Current and future use of "dried blood spot" analyses in clinical chemistry

Clinical Chemistry and Laboratory Medicine

Volumn 51, Issue 10, 2013, Pages 1897-1909

  Lehmann, Sylvain ^a,b,c,d   Delaby, Constance ^b,c,d,e   Vialaret, Jérôme ^b,c,d   Ducos, Jacques ^a,f   Hirtz, Christophe ^b,c,d  

^a MONTPELLIER UNIVERSITY HOSPITAL   (France)

^b HÔPITAL SAINT ELOI   (France)

^c UNIV MONTPELLIER   (France)

^d INSERM   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f UMR 1058 University of Montpellier   (France)

Author keywords

Dry blood spot; Enzyme linked immunosorbent assay (ELISA); Mass spectrometry; Polymerase chain reaction (PCR); Pre analytics

Indexed keywords

ADENINE PHOSPHORIBOSYLTRANSFERASE; ADENOSINE DEAMINASE; ALPHA 1 ANTITRYPSIN; ALPHA FETOPROTEIN; APOLIPOPROTEIN B; BIOTINIDASE; C REACTIVE PROTEIN; CALCITONIN GENE RELATED PEPTIDE; CD4 ANTIGEN; CERULOPLASMIN; CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN BETA SUBUNIT; DESICCANT; FOLLITROPIN; GLUCAN 1,4 ALPHA GLUCOSIDASE; HEMOGLOBIN; HEMOGLOBIN A1C; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IDURONATE 2 SULFATASE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INSULIN; LEVO IDURONIDASE; LUTEINIZING HORMONE; PROLACTIN; PROSTATE SPECIFIC ANTIGEN; SOMATOMEDIN; THYROGLOBULIN; TRANSFERRIN RECEPTOR;

ALPHA ANTITRYPSIN DEFICIENCY; AUTISM; BIOTINIDASE DEFICIENCY; BLOOD SAMPLING; BLOTTING; BRUCELLOSIS; CANCER SCREENING; CD4 LYMPHOCYTE COUNT; CHAGAS DISEASE; CHEMOLUMINESCENCE; CLINICAL CHEMISTRY; CONGENITAL TOXOPLASMOSIS; COPY NUMBER VARIATION; CYSTIC FIBROSIS; CYTOMEGALOVIRUS; DIABETES MELLITUS; DIGEORGE SYNDROME; DISORDERS OF PEROXISOMAL FUNCTIONS; DOWN SYNDROME; DRIED BLOOD SPOT TESTING; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPILEPSY; EPSTEIN BARR VIRUS; EXTRACTION; FRAGILE X SYNDROME; GALACTOSEMIA; GENOMICS; GLYCOGEN STORAGE DISEASE TYPE 2; HEPATITIS B; HEPATITIS C; HEPATITIS C VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN HERPESVIRUS 6; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T CELL LEUKEMIA VIRUS; HUMIDITY; HUNTER SYNDROME; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERINSULINEMIA; IRON DEFICIENCY; MALARIA; NEURAL TUBE DEFECT; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PSEUDOMONAS AERUGINOSA; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; ROOM TEMPERATURE; SEROEPIDEMIOLOGY; SPINAL MUSCULAR ATROPHY; SYPHILIS; TANDEM MASS SPECTROMETRY; THALASSEMIA; TRICHOMONAS VAGINALIS; TURBIDIMETRY; VEIN PUNCTURE; WILSON DISEASE;

ADULT; BLOOD SPECIMEN COLLECTION; CHROMATOGRAPHY, LIQUID; CLINICAL ENZYME TESTS; COMMUNICABLE DISEASES; DRIED BLOOD SPOT TESTING; GENETIC TESTING; HUMANS; INFANT, NEWBORN; MASS SPECTROMETRY; METABOLIC DISEASES; POLYMERASE CHAIN REACTION; PRESERVATION, BIOLOGICAL;

EID: 84888079649     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2013-0228     Document Type: Review

References (125)

