Inhibition of Key Enzymes Linked to Obesity by Preparations From Mediterranean Dietary Plants: Effects on α-Amylase and Pancreatic Lipase Activities

Plant Foods for Human Nutrition

Volumn 68, Issue 4, 2013, Pages 340-346

  Marrelli, Mariangela ^a   Loizzo, Monica Rosa ^a   Nicoletti, Marcello ^b   Menichini, Francesco ^a   Conforti, Filomena ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

amylase; Inhibitors; Lipophilic composition; Pancreatic lipase; Phenolic composition; Wild edible plants

Indexed keywords

AMYLASE; ANTIOBESITY AGENT; ENZYME INHIBITOR; PHENOL DERIVATIVE; PLANT EXTRACT; TRIACYLGLYCEROL LIPASE;

ANGIOSPERM; ARTICLE; CARDUUS; CHEMISTRY; CLEMATIS; DIET THERAPY; DRUG ANTAGONISM; EDIBLE PLANT; ENZYMOLOGY; HUMAN; ITALY; LEPIDIUM; MALVA; OBESITY; SOUTHERN EUROPE;

AMYLASES; ANGIOSPERMS; ANTI-OBESITY AGENTS; CARDUUS; CLEMATIS; ENZYME INHIBITORS; HUMANS; ITALY; LEPIDIUM; LIPASE; MALVA; MEDITERRANEAN REGION; OBESITY; PHENOLS; PLANT EXTRACTS; PLANTS, EDIBLE;

EID: 84887882656     PISSN: 09219668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11130-013-0390-9     Document Type: Article

References (20)

1. Morikawa T, Muraoka O, Yoshikawa M (2010) Pharmaceutical food science; search for anti-obese constituents from the flowers of Bellis perennis. Yakugaku Zasshi 130: 673-678.
2. Lowe ME (1994) Pancreatic triglyceride lipase and colipase: insights into dietary fat digestion. Gastroenterology 107: 1524-1536.
3. Chiasson JL (2006) Acarbose for the prevention of diabetes, hypertension, and cardiovascular disease in subjects with impaired glucose tolerance: the Study to Prevent Non-Insulin-Dependent Diabetes Mellitus (STOP-NIDDM) Trial. Trial End Pract 1: 25-30.
4. Conforti F, Perri V, Menichini F, Marrelli M, Uzunov D, Statti GA, Menichini F (2012) Wild Mediterranean dietary plants as inhibitors of pancreatic lipase. Phytother Res 26: 600-604.
5. Birari RB, Bhutani KK (2007) Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discov Today 12: 879-889.
6. Chen X, Zheng Y, Shen Y (2006) Voglibose (Basen̈, AO-128), one of the most important α-glucosidase inhibitors. Curr Med Chem 13: 109-116.
7. Soobrattee MA, Neergheen VS, Luximon-Ramma A, Aruoma OI, Bahorun T (2005) Phenolics as potential antioxidant therapeutic agents: mechanism and actions. Mutat Res 579: 200-213.
8. Loizzo MR, Tundis R, Menichini F, Statti GA, Menichini F (2008) Influence of ripening stage on health benefits properties of Capsicum annuum var. acuminatum L.: in vitro studies. J Med Food 11: 184-189.
9. Nicoletti M (2011) HPTLC fingerprint: a modern approach for the analytical determination of Botanicals. Rev Bras Farmacogn 21: 818-823. doi: 10. 1590/S0102-695X2011005000131.
10. Gallo FR, Multari G, Federici E, Palazzino G, Nicoletti M, Petitto V (2012) Studies in natural products chemistry. Atta-ur-Rahman (ed.). Elsevier, 37: 217-258.
11. Piccin A, Toniolo C, Nicoletti M (2012) Analytical tools for digestive plant extracts. Nutrifoods 11: 29-35.
12. Conforti F, Ioele G, Statti GA, Marrelli M, Ragno G, Menichini F (2008) Antiproliferative activity against human tumor cell lines and toxicity test on Mediterranean dietary plants. Food Chem Toxicol 46: 3325-3332.
13. Glensk M, Wray V, Nimtz M, Schöpke T (1999) Silenosides A-C, triterpenoid saponins from Silene vulgaris. J Nat Prod 62: 717-721.
14. Elkhayat ES, Ibrahim SR, Aziz MA (2008) Portulene, a new diterpene from Portulaca oleracea L. J Asian Nat Prod Res 10: 1039-1043.
15. Mulimani VH, Supriya D (1993) Effect of heat treatments on alpha-amylase inhibitor activity in sorghum (Sorghum bicolour L.). Plant Foods Hum Nutr 44: 181-186.
16. Rekha MR, Padmaja G (2002) Alpha-amylase inhibitor changes during processing of sweet potato and taro tubers. Plant Foods Hum Nutr 57: 285-294.
17. Tundis R, Loizzo MR, Menichini F (2010) Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update. Mini Rev Med Chem 10: 315-331.
18. Adisakwattana S, Lerdsuwankij O, Poputtachai U, Minipun A, Suparpprom C (2013) Inhibitory activity of Cinnamon bark species and their combination effect with acarbose against intestinal α-glucosidase and pancreatic α-amylase. Plant Foods Hum Nutr 66: 143-148.
19. Barrett ML, Udani JK (2011) A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): a review of clinical studies on weight loss and glycemic control. Nutr J 10: 24. doi: 10. 1186/1475-2891-10-24.
20. Nair SS, Kavrekar V, Mishra A (2013) In vitro studies on alpha amylase and alpha glucosidase inhibitory activities of selected plant extracts. Euro J Exp Bio 3: 128-132, NML Unique ID: 101567726.