Role of 18F-DOPA PET/CT imaging in congenital hyperinsulinism

Reviews in Endocrine and Metabolic Disorders

Volumn 11, Issue 3, 2010, Pages 165-169

  Ismail, Dunia ^a   Hussain, Khalid ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Dopamine; Glucose; Hypoglycaemia; PET scan

Indexed keywords

6 FLUORODOPA F 18; AROMATIC LEVO AMINO ACID DECARBOXYLASE; DIAZOXIDE; DOPAMINE; LEVODOPA; OCTREOTIDE; TYROSINE;

ARTICLE; CHROMOSOME 11; COMPUTER ASSISTED TOMOGRAPHY; ENDOCRINE FUNCTION; GENE DUPLICATION; GENE FREQUENCY; GENE MUTATION; GENETIC SCREENING; GENOME IMPRINTING; HISTOPATHOLOGY; HUMAN; INSULIN HYPOGLYCEMIA; NEUROSECRETORY CELL; NONHUMAN; PANCREAS FUNCTION; PANCREAS ISLET; PANCREAS RESECTION; PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA OF INFANCY; POSITRON EMISSION TOMOGRAPHY; PREOPERATIVE EVALUATION; SOMATIC MUTATION;

DIHYDROXYPHENYLALANINE; HUMANS; INFANT, NEWBORN; MODELS, BIOLOGICAL; PERSISTENT HYPERINSULINEMIA HYPOGLYCEMIA OF INFANCY; POSITRON-EMISSION TOMOGRAPHY; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 78650559725     PISSN: 13899155     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11154-010-9145-1     Document Type: Article

References (44)

