-
-
Wee, S.1
Jagani, Z.2
Xiang, K.X.3
-
78
-
-
58349091262
-
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
-
Mirzoeva OK, Das D, Heiser LM, et al. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009;69(2):565-572.
-
(2009)
Cancer Res
, vol.69
, Issue.2
, pp. 565-572
-
-
Mirzoeva, O.K.1
Das, D.2
Heiser, L.M.3
-
79
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF (V600E) inhibition through feedback activation of EGFR
-
Prahallad A, Sun C, Huang S, et al. Unresponsiveness of colon cancer to BRAF (V600E) inhibition through feedback activation of EGFR. Nature. 2012;483(7387):100-103.
-
(2012)
Nature
, vol.483
, Issue.7387
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
-
80
-
-
80052591747
-
Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
-
99ra86
-
Yonesaka K, Zejnullahu K, Okamoto I, et al. Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci Transl Med. 2011;3(99):99ra86.
-
(2011)
Sci Transl Med
, vol.3
, Issue.99
-
-
Yonesaka, K.1
Zejnullahu, K.2
Okamoto, I.3
-
81
-
-
84862772839
-
A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
-
Bertotti A, Migliardi G, Galimi F, et al. A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discov. 2011;1(6):508-523.
-
(2011)
Cancer Discov
, vol.1
, Issue.6
, pp. 508-523
-
-
Bertotti, A.1
Migliardi, G.2
Galimi, F.3
-
82
-
-
80455173816
-
EGFR-targeted therapy
-
Vecchione L, Jacobs B, Normanno N, Ciardiello F, Tejpar S. EGFR-targeted therapy. Exp Cell Res. 2011;317(19):2765-2771.
-
(2011)
Exp Cell Res
, vol.317
, Issue.19
, pp. 2765-2771
-
-
Vecchione, L.1
Jacobs, B.2
Normanno, N.3
Ciardiello, F.4
Tejpar, S.5
-
83
-
-
10044280618
-
Mechanisms of resistance to Erbitux (anti-epidermal growth factor receptor) combination therapy in pancreatic adenocarcinoma cells
-
discussion 969-970
-
Arnoletti JP, Buchsbaum DJ, Huang ZQ, et al. Mechanisms of resistance to Erbitux (anti-epidermal growth factor receptor) combination therapy in pancreatic adenocarcinoma cells. J Gastrointest Surg. 2004;8(8):960-969; discussion 969-970.
-
(2004)
J Gastrointest Surg
, vol.8
, Issue.8
, pp. 960-969
-
-
Arnoletti, J.P.1
Buchsbaum, D.J.2
Huang, Z.Q.3
-
84
-
-
79952607191
-
The role of HER-3 expression in the prediction of clinical outcome for advanced colorectal cancer patients receiving irinotecan and cetuximab
-
Scartozzi M, Mandolesi A, Giampieri R, et al. The role of HER-3 expression in the prediction of clinical outcome for advanced colorectal cancer patients receiving irinotecan and cetuximab. Oncologist. 2011;16(1): 53-60.
-
(2011)
Oncologist
, vol.16
, Issue.1
, pp. 53-60
-
-
Scartozzi, M.1
Mandolesi, A.2
Giampieri, R.3
-
85
-
-
77956996167
-
Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan
-
Scartozzi M, Mandolesi A, Giampieri R, et al. Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan. Int J Cancer. 2010;127(8):1941-1947.
-
(2010)
Int J Cancer
, vol.127
, Issue.8
, pp. 1941-1947
-
-
Scartozzi, M.1
Mandolesi, A.2
Giampieri, R.3
-
86
-
-
46349092797
-
Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients
-
Cappuzzo F, Varella-Garcia M, Finocchiaro G, et al. Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients. Br J Cancer. 2008;99(1):83-89.
-
(2008)
Br J Cancer
, vol.99
, Issue.1
, pp. 83-89
-
-
Cappuzzo, F.1
Varella-Garcia, M.2
Finocchiaro, G.3
-
87
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316(5827):1039-1043.
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
88
-
-
34548278840
-
Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells
-
Bonine-Summers AR, Aakre ME, Brown KA, et al. Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells. Cancer Biol Ther. 2007;6(4):561-570.
-
(2007)
Cancer Biol Ther
, vol.6
, Issue.4
, pp. 561-570
-
-
Bonine-Summers, A.R.1
Aakre, M.E.2
Brown, K.A.3
-
89
-
-
33847326735
-
Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome
-
Kammula US, Kuntz EJ, Francone TD, et al. Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome. Cancer Lett. 2007;248(2):219-228.
