Is early limited surgery associated with a more benign disease course in Crohn's disease?

World Journal of Gastroenterology

Volumn 19, Issue 43, 2013, Pages 7701-7710

  Golovics, Petra Anna ^a   Lakatos, Laszlo ^a   Nagy, Attila ^b   Pandur, Tunde ^b   Szita, Istvan ^b   Balogh, Mihaly ^c   Molnar, Csaba ^d   Komaromi, Erzsebet ^e   Lovasz, Barbara Dorottya ^a   Mandel, Michael ^a   Veres, Gabor ^a   Kiss, Lajos S ^a   Vegh, Zsuzsanna ^a   Lakatos, Peter Laszlo ^a,b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b Csolnoky F Province Hospital   (Hungary)

^c Grof Eszterhazy Hospital   (Hungary)

^d Magyar Imre Hospital   (Hungary)

^e Municipal Hospital   (Hungary)

Author keywords

Crohn's disease; Disease behavior; Disease course; Early surgery; Treatment strategy

Indexed keywords

AZATHIOPRINE; INFLIXIMAB; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; OLSALAZINE; PREDNISONE; SALAZOSULFAPYRIDINE;

ADULT; ARTICLE; BIOLOGICAL THERAPY; CROHN DISEASE; DISEASE COURSE; DRUG DOSE REDUCTION; DRUG EXPOSURE; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PREDICTION; PREVALENCE; PROPENSITY SCORE; PROSPECTIVE STUDY; REOPERATION; SMOKING;

CROHN'S DISEASE; DISEASE BEHAVIOR; DISEASE COURSE; EARLY SURGERY; TREATMENT STRATEGY;

ADOLESCENT; ADULT; BIOLOGICAL PRODUCTS; CHI-SQUARE DISTRIBUTION; COLECTOMY; CROHN DISEASE; DISEASE PROGRESSION; FEMALE; HUMANS; HUNGARY; INCIDENCE; KAPLAN-MEIER ESTIMATE; LAPAROSCOPY; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROPENSITY SCORE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; REOPERATION; RETROSPECTIVE STUDIES; RISK FACTORS; STEROIDS; TIME FACTORS; TIME-TO-TREATMENT; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84888095716     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i43.7701     Document Type: Article

References (25)