1. A Aynsley-Green K Hussain J Hall JM Saudubray C Nihoul- Fékété P De Lonlay-Debeney, et al. 2000 The Practical Management of Hyperinsulinism in Infancy Arch Dis Child Fetal Neonatal Ed 82 F98 F107 1:STN:280:DC%2BD3c7ltVegtw%3D%3D 10.1136/fn.82.2.F98 10685981
2. RR Kapoor SE Flanagan C James J Shield S Ellard K Hussain 2009 Hyperinsulinaemic hypoglycaemia Arch Dis Child 94 6 450 457 1:STN:280: DC%2BD1MzlvFyjsw%3D%3D 10.1136/adc.2008.148171 19193661
3. K Hussain A Aynsley-Green CA Stanley 2004 Medications used in the treatment of hypoglycemia due to congenital hyperinsulinism of infancy (HI) Pediatr Endocrinol Rev 2 Suppl 1 163 167 16456495
4. K Mohnike O Blankenstein HT Christesen J De Lonlay K Hussain KP Koopmans, et al. 2006 Proposal for a standardized protocol for 18F-DOPA-PET (PET/CT) in congenital hyperinsulinism Horm Res 66 1 40 42 1:CAS:528:DC%2BD28XmtVaktbc%3D 10.1159/000093471 16710094 (Pubitemid 43952587)
5. J Rahier Y Guiot C Sempoux 2002 Persistent hyperinsulinaemic hypoglycaemia of infancy: a heterogeneous syndrome unrelated to nesidioblastosis Arch Dis Child Fetal Neonatal Ed 82 2 F108 F112 10.1136/fn.82.2.F108
6. P Thomas Y Ye E Lightner 1996 Mutation of the pancreatic islet inward rectifier Kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy Hum Mol Genet 5 11 1809 1812 1:CAS:528:DyaK28XmslKls78%3D 10.1093/hmg/5.11.1809 8923010 (Pubitemid 26372418)
7. PM Thomas GJ Cote N Wohllk B Haddad PM Mathew W Rabl, et al. 1995 Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy Science 268 5209 426 429 1:CAS:528:DyaK2MXltFKktb0%3D 10.1126/science.7716548 7716548
8. A Nestorowicz N Inagaki T Gonoi KP Schoor BA Wilson B Glaser, et al. 1997 A nonsense mutation in the inward rectifier potassium channel gene, Kir6.2, is associated with familial hyperinsulinism Diabetes 46 11 1743 1748 1:CAS:528:DyaK2sXntVKis70%3D 10.2337/diabetes.46.11.1743 9356020
9. H Huopio F Reimann R Ashfield J Komulainen HL Lenko J Rahier, et al. 2000 Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1 J Clin Invest 106 7 897 906 1:CAS:528:DC%2BD3cXntVyhsrw%3D 10.1172/JCI9804 11018078
10. SE Pinney C MacMullen S Becker Y Lin C Hanna P Thornton, et al. 2008 Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations J Clin Invest 118 8 2877 2886 1:CAS:528:DC%2BD1cXpsVOktbc%3D 10.1172/JCI35414 18596924
11. Flanagan SE, Kapoor RR, Banerjee I, Hall C, Smith VV, Hussain K, et al. Dominantly acting ABCC8 mutations in patients with medically unresponsive hyperinsulinaemic hypoglycaemia. Clin Genet. 2010 May 22.
12. CN Fékété P de Lonlay F Jaubert J Rahier F Brunelle JM Saudubray 2004 The surgical management of congenital hyperinsulinemic hypoglycemia in infancy J Pediatr Surg 39 3 267 269 10.1016/j.jpedsurg.2003.11. 004 15017535 (Pubitemid 38338332)
13. G Leibowitz B Glaser AA Higazi M Salameh E Cerasi H Landau 1995 Hyperinsulinemic hypoglycemia of infancy (nesidioblastosis) in clinical remission: high incidence of diabetes mellitus and persistent beta-cell dysfunction at long-term follow-up J Clin Endocrinol Metab 80 2 386 392 1:CAS:528:DyaK2MXjs1KltL0%3D 10.1210/jc.80.2.386 7852494
14. C Sempoux Y Guiot F Jaubert J Rahier 2004 Focal and diffuse forms of congenital hyperinsulinism: the keys for differential diagnosis Endocr Pathol 15 3 241 246 10.1385/EP:15:3:241 15640550 (Pubitemid 40169417)
15. V Verkarre JC Fournet P de Lonlay MS Gross-Morand M Devillers J Rahier, et al. 1998 Paternal mutation of the sulfonylurea receptor (SUR1) gene and maternal loss of 11p15 imprinted genes lead to persistent hyperinsulinism in focal adenomatous hyperplasia J Clin Invest 102 7 1286 1291 1:CAS:528: DyaK1cXmsFOku7c%3D 10.1172/JCI4495 9769320
16. JC Fournet C Mayaud P de Lonlay MS Gross-Morand V Verkarre M Castanet, et al. 2001 Unbalanced expression of 11p15 imprinted genes in focal forms of congenital hyperinsulinism: association with a reduction to homozygosity of a mutation in ABCC8 or KCNJ11 Am J Pathol 158 6 2177 2184 1:CAS:528: DC%2BD3MXkvFyktr4%3D 11395395