1. Bang I. Ein verfahren zur mikrobestimmung von blutbestandteilen. Biochem Ztschr 1913;49: 19-39.
2. Guthrie R, Susi A. A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants. Pediatrics 1963;32: 338-43.
3. Mei JV, Alexander JR, Adam BW, Hannon WH. Use of filter paper for the collection and analysis of human whole blood specimens. J Nutr 2001;131:1631S-6S. (Pubitemid 32422996)
4. Parker SP, Cubitt WD. The use of the dried blood spot sample in epidemiological studies. J Clin Pathol 1999;52: 633-9. (Pubitemid 29456898)
5. Costa X, Jardi R, Rodriguez F, Miravitlles M, Cotrina M, Gonzalez C, et al. Simple method for alpha1-antitrypsin deficiency screening by use of dried blood spot specimens. Eur Respir J 2000;15: 1111-5. (Pubitemid 30399283)
6. Xu H, Zhao Y, Liu Z, Zhu W, Zhou Y, Zhao Z. Bisulfite genomic sequencing of DNA from dried blood spot microvolume samples. Forensic Sci Int Genet 2012;6: 306-9.
7. Tuaillon E, Mondain AM, Meroueh F, Ottomani L, Picot MC, Nagot N, et al. Dried blood spot for hepatitis C virus serology and molecular testing. Hepatology 2010;51: 752-8.
8. Uttayamakul S, Likanonsakul S, Sunthornkachit R, Kuntiranont K, Louisirirotchanakul S, Chaovavanich A, et al. Usage of dried blood spots for molecular diagnosis and monitoring HIV-1 infection. J Virol Methods 2005;128: 128-34. (Pubitemid 40980218)
9. Little RR, Wiedmeyer HM, England JD, Knowler WC, Goldstein DE. Measurement of glycosylated whole-blood protein for assessing glucose control in diabetes: collection and storage of capillary blood on filter paper. Clin Chem 1985;31: 213-6. (Pubitemid 16209716)
10. Caggana M, Conroy JM, Pass KA. Rapid, efficient method for multiplex amplification from filter paper. Hum Mutat 1998;11: 404-9. (Pubitemid 28196641)
11. Strenger V, Pfurtscheller K, Wendelin G, Aberle SW, Nacheva EP, Zohrer B, et al. Differentiating inherited human herpesvirus type 6 genome from primary human herpesvirus type 6 infection by means of dried blood spot from the newborn screening card. J Pediatr 2011;159: 859-61.
12. Lewensohn-Fuchs I, Osterwall P, Forsgren M, Malm G. Detection of herpes simplex virus DNA in dried blood spots making a retrospective diagnosis possible. J Clin Virol 2003;26: 39-48.
13. De Crignis E, Re MC, Cimatti L, Zecchi L, Gibellini D. HIV-1 and HCV detection in dried blood spots by SYBR green multiplex real-time RT-PCR. J Virol Methods 2010;165: 51-6.
14. Jardi R, Rodriguez-Frias F, Buti M, Schaper M, Valdes A, Martinez M, et al. Usefulness of dried blood samples for quantification and molecular characterization of HBV-DNA. Hepatology 2004;40: 133-9. (Pubitemid 38868932)
15. Gohring K, Dietz K, Hartleif S, Jahn G, Hamprecht K. Influence of different extraction methods and PCR techniques on the sensitivity of HCMV-DNA detection in dried blood spot (DBS) filter cards. J Clin Virol 2010;48: 278-81.
16. Scanga L, Chaing S, Powell C, Aylsworth AS, Harrell LJ, Henshaw NG, et al. Diagnosis of human congenital cytomegalovirus infection by amplification of viral DNA from dried blood spots on perinatal cards. J Mol Diagn 2006;8: 240-5. (Pubitemid 43811248)
17. Yourno J, Conroy J. A novel polymerase chain reaction method for detection of human immunodeficiency virus in dried blood spots on filter paper. J Clin Microbiol 1992;30: 2887-92.
18. Barin F, Plantier JC, Brand D, Brunet S, Moreau A, Liandier B, et al. Human immunodeficiency virus serotyping on dried serum spots as a screening tool for the surveillance of the aids epidemic. J Med Virol 2006;78(Suppl 1):S13-8. (Pubitemid 43993458)
19. Brindle E, Fujita M, Shofer J, O'Connor KA. Serum, plasma, and dried blood spot high-sensitivity C-reactive protein enzyme immunoassay for population research. J Immunol Methods 2010;362: 112-20.
