The SERM raloxifene improves diaphyseal fracture healing in mice

Journal of Bone and Mineral Metabolism

Volumn 31, Issue 6, 2013, Pages 629-636

  Spiro, Alexander S ^a   Khadem, Shahram ^a   Jeschke, Anke ^a   Marshall, Robert Percy ^a   Pogoda, Pia ^a   Ignatius, Anita ^b   Amling, Michael ^a   Beil, Frank Timo ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Estrogen; Fracture healing; Mice; Ovariectomy; Raloxifene

Indexed keywords

ESTROGEN; RALOXIFENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MINERALIZATION; CALLUS; CONTROLLED STUDY; DRUG EFFECT; EPIPHYSEAL CARTILAGE; ESTROGEN BLOOD LEVEL; FEMALE; FEMUR FRACTURE; FEMUR OSTEOTOMY; FRACTURE HEALING; MORPHOMETRICS; MOUSE; NONHUMAN; OVARIECTOMY; PERIOSTEUM; PRIORITY JOURNAL; TRABECULAR BONE;

ANIMALS; DIAPHYSES; ESTROGENS; FEMALE; FEMORAL FRACTURES; FEMUR; FRACTURE HEALING; FRACTURES, BONE; HUMANS; MICE; MICE, INBRED C57BL; OSTEOPOROSIS, POSTMENOPAUSAL; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATORS;

EID: 84887905475     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-013-0461-x     Document Type: Article

References (25)

