An immunohistochemical and molecular analysis of problematic and unclassified ovarian sex cord-stromal tumors

Human Pathology

Volumn 44, Issue 12, 2013, Pages 2774-2781

  Stewart, Colin J R ^a,b   Alexiadis, Maria ^c   Crook, Maxine L ^a   Fuller, Peter J ^c  

^a KING EDWARD MEMORIAL HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

DICER1; FOXL2; Immunohistochemistry; Molecular; Ovary; Sex cord stromal tumor; Unclassified

Indexed keywords

CALRETININ; CD56 ANTIGEN; CD99 ANTIGEN; DICER; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; INHIBIN; PROGESTERONE RECEPTOR; STEROIDOGENIC FACTOR 1;

ADULT; AGED; ANDROBLASTOMA; ARTICLE; CLINICAL ARTICLE; FEMALE; GENE MUTATION; GRANULOSA CELL TUMOR; HUMAN; IMMUNOHISTOCHEMISTRY; MOLECULAR GENETICS; OVARIAN SEX CORD STROMAL TUMOR; OVARY TUMOR; PROTEIN EXPRESSION; SEX CORD TUMOR; TUMOR CLASSIFICATION;

DICER1; FOXL2; IMMUNOHISTOCHEMISTRY; MOLECULAR; OVARY; SEX CORD-STROMAL TUMOR; UNCLASSIFIED;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; OVARIAN NEOPLASMS; SEX CORD-GONADAL STROMAL TUMORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84888068259     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.07.028     Document Type: Article

References (34)