20. Cowans NJ, Stamatopoulou A, Liitti P, Suonpaa M, Spencer K. The stability of free-beta human chorionic gonadotrophin and pregnancy-associated plasma protein-A in first trimester dried blood spots. Prenatal Diagn 2011;31: 293-8.
21. Worthman CM, Stallings JF. Measurement of gonadotropins in dried blood spots. Clin Chem 1994;40: 448-53. (Pubitemid 24097809)
22. Hoffman DL. Purification and large-scale preparation of antithrombin III. Am J Med 1989;87:23S-6S. (Pubitemid 19249547)
23. Mitchell ML, Hermos RJ, Moses AC. Radioimmunoassay of somatomedin-C in filter paper discs containing dried blood. Clin Chem 1987;33: 536-8. (Pubitemid 17157871)
24. Wang XL, Dudman NP, Blades BL, Wilcken DE. Changes in the immunoreactivity of APO A-I during storage. Clin Chim Acta 1989;179: 285-93.
25. Macri JN, Anderson RW, Krantz DA, Larsen JW, Buchanan PD. Prenatal maternal dried blood screening with alpha-fetoprotein and free beta-human chorionic gonadotropin for open neural tube defect and down syndrome. Am J Obstet Gynecol 1996;174: 566-72. (Pubitemid 26070144)
26. Yamaguchi A, Fukushi M, Arai O, Mizushima Y, Sato Y, Shimizu Y, et al. A simple method for quantification of biotinidase activity in dried blood spot and its application to screening of biotinidase deficiency. Tohoku J Exp Med 1987;152: 339-46.
27. Song EY, Vandunk C, Kuddo T, Nelson PG. Measurement of CGRP in dried blood spots using a modified sandwich enzyme immunoassay. J Neurosci Methods 2006;155: 92-7. (Pubitemid 43870122)
28. deWilde A, Sadilkova K, Sadilek M, Vasta V, Hahn SH. Tryptic peptide analysis of ceruloplasmin in dried blood spots using liquid chromatography- tandem mass spectrometry: application to newborn screening. Clin Chem 2008;54: 1961-8. (Pubitemid 352774028)
29. O'Broin SD, Gunter EW. Screening of folate status with use of dried blood spots on filter paper. Am J Clin Nutr 1999;70: 359-67. (Pubitemid 29407156)
30. Lakshmy R, Gupta R. Measurement of glycated hemoglobin A1c from dried blood by turbidimetric immunoassay. J Diabetes Sci Technol 2009;3: 1203-6.
31. Daniel YA, Turner C, Haynes RM, Hunt BJ, Dalton RN. Quantification of hemoglobin A2 by tandem mass spectrometry. Clin Chem 2007;53: 1448-54. (Pubitemid 47206340)
32. Jacomelli G, Micheli V, Peruzzi L, Notarantonio L, Cerboni B, Sestini S, et al. Simple non-radiochemical HPLC-linked method for screening for purine metabolism disorders using dried blood spot. Clin Chim Acta 2002;324: 135-9. (Pubitemid 35245504)
33. Wang D, Wood T, Sadilek M, Scott CR, Turecek F, Gelb MH. Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: application to newborn screening for mucopolysaccharidosis II (Hunter disease). Clin Chem 2007;53: 137-40. (Pubitemid 46047775)
34. Diamandi A, Khosravi MJ, Mistry J, Martinez V, Guevara-Aguirre J. Filter paper blood spot assay of human insulin-like growth factor I (IGF-I) and IGF-binding protein-3 and preliminary application in the evaluation of growth hormone status. J Clin Endocrinol Metab 1998;83: 2296-301. (Pubitemid 28503017)
35. Fisher RS, Chan DW, Bare M, Lesser RP. Capillary prolactin measurement for diagnosis of seizures. Ann Neurol 1991;29: 187-90.
36. McDade TW, Shell-Duncan B. Whole blood collected on filter paper provides a minimally invasive method for assessing human transferrin receptor level. J Nutr 2002;132: 3760-3. (Pubitemid 35435060)
37. Zimmermann MB, Moretti D, Chaouki N, Torresani T. Development of a dried whole-blood spot thyroglobulin assay and its evaluation as an indicator of thyroid status in goitrous children receiving iodized salt. Am J Clin Nutr 2003;77: 1453-8. (Pubitemid 39655279)
38. Mwaba P, Cassol S, Pilon R, Chintu C, Janes M, Nunn A, et al. Use of dried whole blood spots to measure CD4+ lymphocyte counts in HIV-1-infected patients. Lancet 2003;362: 1459-60. (Pubitemid 37352885)
39. Helfand RF, Keyserling HL, Williams I, Murray A, Mei J, Moscatiello C, et al. Comparative detection of measles and rubella IGM and IGG derived from filter paper blood and serum samples. J Med Virol 2001;65: 751-7. (Pubitemid 33135105)
