Dynamics of organohalogenated contaminants in human serum from obese individuals during one year of weight loss treatment

Environmental Science and Technology

Volumn 47, Issue 21, 2013, Pages 12441-12449

  Dirtu, Alin C ^a   Dirinck, Eveline ^a   Malarvannan, Govindan ^a   Neels, Hugo ^a   Van Gaal, Luc ^a   Jorens, Philippe G ^a   Covaci, Adrian ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOCRINE EFFECTS; HYDROXYLATED METABOLITES; METABOLIC ACTIVITY; OBESE POPULATION; OCTANOL-WATER PARTITION COEFFICIENT; ORGANOCHLORINE PESTICIDES; POLYBROMINATED DIPHENYL ETHER (PBDES); POLYCHLORINATED BIPHENYL (PCBS);

BIOMOLECULES; BODY FLUIDS; METABOLISM; METABOLITES; POLYCHLORINATED BIPHENYLS; TISSUE;

ORGANIC POLLUTANTS;

OCTANOL; ORGANOCHLORINE PESTICIDE; ORGANOHALOGEN DERIVATIVE; ORGANOHALOGENATED CONTAMINANT; PENTACHLOROPHENOL; POLYBROMINATED DIPHENYL ETHER; POLYCHLORINATED BIPHENYL; UNCLASSIFIED DRUG; WATER; CHLORINATED HYDROCARBON; POLLUTANT;

CONCENTRATION (COMPOSITION); DILUTION; HEALTH IMPACT; HEALTH MONITORING; METABOLITE; OBESITY; ORGANOHALOGEN; PUBLIC HEALTH; SERUM;

ADIPOSE TISSUE; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DYNAMICS; FEMALE; HUMAN; HYDROXYLATION; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; METABOLITE; OBESITY; PARTITION COEFFICIENT; WEIGHT REDUCTION; BELGIUM; BLOOD; ENVIRONMENTAL MONITORING; MIDDLE AGED; POLLUTANT; PRINCIPAL COMPONENT ANALYSIS;

ADULT; BELGIUM; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; HYDROCARBONS, CHLORINATED; MALE; MIDDLE AGED; OBESITY; PRINCIPAL COMPONENT ANALYSIS; WEIGHT LOSS;

EID: 84887955631     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es400657t     Document Type: Article

References (37)