17. P de Lonlay JC Fournet J Rahier MS Gross-Morand F Poggi-Travert V Foussier, et al. 1997 Somatic deletion of the imprinted 11p15 region in sporadic persistent hyperinsulinemic hypoglycemia of infancy is specific of focal adenomatous hyperplasia and endorses partial pancreatectomy J Clin Invest 100 4 802 807 10.1172/JCI119594 9259578
18. L Damaj M le Lorch V Verkarre C Werl L Hubert C Nihoul- Fékété, et al. 2008 Chromosome 11p15 paternal isodisomy in focal forms of neonatal hyperinsulinism J Clin Endocrinol Metab 93 12 4941 4947 1:CAS:528:DC%2BD1cXhsVyqtbnJ 10.1210/jc.2008-0673 18796520
19. CA Stanley PS Thornton A Ganguly C MacMullen P Underwood P Bhatia, et al. 2004 Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulation J Clin Endocrinol Metab 89 1 288 296 1:CAS:528:DC%2BD2cXmvFCisw%3D%3D 10.1210/jc.2003-030965 14715863 (Pubitemid 38183895)
20. RJ Ferry Jr A Kelly A Grimberg S Koo-McCoy MJ Shapiro KE Fellows, et al. 2000 Calcium-stimulated insulin secretion in diffuse and focal forms of congenital hyperinsulinism J Pediatr 137 2 239 246 1:CAS:528: DC%2BD3cXmslaqsrg%3D 10.1067/mpd.2000.107386 10931418 (Pubitemid 30659233)
21. I Giurgea K Laborde G Touati C Bellanné-Chantelot MC Nassogne C Sempoux, et al. 2004 Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism J Clin Endocrinol Metab 89 2 925 929 1:CAS:528:DC%2BD2cXhsFOjtLg%3D 10.1210/jc.2003-030941 14764815 (Pubitemid 38269912)
22. P de Lonlay-Debeney F Poggi-Travert JC Fournet C Sempoux CD Vici F Brunelle, et al. 1999 Clinical features of 52 neonates with hyperinsulinism N Engl J Med 340 15 1169 1175 10.1056/NEJM199904153401505 10202168 (Pubitemid 29177876)
23. T Otonkoski K Näntö-Salonen M Seppänen R Veijola H Huopio K Hussain, et al. 2006 Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography Diabetes 55 1 13 18 1:CAS:528:DC%2BD28XlvVSmsw%3D%3D 10.2337/diabetes.55.01.06.db05-1128 16380471 (Pubitemid 43343294)
24. MJ Ribeiro P De Lonlay T Delzescaux N Boddaert F Jaubert S Bourgeois, et al. 2005 Characterization of hyperinsulinism in infancy assessed with PET and 18F-fluoro-L-DOPA J Nucl Med 46 4 560 566 15809476
25. PL Jager R Chirakal CJ Marriott AH Brouwers KP Koopmans KY Gulenchyn 2008 6-L-18F-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications J Nucl Med 49 4 573 586 1:CAS:528:DC%2BD1cXltl2gtLg%3D 10.2967/jnumed.107.045708 18344441 (Pubitemid 351520605)
26. P de Lonlay A Simon-Carre MJ Ribeiro N Boddaert I Giurgea K Laborde, et al. 2006 Congenital hyperinsulinism: pancreatic [18F]fluoro-L- dihydroxyphenylalanine (DOPA) positron emission tomography and immunohistochemistry study of DOPA decarboxylase and insulin secretion J Clin Endocrinol Metab 91 3 933 940 10.1210/jc.2005-1713 16403819 (Pubitemid 43357761)
27. KP Koopmans ON Neels IP Kema PH Elsinga TP Links EG de Vries, et al. 2009 Molecular imaging in neuroendocrine tumors: molecular uptake mechanisms and clinical results Crit Rev Oncol Hematol 71 3 199 213 10.1016/j.critrevonc.2009. 02.009 19362010
28. MJ Rodríguez J Saura CC Finch N Mahy EE Billett 2000 Localization of monoamine oxidase A and B in human pancreas, thyroid, and adrenal glands J Histochem Cytochem 48 1 147 151 10653595
29. H Orlefors A Sundin KJ Fasth K Oberg B Långström B Eriksson 2003 Bergström M Demonstration of high monoaminoxidase-A levels in neuroendocrine gastroenteropancreatic tumors in vitro and in vivo-tumor visualization using positron emission tomography with 11C-harmine Nucl Med Biol 30 6 669 679 1:CAS:528:DC%2BD3sXlvFyntr0%3D 10.1016/S0969-8051(03)00034-9 12900293 (Pubitemid 37289329)
30. LE Ericson R Håkanson I Lundquist 1977 Accumulation of dopamine in mouse pancreatic B-cells following injection of L-DOPA. Localization to secretory granules and inhibition of insulin secretion Diabetologia 13 2 117 124 1:CAS:528:DyaE2sXksVyhu78%3D 10.1007/BF00745138 404204
