Successful subcutaneous glucagon use for persistent hypoglycaemia in congenital hyperinsulinism

Journal of Pediatric Endocrinology and Metabolism

Volumn 26, Issue 11-12, 2013, Pages 1157-1161

  Neylon, Orla M ^a   Moran, Margaret M ^a   Pellicano, Anastasia ^a   Nightingale, Michael ^a   O'Connell, Michele A ^a  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Glucagon; Hyperinsulinism; Hypoglycaemia; Subcutaneous

Indexed keywords

ABC TRANSPORTER; ABCC8 PROTEIN; DIAZOXIDE; GLUCAGEN HYPOKIT; GLUCAGON; GLUCOSE; INSULIN; NIFEDIPINE; OCTREOTIDE; RECOMBINANT GLUCAGON; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ANAPHYLAXIS; ARTICLE; CALORIC INTAKE; CASE REPORT; CESAREAN SECTION; CHILD DEVELOPMENT; CONTINUOUS INFUSION; DISOMY; DRUG TREATMENT FAILURE; ENDOSCOPIC SURGERY; GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INFANT; INFUSION PUMP; INHERITANCE; INSULIN BLOOD LEVEL; MACROSOMIA; MALE; NONSENSE MUTATION; PANCREAS RESECTION; PERCUTANEOUS ENDOSCOPIC GASTROSTOMY; PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA OF INFANCY; POSITRON EMISSION TOMOGRAPHY; STOMACH FUNDOPLICATION; STOMACH TUBE;

CONGENITAL HYPERINSULINISM; GLUCAGON; HUMANS; HYPOGLYCEMIA; INFANT, NEWBORN; MALE; PANCREAS; PANCREATECTOMY;

EID: 84888083755     PISSN: 0334018X     EISSN: 21910251     Source Type: Journal    
DOI: 10.1515/jpem-2013-0115     Document Type: Article

References (29)

