The potential of stem cell therapy for osteoarthritis and rheumatoid arthritis

Current Stem Cell Research and Therapy

Volumn 8, Issue 6, 2013, Pages 444-450

  Keerthi, Naveen ^a   Chimutengwende Gordon, Mukai ^a   Sanghani, Anita ^a   Khan, Wasim ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cartilage; Inflammation; Osteoarthritis; Rheumatoid arthritis; Stem cells; Synovium

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; HYDROXYCHLOROQUINE; INFLIXIMAB; LEFLUNOMIDE; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; RITUXIMAB; SALAZOSULFAPYRIDINE;

ARTHROPLASTY; ARTICLE; CLINICAL STUDY; CORTICOSTEROID THERAPY; DISEASE MODEL; DRUG MEGADOSE; FUNCTIONAL STATUS; HEALTH CARE COST; HEALTH CARE UTILIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HIP OSTEOARTHRITIS; HUMAN; IMMUNOMODULATION; IMMUNOPATHOGENESIS; KNEE OSTEOARTHRITIS; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PRODUCTIVITY; QUALITY OF LIFE; RHEUMATOID ARTHRITIS; UNSPECIFIED SIDE EFFECT;

ANIMALS; ARTHRITIS, RHEUMATOID; GUIDED TISSUE REGENERATION; HUMANS; MESENCHYMAL STROMAL CELLS; MODELS, ANIMAL; OSTEOARTHRITIS; STEM CELL TRANSPLANTATION;

EID: 84888081959     PISSN: 1574888X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1574888X1130800062     Document Type: Article

References (94)