-
(2007)
Cancer Lett
, vol.248
, Issue.2
, pp. 219-228
-
-
Kammula, U.S.1
Kuntz, E.J.2
Francone, T.D.3
-
90
-
-
69449084698
-
Radiological tumor size decrease at week 6 is a potent predictor of outcome in chemorefractory metastatic colorectal cancer treated with cetuximab (BOND trial)
-
Piessevaux H, Buyse M, De Roock W, et al. Radiological tumor size decrease at week 6 is a potent predictor of outcome in chemorefractory metastatic colorectal cancer treated with cetuximab (BOND trial). Ann Oncol. 2009;20(8):1375-1382.
-
(2009)
Ann Oncol
, vol.20
, Issue.8
, pp. 1375-1382
-
-
Piessevaux, H.1
Buyse, M.2
de Roock, W.3
-
91
-
-
40149088765
-
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
-
De Roock W, Piessevaux H, De Schutter J, et al. KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol. 2008;19(3):508-515.
-
(2008)
Ann Oncol
, vol.19
, Issue.3
, pp. 508-515
-
-
de Roock, W.1
Piessevaux, H.2
de Schutter, J.3
-
92
-
-
38349189743
-
Response-independent survival benefit in metastatic colorectal cancer: A comparative analysis of N9741 and AVF2107
-
Grothey A, Hedrick EE, Mass RD, et al. Response-independent survival benefit in metastatic colorectal cancer: a comparative analysis of N9741 and AVF2107. J Clin Oncol. 2008;26(2):183-189.
-
(2008)
J Clin Oncol
, vol.26
, Issue.2
, pp. 183-189
-
-
Grothey, A.1
Hedrick, E.E.2
Mass, R.D.3
-
93
-
-
84869869929
-
Early tumor shrinkage for the prediction of efficacy of cetuximab in metastatic colorectal cancer (MCRC): Analysis from the CRYSTAL study
-
Piessevaux H, Schlichtling M, Heeger S, van Cutsem E, Tejpar S. Early tumor shrinkage for the prediction of efficacy of cetuximab in metastatic colorectal cancer (MCRC): analysis from the CRYSTAL study. Ann Oncol. 2010;21 Suppl 8:viii193.
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 8
-
-
Piessevaux, H.1
Schlichtling, M.2
Heeger, S.3
van Cutsem, E.4
Tejpar, S.5
-
94
-
-
79959199867
-
The challenges of integrating molecular imaging into the optimization of cancer therapy
-
Patel GS, Kiuchi T, Lawler K, et al. The challenges of integrating molecular imaging into the optimization of cancer therapy. Integr Biol (Camb). 2011;3(6):603-631.
-
(2011)
Integr Biol (Camb)
, vol.3
, Issue.6
, pp. 603-631
-
-
Patel, G.S.1
Kiuchi, T.2
Lawler, K.3
-
95
-
-
33748996814
-
Molecular imaging of EGFR kinase activity in tumors with 124I-labeled small molecular tracer and positron emission tomography
-
Pal A, Glekas A, Doubrovin M, et al. Molecular imaging of EGFR kinase activity in tumors with 124I-labeled small molecular tracer and positron emission tomography. Mol Imaging Biol. 2006;8(5): 262-277.
-
(2006)
Mol Imaging Biol
, vol.8
, Issue.5
, pp. 262-277
-
-
Pal, A.1
Glekas, A.2
Doubrovin, M.3
-
96
-
-
77955388676
-
EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma
-
Hadjipanayis CG, Machaidze R, Kaluzova M, et al. EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma. Cancer Res. 2010;70(15):6303-6312.
-
(2010)
Cancer Res
, vol.70
, Issue.15
, pp. 6303-6312
-
-
Hadjipanayis, C.G.1
Machaidze, R.2
Kaluzova, M.3
-
97
-
-
33847261015
-
Phase II trial of capecitabine and oxaliplatin (CAPOX) plus cetuximab in patients with metastatic colorectal cancer who progressed after oxaliplatin-based chemotherapy
-
Souglakos J, Kalykaki A, Vamvakas L, et al. Phase II trial of capecitabine and oxaliplatin (CAPOX) plus cetuximab in patients with metastatic colorectal cancer who progressed after oxaliplatin-based chemotherapy. Ann Oncol. 2007;18(2):305-310.
-
(2007)
Ann Oncol
, vol.18
, Issue.2
, pp. 305-310
-
-
Souglakos, J.1
Kalykaki, A.2
Vamvakas, L.3
-
98
-
-
33750615769
-
Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines
-
Lenz HJ, Van Cutsem E, Khambata-Ford S, et al. Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines. J Clin Oncol. 2006;24(30):4914-4921.