1. Wolters FL, Russel MG, Stockbrügger RW. Systematic review: has disease outcome in Crohn's disease changed during the last four decades? Aliment Pharmacol Ther 2004; 20: 483-496 [PMID: 15339320 DOI: 10.1111/j.1365-2036.2004.02123.x]
2. Peyrin-Biroulet L, Loftus EV, Colombel JF, Sandborn WJ. The natural history of adult Crohn's disease in populationbased cohorts. Am J Gastroenterol 2010; 105: 289-297 [PMID: 19861953 DOI: 10.1038/ajg.2009.579]
3. Bernstein CN, Loftus EV, Ng SC, Lakatos PL, Moum B. Hospitalisations and surgery in Crohn's disease. Gut 2012; 61: 622-629 [PMID: 22267595 DOI: 10.1136/gutjnl-2011-301397]
4. Jess T, Riis L, Vind I, Winther KV, Borg S, Binder V, Langholz E, Thomsen OØ, Munkholm P. Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen, Denmark. Inflamm Bowel Dis 2007; 13: 481-489 [PMID: 17206705 DOI: 10.1002/ibd.20036]
5. Lakatos PL, Golovics PA, David G, Pandur T, Erdelyi Z, Horvath A, Mester G, Balogh M, Szipocs I, Molnar C, Komaromi E, Veres G, Lovasz BD, Szathmari M, Kiss LS, Lakatos L. Has there been a change in the natural history of Crohn's disease? Surgical rates and medical management in a population-based inception cohort from Western Hungary between 1977-2009. Am J Gastroenterol 2012; 107: 579-588 [PMID: 22233693 DOI: 10.1038/ajg.2011.448]
6. Ramadas AV, Gunesh S, Thomas GA, Williams GT, Hawthorne AB. Natural history of Crohn's disease in a population-based cohort from Cardiff (1986-2003): a study of changes in medical treatment and surgical resection rates. Gut 2010; 59: 1200-1206 [PMID: 20650924 DOI: 10.1136/ gut.2009.202101]
7. Peyrin-Biroulet L, Oussalah A, Williet N, Pillot C, Bresler L, Bigard MA. Impact of azathioprine and tumour necrosis factor antagonists on the need for surgery in newly diagnosed Crohn's disease. Gut 2011; 60: 930-936 [PMID: 21228429 DOI: 10.1136/gut.2010.227884]
8. Cosnes J, Nion-Larmurier I, Beaugerie L, Afchain P, Tiret E, Gendre JP. Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. Gut 2005; 54: 237-241 [PMID: 15647188 DOI: 10.1136/ gut.2004.045294]
9. Aratari A, Papi C, Leandro G, Viscido A, Capurso L, Caprilli R. Early versus late surgery for ileo-caecal Crohn's disease. Aliment Pharmacol Ther 2007; 26: 1303-1312 [PMID: 17848181 DOI: 10.1111/j.1365-2036.2007.03515.x]
10. Lakatos L, Mester G, Erdelyi Z, Balogh M, Szipocs I, Kamaras G, Lakatos PL. Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977-2001. World J Gastroenterol 2004; 10: 404-409 [PMID: 14760767]
11. Lakatos L, Pandur T, David G, Balogh Z, Kuronya P, Tollas A, Lakatos PL. Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: results of a 25-year follow-up study. World J Gastroenterol 2003; 9: 2300-2307 [PMID: 14562397]
12. Lakatos L, Kiss LS, David G, Pandur T, Erdelyi Z, Mester G, Balogh M, Szipocs I, Molnar C, Komaromi E, Lakatos PL. Incidence, disease phenotype at diagnosis, and early disease course in inflammatory bowel diseases in Western Hungary, 2002-2006. Inflamm Bowel Dis 2011; 17: 2558-2565 [PMID: 22072315 DOI: 10.1002/ibd.21607]
13. Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR, Caprilli R, Colombel JF, Gasche C, Geboes K, Jewell DP, Karban A, Loftus EV, Peña AS, Riddell RH, Sachar DB, Schreiber S, Steinhart AH, Targan SR, Vermeire S, Warren BF. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 2005; 19 Suppl A: 5A-36A [PMID: 16151544]
14. Stange EF, Travis SP, Vermeire S, Beglinger C, Kupcinkas L, Geboes K, Barakauskiene A, Villanacci V, Von Herbay A, Warren BF, Gasche C, Tilg H, Schreiber SW, Schölmerich J, Reinisch W. European evidence based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis. Gut 2006; 55 Suppl 1: i1-15 [PMID: 16481628 DOI: 10.1136/gut.2005.081950a]
15. Austin PC. An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Multivariate Behav Res 2011; 46: 399-424 [PMID: 21818162 DOI: 10.1080/00273171.2011.568786]
16. Solberg IC, Vatn MH, Høie O, Stray N, Sauar J, Jahnsen J, Moum B, Lygren I. Clinical course in Crohn's disease: results of a Norwegian population-based ten-year follow-up study. Clin Gastroenterol Hepatol 2007; 5: 1430-1438 [PMID: 18054751 DOI: 10.1016/j.cgh.2007.09.002]
17. Bernell O, Lapidus A, Hellers G. Risk factors for surgery and postoperative recurrence in Crohn's disease. Ann Surg 2000; 231: 38-45 [PMID: 10636100]
18. Szamosi T, Banai J, Lakatos L, Czegledi Z, David G, Zsigmond F, Pandur T, Erdelyi Z, Gemela O, Papp M, Papp J, Lakatos PL. Early azathioprine/biological therapy is associated with decreased risk for first surgery and delays time to surgery but not reoperation in both smokers and nonsmokers with Crohn's disease, while smoking decreases the risk of colectomy in ulcerative colitis. Eur J Gastroenterol Hepatol 2010; 22: 872-879 [PMID: 19648821 DOI: 10.1097/ MEG.0b013e32833036d9]
19. Bernell O, Lapidus A, Hellers G. Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn's disease. Br J Surg 2000; 87: 1697-1701 [PMID: 11122187 DOI: 10.1046/j.1365-2168.2000.01589.x]
20. Margagnoni G, Aratari A, Mangone M, Moretti A, Spagnolo A, Fascì Spurio F, Luchetti R, Papi C. Natural history of ileo-caecal Crohn's disease after surgical resection. A long term study. Minerva Gastroenterol Dietol 2011; 57: 335-344 [PMID: 22105722]
21. Latella G, Cocco A, Angelucci E, Viscido A, Bacci S, Necozione S, Caprilli R. Clinical course of Crohn's disease first diagnosed at surgery for acute abdomen. Dig Liver Dis 2009; 41: 269-276 [PMID: 18955023 DOI: 10.1016/j.dld.2008.09.010]
22. van der Valk ME, Mangen MJ, Leenders M, Dijkstra G, van Bodegraven AA, Fidder HH, de Jong DJ, Pierik M, van der Woude CJ, Romberg-Camps MJ, Clemens CH, Jansen JM, Mahmmod N, van de Meeberg PC, van der Meulen-de Jong AE, Ponsioen CY, Bolwerk CJ, Vermeijden JR, Siersema PD, van Oijen MG, Oldenburg B; on behalf of the COIN study group and the Dutch Initiative on Crohn and Colitis. Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFα therapy: results from the COIN study. Gut 2012 Nov 7; Epub ahead of print [PMID: 23135759 DOI: 10.1136/gutjnl-2012-303376]
23. Schnitzler F, Fidder H, Ferrante M, Noman M, Arijs I, Van Assche G, Hoffman I, Van Steen K, Vermeire S, Rutgeerts P. Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease: results from a single-centre cohort. Gut 2009; 58: 492-500 [PMID: 18832518 DOI: 10.1136/ gut.2008.155812]
24. Lazarev M, Ullman T, Schraut WH, Kip KE, Saul M, Regueiro M. Small bowel resection rates in Crohn's disease and the indication for surgery over time: experience from a large tertiary care center. Inflamm Bowel Dis 2010; 16: 830-835 [PMID: 19798731 DOI: 10.1002/ibd.21118]
25. Domènech E, Zabana Y, Garcia-Planella E, López San Román A, Nos P, Ginard D, Gordillo J, Martínez-Silva F, Beltrán B, Mañosa M, Cabré E, Gassull MA. Clinical outcome of newly diagnosed Crohn's disease: a comparative, retrospective study before and after infliximab availability. Aliment Pharmacol Ther 2010; 31: 233-239 [PMID: 19832727 DOI: 10.1111/j.1365-2036.2009.04170.x]