Elevated α-Methyl-γ-hydroxy-1, N 2-propano-2′- deoxyguanosine levels in urinary samples from individuals exposed to urban air pollution

Chemical Research in Toxicology

Volumn 26, Issue 11, 2013, Pages 1602-1604

  Garcia, Camila C M ^a   Freitas, Floreîncio P ^a   Sanchez, Angélica B ^a   Di Mascio, Paolo ^a   Medeiros, Marisa H G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

1,N 2 ETHENO 2' DEOXYGUANOSINE; 8 HYDROXYDEOXYGUANOSINE; ALPHA METHYL GAMMA HYDROXY 1,N 2 PROPANO 2' DEOXYGUANOSINE; DEOXYGUANOSINE DERIVATIVE; UNCLASSIFIED DRUG;

AIR POLLUTION; ARTICLE; HUMAN; ONLINE ANALYSIS; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RURAL AREA; TANDEM MASS SPECTROMETRY; URBAN AREA; URBAN RURAL DIFFERENCE; URINALYSIS; URINE LEVEL;

ACETALDEHYDE; ADOLESCENT; ADULT; AIR POLLUTANTS; ALDEHYDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGUANOSINE; DNA; DNA ADDUCTS; HUMANS; MALE; MIDDLE AGED; SMOKING; SOLID PHASE EXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; VEHICLE EMISSIONS; YOUNG ADULT;

EID: 84888072342     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx400273q     Document Type: Article

References (25)

1. CETESB (2012) Qualidade do ar no Estado de São Paulo 2012. CETESB: São Paulo (Série Relatórios/CETESB, ISSN 0103-4103).
2. DetranHome Page, http://www.detran.sp.gov.br (accessed Jul 15, 2013).
3. De Martinis, B. S., Kado, N. Y., de Carvalho, L. R. F., Okamoto, R. A., and Gundel, L. A. (1999) Genotoxicity of fractionated organic material in airborne particles from São Paulo, Brazil Mutat. Res., Genet. Toxicol. Environ. Mutagen. 446, 83-94
4. IARC (1999) Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide IARC Monogr. Eval. Carcinog. Risks Hum. 71, 319-335
5. Ward, E. M., Schulte, P. A., Straif, K., Hopf, N. B., Caldwell, J. C., Carreon, T., DeMarini, D. M., Fowler, B. A., Goldstein, B. D., and Hemminki, K. 2010, Research recommendations for selected IARC-classified agents Environ. Health Perspect. 118, 1355-1362
6. IARC (1995) Dry Cleaning, Some Chlorinated Solvents and Other Industrial Chemicals IARC Monogr. Eval. Carcinog. Risks Hum. 63, 373-391
7. Brooks, P. J. and Theruvathu, J. A. (2005) DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis Alcohol 35, 187-193
8. Hecht, S. S., McIntee, E. J., and Wang, M. Y. (2001) New DNA adducts of crotonaldehyde and acetaldehyde Toxicology 166, 31-36
9. 2-propano-2′-deoxyguanosine in human cells J. Am. Chem. Soc. 133, 9140-9143
10. Wang, M. Y., Upadhyaya, P., Dinh, T. T., Bonilla, L. E., and Hecht, S. S. (1998) Lactols in hydrolysates of DNA treated with alpha-acetoxy-N- nitrosopyrrolidine or crotonaldehyde Chem. Res. Toxicol. 11, 1567-1573
11. Medeiros, M. H. G. (2009) Exocyclic DNA adducts as biomarkers of lipid oxidation and predictors of disease. Challenges in developing sensitive and specific methods for clinical studies Chem. Res. Toxicol. 22, 419-425
12. Blair, I. A. (2008) DNA adducts with lipid peroxidation products J. Biol. Chem. 283, 15545-15549
13. Cadet, J., Douki, T., and Ravanat, J. L. (2010) Oxidatively generated base damage to cellular DNA Free Radical Biol. Med. 49, 9-21
14. 6-etheno-2′-deoxyadenosine in human urine by column-switching LC/APCI-MS/MS Free Radical Biol. Med. 36, 1383-1392
15. Nair, L., Srivatanakul, P., Haas, C., Jedpiyawongse, A., Khuhaprema, T., Seitz, H., and Bartsch, H. (2010) High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases Mutat. Res., Fundam. Mol. Mech. Mutagen. 683, 23-28
16. Evans, M. D., Saparbaev, M., and Cooke, M. S. (2010) DNA repair and the origins of urinary oxidized 2′-deoxyrybonucleosides Mutagenesis 25, 433-442
17. Evans, M. D., Olinski, R., Loft, S., and Cooke, M. S. (2010) Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2 ′-deoxyguanosine as a noninvasive biomarker of oxidative stress FASEB J. 24, 1249-1260
18. Cooke, M. S., Evans, M. D., Dove, R., Rozalski, R., Gackowski, D., Siomek, A., Lunec, J., and Olinski, R. (2005) DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine Mutat. Res., Fundam. Mol. Mech. Mutagen. 574, 58-66
19. Berra, C. M., de Oliveira, C. S., Garcia, C. C. M., Rocha, C. R. R., Lerner, L. K., Lima, L. C. A., Baptista, M. S., and Menck, C. F. M. (2013) Nucleotide excision repair activity on DNA damage induced by photoactivated methylene blue Free Radical Biol. Med. 61, 343-356
20. Hang, B. (2004) Repair of exocyclic DNA adducts: rings of complexity BioEssays 26, 1195-1208
21. Obtulowicz, T., Winczura, A., Speina, E., Swoboda, M., Janik, J., Janowska, B., Ciesla, J. M., Kowalczyk, P., Jawien, A., and Gackowski, D. 2010, Aberrant repair of etheno-DNA adducts in leukocytes and colon tissue of colon cancer patients Free Radical Biol. Med. 49, 1064-1071
22. Mechilli, M., Schinoppi, A., Kobos, K., Natarajan, A. T., and Palitti, F. (2008) DNA repair deficiency and acetaldehyde-induced chromosomal alterations in CHO cells Mutagenesis 23, 51-56
23. Dockery, D. W. (2009) Health effects of particulate air pollution Ann. Epidemiol. 19, 257-263
24. Moller, P. and Loft, S. (2010) Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution Environ. Health Perspect. 118, 1126-1136
25. 2-propanodeoxyguanosine DNA adducts in human cells Mutat. Res., Genet. Toxicol. Environ. Mutagen. 608, 1-7