40. Sorensen T, Spenter J, Jaliashvili I, Christiansen M, Norgaard-Pedersen B, Petersen E. Automated time-resolved immunofluorometric assay for toxoplasma gondii-specific IGM and IGA antibodies: study of more than 130,000 filter-paper blood-spot samples from newborns. Clin Chem 2002;48: 1981-6. (Pubitemid 35222757)
41. Dowlati B, Dunhardt PA, Smith MM, Shaheb S, Stuart CA. Quantification of insulin in dried blood spots. J Lab Clin Med 1998;131: 370-4. (Pubitemid 28209565)
42. Chamoles NA, Niizawa G, Blanco M, Gaggioli D, Casentini C. Glycogen storage disease type II: enzymatic screening in dried blood spots on filter paper. Clin Chim Acta 2004;347: 97-102. (Pubitemid 39099610)
43. Chamoles NA, Blanco MB, Gaggioli D, Casentini C. Hurler-like phenotype: enzymatic diagnosis in dried blood spots on filter paper. Clin Chem 2001;47: 2098-102. (Pubitemid 33108873)
44. Chamoles NA, Blanco M, Gaggioli D. Diagnosis of alpha-liduronidase deficiency in dried blood spots on filter paper: the possibility of newborn diagnosis. Clin Chem 2001;47: 780-1. (Pubitemid 32275835)
45. ten Brink HJ, van den Heuvel CM, Christensen E, Largilliere C, Jakobs C. Diagnosis of peroxisomal disorders by analysis of phytanic and pristanic acids in stored blood spots collected at neonatal screening. Clin Chem 1993;39: 1904-6. (Pubitemid 23277026)
46. Vladutiu GD, Glueck CJ, Schultz MT, McNeely S, Guthrie R. Beta-lipoprotein quantitation in cord blood spotted on filter paper: a screening test. Clin Chem 1980;26: 1285-90. (Pubitemid 10035229)
47. Laberge C, Grenier A, Valet JP, Morissette J. Fumarylacetoacetase measurement as a mass-screening procedure for hereditary tyrosinemia type I. Am J Hum Genet 1990;47: 325-8.
48. Skogstrand K, Ekelund CK, Thorsen P, Vogel I, Jacobsson B, Norgaard-Pedersen B, et al. Effects of blood sample handling procedures on measurable inflammatory markers in plasma, serum and dried blood spot samples. J Immunol Methods 2008;336: 78-84.
49. Tanner S, McDade TW. Enzyme immunoassay for total immunoglobulin E in dried blood spots. Am J Human Biol 2007;19: 440-2. (Pubitemid 46839455)
50. Fachiroh J, Prasetyanti PR, Paramita DK, Prasetyawati AT, Anggrahini DW, Haryana SM, et al. Dried-blood sampling for epstein-barr virus immunoglobulin g (IGG) and IGA serology in nasopharyngeal carcinoma screening. J Clin Microbiol 2008;46: 1374-80. (Pubitemid 351563582)
51. Chamoles NA, Blanco MB, Iorcansky S, Gaggioli D, Specola N, Casentini C. Retrospective diagnosis of GM1 gangliosidosis by use of a newborn-screening card. Clin Chem 2001;47: 2068-9.
52. Xu YY, Pettersson K, Blomberg K, Hemmila I, Mikola H, Lovgren T. Simultaneous quadruple-label fluorometric immunoassay of thyroid-stimulating hormone, 17 alpha-hydroxyprogesterone, immunoreactive trypsin, and creatine kinase MM isoenzyme in dried blood spots. Clin Chem 1992;38: 2038-43.
53. Dussault JH, Morissette J, Letarte J, Guyda H, Laberge C. Thyroxine-binding globulin capacity and concentration evaluated from blood spots on filter-paper in a screening program for neonatal hypothyroidism. Clin Chem 1980;26: 463-5. (Pubitemid 10134034)
54. Kirby LT, Applegarth DA, Davidson AG, Wong LT, Hardwick DF. Use of a dried blood spot in immunoreactive-trypsin assay for detection of cystic fibrosis in infants. Clin Chem 1981;27: 678-8.
55. de Almeida LM, Azevedo RS, Guimaraes AA, Coutinho Eda S, Struchiner CJ, Massad E. Detection of antibodies against hepatitis a virus in eluates of blood spotted on filter-paper: a pilot study in Rio De Janeiro, Brazil. Trans R Soc Trop Med Hyg 1999;93: 401-4. (Pubitemid 29405869)
56. Gil A, Gonzalez A, Dal-Re R, Dominguez V, Astasio P, Aguilar L. Detection of antibodies against hepatitis a in blood spots dried on filter paper. Is this a reliable method for epidemiological studies? Epidemiol Infect 1997;118: 189-91. (Pubitemid 27170811)
