Improved fracture risk assessment based on nonlinear micro-finite element simulations from HRpQCT images at the distal radius

Journal of Bone and Mineral Research

Volumn 28, Issue 12, 2013, Pages 2601-2608

  Christen, David ^a   Melton III, L Joseph ^b   Zwahlen, Alexander ^a   Amin, Shreyasee ^b   Khosla, Sundeep ^b   Müller, Ralph ^a  

^a ETH ZURICH   (Switzerland)

^b Department of Health Sciences Research   (United States)

Author keywords

bone microstructure; Distal forearm fracture; high resolution peripheral quantitative computed tomography; nonlinear micro finite element analysis; risk assessment

Indexed keywords

AGED; ARTICLE; BONE DENSITY; BONE STRENGTH; BONE STRUCTURE; BONE TISSUE; CONTROLLED STUDY; ENERGY ABSORPTION; FEMALE; FINITE ELEMENT ANALYSIS; FOREARM FRACTURE; FRACTURE RISK; FRAGILITY FRACTURE; HEIGHT; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; NONLINEAR MICRO FINITE ELEMENT ANALYSIS; POSTMENOPAUSE; RADIUS FRACTURE; RIGIDITY; RISK; RISK ASSESSMENT; YOUNG MODULUS;

BONE MICROSTRUCTURE; DISTAL FOREARM FRACTURE; HIGH-RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; NONLINEAR MICRO-FINITE ELEMENT ANALYSIS; RISK ASSESSMENT;

BONE DENSITY; CASE-CONTROL STUDIES; COMPUTER SIMULATION; FEMALE; FINITE ELEMENT ANALYSIS; HUMANS; NONLINEAR DYNAMICS; ODDS RATIO; RADIUS; RADIUS FRACTURES; RISK ASSESSMENT; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84888059970     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1996     Document Type: Article

References (37)

