Identifying 2 prenylflavanones as potential hepatotoxic compounds in the ethanol extract of sophora flavescens

Journal of Food Science

Volumn 78, Issue 11, 2013, Pages

  Yu, Qianqian ^a   Cheng, Nengneng ^a   Ni, Xiaojun ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Hepatotoxicity; Kurarinone; Rats; Sophora flavescens; Sophoraflavanone G

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; FLAVANONE; FLAVANONE DERIVATIVE; FLAVONOID; KURARINONE; PLANT EXTRACT; SOPHORAFLAVANONE G; VEXIBINOL;

ANIMAL; ARTICLE; BIOASSAY; BLOOD; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; ISOLATION AND PURIFICATION; LIVER CELL; LIVER TOXICITY; MALE; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT ROOT; PRENYLATION; RAT; SOPHORA; SOPHORA FLAVESCENS; SPRAGUE DAWLEY RAT; WISTAR RAT;

HEPATOTOXICITY; KURARINONE; RATS; SOPHORA FLAVESCENS; SOPHORAFLAVANONE G;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL ASSAY; CELL SURVIVAL; ETHANOL; FLAVANONES; FLAVONOIDS; HEPATOCYTES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; PLANT EXTRACTS; PLANT ROOTS; PRENYLATION; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SOPHORA;

EID: 84888021095     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/1750-3841.12275     Document Type: Article

References (33)