1. Van Gaal, L.; Mertens, I. L.; De Block, C. E. Mechanisms linking obesity with cardiovascular disease Nature 2006, 444 (7121) 875-880 10.1038/nature05487
2. Yach, D.; Stuckler, D.; Brownell, K. D. Epidemiologic and economic consequences of the global epidemics of obesity and diabetes Nat. Med. 2006, 12 (1) 62-66 10.1038/nm0106-62
3. Grün, F. Obesogens Curr. Opin. Endocrinol. 2010, 17 (5) 453-459 10.1097/MED.0b013e32833ddea0
4. Grün, F.; Blumberg, B. Endocrine disrupters as obesogens Mol. Cell. Endocrinol. 2009, 304 (1-2) 19-29 10.1016/j.mce.2009.02.018
5. Grün, F.; Blumberg, B. Minireview: The case for obesogens Mol. Endocrinol. 2009, 23 (8) 1127-1134 10.1210/me.2008-0485
6. Lee, D. H.; Steffes, M. W.; Sjödin, A.; Jones, R. S.; Needham, L. L.; Jacobs, D. R., Jr. Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes PLoS One 2011, 26 (6) e15977 10.1371/journal.pone.0015977
7. Newbold, R. R.; Padilla-Banks, E.; Jefferson, W. N. Environmental estrogens and obesity Mol. Cell. Endocrinol. 2009, 304 (1-2) 84-89 10.1016/j.mce.2009.02.024
8. Kim, M. J.; Marchand, P.; Henegar, C.; Antignac, J. P.; Alili, R.; Poitou, C.; Buillot, J. L.; Basdevant, A.; Le Bizec, B.; Barouki, R.; Clément, K. Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss Environ. Health Perspect. 2011, 119 (3) 377-383 10.1289/ehp.1002848
9. Min, J. Y.; Cho, J. S.; Lee, K. J.; Park, J. B.; Park, S. G.; Kim, J. Y.; Min, K. B. Potential role for organochlorine pesticides in the prevalence of peripheral arterial diseases in obese persons: Results from the National Health and Nutrition Examination Survey 1999-2004 Atherosclerosis 2011, 218 (1) 200-206 10.1016/j.atherosclerosis.2011.04.044
10. Hardell, E.; Carlberg, M.; Nordström, M.; van Bavel, B. Time trends of persistent organic pollutants in Sweden during 1993-2007 and relation to age, gender, body mass index, breast-feeding and parity Sci. Total Environ. 2010, 408 (20) 4412-4419 10.1016/j.scitotenv.2010.06.029
11. Pelletier, C.; Despres, J. P.; Tremblay, A. Plasma organochlorine concentrations in endurance athletes and obese individuals Med. Sci. Sports Exerc. 2002, 34 (12) 1971-1975 10.1249/01.MSS.0000040820.48707.99
12. Agudo, A.; Goni, F.; Etxeandia, A.; Vives, A.; Millan, E.; Lopez, R.; Amiano, P.; Ardanaz, E.; Barricarte, A.; Chirlaque, M. D.; Dorronsoro, M.; Jakszyn, P.; Larranaga, N.; Martinez, C.; Navarro, C.; Rodriguez, L.; Sanchez, M. J.; Tormo, M. J.; Gonzalez, C. A. Polychlorinated biphenyls in Spanish adults: determinants of serum concentrations Environ. Res. 2009, 109 (5) 620-628 10.1016/j.envres.2009.03.009
13. De Roos, A. J.; Ulrich, C. M.; Sjodin, A.; McTiernan, A. Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations J. Exp. Sci. Environ. Epidemiol. 2012, 22 (6) 617-624 10.1038/jes.2012.43
14. Sandanger, T. M.; Sinotte, M.; Dumas, P.; Marchand, M.; Sandau, C. D.; Pereg, D.; Berube, S.; Brisson, J.; Ayotte, P. Plasma concentrations of selected organobromine compounds and polychlorinated biphenyls in postmenopausal women of Quebec, Canada Environ. Health Perspect. 2007, 115 (10) 1429-1434 10.1289/ehp.10303
15. Chevrier, J.; Dewailly, E.; Ayotte, P.; Mauriege, P.; Despres, J. P.; Tremblay, A. Body weight loss increases plasma and adipose tissue concentrations of potentially toxic pollutants in obese individuals Int. J. Obes. Relat. Metab. Disord. 2000, 24 (10) 1272-1278 10.1038/sj.ijo.0801380
16. Hue, O.; Marcotte, J.; Berrigan, F.; Simoneau, M.; Dore, J.; Marceau, P.; Marceau, S.; Tremblay, A.; Teasdale, N. Increased plasma levels of toxic pollutants accompanying weight loss induced by hypocaloric diet or by bariatric surgery Obes. Surg. 2006, 16 (9) 1145-1154 10.1381/096089206778392356
17. Imbeault, P.; Chevrier, J.; Dewailly, E.; Ayotte, P.; Despres, J. P.; Mauriege, P.; Tremblay, A. Increase in plasma pollutant levels in response to weight loss is associated with the reduction of fasting insulin levels in men but not in women Metab., Clin. Exp. 2002, 51 (4) 482-486 10.1053/meta.2002.31338
18. Pelletier, C.; Doucet, E.; Imbeault, P.; Tremblay, A. Associations between weight loss-induced changes in plasma organochlorine concentrations, serum T(3) concentration, and resting metabolic rate Toxicol. Sci. 2002, 67 (1) 46-51 10.1093/toxsci/67.1.46
19. Dirtu, A. C.; Jaspers, V. L. B.; Cernat, R.; Neels, H.; Covaci, A. Distribution of PCBs, their hydroxylated metabolites, and other phenolic contaminants in human serum from two European countries Environ. Sci. Technol. 2010, 44 (8) 2876-2883 10.1021/es902149b
