Scientific letter: Could tranexamic acid use in surgery reduce perioperative myocardial infarction?

Heart

Volumn 99, Issue 23, 2013, Pages 1785-

  Roberts, Ian ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; PLASMIN; PLASMINOGEN; TRANEXAMIC ACID;

ANTIINFLAMMATORY ACTIVITY; ATHEROSCLEROTIC PLAQUE; BLEEDING; ENZYME ACTIVATION; HEART INFARCTION; HEART MUSCLE OXYGEN CONSUMPTION; HEART RATE; HUMAN; INFLAMMATION; INJURY; LETTER; LOADING DRUG DOSE; OCCLUSION; OXYGEN SUPPLY; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN DEGRADATION; SENSITIVITY AND SPECIFICITY; THROMBOSIS;

MYOCARDIAL DISEASE;

ANTIFIBRINOLYTIC AGENTS; HUMANS; INTRAOPERATIVE COMPLICATIONS; MULTICENTER STUDIES AS TOPIC; MYOCARDIAL INFARCTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRANEXAMIC ACID;

EID: 84888027015     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2013-304292     Document Type: Letter

References (6)

1. CRASH-2 Trial Collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010;376:23-32.
2. CRASH-2 Trial Collaborators. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet 2011;377:1096-101, 101 e1-2.
3. Roberts I, Perel P, Prieto-Merino D, et al. Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespeci fied analysis of data from randomised controlled trial. BMJ 2012;345:e5839.
4. Shah PK. Inflammation and plaque vulnerability. Cardiovasc Drugs Ther 2009;23:31-40.
5. Ker K, Edwards P, Perel P, et al. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 2012;17:344:e3054.
6. The VISION Study Investigators. Association between postoperative troponin levels and 30-day mortality among patients undergoing non-cardiac surgery. JAMA 2012;307:2295-304.