-
(2006)
J Clin Oncol
, vol.24
, Issue.30
, pp. 4914-4921
-
-
Lenz, H.J.1
van Cutsem, E.2
Khambata-Ford, S.3
-
99
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz LB, Meropol NJ, Loehrer PJ Sr, Needle MN, Kopit J, Mayer RJ. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol. 2004;22(7):1201-1208.
-
(2004)
J Clin Oncol
, vol.22
, Issue.7
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer Sr., P.J.3
Needle, M.N.4
Kopit, J.5
Mayer, R.J.6
-
100
-
-
63449142391
-
Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy
-
Peeters M, Siena S, Van Cutsem E, et al. Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy. Cancer. 2009;115(7):1544-1554.
-
(2009)
Cancer
, vol.115
, Issue.7
, pp. 1544-1554
-
-
Peeters, M.1
Siena, S.2
van Cutsem, E.3
-
101
-
-
84865092896
-
Intrapatient cetuximab dose escalation in metastatic colorectal cancer according to the grade of early skin reactions: The randomized EVEREST study
-
Van Cutsem E, Tejpar S, Vanbeckevoort D, et al. Intrapatient cetuximab dose escalation in metastatic colorectal cancer according to the grade of early skin reactions: the randomized EVEREST study. J Clin Oncol. 2012;30(23):2861-2868.
-
(2012)
J Clin Oncol
, vol.30
, Issue.23
, pp. 2861-2868
-
-
van Cutsem, E.1
Tejpar, S.2
Vanbeckevoort, D.3
-
102
-
-
33751373088
-
Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer
-
Dignam JJ, Polite BN, Yothers G, et al. Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer. J Natl Cancer Inst. 2006;98(22):1647-1654.
-
(2006)
J Natl Cancer Inst
, vol.98
, Issue.22
, pp. 1647-1654
-
-
Dignam, J.J.1
Polite, B.N.2
Yothers, G.3
-
103
-
-
51649093534
-
Impact of body mass index and weight change after treatment on cancer recurrence and survival in patients with stage III colon cancer: Findings from Cancer and Leukemia Group B 89803
-
Meyerhardt JA, Niedzwiecki D, Hollis D, et al. Impact of body mass index and weight change after treatment on cancer recurrence and survival in patients with stage III colon cancer: findings from Cancer and Leukemia Group B 89803. J Clin Oncol. 2008;26(25):4109-4115.
-
(2008)
J Clin Oncol
, vol.26
, Issue.25
, pp. 4109-4115
-
-
Meyerhardt, J.A.1
Niedzwiecki, D.2
Hollis, D.3
-
104
-
-
77749306533
-
Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer
-
Guiu B, Petit JM, Bonnetain F, et al. Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer. Gut. 2010;59(3):341-347.
-
(2010)
Gut
, vol.59
, Issue.3
, pp. 341-347
-
-
Guiu, B.1
Petit, J.M.2
Bonnetain, F.3
-
105
-
-
77955010927
-
Cigarette smoking and colorectal cancer risk by molecularly defined subtypes
-
Limsui D, Vierkant RA, Tillmans LS, et al. Cigarette smoking and colorectal cancer risk by molecularly defined subtypes. J Natl Cancer Inst. 2010;102(14):1012-1022.
-
(2010)
J Natl Cancer Inst
, vol.102
, Issue.14
, pp. 1012-1022
-
-
Limsui, D.1
Vierkant, R.A.2
Tillmans, L.S.3
-
106
-
-
79954430604
-
Neutrophil/lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer
-
Chua W, Charles KA, Baracos VE, Clarke SJ. Neutrophil/lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer. Br J Cancer. 2011;104(8):1288-1295.
-
(2011)
Br J Cancer
, vol.104
, Issue.8
, pp. 1288-1295
-
-
Chua, W.1
Charles, K.A.2
Baracos, V.E.3
Clarke, S.J.4
-
107
-
-
79955505250
-
Early magnesium modifications as a surrogate marker of efficacy of cetuximab-based anticancer treatment in KRAS wild-type advanced colorectal cancer patients
-
Vincenzi B, Galluzzo S, Santini D, et al. Early magnesium modifications as a surrogate marker of efficacy of cetuximab-based anticancer treatment in KRAS wild-type advanced colorectal cancer patients. Ann Oncol. 2011;22(5):1141-1146.