20. Phillips, D. L.; Pirkle, J. L.; Burse, V. W.; Bernert, J. T.; Omar Henderson, L.; Needham, L. L. 1989. Chlorinated hydrocarbon levels in human serum: Effects of fasting and feeding Arch. Environ. Contam. Toxicol. 1989, 18 (4) 495-500 10.1007/BF01055015
21. AMAP (The Arctic Monitoring and Assessment Program). Ring Test; Institute National de Sauté Publique Quebéc, Centre de Toxicologie, Report 2012.
22. Voorspoels, S.; Covaci, A.; Maervoet, J.; Schepens, P. Relationship between age and levels of organochlorine contaminants in human serum of a Belgian population Bull. Environ. Contam. Toxicol. 2002, 69 (1) 22-29 10.1007/s00128-002-0004-y
23. Echols, K. R.; Gale, R. W.; Schwartz, T. R.; Huckins, J. N.; Williams, L. L.; Meadows, J. C.; Morse, D.; Petty, J. D.; Orazio, C. E.; Tillitt, D. E. Comparing polychlorinated biphenyl concentrations and patterns in the Saginaw River using sediment, caged fish, and semipermeable membrane devices Environ. Sci. Technol. 2000, 34 (19) 4095-4102 10.1021/es001169f
24. Dirinck, E.; Jorens, P. G.; Covaci, A.; Geens, T.; Roosens, L.; Neels, H.; Mertens, I.; Van Gaal, L. Obesity and persistent organic pollutants: possible obesogenic effect of organochlorine pesticides and polychlorinated biphenyls Obesity 2011, 19 (4) 709-714 10.1038/oby.2010.133
25. Letcher, R. J.; Methyl sulfone and hydroxylated metabolites of polychlorinated biphenyls. In The Handbook of Environmental Chemistry; Paasivirta, J Ed.; Springer-Verlag: Berlin-Heidelberg, 2000; Vol 3, Part K; pp 315.
26. Hagmar, L.; Wallin, E.; Vessby, B.; Jönsson, B. A.; Bergman, Å.; Rylander, L. Intra-individual variations and time trends 1991-2001 in human serum levels of PCB, DDE and hexachlorobenzene Chemosphere 2006, 64 (9) 1507-1513 10.1016/j.chemosphere.2005.12.054
27. Polder, A.; Savinova, T. N.; Tkachev, A.; Løken, K. B.; Odland, J. O.; Skaare, J. U. Levels and patterns of Persistent Organic Pollutants (POPs) in selected food items from Northwest Russia (1998-2002) and implications for dietary exposure Sci. Total Environ. 2010, 408 (22) 5352-5361 10.1016/j.scitotenv.2010.07.036
28. Wronska, A.; Kmiec, Z. Review-Structural and biochemical characteristics of various white adipose tissue depots Acta Physiol. 2012, 205 (2) 194-208 10.1111/j.1748-1716.2012.02409.x
29. Brill, M. J. E.; Diepstraten, J.; van Rongen, A.; van Kralingen, S.; van den Anker, J. N.; Knibbe, C. A. J. Impact of obesity on drug metabolism and elimination in adults and children Clin. Pharmacokinet. 2012, 51 (5) 277-304 10.2165/11599410-000000000-00000
30. Lukaski, H. C.; Bolonchuk, W. W. Estimation of body-fluid volumes using tetrapolar bioelectrical impedance measurements Aviat. Space. Environ. Med. 1988, 59 (12) 1163-1169
31. Malarvannan, G.; Dirinck, E.; Dirtu, A. C.; Pereira-Fernandes, A.; Neels, H.; Jorens, P. G.; Van Gaal, L.; Blust, R.; Covaci, A. Distribution of persistent organic pollutants in two different fat compartments from obese individuals Environ. Intern. 2013, 55, 33-42 10.1016/j.envint.2013.02.012
32. Boon, J. P.; van der Meer, J.; Allchin, C. R.; Law, R. J.; Klungsøyr, J.; Leonards, P. E. G.; Spliid, H.; Storr-Hansen, E.; Mckenzie, C.; Wells, D. E. Concentration-dependent changes of PCB patterns in fish-eating mammals: Structural evidence for induction of cytochrome P450 Arch. Environ. Contam. Toxicol. 1997, 33 (3) 298-311 10.1007/s002449900257
33. Wamberg, L.; Christiansen, T.; Paulsen, S. K.; Fisker, S.; Rask, P.; Rejnmark, L.; Richelsen, B.; Pedersen, S. B. Expression of vitamin D-metabolizing enzymes in human adipose tissue-the effect of obesity and diet-induced weight loss. Int. J. Obesity 2012; DOI 10.1038/ijo.2012.112 [Online 17 July 2012].
34. ow) of all PCB congeners by ab initio and a Cl substitution position method QSAR Comb. Sci. 2006, 25 (4) 333-341 10.1002/qsar.200530141
35. US EPA (United States Environmental Protection Agency). http://www.epa.gov, (accessed December 2012).
36. Sierra-Santoyo, A.; Hernandez, M.; Albores, A.; Cebrian, M. E. DDT increases hepatic testosterone metabolism in rats Arch. Toxicol. 2005, 79 (1) 7-12 10.1007/s00204-004-0603-y
37. Van den Berg, K. J. Interaction of chlorinated phenols with thyroxine binding sites of human transthyretin, albumin and thyroid binding globulin Chem. Biol. Interact. 1990, 76 (1) 63-75 10.1016/0009-2797(90)90034-k