57. Villar LM, de Oliveira JC, Cruz HM, Yoshida CF, Lampe E, Lewis-Ximenez LL. Assessment of dried blood spot samples as a simple method for detection of hepatitis B virus markers. J Med Virol 2011;83: 1522-9.
58. Tappin DM, Greer K, Cameron S, Kennedy R, Brown AJ, Girdwood RW. Maternal antibody to hepatitis B core antigen detected in dried neonatal blood spot samples. Epidemiol Infect 1998;121: 387-90. (Pubitemid 28493158)
59. Judd A, Parry J, Hickman M, McDonald T, Jordan L, Lewis K, et al. Evaluation of a modified commercial assay in detecting antibody to hepatitis C virus in oral fluids and dried blood spots. J Med Virol 2003;71: 49-55. (Pubitemid 37121912)
60. Parker SP, Khan HI, Cubitt WD. Detection of antibodies to hepatitis C virus in dried blood spot samples from mothers and their offspring in Lahore, Pakistan. J Clin Microbiol 1999;37: 2061-3. (Pubitemid 29235280)
61. Corran PH, Cook J, Lynch C, Leendertse H, Manjurano A, Griffin J, et al. Dried blood spots as a source of anti-malarial antibodies for epidemiological studies. Malar J 2008;7: 195-207.
62. Thanasekaraan V, Wiseman MS, Rayner RJ, Hiller EJ, Shale DJ. Pseudomonas aeruginosa antibodies in blood spots from patients with cystic fibrosis. Arch Dis Child 1989;64: 1599-603. (Pubitemid 19266068)
63. Hofman LF, Foley TP, Henry JJ, Naylor EW. The use of filter paper-dried blood spots for thyroid-antibody screening in adults. J Lab Clin Med 2004;144: 307-12. (Pubitemid 40018018)
64. Hong HA, Ke NT, Nhon TN, Thinh ND, van der Gun JW, Hendriks JT, et al. Validation of the combined toxin-binding inhibition test for determination of neutralizing antibodies against tetanus and diphtheria toxins in a vaccine field study in Vietnam. Bull World Health Organ 1996;74: 275-82. (Pubitemid 26299344)
65. Takkouche B, Iglesias J, Alonso-Fernandez JR, Fernandez-Gonzalez C, Gestal-Otero JJ. Detection of brucella antibodies in eluted dried blood: a validation study. Immunol Letters 1995;45: 107-8.
66. Peralta RH, Macedo HW, Vaz AJ, Machado LR, Peralta JM. Detection of anti-cysticercus antibodies by ELISA using whole blood collected on filter paper. Trans R Soc Trop Med Hyg 2001;95: 35-6. (Pubitemid 34202220)
67. de la Fuente L, Toro C, Soriano V, Brugal MT, Vallejo F, Barrio G, et al. HTLV infection among young injection and non-injection heroin users in Spain: prevalence and correlates. J Clin Virol 2006;35: 244-9. (Pubitemid 43188968)
68. Fenollar F, Raoult D. Diagnosis of Rickettsial diseases using samples dried on blotting paper. Clin Diagn Lab Immunol 1999;6: 483-8. (Pubitemid 29330727)
69. Stevens R, Pass K, Fuller S, Wiznia A, Noble L, Duva S, et al. Blood spot screening and confirmatory tests for syphilis antibody. J Clin Microbiol 1992;30: 2353-8.
70. Backhouse JL. Dried blood spot technique for detecting treponema infection. Trans R Soc Trop Med Hyg 1998;92: 469-76.
71. Zicker F, Smith PG, Luquetti AO, Oliveira OS. Mass screening for trypanosoma cruzi infections using the immunofluorescence, ELISA and haemagglutination tests on serum samples and on blood eluates from filter-paper. Bull World Health Organ 1990;68: 465-71. (Pubitemid 20295576)
72. Mason PR, Fiori PL, Cappuccinelli P, Rappelli P, Gregson S. Seroepidemiology of trichomonas vaginalis in rural women in Zimbabwe and patterns of association with HIV infection. Epidemiol Infect 2005;133: 315-23. (Pubitemid 40439312)
73. Fujimoto A, Okano Y, Miyagi T, Isshiki G, Oura T. Quantitative beutler test for newborn mass screening of galactosemia using a fluorometric microplate reader. Clin Chem 2000;46: 806-10. (Pubitemid 30397443)
74. Hardelid P, Williams D, Dezateux C, Cubitt WD, Peckham CS, Tookey PA, et al. Agreement of rubella IGG antibody measured in serum and dried blood spots using two commercial enzymelinked immunosorbent assays. J Med Virol 2008;80: 360-4.
