Analysis of localized immune responses reveals presence of Th17 and Treg cells in cutaneous leishmaniasis due to Leishmania tropica

BMC Immunology

Volumn 14, Issue 1, 2013, Pages

  Katara, Gajendra K ^a,c   Raj, Anand ^a,d   Kumar, Rajesh ^a,e   Avishek, Kumar ^a   Kaushal, Himanshu ^a   Ansari, Nasim A ^a,f   Bumb, Ram A ^b   Salotra, Poonam ^a  

^a SAFDARJUNG HOSPITAL CAMPUS   (India)

^b S P MEDICAL COLLEGE   (India)

^c ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^d National Dope Testing Laboratory   (India)

^e TULANE UNIVERSITY   (United States)

^f JAZAN UNIVERSITY   (Saudi Arabia)

Author keywords

CDNA array; Cutaneous Leishmaniasis; Cytokines; Th17 cell; Treg cell

Indexed keywords

CHEMOKINE RECEPTOR CCR2; COMPLEMENTARY DNA; CXCL9 CHEMOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; FAS LIGAND; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 23; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PLEIOTROPHIN; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; FAS ANTIGEN; GAMMA INTERFERON; LYMPHOCYTE SURFACE MARKER; PROTEIN ROR GAMMA T; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DETERMINATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTERFERON GAMMA RELEASE ASSAY; LEISHMANIA TROPICA; LYMPHOCYTE FUNCTION; MALE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; SKIN LEISHMANIASIS; TH17 CELL; TISSUE INJURY; DNA MICROARRAY; EX VIVO STUDY; GENE EXPRESSION PROFILING; HUMAN TISSUE; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RNA ANALYSIS;

ADOLESCENT; ADULT; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HOST-PARASITE INTERACTIONS; HUMANS; INTERLEUKIN-17; LEISHMANIA TROPICA; LEISHMANIASIS, CUTANEOUS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSCRIPTOME; YOUNG ADULT;

EID: 84887868453     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-14-52     Document Type: Article

References (31)