1. Osteoarthritis. National clinical guideline for care and management in adults. The National Collaborating Centre for Chronic Conditions http://www.nice.org.uk/nicemedia/pdf/CG059FullGuideline.pdf.
2. Litwic A, Edwards MH, Dennison EM, Cooper C. Epidemiology and burden of osteoarthritis. Br Med Bull 2013; 105: 185-99.
3. Hunter DJ, Felson DT. Osteoarthritis. Bmj 2006; 332: 639-42.
4. NICE. The care and management of osteoarthritis in adults. In: NICE, editor. 2008. 2008.
5. Dixon T, Shaw M, Ebrahim S, Dieppe P. Trends in hip and knee joint replacement: socioeconomic inequalities and projections of need. Ann Rheum Dis 2004; 63: 825-30.
6. Osteoarthritis Resource Bundle http://bundlr.com/b/osteoarthritisresource-bundle.
7. Gupta PK, Das AK, Chullikana A, Majumdar AS. Mesenchymal stem cells for cartilage repair in osteoarthritis. Stem Cell Res Ther 2012; 3: 25.
8. Krasnokutsky S, Attur M, Palmer G, Samuels J, Abramson SB. Current concepts in the pathogenesis of osteoarthritis. Osteoarthritis Cartilage 2008; 16 Suppl 3: S1-3.
9. Goldring MB, Goldring SR. Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann N Y Acad Sci 2010; 1192: 230-7.
10. Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 2008; 16: 137-62.
11. Rissanen P, Aro S, Sintonen H, et al. Costs and cost-effectiveness in hip and knee replacements. A prospective study. Int J Technol Assess Health Care 1997; 13: 575-88.
12. Gomoll AH, Filardo G, Almqvist FK, et al. Surgical treatment for early osteoarthritis. Part II: allografts and concurrent procedures. Knee Surg Sports Traumatol Arthrosc 2012; 20: 468-86.
13. NICE. Cartilage injury - autologous chondrocyte implantation (ACI) (review). http://www.nice.org.uk/.
14. Johnson LL. Arthroscopic abrasion arthroplasty: a review. Clin Orthop Relat Res 2001: S306-17.
15. Haque R, Lei F, Xong X, Song J. Stem cell-based cellular therapy in rheumatoid arthritis. In: Chan J, editor. Autoimmune Diseases - Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies: Medical Textbooks Open Access Medical Books; 2012. p. 319-42.
16. van Lent PL, van den Berg WB. Mesenchymal stem cell therapy in osteoarthritis: advanced tissue repair or intervention with smouldering synovial activation? Arthritis Res Ther 2013; 15: 112.
17. Cojocaru M, Cojocaru IM, Silosi I, Vrabie CD, Tanasescu R. Extra-articular Manifestations in Rheumatoid Arthritis. Maedica (Buchar) 2010; 5: 286-91.
18. NICE. CG79 Rheumatoid arthritis: NICE guideline. http://publications.nice.org.uk/rheumatoid-arthritis-cg79.
19. Akil M, Amos RS. ABC of rheumatology. Rheumatoid arthritis--I: Clinical features and diagnosis. Bmj 1995; 310: 587-90.
20. Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med 1977; 146: 857-68.
21. Burkhardt H, Sehnert B, Bockermann R, et al. Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis. Eur J Immunol 2005; 35: 1643-52.
22. Ichim TE, Zheng X, Suzuki M, et al. Antigen-specific therapy of rheumatoid arthritis. Expert Opin Biol Ther 2008; 8: 191-9.
23. Jurgens MS, Jacobs JW, Bijlsma JW. The use of conventional disease-modifying anti-rheumatic drugs in established RA. Best Pract Res Clin Rheumatol 2011; 25: 523-33.
24. Kolf CM, Cho E, Tuan RS. Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res Ther 2007; 9: 204.
25. Peng L, Jia Z, Yin X, et al. Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue. Stem Cells Dev 2008; 17: 761-73.
26. Bouffi C, Djouad F, Mathieu M, Noel D, Jorgensen C. Multipotent mesenchymal stromal cells and rheumatoid arthritis: risk or benefit? Rheumatology (Oxford) 2009; 48: 1185-9.
27. Mafi R, Hindocha S, Mafi P, Griffin M, Khan WS. Sources of adult mesenchymal stem cells applicable for musculoskeletal applications - a systematic review of the literature. Open Orthop J 2011; 5 Suppl 2: 242-248.
28. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997; 276: 71-4.
29. Barry F, Boynton RE, Liu B, Murphy JM. Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Exp Cell Res 2001; 268: 189-200.
30. Fibbe WE. Mesenchymal stem cells. A potential source for skeletal repair. Ann Rheum Dis 2002; 61 Suppl 2: ii29-ii31.
31. Mahapatra C, Pramanik K, Gupta MK. Factors Modulating Chondrogenesis and Mechano-Inductive Systems for Cartilage Tissue Engineering from Mesenchymal Stem Cells: A Review. Current Tissue Engineering 2013; 2: 41-50.
32. Bosetti M, Boccafoschi F, Leigheb M, Bianchi AE, Cannas M. Chondrogenic induction of human mesenchymal stem cells using combined growth factors for cartilage tissue engineering. J Tissue Eng Regen Med 2012; 6: 205-13.
33. Indrawattana N, Chen G, Tadokoro M, et al. Growth factor combination for chondrogenic induction from human mesenchymal stem cell. Biochem Biophys Res Commun 2004; 320: 914-9.
34. Djouad F, Bouffi C, Ghannam S, Noel D, Jorgensen C. Mesenchymal stem cells: innovative therapeutic tools for rheumatic diseases. Nat Rev Rheumatol 2009; 5: 392-9.