75. Balmaseda A, Saborio S, Tellez Y, Mercado JC, Perez L, Hammond SN, et al. Evaluation of immunological markers in serum, filter-paper blood spots, and saliva for dengue diagnosis and epidemiological studies. J Clin Virol 2008;43: 287-91.
76. Sorensen KM, Agergaard P, Olesen C, Andersen PS, Larsen LA, Ostergaard JR, et al. Detecting 22q11.2 deletions by use of multiplex ligation-dependent probe amplification on DNA from neonatal dried blood spot samples. J Mol Diagn 2010;12: 147-51.
77. Klotz J, Bryant P, Wilcox HB, Dillon M, Wolf B, Fagliano J. Population-based retrieval of newborn dried blood spots for researching paediatric cancer susceptibility genes. Paediatr Perinat Epidemiol 2006;20: 449-52.
78. Waterboer T, Dondog B, Michael KM, Michel A, Schmitt M, Vaccarella S, et al. Dried blood spot samples for seroepidemiology of infections with human papillomaviruses, helicobacter pylori, hepatitis C virus, and JC virus. Cancer Epidemiol Biomarkers Prev 2012;21: 287-93.
79. Quraishi R, Lakshmy R, Prabhakaran D, Mukhopadhyay AK, Jailkhani B. Use of filter paper stored dried blood for measurement of triglycerides. Lipids Health Disease 2006;5:20.
80. Zytkovicz TH, Fitzgerald EF, Marsden D, Larson CA, Shih VE, Johnson DM, et al. Tandem mass spectrometric analysis for amino, organic, and fatty acid disorders in newborn dried blood spots: a two-year summary from the New England newborn screening program. Clin Chem 2001;47: 1945-55. (Pubitemid 33010710)
81. Accinni R, Campolo J, Parolini M, De Maria R, Caruso R, Maiorana A, et al. Newborn screening of homocystinuria: quantitative analysis of total homocyst(e)ine on dried blood spot by liquid chromatography with fluorimetric detection. J Chromatogr B Analyt Technol Biomed Life Sci 2003;785: 219-26. (Pubitemid 36126161)
82. Burrin JM, Price CP. Performance of three enzymic methods for filter paper glucose determination. Ann Clin Biochem 1984;21 (Pt 5): 411-6. (Pubitemid 14028921)
83. Lacey JM, Minutti CZ, Magera MJ, Tauscher AL, Casetta B, McCann M, et al. Improved specificity of newborn screening for congenital adrenal hyperplasia by second-tier steroid profiling using tandem mass spectrometry. Clin Chem 2004;50: 621-5. (Pubitemid 38297314)
84. Erhardt JG, Craft NE, Heinrich F, Biesalski HK. Rapid and simple measurement of retinol in human dried whole blood spots. J Nutr 2002;132: 318-21. (Pubitemid 34135615)
85. Chace DH, Singleton S, Diperna J, Aiello M, Foley T. Rapid metabolic and newborn screening of thyroxine (t4) from dried blood spots by MS/MS. Clin Chim Acta 2009;403: 178-83.
86. Pacchiarotti A, Bartalena L, Falcone M, Buratti L, Grasso L, Martino E, et al. Free thyroxine and free triiodothyronine measurement in dried blood spots on filter paper by column adsorption chromatography followed by radioimmunoassay. Horm Metab Res 1988;20: 293-7.
87. Schulze A, Schmidt C, Kohlmuller D, Hoffmann GF, Mayatepek E. Accurate measurement of free carnitine in dried blood spots by isotope-dilution electrospray tandem mass spectrometry without butylation. Clin Chim Acta 2003;335: 137-45. (Pubitemid 37338318)
88. Kuhara T, Ohse M, Inoue Y, Yorifuji T, Sakura N, Mitsubuchi H, et al. Gas chromatographic-mass spectrometric newborn screening for propionic acidaemia by targeting methylcitrate in dried filter-paper urine samples. J Inherit Metab Dis 2002;25: 98-106. (Pubitemid 34700298)
89. Kimura M, Yoon HR, Wasant P, Takahashi Y, Yamaguchi S. A sensitive and simplified method to analyze free fatty acids in children with mitochondrial beta oxidation disorders using gas chromatography/mass spectrometry and dried blood spots. Clin Chim Acta 2002;316: 117-21. (Pubitemid 34028195)