1. World Health Organization Control of the Leishmaniases. World Health Organ Tech Rep Ser 2010, 949:91-106. World Health Organization.
2. Kumar R, Bumb RA, Ansari NA, Mehta RD, Salotra P. Cutaneous leishmaniasis caused by Leishmania tropica in Bikaner, India: Parasite identification and characterization using molecular and immunological tools. Am J Trop Med Hyg 2007, 76:896-901.
3. Dogra J, Aneja N, Lal BB, Mishra SN. Cutaneous leishmaniasis in India. Clinical experience with itraconazole. Int J Dermatol 1990, 29:661-662. 10.1111/j.1365-4362.1990.tb02593.x, 2177041.
4. Soni P, Prasad N, Khandelwal K, Ghiya BC, Mehta RD, Bumb RA, Salotra P. Unresponsive cutaneous leishmaniasis and HIV co-infection: report of three cases. Indian J Dermatol Venereol Leprol 2011, 77:251.
5. Prasad N, Ghiya BC, Bumb RA, Kaushal H, Saboskar AA, Lezama-Davila CM, Salotra P, Satoskar AR. Heat, Oriental sore, and HIV. Lancet 2011, 377:610. 10.1016/S0140-6736(10)61495-X, 21315946.
6. Bastien P, Killick-Kendrick R. Leishmania tropica infection in hamsters and a review of the animal pathogenicity of this species. Exp Parasitol 1992, 75:433-441. 10.1016/0014-4894(92)90256-A, 1493875.
7. Kumar R, Bumb RA, Salotra P. Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors. Immunology 2010, 130:193-201. 10.1111/j.1365-2567.2009.03223.x, 2878464, 20102417.
8. Kumar R, Bumb RA, Salotra P. Correlation of parasitic load with interleukin-4 response in patients with cutaneous leishmaniasis due to Leishmania tropica. FEMS Immunol Med Microbiol 2009, 57:239-246. 10.1111/j.1574-695X.2009.00607.x, 19799628.
9. Khader SA, Gopal R. IL-17 in protective immunity to intracellular pathogens. Virulence 2010, 1:423-427. 10.4161/viru.1.5.12862, 2953849,2953849, 21178483.
10. Pitta MG, Romano A, Cabantous S, Henri S, Hammad A, Kouriba B, Argiro L, el Kheir M, Bucheton B, Mary C, et al. IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani. J Clin Invest 2009, 119:2379-2387. 2719936, 19620772.
11. Bacellar O, Faria D, Nascimento M, Cardoso TM, Gollob KJ, Dutra WO, Scott P, Carvalho EM. Interleukin 17 production among patients with American cutaneous leishmaniasis. J Infect Dis 2009, 200:75-78. 10.1086/599380, 2732405, 19476435.
12. Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 2002, 420:502-507. 10.1038/nature01152, 12466842.
13. Campanelli AP, Roselino AM, Cavassani KA, Pereira MS, Mortara RA, Brodskyn CI, Goncalves HS, Belkaid Y, Barral-Netto M, Barral A, et al. CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. J Infect Dis 2006, 193:1313-1322. 10.1086/502980, 16586370.
14. Bourreau E, Ronet C, Darsissac E, Lise MC, Marie DS, Clity E, Tacchini-Cottier F, Couppie P, Launois P. In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment. J Infect Dis 2009, 199:576-579. 10.1086/596508, 19125672.
15. Katara GK, Ansari NA, Verma S, Ramesh V, Salotra P. Foxp3 and IL -10 expression correlates with parasite burden in lesional tissues of post kala azar dermal leishmaniasis (PKDL) patients. PLoS Neg Trop Dis 2011, 5:e1171.
16. Buates S, Matlashewski G. General suppression of macrophage gene expression during Leishmania donovani infection. J Immunol 2001, 166:3416-3422.
17. Chaussabel D, Semnani RT, McDowell MA, Sacks D, Sher A, Nutman TB. Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites. Blood 2003, 102:672-681. 10.1182/blood-2002-10-3232, 12663451.
18. Rodriguez NE, Chang HK, Wilson ME. Novel program of macrophage gene expression induced by phagocytosis of Leishmania chagasi. Infect Immun 2004, 72:2111-2122. 10.1128/IAI.72.4.2111-2122.2004, 375188, 15039333.
19. Eckmann L, Smith JR, Housley MP, Dwinell MB, Kagnoff MF. Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella. J Biol Chem 2000, 275:14084-14094. 10.1074/jbc.275.19.14084, 10799483.
20. Coombes BK, Mahony JB. cDNA array analysis of altered gene expression in human endothelial cells in response to Chlamydia pneumoniae infection. Infect Immun 2001, 69:1420-1427. 10.1128/IAI.69.3.1420-1427.2001, 98036, 11179307.
21. Bogdan C, Gessner A, Solbach W, Röllinghoff M. Invasion, control and persistence of Leishmania parasites. Curr Opin Immunol 1996, 4:517-525.
22. Ansari NA, Ramesh V, Salotra P. Interferon (IFN)-gamma, tumor necrosis factor-alpha, interleukin-6, and IFN-gamma receptor 1 are the major immunological determinants associated with post-kala azar dermal leishmaniasis. J Infect Dis 2006, 194:958-965. 10.1086/506624, 16960784.
23. Katara GK, Ansari NA, Singh A, Ramesh V, Salotra P. Evidence for involvement of Th17 type responses in post kala azar dermal leishmaniasis (PKDL). PLoS Negl Trop Dis 2012, 6:e1703. 10.1371/journal.pntd.0001703, 3378621, 22724038.
24. Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupé P, Barillot E, Soumelis V. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 2008, 9:650-657.
25. Ansari NA, Kumar R, Gautam S, Nylén S, Singh OP, Sundar S, Sacks D. IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis. J Immunol 2011, 186:3977-3985. 10.4049/jimmunol.1003588, 3076633, 21357266.
26. Anderson CF, Stumhofer JS, Hunter CA, Sacks D. IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. J Immunol 2009, 183:4619-4627. 10.4049/jimmunol.0804024, 2749572, 19748991.
27. Boaventura VS, Santos CS, Cardoso CR, de Andrade J, dos Santos WL, Clarêncio J, Silva JS, Borges VM, Barral-Netto M, Brodskyn CI, et al. Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines. Eur J Immunol 2010, 40:2830-2836. 10.1002/eji.200940115, 20812234.
28. Kobets T, Havelková H, Grekov I, Volkova V, Vojtíšková J, Slapničková M, Kurey I, Sohrabi Y, Svobodová M, Demant P, et al. Genetics of host response to Leishmania tropica in mice - different control of skin pathology, chemokine reaction, and invasion into spleen and liver. PLoS Negl Trop Dis 2012, 6:e1667. 10.1371/journal.pntd.0001667, 3367980, 22679519.
29. Marin ND, París SC, Vélez VM, Rojas CA, Rojas M, García LF. Regulatory T cell frequency and modulation of IFN-gamma and IL-17 in active and latent tuberculosis. Tuberculosis 2010, 90:252-261. 10.1016/j.tube.2010.05.003, 20594914.
30. Wang Q, Zheng Y, Huang Z, Tian Y, Zhou J, Mao Q, Wu Y, Ni B. Activated IL-23/IL-17 pathway closely correlates with increased Foxp3 expression in livers of chronic hepatitis B patients. BMC Immunol 2011, 12:25. 10.1186/1471-2172-12-25, 3094328, 21489307.
31. Zhang L, Yang XQ, Cheng J, Hui RS, Gao TW. Increased Th17 cells are accompanied by FoxP3 (+) Treg cell accumulation and correlated with psoriasis disease severity. Clin Immunol 2010, 135:108-117. 10.1016/j.clim.2009.11.008, 20006553.