1. Cummings SR, Melton LJ., Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002; 359 (9319): 1761-7.
2. Wang X, Shen X, Li X, Agrawal CM., Age-related changes in the collagen network and toughness of bone. Bone. 2002; 31 (1): 1-7.
3. Official Positions of the International Society for Clinical Densitometry (ISCD) 2007 [Internet]. Middletown, CT: ISCD, 2007 [cited 2013 May 28]. Available from: http://www.iscd.org/official-positions/official-positions.
4. Seeman E, Delmas PD., Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med. 2006; 354: 2250-61.
5. Krug R, Burghardt AJ, Majumdar S, Link TM., High-resolution imaging techniques for the assessment of osteoporosis. Radiol Clin North Am. 2010; 48: 601-21.
6. MacNeil JA, Boyd SK., Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys. 2007; 29: 1096-105.
7. Mueller TL, Stauber M, Kohler T, Eckstein F, Müller R, van Lenthe GH., Non-invasive bone competence analysis by high-resolution pQCT: an in vitro reproducibility study on structural and mechanical properties at the human radius. Bone. 2009; 44: 364-71.
8. Pistoia W, van Rietbergen B, Lochmüller EM, Lill CA, Eckstein F, Ruegsegger P., Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone. 2002; 30 (6): 842-8.
9. Melton LJ, Riggs BL, Keaveny TM, Achenbach SJ, Hoffmann PF, Camp JJ, Rouleau PA, Bouxsein ML, Amin S, Atkinson EJ, Robb RA, Khosla S., Structural determinants of vertebral fracture risk. J Bone Miner Res. 2007; 22: 1885-92.
10. MacNeil JA, Boyd SK., Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method. Bone. 2008; 42 (6): 1203-13.
11. Boutroy S, van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD., Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Miner Res. 2008; 23 (3): 392-9.
12. Vilayphiou N, Boutroy S, Sornay-Rendu E, van Rietbergen B, Munoz F, Delmas PD, Chapurlat R., Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in postmenopausal women. Bone. 2010; 46: 1030-7.
13. Liu XS, Stein EM, Zhou B, Zhang CA, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Cosman F, Nieves J, Shane E, Guo XE., Individual trabecula segmentation (ITS)-based morphological analyses and microfinite element analysis of HR-pQCT images discriminate postmenopausal fragility fractures independent of DXA measurements. J Bone Miner Res. 2012; 27: 263-72.
14. Melton LJ, Christen D, Riggs BL, Achenbach SJ, Müller R, van Lenthe GH, Amin S, Atkinson EJ, Khosla S., Assessing forearm fracture risk in postmenopausal women. Osteoporos Int. 2010; 21: 1161-9.
15. Christen DB., Nonlinear failure prediction in human bone. a clinical approach based on high resolution imaging [dissertation] [Internet]. [Zurich]: Department of Health Sciences and Technology, ETH Zurich; 2012 [cited. 2013 May 28]. 182 p. Available from: http://e-collection.library.ethz.ch/view/eth:6201. DOI: 10.3929/ethz-a-007575364
16. Melton LJ III, Amadio PC, Crowson CS, O'Fallon WM., Long-term trends in the incidence of distal forearm fractures. Osteoporos Int. 1998; 8: 341-18.
17. van Rietbergen B, Weinans H, Huiskes R, Odgaard A., A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models. J Biomech. 1995 Jan; 28 (1): 69-81.
18. Helgason B, Perilli E, Schileo E, Taddei F, Brynjolfsson S, Viceconti M., Mathematical relationships between bone density and mechanical properties: a literature review. Clin Biomech. 2008; 23 (2): 135-46.
19. Morgan EF, Bayraktar HH, Keaveny TM., Trabecular bone modulus-density relationships depend on anatomic site. J Biomech. 2003; 36: 897-04.
20. Bayraktar HH, Morgan EF, Niebur GL, Morris GE, Wong EK, Keaveny TM., Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue. J Biomech. 2004; 37 (1): 27-35.
21. Burstein AH, Zika JM, Heiple KG, Klein L., Contribution of collagen and mineral to the elastic-plastic properties of bone. J Bone Joint Surg Am. 1975; 57: 956-61.
22. Isaksson H, van Donkelaar CC, Ito K., Sensitivity of tissue differentiation and bone healing predictions to tissue properties. J Biomech. 2009; 42: 555-64.
23. Bevill G, Eswaran SK, Gupta A, Papadopoulos P, Keaveny TM., Influence of bone volume fraction and architecture on computed large-deformation failure mechanisms in human trabecular bone. Bone. 2006; 39 (6): 1218-25.
24. Stolken JS, Kinney JH., On the importance of geometric nonlinearity in finite-element simulations of trabecular bone failure. Bone. 2003; 33 (4): 494-504.
25. Arbenz P, van Lenthe GH, Mennel U, Müller R, Sala M., A scalable multi-level preconditioner for matrix-free mu-finite element analysis of human bone structures. Int J Numer Methods Eng. 2008; 73 (7): 927-47.
26. Chiu J, Robinovitch SN., Prediction of upper extremity impact forces during falls on the outstretched hand. J Biomech. 1998; 31: 1169-76.
27. Mueller TL, Christen D, Sandercott S, Boyd SK, van Rietbergen B, Eckstein F, Lochmüller E-M, Müller R, van Lenthe GH., Computational finite element bone mechanics accurately predicts mechanical competence in the human radius of an elderly population. Bone. 2011; 48: 1232-8.
28. Pahr DH, Dall'Ara E, Varga P, Zysset PK., HR-pQCT-based homogenised finite element models provide quantitative predictions of experimental vertebral body stiffness and strength with the same accuracy as muFE models. Comput Methods Biomech Biomed Engin. 2012; 15 (7): 711-20.
29. R Development Core Team. R: a language and environment for statistical computing [Internet]. Vienna, Austria: R Foundation for Statistical Computing; 2012. [cited 2013 May 28]. Available from:http://www.r-project.org.
30. Melton LJ, Riggs BL, van Lenthe GH, Achenbach SJ, Müller R, Bouxsein ML, Amin S, Atkinson EJ, Khosla S., Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women. J Bone Miner Res. 2007; 22: 1442-8.
31. Sornay-Rendu E, Boutroy S, Munoz F, Delmas PD., Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J Bone Miner Res. 2007; 22: 425-33.
32. Morgan EF, Keaveny TM., Dependence of yield strain of human trabecular bone on anatomic site. J Biomech. 2001; 34: 569-77.
33. Bayraktar HH, Keaveny TM., Mechanisms of uniformity of yield strains for trabecular bone. J Biomech. 2004; 37 (11): 1671-8.
34. Kopperdahl DL, Keaveny TM., Yield strain behavior of trabecular bone. J Biomech. 1998; 31 (7): 601-8.
35. Homminga J, Mccreadie BR, Weinans H, Huiskes R., The dependence of the elastic properties of osteoporotic cancellous bone on volume fraction and fabric. J Biomech. 2003; 36 (10): 1461-7.
36. Niebur GL, Feldstein MJ, Yuen JC, Chen TJ, Keaveny TM., High-resolution finite element models with tissue strength asymmetry accurately predict failure of trabecular bone. J Biomech. 2000; 33 (12): 1575-83.
37. Verhulp E, van Rietbergen B, Müller R, Huiskes R., Indirect determination of trabecular bone effective tissue failure properties using micro-finite element simulations. J Biomech. 2008; 41 (7): 1479-85.