1. Schuiling KD, Robinia K, Nye R (2011) Osteoporosis update. J Midwifery Womens Health 56:615-627
2. Tu Z, Ma Y, Tian J, Li H, Akers W, Achilefu S, Gu Y (2012) Estrogen receptor β potentiates the antiproliferative effect of raloxifene and affects the cell migration and invasion in HCT-116 colon cancer cells. J Cancer Res Clin Oncol 138:1091-1103
3. Ettinger B, Black DM, Mitlak BH, Knickerbocker RK, Nickelsen T, Genant HK, Christiansen C, Delmas PD, Zanchetta JR, Stakkestad J, Gluer CC, Krueger K, Cohen FJ, Eckert S, Ensrud K, Avioli LV, Lips P, Cummings SR (1999) Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: Results from a 3-year randomized clinical trial. JAMA 282:637-645
4. Delmas PD, Ensrud KE, Adachi JD, Harper KD, Sarkar S, Gennari C, Reginster JY, Pols HA, Recker RR, Harris ST, Wu W, Genant HK, Black DM, Eastell R (2002) Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: Four-year results from a randomized clinical trial. J Clin Endocrinol Metab 87:3609-3617
5. Beil FT, Barvencik F, Gebauer M, Seitz S, Rueger JM, Ignatius A, Pogoda P, Schinke T, Amling M (2010) Effects of estrogen on fracture healing in mice. J Trauma 69:1259-1265
6. He YX, Zhang G, Pan XH, Liu Z, Zheng LZ, Chan CW, Lee KM, Cao YP, Li G, Wei L, Hung LK, Leung KS, Qin L (2011) Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: a drill-hole defect model. Bone 48:1388-1400
7. Boden SD, Joyce ME, Oliver B, Heydemann A, Bolander ME (1989) Estrogen receptor mRNA expression in callus during fracture healing in the rat. Calcif Tissue Int 45:324-325
8. Kolios L, Hoerster AK, Sehmisch S, Malcherek MC, Rack T, Tezval M, Seidlova-Wuttke D, Wuttke W, Stuermer KM, Stuermer EK (2010) Do estrogen and alendronate improve metaphyseal fracture healing when applied as osteoporosis prophylaxis? Calcif Tissue Int 86:23-32
9. Namkung-Matthai H, Appleyard R, Jansen J, Hao Lin J, Maastricht S, Swain M, Mason RS, Murrell GA, Diwan AD, Diamond T (2001) Osteoporosis influences the early period of fracture healing in a rat osteoporotic model. Bone 28:80-86
10. Black LJ, Sato M, Rowley ER, Magee DE, Bekele A, Williams DC, Cullinan GJ, Bendele R, Kauffman RF, Bensch WR, Frolik CA, Termine JD, Bryant HU (1994) Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J Clin Invest 93:63-69
11. Sato M, Kim J, Short LL, Slemenda CW, Bryant HU (1995) Longitudinal and cross-sectional analysis of raloxifene effects on tibiae from ovariectomized aged rats. J Pharmacol Exp Ther 272:1252-1259
12. Spiro AS, Beil FT, Schinke T, Schilling AF, Eulenburg C, Rueger JM, Amling M (2010) Short-term application of dexamethasone enhances bone morphogenetic protein-7-induced ectopic bone formation in vivo. J Trauma 69:1473-1480
13. Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, Baron R, Demay MB (1999) Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 140:4982-4987
14. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR (1987) Bone histomorphometry: standardization of nomenclature, symbols and units. J Bone Miner Res 6:595-610
15. Spiro AS, Beil FT, Baranowsky A, Barvencik F, Schilling AF, Nguyen K, Khadem S, Seitz S, Rueger JM, Schinke T, Amling M (2010) BMP-7-induced ectopic bone formation and fracture healing is impaired by systemic NSAID application in C57BL/6-mice. J Orthop Res 28:785-791
16. Beil FT, Barvencik F, Gebauer M, Beil B, Pogoda P, Rueger JM, Ignatius A, Schinke T, Amling M (2011) Effects of increased bone formation on fracture healing in mice. J Trauma 70:857-862
17. Stuermer EK, Sehmisch S, Rack T, Wenda E, Seidlova-Wuttke D, Tezval M, Wuttke W, Frosch KH, Stuermer KM (2010) Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat. Langenbecks Arch Surg 395:163-172
18. Cao Y, Mori S, Mashiba T, Westmore MS, Ma L, Sato M, Akiyama T, Shi L, Komatsubara S, Miyamoto K, Norimatsu H (2002) Raloxifene, estrogen, and alendronate affect the processes of fracture repair differently in ovariectomized rats. J Bone Miner Res 17:2237-2246
19. Takada J, Miki T, Imanishi Y, Nakatsuka K, Wada H, Naka H, Yoshizaki T, Iba K, Beck TJ, Yamashita T (2010) Effects of raloxifene treatment on the structural geometry of the proximal femur in Japanese women with osteoporosis. J Bone Miner Metab 28:561-567
20. Gorai I, Hattori S, Tanaka Y, Iwaoki Y (2012) Alfacalcidol-supplemented raloxifene therapy has greater bone-sparing effect than raloxifene-alone therapy in postmenopausal Japanese women with osteoporosis or osteopenia. J Bone Miner Metab 30:349-358
21. Hatano H, Siegel HJ, Yamagiwa H, Bronk JT, Turner RT, Bolander ME, Sarkar G (2004) Identification of estrogen-regulated genes during fracture healing, using DNA microarray. J Bone Miner Metab 22:224-235
22. Zhou S, Zilberman Y, Wassermann K, Bain SD, Sadovsky Y, Gazit D (2001) Estrogen modulates estrogen receptor alpha and beta expression, osteogenic activity, and apoptosis in mesenchymal stem cells (MSCs) of osteoporotic mice. J Cell Biochem 36:144-155
23. He YX, Liu Z, Pan XH, Tang T, Guo BS, Zheng LZ et al (2012) Deletion of estrogen receptor beta accelerates early stage of bone healing in a mouse osteotomy model. Osteoporos Int 23:377-389
24. Yang NN, Bryant HU, Hardikar S, Sato M, Galvin RJ, Glasebrook AL, Termine JD (1996) Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance. Endocrinology 137:2075-2084
25. Glasebrook AL, Phillips DL, Sluka JP (1993) Multiple binding sites for the anti-estrogen raloxifene. J Bone Miner Res 8(Suppl 1):268