1. Botta B, Vitali A, Menendez P, Misiti D, Monache GD. 2005. Prenylated flavonoids: pharmacology and biotechnology. Curr Med Chem 12(6):713-39.
2. Danan, G, Benichou, C.1993. Causality assessment of adverse reactions to drugs-1. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 46(11):1323-30.
3. Gan G, Sun J. 2009. Analysis of 14 adverse drug reaction/event reports on liver damage induced by Zhixue capsule. Chin J Pharmacovigilance 6(6):351-3.
4. Han J, Sun M, Cui Y, Wang T, Zhang W, Guo M, Zhou Y, Liu W, Zhang M, Duan J. 2007. Kushen flavonoids induce apoptosis in tumor cells by inhibition of NF-κB activation and multiple receptor tyrosine kinase activities. Phytother Res 21(3):262-8.
5. Hwang JS, Lee SA, Hong SS, Lee KS, Lee MK, Hwang BY, Ro JS. 2005. Monoamine oxidase inhibitory components from the roots of Sophora flavescens. Arch Pharm Res 28(2):190-4.
6. Jung HJ, Kang SS, Hyun SK, Choi JS. 2005. In vitro free radical and ONOO- scavengers from Sophora flavescens. Arch Pharm Res 28(5):534-40.
7. Kim DW, Chi YS, Son KH, Chang HW, Kim JS, Kang SS, Kim HP. 2002. Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory response. Arch Pharm Res 25(3):329-35.
8. Kuroyanagi M, Arakawa T, Hirayama Y, Hayashi T. 1999. Antibacterial and antiandrogen flavonoids from Sophora flavescens. J Nat Prod 62(12):1595-9.
9. Li W, Liang H, Yin T, Wang B, Zhao YY. 2008. Main flavonoids from Sophora flavescenes. Acta Pharm Sin 43(8):833-7.
10. Liu X-S, Jiang J. 2006. Molecular mechanism of matrine-induced apoptosis in leukemia K562 cells. Amer J Chin Med 34(06):1095-103.
11. Luo C, Zhu Y, Jiang T, Lu X, Zhang W, Jing Q, Li J, Pang L, Chen K, Qiu F. 2007. Matrine induced gastric cancer MKN45 cells apoptosis via increasing pro-apoptotic molecules of Bcl-2 family. Toxicology 229(3):245-52.
12. Ma XC, Xin XL, Liu KX, Zhang BJ, Li FY, Guo DA. 2008. Simultaneous determination of nine major flavonoids in Sophora flavescens by RP-LC. Chromatography 68(5-6):471-4.
13. Natl. Center for ADR Monitoring C. 2009. Introduction to pharmacovigilance. Chin J Pharmacovigilance 6(1):55-6.
14. Natl. Pharmacopoeia Committee. 2010. Chinese pharmacopoeia. Beijing: China Medical Science Press. p 141.
15. Ni XJ, Cheng NN. 2010. Study on toxicity of medicinal ingredients of Zhixue capsule in primary rat hepatocytes and mice. Chin J Clin Pharm 19(5):271-5.
16. Piao XL, Piao XS, Kim SW, Park JH, Kim HY, Cai SQ. 2006. Identification and characterization of antioxidants from Sophora flavescens. Biol Pharm Bull 29(9):1911-5.
17. Ryu SY, Lee HS, Kim YK, Kim SH. 1997. Determination of isoprenyl and lavandulyl positions of flavonoids from Sophora flavescens by NMR experiment. Arch Pharm Res 20(5):491-5.
18. Sato S, Takeo J, Aoyama C, Kawahara H. 2007. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flaveseens. Bioorgan Med Chem 15(10):3445-9.
19. Seglen PO. 1976. Preparation of isolated rat liver cells. Methods Cell Biol 13(1):29-83.
20. Shin HJ, Kim HJ, Kwak JH, Chun HO, Kim JH, Park H, Kim DH, Lee YS. 2002. A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett 12(17):2313-6.
21. Shirataki Y, Motohashi N, Tani S, Sakagami H, Satoh K, Nakashima H, Mahapatra SK, Ganguly K, Dastidar SG, Chakrabarty AN. 2001. In vitro biological activity of prenylflavanones. Anticancer Res 21(1A):275-80.
22. Son JK, Park JS, Kim JA, Kim Y, Chung SR, Lee SH. 2003. Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity. Planta Medica 69(6):559-61.
23. State Administration of Traditional Chinese Medicine. 1999. Sophora flavescens. Zhonghua Bencao. 1st ed. Shanghai: Shanghai Science and Technology Press. p 634-43.
24. Stockham SL, Scott MA. 2002. Fundamentals of veterinary clinical pathology. Ames, Iowa: Iowa State Univ. Press.
25. Wang Y. 1997. Research progress on chemical constituents, preparative separation and quality of Sophora flavescens. Chin Trad Pat Med 19:39-41.
26. Wang XJ, Cheng CW, Fu QQ.2009. Drug-induced liver injury related with Zhixue Capsules:an analysis of 30 gregarious patients. Chin Hepatol 14(4):287-90
27. Wu YR, Zhang YP. 2007. Liver damage caused by Xiaoyin tablets. Adverse Drug React J 9(2):143.
28. Yagi A, Fukunaga M, Okuzako N, Mifuchi I, Kawamoto F. 1989. Antifungal substances from Sophora flavescens. Jap J Pharmacogn 43(4):343-7.
29. Ye GA, Zhu HY, Li ZX, Ma CH, Fan MS, Sun ZL, Huang CG. 2007. LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts. Biomed Chromatogr 21(6):655-60.
30. Yu P, Liu Q, Liu K, Yagasaki K, Wu E, Zhang G. 2009. Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-κB signaling. Cytotechnology 59(3):219-29.
31. Zhang Y, Zhang H, Yu P, Liu Q, Liu K, Duan H, Luan G, Yagasaki K, Zhang G. 2009. Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology 59(3):191-200.
32. Zhang J-Q, Li Y-M, Liu T, He W-T, Chen Y-T, Chen X-H, Li X, Zhou W-C, Yi J-F, Ren Z-J. 2010. Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy. World J Gastroentero 16(34):4281.
33. Zhao Y, Zhang R. 1991. Research on chemical constituents of Sophora flavescens. Nat Prodt Res Dev 3:93-103.