35. van Buul GM, Villafuertes E, Bos PK, et al. Mesenchymal stem cells secrete factors that inhibit inflammatory processes in shortterm osteoarthritic synovium and cartilage explant culture. Osteoarthritis Cartilage. 2012; 20: 1186-96.
36. Chen FH, Rousche KT, Tuan RS. Technology Insight: adult stem cells in cartilage regeneration and tissue engineering. Nat Clin Pract Rheumatol 2006; 2: 373-82.
37. Murphy JM, Dixon K, Beck S, et al. Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis. Arthritis Rheum 2002; 46: 704-13.
38. Murphy JM, Fink DJ, Hunziker EB, Barry FP. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 2003; 48: 3464-74.
39. Grigolo B, Lisignoli G, Desando G, et al. Osteoarthritis treated with mesenchymal stem cells on hyaluronan-based scaffold in rabbit. Tissue Eng Part C Methods 2009; 15: 647-58.
40. Mokbel AN, El Tookhy OS, Shamaa AA, et al. Homing and reparative effect of intra-articular injection of autologus mesenchymal stem cells in osteoarthritic animal model. BMC Musculoskelet Disord 2011; 12: 259.
41. Black LL, Gaynor J, Gahring D, et al. Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. Vet Ther 2007; 8: 272-84.
42. Black LL, Gaynor J, Adams C, et al. Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. Vet Ther 2008; 9: 192-200.
43. Manferdini C, Maumus M, Gabusi E, et al. Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2. Arthritis Rheum 2013; 65: 1271-81.
44. Maumus M, Manferdini C, Toupet K, et al. Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis. Stem Cell Res 2013; 11: 834-44.
45. Diekman BO, Wu CL, Louer CR, et al. Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents post-traumatic arthritis. Cell Transplant 2013; 22(8): 1395-408.
46. Orozco L, Munar A, Soler R, et al. Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study. Transplantation 2013; 95(12): 1535-41.
47. Emadedin M, Aghdami N, Taghiyar L, et al. Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. Arch Iran Med 2012; 15(7): 422-8.
48. Davatchi F, Abdollahi BS, Mohyeddin M, Shahram F, Nikbin B. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis 2011; 14: 211-5.
49. Haleem AM, Singergy AAE, Sabry D, et al. The Clinical Use of Human Culture-Expanded Autologous Bone Marrow Mesenchymal Stem Cells Transplanted on Platelet-Rich Fibrin Glue in the Treatment of Articular Cartilage Defects: A Pilot Study and Preliminary Results. Cartilage 2010; 1: 253-61.
50. Wakitani S, Nawata M, Tensho K, et al. Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees. J Tissue Eng Regen Med 2007; 1: 74-9.
51. Nejadnik H, Hui JH, Feng Choong EP, Tai BC, Lee EH. Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Am J Sports Med 2010; 38: 1110-6.
52. Liu Y, Mu R, Wang S, et al. Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis. Arthritis Res Ther 2010; 12: R210.
53. Djouad F, Charbonnier LM, Bouffi C, et al. Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6-dependent mechanism. Stem Cells 2007; 25: 2025-32.
54. Ren G, Zhang L, Zhao X, et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008; 2: 141-50.
55. Alexander AM, Crawford M, Bertera S, et al. Indoleamine 2,3- dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes 2002; 51: 356-65.
56. Selmani Z, Naji A, Zidi I, et al. Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells. Stem Cells 2008; 26: 212-22.
57. Liu CH, Hwang SM. Cytokine interactions in mesenchymal stem cells from cord blood. Cytokine 2005; 32: 270-9.
58. Shi M, Liu Z-W, Wang F-S. Immunomodulatory properties and therapeutic application of mesenchymal stem cells. Clin Exp Immunol. 2011; 164: 1-8.
59. Djouad F, Fritz V, Apparailly F, et al. Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor alpha in collagen-induced arthritis. Arthritis Rheum 2005; 52: 1595-603.
60. Augello A, Tasso R, Negrini SM, Cancedda R, Pennesi G. Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis. Arthritis Rheum 2007; 56: 1175-86.
61. Choi JJ, Yoo SA, Park SJ, et al. Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice. Clin Exp Immunol 2008; 153: 269-76.
62. Gonzalez-Rey E, Gonzalez MA, Varela N, et al. Human adiposederived mesenchymal stem cells reduce inflammatory and T cell responses and induce regulatory T cells in vitro in rheumatoid arthritis. Ann Rheum Dis 2010; 69: 241-8.
63. Chen B, Hu J, Liao L, et al. Flk-1+ mesenchymal stem cells aggravate collagen-induced arthritis by up-regulating interleukin-6. Clin Exp Immunol 2010; 159: 292-302.
64. Papadopoulou A, Yiangou M, Athanasiou E, et al. Mesenchymal stem cells are conditionally therapeutic in preclinical models of rheumatoid arthritis. Ann Rheum Dis 2012; 71: 1733-40.
65. Burt RK, Georganas C, Schroeder J, et al. Autologous hematopoietic stem cell transplantation in refractory rheumatoid arthritis: sustained response in two of four patients. Arthritis Rheum 1999; 42: 2281-5.
66. Burt RK, Oyama Y, Verda L, et al. Induction of remission of severe and refractory rheumatoid arthritis by allogeneic mixed chimerism. Arthritis Rheum 2004; 50: 2466-70.