1. Steinkrauss L, Lipman TH, Hendell CD, Gerdes M, Thornton PS, et al. Effects of hypoglycemia on developmental outcome in children with congenital hyperinsulinism. J Pediatr Nurs 2005;20:109-18.
2. Hussain K, Blankenstein O, De Lonlay P, Christesen HT. Hyperinsulinaemic hypoglycaemia: biochemical basis and the importance of maintaining normoglycaemia during management. Arch Dis Child 2007;92:568-70.
3. Menni F, de Lonlay P, Sevin C, Touati G, Peigne C, et al. Neurologic outcomes of 90 neonates and infants with persistent hyperinsulinemic hypoglycemia. Pediatrics 2001;107:476-9.
4. Hussain K, Bryan J, Christesen HT, Brusgaard K, Aguilar- Bryan L. Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinism. Diabetes 2005;54:2946-51.
5. Christesen HT, Brusgaard K, Hussain K. Recurrent spontaneous hypoglycaemia causes loss of neurogenic and neuroglycopaenic signs in infants with congenital hyperinsulinism. Clin Endocrinol (Oxf) 2012;76:548-54.
6. Damaj L, le Lorch M, Verkarre V, Werl C, Hubert L, et al. Chromosome 11p15 paternal isodisomy in focal forms of neonatal hyperinsulinism. J Clin Endocrinol Metab 2008;93:4941-7.
7. Dunne MJ, Cosgrove KE, Shepherd RM, Aynsley-Green A, Lindley KJ. Hyperinsulinism in infancy: from basic science to clinical disease. Physiol Rev 2004;84:239-75.
8. Hussain K, Flanagan SE, Smith VV, Ashworth M, Day M, et al. An ABCC8 gene mutation and mosaic uniparental isodisomy resulting in atypical diffuse congenital hyperinsulinism. Diabetes 2008;57:259-63.
9. Sempoux C, Capito C, Bellanne-Chantelot C, Verkarre V, de Lonlay P, et al. Morphological mosaicism of the pancreatic islets: a novel anatomopathological form of persistent hyperinsulinemic hypoglycemia of infancy. J Clin Endocrinol Metab 2011;96:3785-93.
10. Suchi M, MacMullen C, Thornton PS, Ganguly A, Stanley CA, et al. Histopathology of congenital hyperinsulinism: retrospective study with genotype correlations. Pediatr Dev Pathol 2003;6:322-33.
11. Flanagan SE, Kapoor RR, Hussain K. Genetics of congenital hyperinsulinemic hypoglycemia. Semin Pediatr Surg 2011;20:13-7.
12. Kapoor RR, Flanagan SE, James C, Shield J, Ellard S, et al. Hyperinsulinaemic hypoglycaemia. Arch Dis Child 2009;94:450-7.
13. Bellanne-Chantelot C, Saint-Martin C, Ribeiro MJ, Vaury C, Verkarre V, et al. ABCC8 and KCNJ11 molecular spectrum of 109 patients with diazoxide-unresponsive congenital hyperinsulinism. J Med Genet 2010;47:752-9.
14. Sattiraju S, Reyes S, Kane GC, Terzic A. K(ATP) channel pharmacogenomics: from bench to bedside. Clin Pharmacol Ther 2008;83:354-7.
15. Arnoux J-B, Verkarre V, Saint-Martin C, Montravers F, Brassier A, et al. Congenital hyperinsulinism: current trends in diagnosis and therapy. Orphanet J Rare Dis 2011;6:63.
16. Shilyansky J, Fisher S, Cutz E, Perlman K, Filler RM. Is 95% pancreatectomy the procedure of choice for treatment of persistent hyperinsulinemic hypoglycemia of the neonate? J Pediatr Surg 1997:32:342-6.
17. Calton E, Temple K, Mackay D, Lever M, Ellard S, et al. Hepatoblastoma in a child with a paternally-inherited ABCC8 mutation and mosaic paternal uniparental disomy 11p causing focal congenital hyperinsulinism. Eur J Med Gen 2013;56: 114-7.
18. Mohnike K, Blankenstein O, Pfuetzner A, Potzsch S, Schober E, et al. Long-term non-surgical therapy of severe persistent congenital hyperinsulinism with glucagon. Horm Res 2008;70:59-64.
19. Castle JR, Engle JM, El Youssef J, Massoud RG, Yuen KC, et al. Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetes. Diabetes Care 2010;33:1282-7.
20. Wald M, Lawrenz K, Luckner D, Seimann R, Mohnike K, et al. Glucagon therapy as a possible cause of erythema necrolyticum migrans in two neonates with persistent hyperinsulinaemic hypoglycaemia. Eur J Pediatr 2002;161:600-3.
21. Hussain K. Diagnosis and management of hyperinsulinaemic hypoglycaemia of infancy. Horm Res 2008;69:2-13.
22. Abdel Khalek M, Kandil E. Is octreotide safe for the management of persistent hyperinsulinemic hypoglycemia of infancy? Eur J Pediatr Surg 2011;21:188-9.
23. Laje P, Halaby L, Adzick NS, Stanley CA. Necrotizing enterocolitis in neonates receiving octreotide for the management of congenital hyperinsulinism. Pediatric Diabetes 2010; 11:142-7.
24. Ben-Ari J, Greenberg M, Nemet D, Edelstein E, Eliakim A. Octreotide-induced hepatitis in a child with persistent hyperinsulinemic hypoglycemia of infancy. J Pediatr Endocrinol Metab 2013;26:179-82.
25. Koren I, Riskin A, Barthlen W, Gillis D. Hepatitis in an infant treated with octreotide for congenital hyperinsulinism. J Pediatr Endocrinol Metab 2013;26:183-5.
26. Le Quan Sang K-H, Arnoux J-B, Mamoune A, Saint-Martin C, Bellanne-Chantelot C, et al. Successful treatment of congenital hyperinsulinism with long-acting release octreotide. Eur J Endocrinol 2012;166:333-9.
27. Modan-Moses D, Koren I, Mazor-Aronovitch K, Pinhas-Hamiel O, Landau H. Treatment of congenital hyperinsulinism with lanreotide acetate (Somatuline Autogel). J Clin Endocrinol Metab 2011;96:2312-7.
28. Ismail D, Hussain K. Role of 18F-DOPA PET/CT imaging in congenital hyperinsulinism. Rev Endocr Metab Disord 2010;11:165-9.
29. Zani A, Nah SA, Ron O, Totonelli G, Ismail D, et al. The predictive value of preoperative fluorine-18-L-3,4-dihydroxyphenylalanine positron emission tomography-computed tomography scans in children with congenital hyperinsulinism of infancy. J Pediatr Surg 2011;46:204-8.