Aplastic anemia secondary to azathioprine in systemic lupus erythematosus: Report of a case with normal thiopurine S-methyltransferase enzyme activity and review of the literature

Lupus

Volumn 22, Issue 14, 2013, Pages 1526-1528

  Yeter, K C ^a   Afkhami, M ^b   Brynes, R K ^b   Quismorio Jr , F P ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b LAC USC MEDICAL CENTER   (United States)

Author keywords

azathioprine; hematologic changes; musculoskeletal; Systemic lupus erythematosus

Indexed keywords

AMPHOTERICIN B; AZATHIOPRINE; DEXAMETHASONE; GRANULOCYTE COLONY STIMULATING FACTOR; HYDROCORTISONE; MEROPENEM; METHYLPREDNISOLONE; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; POSACONAZOLE; THIOPURINE METHYLTRANSFERASE; VANCOMYCIN;

ADULT; ANTIBIOTIC THERAPY; ARTICLE; BLOOD CULTURE; BONE MARROW BIOPSY; CASE REPORT; CLINICAL FEATURE; DISEASE COURSE; DRUG DOSE INCREASE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ECHOCARDIOGRAPHY; ELECTROMYOGRAPHY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FATALITY; FEMALE; FLOW CYTOMETRY; HUMAN; LABORATORY TEST; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MUCORMYCOSIS; NERVE CONDUCTION; PANCYTOPENIA; PERIPHERAL NEUROPATHY; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RHIZOPUS; STAPHYLOCOCCUS INFECTION; SYSTEMIC LUPUS ERYTHEMATOSUS; THORAX RADIOGRAPHY; TREATMENT DURATION; URINE CULTURE;

AZATHIOPRINE; HEMATOLOGIC CHANGES; MUSCULOSKELETAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANEMIA, APLASTIC; AZATHIOPRINE; FATAL OUTCOME; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LUPUS ERYTHEMATOSUS, SYSTEMIC; METHYLTRANSFERASES; MIDDLE AGED;

EID: 84887967590     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203313504636     Document Type: Article

References (10)

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2. Whisnant JK, Pelkey J. Rheumatoid arthritis: Treatment with azathioprine (IMURAN R). Clinical side effects and laboratory abnormalities. Ann Rheum Dis. 1982 ; 41: 44-47
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5. Naughton MA, Battaglia E, O'Brien S, et al. Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine. Rheumatology. 1999 ; 38: 640-644
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