90. Allard P, Grenier A, Korson MS, Zytkovicz TH. Newborn screening for hepatorenal tyrosinemia by tandem mass spectrometry: analysis of succinylacetone extracted from dried blood spots. Clin Biochem 2004;37: 1010-5. (Pubitemid 39388663)
91. Carducci C, Santagata S, Leuzzi V, Artiola C, Giovanniello T, Battini R, et al. Quantitative determination of guanidinoacetate and creatine in dried blood spot by flow injection analysiselectrospray tandem mass spectrometry. Clin Chim Acta 2006;364: 180-7. (Pubitemid 43120639)
92. D'Avolio A, Simiele M, Siccardi M, Baietto L, Sciandra M, Bonora S, et al. HPLC-MS method for the quantification of nine anti-HIV drugs from dry plasma spot on glass filter and their long-term stability in different conditions. J Pharm Biomed Anal 2010;52: 774-80.
93. Koal T, Burhenne H, Romling R, Svoboda M, Resch K, Kaever V. Quantification of antiretroviral drugs in dried blood spot samples by means of liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 2005;19: 2995-3001. (Pubitemid 41540724)
94. Henderson LO, Powell MK, Hannon WH, Miller BB, Martin ML, Hanzlick RL, et al. Radioimmunoassay screening of dried blood spot materials for benzoylecgonine. J Anal Toxicol 1993;17: 42-7. (Pubitemid 23030890)
95. Blessborn D, Romsing S, Bergqvist Y, Lindegardh N. Assay for screening for six antimalarial drugs and one metabolite using dried blood spot sampling, sequential extraction and ion-trap detection. Bioanalysis 2010;2: 1839-47.
96. Lindkvist J, Malm M, Bergqvist Y. Straightforward and rapid determination of sulfadoxine and sulfamethoxazole in capillary blood on sampling paper with liquid chromatography and UV detection. Trans R Soc Trop Med Hyg 2009;103: 371-6.
97. Burse VW, DeGuzman MR, Korver MP, Najam AR, Williams CC, Hannon WH, et al. Preliminary investigation of the use of dried-blood spots for the assessment of in utero exposure to environmental pollutants. Biochem Mol Med 1997;61: 236-9. (Pubitemid 27347227)
98. Li PK, Lee JT, Conboy KA, Ellis EF. Fluorescence polarization immunoassay for theophylline modified for use with dried blood spots on filter paper. Clin Chem 1986;32: 552-5. (Pubitemid 17016984)
99. Conroy JM, Trivedi G, Sovd T, Caggana M. The allele frequency of mutations in four genes that confer enhanced susceptibility to venous thromboembolism in an unselected group of New York State newborns. Thromb Res 2000;99: 317-24. (Pubitemid 30645685)
100. Bobillo Lobato J, Sanchez Peral BA, Duran Parejo P, Jimenez Jimenez LM. Detection of c. -32t > g (ivs1-13t > g) mutation of pompe disease by real-time PCR in dried blood spot specimen. Clin Chim Acta 2013;418C: 107-8.
101. Chien YH, Lee NC, Chiang SC, Desnick RJ, Hwu WL. Fabry disease: incidence of the common later-onset alphagalactosidase a ivs4+919g- > a mutation in Taiwanese newborns-superiority of DNA-based to enzyme-based newborn screening for common mutations. Mol Med 2012;18: 780-4.
102. Abdallah MW, Larsen N, Grove J, Bonefeld-Jorgensen EC, Norgaard-Pedersen B, Hougaard DM, et al. Neonatal chemokine levels and risk of autism spectrum disorders: findings from a Danish historic birth cohort follow-up study. Cytokine 2012;61: 370-6.
103. McCandless SE, Chandrasekar R, Linard S, Kikano S, Rice L. Sequencing from dried blood spots in infants with "false positive" newborn screen for MCAD deficiency. Mol Genet Metab 2013;108: 51-5.
104. Cordovado SK, Hendrix M, Greene CN, Mochal S, Earley MC, Farrell PM, et al. CFTR mutation analysis and haplotype associations in CF patients. Mol Genet Metab 2012;105: 249-54.
105. Karthipan SN, George E, Jameela S, Lim WF, Teh LK, Lee TY, et al. An assessment of three noncommercial DNA extraction methods from dried blood spots for beta-thalassaemia mutation identification. Int J Lab Hematol 2011;33: 540-4.
106. Harahap NI, Harahap IS, Kaszynski RH, Nurputra DK, Hartomo TB, Pham HT, et al. Spinal muscular atrophy patient detection and carrier screening using dried blood spots on filter paper. Genet Test Mol Biomarkers 2012;16: 123-9.