31. B Ahrén I Lundquist 1985 Effects of L-dopa-induced dopamine accumulation on 45Ca2+ efflux and insulin secretion in isolated rat islets Pharmacology 30 2 71 82 10.1159/000138053 3883370
32. W Barthlen O Blankenstein H Mau M Koch C Höhne W Mohnike, et al. 2008 Evaluation of [18F]fluoro-L-DOPA positron emission tomography-computed tomography for surgery in focal congenital hyperinsulinism J Clin Endocrinol Metab. 93 3 869 875 1:CAS:528:DC%2BD1cXjsFynurY%3D 10.1210/jc.2007-2036 18073294 Epub 2007 Dec 11 (Pubitemid 351398565)
33. V Cherubini LS Bagalini A Ianilli M Marigliano M Biagioni V Carnielli, et al. 2010 Rapid genetic analysis, imaging with 18F-DOPA-PET/CT scan and laparoscopic surgery in congenital hyperinsulinism J Pediatr Endocrinol Metab 23 1-2 171 177 20432820
34. RM Subramaniam D Karantanis PJ Peller 2007 [18F]Fluoro-L-dopa PET/CT in congenital hyperinsulinism J Comput Assist Tomogr 31 5 770 772 10.1097/RCT.0b013e318031f55c 17895790 (Pubitemid 47482499)
35. MJ Ribeiro N Boddaert C Bellanné-Chantelot S Bourgeois V Valayannopoulos T Delzescaux, et al. 2007 The added value of [18F]fluoro-L-DOPA PET in the diagnosis of hyperinsulinism of infancy: a retrospective study involving 49 children Eur J Nucl Med Mol Imaging. 34 12 2120 2128 1:CAS:528:DC%2BD2sXhtlyiurzI 10.1007/s00259-007-0498-y 17661030 Epub 2007 Jul 28 (Pubitemid 350212120)
36. K Mohnike O Blankenstein H Minn W Mohnike F Fuchtner T Otonkoski 2008 [18F]-DOPA positron emission tomography for preoperative localization in congenital hyperinsulinism Horm Res 70 2 65 72 1:CAS:528:DC%2BD1cXps12hurw%3D 10.1159/000137655 18547951
37. C Capito N Khen-Dunlop MJ Ribeiro F Brunelle Y Aigrain C Crétolle, et al. 2009 Value of 18F-fluoro-L-dopa PET in the preoperative localization of focal lesions in congenital hyperinsulinism Radiology 253 1 216 222 10.1148/radiol.2532081445 19709999
38. J Arbizu Lostao A Fernández-Marmiesse P Garrastachu Zumarrán E Martino Casado C Azcona San Julián A Carracedo, et al. 2008 18F-fluoro-L-DOPA PET-CT imaging combined with genetic analysis for optimal classification and treatment in a child with severe congenital hyperinsulinism An Pediatr (Barc) 68 5 481 485 1:STN:280:DC%2BD1c3os1ajtA%3D%3D 10.1157/13120046 (Pubitemid 351716836)
39. OT Hardy M Hernandez-Pampaloni JR Saffer M Suchi E Ruchelli H Zhuang, et al. 2007 Diagnosis and localization of focal congenital hyperinsulinism by (18)F-Fluorodopa PET scan J Pediatr 150 2 140 145 1:CAS:528: DC%2BD2sXntlyquw%3D%3D 10.1016/j.jpeds.2006.08.028 17236890 (Pubitemid 46127552)
40. OT Hardy M Hernandez-Pampaloni JR Saffer JS Scheuermann LM Ernst R Freifelder, et al. 2007 Accuracy of [18F] fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism J Clin Endocrinol Metab 92 12 4706 4711 1:CAS:528:DC%2BD1cXmslWhu7o%3D 10.1210/jc.2007-1637 17895314 Epub 2007 Sep 25 (Pubitemid 350223447)
41. 18Fluoro-L-DOPA-PET-CT Scans in Children with Congenital Hyperinsulinism of Infancy. J Pediatr Surg (2010) (in press).
42. K Hussain M Seppänen K Näntö-Salonen NS Adzick CA Stanley P Thornton, et al. 2006 The diagnosis of ectopic focal hyperinsulinism of infancy with [18F]-dopa positron emission tomography J Clin Endocrinol Metab 91 8 2839 2842 1:CAS:528:DC%2BD28XosFGhsrw%3D 10.1210/jc.2006-0455 16684819 (Pubitemid 44271721)
43. WH Peranteau SM Bathaii B Pawel O Hardy A Alavi CA Stanley, et al. 2007 Multiple ectopic lesions of focal islet adenomatosis identified by positron emission tomography scan in an infant with congenital hyperinsulinism J Pediatr Surg 42 1 188 192 10.1016/j.jpedsurg.2006.09.046 17208563 (Pubitemid 46037734)
44. RR Kapoor C James K Hussain 2009 Advances in the diagnosis and management of hyperinsulinemic hypoglycemia Nat Clin Pract Endocrinol Metab 5 2 101 112 1:CAS:528:DC%2BD1MXpsVeisg%3D%3D 10.1038/ncpendmet1046 19165222