-
(2011)
Ann Oncol
, vol.22
, Issue.5
, pp. 1141-1146
-
-
Vincenzi, B.1
Galluzzo, S.2
Santini, D.3
-
108
-
-
84861325637
-
The influence of hypomagnesemia (hMg) on overall survival (OS) in a phase III randomized study of cetuximab (CET) plus best supportive care (BSC) versus BSC: NCIC CTG/AGITG CO.17
-
Vickers MM, Karapetis CS, Tu D, et al. The influence of hypomagnesemia (hMg) on overall survival (OS) in a phase III randomized study of cetuximab (CET) plus best supportive care (BSC) versus BSC: NCIC CTG/AGITG CO.17. J Clin Oncol. 2011;29 Suppl:3601.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL
, pp. 3601
-
-
Vickers, M.M.1
Karapetis, C.S.2
Tu, D.3
-
109
-
-
4043074258
-
Amount of DNA in plasma and cancer risk: A prospective study
-
Gormally E, Hainaut P, Caboux E, et al. Amount of DNA in plasma and cancer risk: a prospective study. Int J Cancer. 2004;111(5):746-749.
-
(2004)
Int J Cancer
, vol.111
, Issue.5
, pp. 746-749
-
-
Gormally, E.1
Hainaut, P.2
Caboux, E.3
-
110
-
-
34248569300
-
Circulating free DNA in plasma or serum as biomarker of carcinogenesis: Practical aspects and biological significance
-
Gormally E, Caboux E, Vineis P, Hainaut P. Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance. Mutat Res. 2007;635(2-3):105-117.
-
(2007)
Mutat Res
, vol.635
, Issue.2-3
, pp. 105-117
-
-
Gormally, E.1
Caboux, E.2
Vineis, P.3
Hainaut, P.4
-
111
-
-
0037055554
-
Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis
-
Lecomte T, Berger A, Zinzindohoue F, et al. Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis. Int J Cancer. 2002;100(5): 542-548.
-
(2002)
Int J Cancer
, vol.100
, Issue.5
, pp. 542-548
-
-
Lecomte, T.1
Berger, A.2
Zinzindohoue, F.3
-
112
-
-
28044468634
-
Detection and quantification of mutations in the plasma of patients with colorectal tumors
-
Diehl F, Li M, Dressman D, et al. Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci U S A. 2005;102(45):16368-16373.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, Issue.45
, pp. 16368-16373
-
-
Diehl, F.1
Li, M.2
Dressman, D.3
-
113
-
-
51349141191
-
Circulating mutant DNA to assess tumor dynamics
-
Diehl F, Schmidt K, Choti MA, et al. Circulating mutant DNA to assess tumor dynamics. Nat Med. 2008;14(9):985-990.
-
(2008)
Nat Med
, vol.14
, Issue.9
, pp. 985-990
-
-
Diehl, F.1
Schmidt, K.2
Choti, M.A.3
-
114
-
-
1342331479
-
Searching for the elusive targets of farnesyltransferase inhibitors
-
Sebti SM, Der CJ. Opinion: Searching for the elusive targets of farnesyltransferase inhibitors. Nat Rev Cancer. 2003;3(12):945-951.
-
(2003)
Nat Rev Cancer
, vol.3
, Issue.12
, pp. 945-951
-
-
Sebti, S.M.1
Opinion, D.C.J.2
-
115
-
-
33746015955
-
Lately, it occurs to me what a long, strange trip it's been for the farnesyltransferase inhibitors
-
Rowinsky EK. Lately, it occurs to me what a long, strange trip it's been for the farnesyltransferase inhibitors. J Clin Oncol. 2006;24(19): 2981-2984.
-
(2006)
J Clin Oncol
, vol.24
, Issue.19
, pp. 2981-2984
-
-
Rowinsky, E.K.1
-
116
-
-
27244434788
-
A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
-
Calin GA, Ferracin M, Cimmino A, et al. A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005;353(17):1793-1801.
-
(2005)
N Engl J Med
, vol.353
, Issue.17
, pp. 1793-1801
-
-
Calin, G.A.1
Ferracin, M.2
Cimmino, A.3
-
117
-
-
33646444884
-
Let-7 microRNA functions as a potential growth suppressor in human colon cancer cells
-
Akao Y, Nakagawa Y, Naoe T. let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. Biol Pharm Bull. 2006;29(5):903-906.
-
(2006)
Biol Pharm Bull
, vol.29
, Issue.5
, pp. 903-906
-
-
Akao, Y.1
Nakagawa, Y.2
Naoe, T.3
-
118
-
-
62249137047
-
Role of miR-143 targeting KRAS in colorectal tumorigenesis
-
Chen X, Guo X, Zhang H, et al. Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene. 2009;28(10):1385-1392.