107. Coffee B, Keith K, Albizua I, Malone T, Mowrey J, Sherman SL, et al. Incidence of fragile X syndrome by newborn screening for methylated FMR1 DNA. Am J Hum Genet 2009;85: 503-14.
108. Resnick L, Veren K, Salahuddin SZ, Tondreau S, Markham PD. Stability and inactivation of HTLV-III/LAV under clinical and laboratory environments. J Am Med Assoc 1986;255: 1887-91. (Pubitemid 16167459)
109. McDade TW, Williams S, Snodgrass JJ. What a drop can do: dried blood spots as a minimally invasive method for integrating biomarkers into population-based research. Demography 2007;44: 899-925.
110. Burnett JE. Dried blood spot sampling: practical considerations and recommendation for use with preclinical studies. Bioanalysis 2011;3: 1099-107.
111. Garcia Boy R, Henseler J, Mattern R, Skopp G. Determination of morphine and 6-acetylmorphine in blood with use of dried blood spots. Ther Drug Monit 2008;30: 733-9.
112. Hollegaard MV, Grauholm J, Borglum A, Nyegaard M, Norgaard-Pedersen B, Orntoft T, et al. Genome-wide scans using archived neonatal dried blood spot samples. BMC Genomics 2009;10: 297-303.
113. O'Mara M, Hudson-Curtis B, Olson K, Yueh Y, Dunn J, Spooner N. The effect of hematocrit and punch location on assay bias during quantitative bioanalysis of dried blood spot samples. Bioanalysis 2011;3: 2335-47.
114. Snijdewind IJ, van Kampen JJ, Fraaij PL, van der Ende ME, Osterhaus AD, Gruters RA. Current and future applications of dried blood spots in viral disease management. Antiviral Res 2012;93: 309-21.
115. Lehmann S, Hoofnagle A, Hochstrasser D, Brede C, Glueckmann M, Cocho JA, et al. Quantitative clinical chemistry proteomics (QCCP) using mass spectrometry: general characteristics and application. Clin Chem Lab Med 2012: 1-16.
116. Johansson J, Becker C, Persson NG, Fex M, Torn C. C-peptide in dried blood spots. Scand J Clin Lab Invest 2010;70: 404-9.
117. Chambers AG, Percy AJ, Yang J, Camenzind AG, Borchers CH. Multiplexed quantitation of endogenous proteins in dried blood spots by multiple reaction monitoring mass spectrometry. Mol Cell Proteomics 2012;12: 781-91.
118. Newman MS, Brandon TR, Groves MN, Gregory WL, Kapur S, Zava DT. A liquid chromatography/tandem mass spectrometry method for determination of 25-hydroxy vitamin D2 and 25-hydroxy vitamin D3 in dried blood spots: a potential adjunct to diabetes and cardiometabolic risk screening. J Diabetes Sci Technol 2009;3: 156-62.
119. Ruhaak LR, Miyamoto S, Kelly K, Lebrilla CB. N-glycan profiling of dried blood spots. Anal Chem 2012;84: 396-402.
120. Henderson LO, Powell MK, Hannon WH, Bernert JT, Jr., Pass KA, Fernhoff P, et al. An evaluation of the use of dried blood spots from newborn screening for monitoring the prevalence of cocaine use among childbearing women. Biochem Mol Med 1997;61: 143-51. (Pubitemid 27347217)
121. Stove CP, Ingels AS, De Kesel PM, Lambert WE. Dried blood spots in toxicology: from the cradle to the grave? Crit Rev Toxicol 2012;42: 230-43.
122. Saussereau E, Lacroix C, Gaulier JM, Goulle JP. On-line liquid chromatography/tandem mass spectrometry simultaneous determination of opiates, cocainics and amphetamines in dried blood spots. J Chromatogr B Analyt Technol Biomed Life Sci 2012;885-886: 1-7.
123. McCabe ER, Huang SZ, Seltzer WK, Law ML. DNA microextraction from dried blood spots on filter paper blotters: potential applications to newborn screening. Hum Genet 1987;75: 213-6. (Pubitemid 17036794)
124. Makowski GS, Aslanzadeh J, Hopfer SM. In situ PCR amplification of guthrie card DNA to detect cystic fibrosis mutations. Clin Chem 1995;41: 477-9.
125. Sjoholm MI, Dillner J, Carlson J. Assessing quality and functionality of DNA from fresh and archival dried blood spots and recommendations for quality control guidelines. Clin Chem 2007;53:1401-7. (Pubitemid 47206336)