Singlet oxygen mediated DNA damage induced phototoxicity by ketoprofen resulting in mitochondrial depolarization and lysosomal destabilization

Toxicology

Volumn 314, Issue 2-3, 2013, Pages 229-237

  Ray, Ratan Singh ^a   Mujtaba, Syed Faiz ^a   Dwivedi, Ashish ^a   Yadav, Neera ^a   Verma, Ankit ^a   Kushwaha, Hari Narayan ^a   Amar, Saroj Kumar ^a   Goel, Shruti ^a   Chopra, Deepti ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

1O2 generation; Apoptosis; DNA damage; Ketoprofen; Phototoxicity

Indexed keywords

CASPASE 3; COMPLEMENTARY DNA; CYTOCHROME C; KETOPROFEN; LINOLEIC ACID; MITOCHONDRIAL DNA; NONSTEROID ANTIINFLAMMATORY AGENT; OXYGEN; P21 ACTIVATED KINASE; PHOSPHATIDYLSERINE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; SINGLET OXYGEN; SODIUM AZIDE;

APOPTOSIS; ARTICLE; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE M PHASE; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; COMET ASSAY; CONTROLLED STUDY; DEPOLARIZATION; DNA DAMAGE; DNA STRAND BREAKAGE; DOSIMETRY; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVATION; ENZYME RELEASE; FLUORESCENCE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IRRADIATION; LIPID PEROXIDATION; LYSOSOMAL DESTABILIZATION; LYSOSOME; MICROPROCESSOR; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NEOPLASM; PHOTOCHEMISTRY; PHOTODEGRADATION; PHOTODYNAMICS; PHOTOOXIDATION; PHOTOSENSITIVITY; PHOTOSENSITIZATION; PHOTOTOXICITY; PRIORITY JOURNAL; RADIATION DETECTOR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRANDED DNA BREAK; SUNLIGHT; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; ULTRAVIOLET RADIATION; UPREGULATION;

(1)O(2) GENERATION; APOPTOSIS; DNA DAMAGE; KETOPROFEN; PHOTOTOXICITY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DERMATITIS, PHOTOTOXIC; DNA DAMAGE; HUMANS; KERATINOCYTES; KETOPROFEN; LYSOSOMES; MITOCHONDRIA; SINGLET OXYGEN; SUNLIGHT; ULTRAVIOLET RAYS;

EID: 84887934878     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.10.002     Document Type: Article

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