-
(2009)
Oncogene
, vol.28
, Issue.10
, pp. 1385-1392
-
-
Chen, X.1
Guo, X.2
Zhang, H.3
-
119
-
-
84870275439
-
Beyond KRAS mutation status: Influence of KRAS copy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients
-
Mekenkamp LJ, Tol J, Dijkstra JR, et al. Beyond KRAS mutation status: influence of KRAS copy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients. BMC Cancer. 2012;12:292.
-
(2012)
BMC Cancer
, vol.12
, pp. 292
-
-
Mekenkamp, L.J.1
Tol, J.2
Dijkstra, J.R.3
-
120
-
-
84867866638
-
MicroRNA expression in formalin-fixed paraffin embedded tissue using real time quantitative PCR: The strengths and pitfalls
-
Dijkstra JR, Mekenkamp LJ, Teerenstra S, De Krijger I, Nagtegaal ID. MicroRNA expression in formalin-fixed paraffin embedded tissue using real time quantitative PCR: the strengths and pitfalls. J Cell Mol Med. 2012;16(4):683-690.
-
(2012)
J Cell Mol Med
, vol.16
, Issue.4
, pp. 683-690
-
-
Dijkstra, J.R.1
Mekenkamp, L.J.2
Teerenstra, S.3
de Krijger, I.4
Nagtegaal, I.D.5
-
121
-
-
84869221346
-
Fc gamma receptor IIIa polymorphisms in advanced colorectal cancer patients correlated with response to anti-EGFR antibodies and clinical outcome
-
Calemma R, Ottaiano A, Trotta AM, et al. Fc gamma receptor IIIa polymorphisms in advanced colorectal cancer patients correlated with response to anti-EGFR antibodies and clinical outcome. J Transl Med. 2012;10:232.
-
(2012)
J Transl Med
, vol.10
, pp. 232
-
-
Calemma, R.1
Ottaiano, A.2
Trotta, A.M.3
-
122
-
-
79953243501
-
Implementing prognostic and predictive biomarkers in CRC clinical trials
-
Van Schaeybroeck S, Allen WL, Turkington RC, Johnston PG. Implementing prognostic and predictive biomarkers in CRC clinical trials. Nat Rev Clin Oncol. 2011;8(4):222-232.
-
(2011)
Nat Rev Clin Oncol
, vol.8
, Issue.4
, pp. 222-232
-
-
van Schaeybroeck, S.1
Allen, W.L.2
Turkington, R.C.3
Johnston, P.G.4
-
123
-
-
77949270273
-
Microsatellite instability in colorectal cancer - the stable evidence
-
Vilar E, Gruber SB. Microsatellite instability in colorectal cancer - the stable evidence. Nat Rev Clin Oncol. 2010;7(3):153-162.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, Issue.3
, pp. 153-162
-
-
Vilar, E.1
Gruber, S.B.2
-
124
-
-
64649096900
-
Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803
-
Bertagnolli MM, Niedzwiecki D, Compton CC, et al. Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803. J Clin Oncol. 2009;27(11): 1814-1821.
-
(2009)
J Clin Oncol
, vol.27
, Issue.11
, pp. 1814-1821
-
-
Bertagnolli, M.M.1
Niedzwiecki, D.2
Compton, C.C.3
-
125
-
-
35148888718
-
DPD is a molecular determinant of capecitabine efficacy in colorectal cancer
-
Vallbohmer D, Yang DY, Kuramochi H, et al. DPD is a molecular determinant of capecitabine efficacy in colorectal cancer. Int J Oncol. 2007;31(2):413-418.
-
(2007)
Int J Oncol
, vol.31
, Issue.2
, pp. 413-418
-
-
Vallbohmer, D.1
Yang, D.Y.2
Kuramochi, H.3
-
126
-
-
67649304464
-
Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study
-
Koopman M, Venderbosch S, van Tinteren H, et al. Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study. Eur J Cancer. 2009;45(11):1999-2006.
-
(2009)
Eur J Cancer
, vol.45
, Issue.11
, pp. 1999-2006
-
-
Koopman, M.1
Venderbosch, S.2
van Tinteren, H.3
-
127
-
-
77957055294
-
Synthetic lethal screen of an EGFR-centered network to improve targeted therapies
-
Astsaturov I, Ratushny V, Sukhanova A, et al. Synthetic lethal screen of an EGFR-centered network to improve targeted therapies. Sci Signal. 2010;3(140):ra67.
-
(2010)
Sci Signal
, vol.3
, Issue.140
-
-
Astsaturov, I.1
Ratushny, V.2
Sukhanova, A.3
|