67. Snowden JA, Passweg J, Moore JJ, et al. Autologous hemopoietic stem cell transplantation in severe rheumatoid arthritis: a report from the EBMT and ABMTR. J Rheumatol 2004; 31: 482-8.
68. Teng YK, Verburg RJ, Sont JK, et al. Long-term followup of health status in patients with severe rheumatoid arthritis after highdose chemotherapy followed by autologous hematopoietic stem cell transplantation. Arthritis Rheum. 2005; 52: 2272-6.
69. Moore J, Brooks P, Milliken S, et al. A pilot randomized trial comparing CD34-selected versus unmanipulated hemopoietic stem cell transplantation for severe, refractory rheumatoid arthritis. Arthritis Rheum 2002; 46: 2301-9.
70. Farge D, Labopin M, Tyndall A, et al. Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European Group for Blood and Marrow Transplantation Working Party on Autoimmune Diseases. Haematologica 2010; 95: 284-92.
71. Tyndall A, van Laar JM. Stem cells in the treatment of inflammatory arthritis. Best Pract Res Clin Rheumatol 2010; 24: 565-74.
72. Snowden JA, Saccardi R, Allez M, et al. Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 2012; 47: 770-90.
73. Singh JA. Stem cells and other innovative intra-articular therapies for osteoarthritis: what does the future hold? BMC Med 2012; 10: 44.
74. Erickson IE, Huang AH, Chung C, et al. Differential maturation and structure-function relationships in mesenchymal stem cell- and chondrocyte-seeded hydrogels. Tissue Eng Part A 2009; 15: 1041-52.
75. Meretoja VV, Dahlin RL, Wright S, Kasper FK, Mikos AG. The effect of hypoxia on the chondrogenic differentiation of co-cultured articular chondrocytes and mesenchymal stem cells in scaffolds. Biomaterials 2013; 34: 4266-73.
76. Khan WS, Johnson DS, Hardingham TE. The potential of stem cells in the treatment of knee cartilage defects. The Knee 2010; 17: 369-74.
77. Dragoo JL, Samimi B, Zhu M, et al. Tissue-engineeredcartilage and bone using stem cells from human infrapatellar fat pads. J Bone Joint Surg Br 2003; 85-B: 740-7.
78. Sakaguchi Y, Sekiya I, Yagishita K, Muneta T. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum 2005; 52: 2521-9.
79. Kang SK, Shin IS, Ko MS, Jo JY, Ra JC. Journey of mesenchymal stem cells for homing: strategies to enhance efficacy and safety of stem cell therapy. Stem Cells Int 2012; 2012: 342968.
80. Alves da Silva ML, Martins A, Costa-Pinto AR, et al. Chondrogenic differentiation of human bone marrow mesenchymal stem cells in chitosan-based scaffolds using a flow-perfusion bioreactor. J Tissue Eng Regen Med 2011; 5: 722-32.
81. Punwar S, Khan WS. Mesenchymal stem cells and articular cartilage repair: clinical studies and future direction. Open Orthop J 2011; 5: 296-301.
82. Khan WS, Adesida AB, Tew SR, Lowe ET, Hardingham TE. Bone marrow-derived mesenchymal stem cells express the pericyte marker 3G5 in culture and show enhanced chondrogenesis in hypoxic conditions. J Orthop Res 2010; 28: 834-40.
83. Bian L, Guvendiren M, Mauck RL, Burdick JA. Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis. Proc Natl Acad Sci USA 2013; 110: 10117-22.
84. Noth U, Rackwitz L, Heymer A, et al. Chondrogenic differentiation of human mesenchymal stem cells in collagen type I hydrogels. J Biomed Mater Res A 2007; 83: 626-35.
85. Spain TL, Agrawal CM, Athanasiou KA. New Technique to Extend the Useful Life of a Biodegradable Cartilage Implant. Tissue Eng 1998; 4: 343.
86. Connelly JT, Wilson CG, Levenston ME. Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs. Osteoarthritis Cartilage 2008; 16: 1092-100.
87. Nixon AJ, Fortier LA, Williams J, Mohammed H. Enhanced repair of extensive articular defects by insulin-like growth factor-i-laden fibrin composites. J Orthop Res 1999; 17: 475-87.
88. Cook SD, Patron LP, Salkeld SL, Rueger DC. Repair of articular cartilage defects with osteogenic protein-1 (BMP-7) in dogs. J Bone Joint Surg Am 2003; 85-A: 116-23.
89. Fukuda A, Kato K, Hasegawa M, et al. Enhanced repair of large osteochondral defects using a combination of artificial cartilage and basic fibroblast growth factor. Biomaterials 2005; 26: 4301-8.
90. Kuroda R, Usas A, Kubo S, et al. Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Arthritis Rheum 2006; 54: 433-42.
91. Mierisch CM, Cohen SB, Jordan LC, et al. Transforming growth factor-β in calcium alginate beads for the treatment of articular cartilage defects in the rabbit. Arthroscopy 2002; 18: 892-900.
92. Pastides P, Chimutengwende-Gordon M, Maffuli N, Khan W. Stem cell therapy for human cartilage defects: a systematic review. Osteoarthritis Cartilage 2013; 21: 646-54.
93. ClinicalTrials.gov: A service of the U.S. National Institutes of Health http://www.clinicaltrials.gov/ct2/results?term=osteoarthritis+and+mesenchymal+stem+cells.
94. ClinicalTrials.gov: A service of the U.S. National Institutes of Health http://www.clinicaltrials.gov/ct2/results?term=rheumatoid+arthritis+and+stem+cells.