CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusioninmice

Cardiovascular Research

Volumn 100, Issue 1, 2013, Pages 74-83

  Pereira, Flavia E ^a   Cronin, Chunxia ^a   Ghosh, Mallika ^a   Zhou, Si Yuan ^a,b   Agosto, Mariela ^a   Subramani, Jaganathan ^a   Wang, Ruibo ^a   Shen, Jian Bing ^a   Schacke, Wolfgang ^a,c   Liang, Brannen ^a   Yang, Tie Hong ^a   McAulliffe, Beata ^a,d   Liang, Bruce T ^a   Shapiro, Linda H ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c UNITED BIOSOURCE CORPORATION   (United States)

^d YALE NEW HAVEN HOSPITAL   (United States)

Author keywords

CD13; Dendritic cells; Macrophages; Monocytes; Myocardial infarction

Indexed keywords

MICROSOMAL AMINOPEPTIDASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL INFILTRATION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DENDRITIC CELL; FLOW CYTOMETRY; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; WESTERN BLOTTING; WOUND HEALING;

CD13; DENDRITIC CELLS; MACROPHAGES; MONOCYTES; MYOCARDIAL INFARCTION;

ACTINS; ANIMALS; ANTIGENS, CD13; CELL MOVEMENT; CORONARY OCCLUSION; INFLAMMATION; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; MYOFIBROBLASTS; VENTRICULAR REMODELING; WOUND HEALING;

EID: 84887888360     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt155     Document Type: Article

References (49)

1. Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L., Wurdinger T, Figueiredo JL et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 2007; 204: 3037-3047.
2. Virag JI, Murry CE. Myofibroblast and endothelial cell proliferation during murine myo-cardial infarct repair. Am J Pathol 2003; 163: 2433-2440.
3. Auffray C, Sieweke MH, Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Ann Rev Immunol 2009; 27: 669-692.
4. Mosser DM. The many faces of macrophage activation. J Leukoc Biol 2003; 73: 209-212.
5. van Amerongen M.J., Harmsen MC, van Rooijen N, Petersen AH, van Luyn MJ. Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice. Am J Pathol 2007; 170: 818-829.
6. Bujak M, Frangogiannis NG. The role of TGF-beta signalingin MI and cardiacremodeling. Cardiovasc Res 2007; 74: 184-195.
7. Leor J, Rozen L, Zuloff-Shani A, Feinberg M.S., Amsalem Y., Barbash IM et al. Ex vivo activated human macrophages improve healing, remodeling, and function of the infarcted heart. Circulation 2006; 114:I94-100.
8. Swirski FK, Nahrendorf M, Etzrodt M., Wildgruber M, Cortez-Retamozo V, Panizzi P et al. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science 2009; 325: 612-616.
9. Anzai A, Anzai T, Nagai S., Maekawa Y, Naito K, Kaneko H et al. Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling/clinical perspective. Circulation 2012; 125: 1234-1245.
10. Kaikita K, Hayasaki T, Okuma T., Kuziel WA, Ogawa H, Takeya M. Targeted deletion of CC chemokine receptor 2 attenuates left ventricular remodeling after experimental MI. Am J Pathol 2004; 165: 439-447.
11. Maekawa Y, Anzai T, Yoshikawa T., Sugano Y, Mahara K, Kohno T et al. Effect of granulocyte-macrophage colony-stimulating factor inducer on left ventricular remodeling after acute MI. J Am Coll Cardiol 2004; 44: 1510-1520.
12. Lindsey ML, Escobar GP, Dobrucki L.W., Goshorn DK, Bouges S, Mingoia JT et al. Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after MI. AmJ Physiol Heart Circ Physiol 2006; 290: H232-H239.
13. Butler JM, Kobayashi H, Rafii S. Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Nat Rev Cancer 2010; 10: 138-146.
14. Nahrendorf M, Pittet MJ, Swirski FK. Monocytes: protagonists of infarct inflammation and repair after MI. Circulation 2010; 121: 2437-2445.
15. Geissmann F, Manz MG, Jung S, Sieweke M.H., Merad M., Ley K. Development of mono-cytes, macrophages, and dendritic cells. Science 2010; 327: 656-661.
16. Shipp MA, Look AT. Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key! Blood 1993; 82: 1052-1070.
17. Yeager CL, Ashmun RA, Williams R.K., Cardellichio CB, Shapiro LH, Look AT et al. Human aminopeptidase N is a receptor for human coronavirus 229E. Nature 1992; 357: 420-422.
18. Mina-Osorio P., Winnicka B, O'Conor C, Grant CL, Vogel L.K., Rodriguez-Pinto D et al. CD13 is a novel mediator of monocytic/endothelial cell adhesion. J Leukoc Biol 2008; 84: 448-459.
19. Ghosh M, McAuliffe B, Subramani J., Basu S, Shapiro LH. CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake. J Immunol 2012; 188: 5489-5499.
20. Winnicka B, O'Conor C, Schacke W, Vernier K., Grant CL, Fenteany FH et al. CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse. J Leukoc Biol 2010; 88: 347-359.
21. Mina-Osorio P., Shapiro LH, Ortega E. CD13 incell adhesion: aminopeptidase N (CD13) mediates homotypic aggregation of monocytic cells. J Leukoc Biol 2006; 79: 719-730.
22. Buehler A, van Zandvoort MA, Stelt BJ, Hackeng TM, Schrans-Stassen BH, Bennaghmouch A et al. cNGR: a novel homing sequence for CD13/APN targeted molecular imaging of murine cardiac angiogenesis in-vivo. Arterioscler Thromb Vasc Biol 2006; 26: 2681-2687.
23. Petrovic N, Schacke W, Gahagan J.R., O'Conor CA, Winnicka B, Conway RE et al. CD13/APN regulates endothelial invasion and filopodia formation. Blood 2007; 110: 142-150.
24. Sonin D, Zhou SY, Cronin C, Sonina T., Wu J, Jacobson KA et al. Role of P2X purinergic receptors in the rescue of ischemic heart failure. Am J Physiol Heart Circ Physiol 2008; 295: H1191-H1197.
25. Shen JB, Shutt R, Agosto M., Pappano A, Liang BT. Reversal of cardiac myocyte dysfunction as a unique mechanism of rescue by P2X4 receptors in cardiomyopathy. Am J Physiol Heart Circ Physiol 2009; 296: H1089-H1095.
26. Porter KE, Turner NA. Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol Ther 2009; 123: 255-278.
27. Lambert JM, Lopez EF, Lindsey ML. Macrophage roles following MI. Int JCardiol 2008; 130: 147-158.
28. Auffray C, Fogg D, Garfa M., Elain G, Join-Lambert O, Kayal S et al. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science 2007; 317: 666-670.
29. Lijnen PJ, Petrov VV, Fagard RH. Induction of cardiac fibrosis by transforming growth factor-beta(1). Mol Genet Metab 2000; 71: 418-435.
30. McAnulty RJ. Fibroblasts and myofibroblasts: their source, function and role in disease. Int J Biochem Cell Biol 2007; 39: 666-671.
31. Khanna KM, Blair DA, Vella A.T., McSorley SJ, Datta SK, Lefrancois L. T cell and APC dynamics in situ control the outcome of vaccination. J Immunol 2010; 185: 239-252.
32. Bhagwat SV, Lahdenranta J, Giordano R., Arap W, Pasqualini R, Shapiro LH. CD13/APN is activated by angiogenic signals and is essential for capillary tube formation. Blood 2001; 97: 652-659.
33. Frangogiannis NG. The immune system and cardiac repair. Pharmacol Res 2008; 58: 88-111.
34. Saha P, Geissmann F. Toward afunctional characterization of blood monocytes. Immunol Cell Biol 2010; 89: 2-4.
35. Miller JC, Brown BD, Shay T, Gautier E.L., Jojic V., Cohain A et al. Deciphering the transcriptional network of the dendritic cell lineage. Nat Immunol 2012; 13: 888-899.
36. Hart DN, Fabre JW. Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain. J Exp Med 1981; 154: 347-361.
37. Zhang J, Yu ZX, Fujita S, Yamaguchi M.L., Ferrans VJ. Interstitial dendritic cells of the rat heart. Quantitative and ultrastructural changes in experimental MI. Circulation 1993; 87: 909-920.
38. Yilmaz AD, Dietel B, Cicha I., Schubert K, Hausmann R, Daniel WG et al. Emergence of dendritic cells in the myocardium after acute mi-implications for infammatory myocar-dial damage. Int J Biomed Sci 2010; 6: 27-36.
39. Palsson-McDermott E.M., O'Neill LA. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 2004; 113: 153-162.
40. Kagan JC, Su T, Horng T., Chow A, Akira S, Medzhitov R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol 2008; 9: 361-368.
41. Rangel R, Sun Y, Guzman-Rojas L, Ozawa M.G., Sun J., Giordano RJ et al. Impaired angio-genesis in aminopeptidase N-null mice. Proc Natl Acad Sci USA 2007; 104: 4588-4593.
42. Zymek P, Bujak M, Chatila K., Cieslak A, Thakker G, Entman ML et al. The role of platelet-derived growth factor signaling in healing myocardial infarcts. J Am Coll Cardiol 2006; 48: 2315-2323.
43. Armulik A, Genove G, Betsholtz C. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell 2011; 21: 193-215.
44. Carluccio E, Biagioli P, Alunni G., Murrone A, Giombolini C, Ragni T et al. Patients with hibernating myocardium show altered left ventricular volumes and shape, which revert after revascularization: evidence that dyssynergy might directly induce cardiac remodeling. J Am Coll Cardiol 2006; 47: 969-977.
45. 2+transientsinmice during early congestive heart failure. J Mol Cell Cardiol 2007; 43: 177-186.
46. Muller WA. Mechanisms of leukocyte transendothelial migration. Ann Rev Pathol 2011; 6: 323-344.
47. Leuschner F, Rauch PJ, Ueno T, Gorbatov R., Marinelli B, Lee WW et al. Rapid monocyte kinetics in acute MI are sustained by extramedullary monocytopoiesis. J Exp Med 2012; 209: 123-137.
48. Hausenloy DJ, Yellon DM. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest 2013; 123: 92-100.
49. Maekawa Y, Anzai T, Yoshikawa T., Asakura Y, Takahashi T, Ishikawa S et al. Prognostic significance of peripheral monocytosis after reperfused acute MI: a possible role for left ventricular remodeling. J Am Coll Cardiol 2002; 39: 241-246.