1. L.M. Roth Recent advances in the pathology and classification of ovarian sex cord-stromal tumors Int J Gynecol Pathol 25 2006 199 215
2. N. Wilkinson, S. Osborn, and R.H. Young Sex cord-stromal tumours of the ovary: a review highlighting recent advances Diagn Histopathol 14 2008 388 400
3. H. Fox Pathologic prognostic factors in early stage adult-type granulosa cell tumors of the ovary Int J Gynecol Cancer 13 2003 1 4
4. J.D. Seidman Unclassified ovarian gonadal stromal tumors. A clinicopathologic study of 32 cases Am J Surg Pathol 20 1996 699 706
5. J.L. Simpson, H. Michael, and L.M. Roth Unclassified sex cord-stromal tumors of the ovary Arch Pathol Lab Med 122 1998 52 55
6. S.P. Shah, M. Kobel, and J. Senz Mutation of FOXL2 in granulosa-cell tumors of the ovary N Eng J Med 360 2009 2719 2729
7. S. Jamieson, R. Butzow, and N. Andersson The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary Mod Pathol 23 2010 1477 1485
8. E. D'Angelo, A. Mozos, and D. Nakayama Prognostic significance of FOXL2 mutation and mRNA expression in adult and juvenile granulosa cell tumors of the ovary Mod Pathol 24 2011 1360 1367
9. A. Heravi-Moussavi, M.S. Anglesio, and S.-W.G. Cheng Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers N Eng J Med 366 2012 234 242
10. T. Rio Frio, A. Bahubeshi, and C. Kanellopoulou DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors JAMA 305 2011 68 77
11. K.A. Schultz, M.C. Pacheco, and J. Yang Ovarian sex cord-stromal tumors, pleuropulmonary blastoma and DICER1 mutations: a report from the International Pleuropulmonary Blastoma Registry Gynecol Oncol 122 2011 246 250
12. S. Kommoss, M.S. Anglesio, and R. Mackenzie FOXL2 molecular testing in ovarian neoplasms: diagnostic approach and procedural guidelines Mod Pathol 26 2013 860 867
13. J.T. Rabban, and C.J. Zaloudek A practical approach to immunohistochemical diagnosis of ovarian germ cell tumours and sex cord-stromal tumours Histopathology 62 2013 71 88
14. E.M. Leuverink, B.A. Brennan, and M.L. Crook Prognostic value of mitotic counts and Ki-67 immunoreactivity in adult-type granulosa cell tumour of the ovary J Clin Pathol 61 2008 914 919
15. C.J.R. Stewart, D. Doherty, R. Guppy, K. Louwen, and Y. Leung Beta-catenin and E-cadherin expression in stage I adult-type granulosa cell tumour of the ovary: correlation with tumour morphology and clinical outcome Histopathology 62 2013 257 266
16. C. Zhao, T.N. Vinh, K. McManus, D. Dabbs, R. Barner, and R. Vang Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors Am J Surg Pathol 33 2009 354 366
17. W.G. McCluggage, and P. Maxwell Immunohistochemical staining for calretinin is useful in the diagnosis of ovarian sex cord-stromal tumours Histopathology 38 2001 403 408
18. C.J.R. Stewart, C.L. Nandini, and J.A. Richmond Value of A103 (melan-A) immunostaining in the differential diagnosis of ovarian sex cord stromal tumours J Clin Pathol 53 2000 206 211
19. C. Zhao, R. Barner, T.N. Vinh, K. McManus, D. Dabbs, and R. Vang SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian Sertoli cell tumor Int J Gynecol Pathol 27 2008 507 514
20. S.M. Hutton, L.R. Webster, S. Nielsen, Y. Leung, and C.J.R. Stewart Immunohistochemical expression and prognostic significance of oestrogen receptor-α, oestrogen receptor-β, and progesterone receptor in stage 1 adult-type granulosa cell tumour of the ovary Pathology 44 2012 611 616
21. O.M. Al-Agha, H.F. Huwait, and C. Chow FOXL2 is a sensitive and specific marker for sex cord-stromal tumors of the ovary Am J Surg Pathol 35 2011 484 494
22. R.H. Young, A.G. Dudley, and R.E. Scully Granulosa cell, Sertoli-Leydig cell, and unclassified sex cord-stromal tumors associated with pregnancy: a clinicopathological analysis of thirty-six cases Gynecol Oncol 18 1984 181 205
23. C.J.R. Stewart, M.D. Jeffers, and A. Kennedy Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histological mimics Histopathology 31 1997 67 74
24. K.A. Schrader, B. Gorbatcheva, and J. Senz The specificity of the FOXL2 c.402C > G somatic mutation: a survey of solid tumors PLoS One 24 2009 e7988
25. M. Kobel, C.B. Gilks, and D.G. Huntsman Adult-type granulosa cell tumors and FOXL2 mutations Cancer Res 69 2009 9160 9162
26. S. Jamieson, and P.J. Fuller Molecular pathogenesis of granulosa cell tumors of the ovary Endocr Rev 33 2012 109 144
27. R. Oparka, A. Cassidy, S. Reilly, A. Stenhouse, W.G. McCluggage, and C.S. Herrington The C134W (402 C > G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumour Histopathology 60 2012 838 842
28. T. Papageorgiou, and C.A. Stratakis Ovarian tumors associated with multiple endocrine neoplasias and related syndromes (Carney complex, Peutz-Jeghers syndrome, von Hippel-Lindau disease, Cowden's disease) Int J Gynecol Cancer 2 2002 337 347
29. E. Oliva, T. Alvarez, and R.H. Young Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases Am J Surg Pathol 29 2005 143 156
30. R.H. Young, W.R. Welch, G.R. Dickersin, and R.E. Scully Ovarian sex cord tumor with annular tubules: a review of 74 cases including 27 with Peutz-Jegher's syndrome and four with adenoma malignum of the cervix Cancer 50 1982 1384 1402
31. S.A. Hales, I.A. Cree, and S. Pinion A poorly differentiated Sertoli-Leydig cell tumour associated with an ovarian sex cord tumour with annular tubules in a woman with Peutz-Jeghers syndrome Histopathology 25 1994 391 393
32. R.H. Young, G.R. Dickersin, and R.E. Scully A distinctive ovarian sex cord-stromal tumor causing sexual precocity in the Peutz-Jeghers syndrome Am J Surg Pathol 7 1983 233 243
33. D. Barker, R. Sharma, and A. McIndoe An unusual case of sex cord tumor with annular tubules with malignant transformation in a patient with Peutz-Jegher's syndrome Int J Gynecol Pathol 29 2009 27 32
34. V. Launonen Mutations in the human LKB1/STK11 gene Hum Mutat 26 2005 291 297