Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection

International Journal of Obesity

Volumn 37, Issue 11, 2013, Pages 1510-1513

  O'Shea, D ^a,b   Corrigan, M ^a   Dunne, M R ^c   Jackson, R ^d   Woods, C ^a,b   Gaoatswe, G ^a,b   Moynagh, P N ^d   O'Connell, J ^a,b   Hogan, A E ^a,c  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^b St Columcille s Hospital   (Ireland)

^c OUR LADY S CHILDREN S HOSPITAL   (Ireland)

^d NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

dendritic cell; T cell response; vaccination; virus infection

Indexed keywords

CD83 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 4; TOLL LIKE RECEPTOR;

ADULT; ARTICLE; BODY MASS; BODY WEIGHT; CELL COUNT; CELL FUNCTION; CELL MATURATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE PREDISPOSITION; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; LEAN BODY WEIGHT; MALE; METABOLIC PARAMETERS; OBESITY; PRIORITY JOURNAL; T LYMPHOCYTE; UPREGULATION; VIRUS INFECTION;

ADULT; ANTIGENS, CD; DENDRITIC CELLS; DISEASE SUSCEPTIBILITY; FEMALE; FLOW CYTOMETRY; HEPATITIS B ANTIBODIES; HEPATITIS B VACCINES; HUMANS; IMMUNITY, INNATE; IMMUNOGLOBULINS; MALE; MEMBRANE GLYCOPROTEINS; OBESITY, MORBID; T-LYMPHOCYTES; TETANUS TOXOID;

EID: 84887846328     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2013.16     Document Type: Article

References (25)

1. O'Shea D, Cawood TJ, O'Farrelly C, Lynch L. Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PLoS One 2010; 5: e8660.
2. Bories G, Caiazzo R, Derudas B, Copin C, Raverdy V, Pigeyre M et al. Impaired alternative macrophage differentiation of peripheral blood mononuclear cells from obese subjects. Diab Vasc Dis Res 2011; 9: 189-195.
3. Falagas ME, Kompoti M. Obesity and infection. Lancet Infect Dis 2006; 6: 438-446.
4. Kim YH, Kim JK, Kim DJ, Nam JH, Shim SM, Choi YK et al. Diet-induced obesity dramatically reduces the efficacy of a 2009 pandemic H1N1 vaccine in a mouse model. J Infect Dis 2012; 205: 244-251.
5. Weber DJ, Rutala WA, Samsa GP, Bradshaw SE, Lemon SM. Impaired immunogenicity of hepatitis B vaccine in obese persons. N Engl J Med 1986; 314: 1393.
6. Sheridan PA, Paich HA, Handy J, Karlsson EA, Hudgens MG, Sammon AB et al. Obesity is associated with impaired immune response to influenza vaccination in humans. Int J Obes (Lond) 2011; 36: 1072-1077.
7. Fezeu L, Julia C, Henegar A, Bitu J, Hu FB, Grobbee DE et al. Obesity is associated with higher risk of intensive care unit admission and death in influenza A (H1N1) patients: a systematic review and meta-analysis. Obes Rev 2011; 12: 653-659.
8. Kwong JC, Campitelli MA, Rosella LC. Obesity and respiratory hospitalizations during influenza seasons in Ontario, Canada: a cohort study. Clin Infect Dis 2011; 53: 413-421.
9. Klagge IM, Schneider-Schaulies S. Virus interactions with dendritic cells. J Gen Virol 1999; 80(Pt 4): 823-833.
10. Corrales JJ, Almeida M, Burgo RM, Hernandez P, Miralles JM, Orfao A. Decreased production of inflammatory cytokines by circulating monocytes and dendritic cells in type 2 diabetic men with atherosclerotic complications. J Diabetes Complications 2007; 21: 41-49.
11. Macia L, Delacre M, Abboud G, Ouk TS, Delanoye A, Verwaerde C et al. Impairment of dendritic cell functionality and steady-state number in obese mice. J Immunol 2006; 177: 5997-6006.
12. Musilli C, Paccosi S, Pala L, Gerlini G, Ledda F, Mugelli A et al. Characterization of circulating and monocyte-derived dendritic cells in obese and diabetic patients. Mol Immunol 2011; 49: 234-238.
13. Gardner EM, Beli E, Clinthorne JF, Duriancik DM. Energy Intake and Response to Infection with Influenza. Annu Rev Nutri 2011; 31: 353-367.
14. Karlsson EA, Sheridan PA, Beck MA. Diet-induced obesity impairs the T cell memory response to influenza virus infection. J Immunol (Baltimore, MD: 1950) 2010; 184: 3127-3133.
15. Lynch LA, O'Connell JM, Kwasnik AK, Cawood TJ, O'Farrelly C, O'Shea DB. Are natural killer cells protecting the metabolically healthy obese patient? Obesity (Silver Spring) 2009; 17: 601-605.
16. Moulin CM, Marguti I, Peron JP, Halpern A, Rizzo LV. Bariatric surgery reverses natural killer (NK) cell activity and NK-related cytokine synthesis impairment induced by morbid obesity. Obes Surg 2011; 21: 112-118.
17. van der Weerd K, Dik WA, Schrijver B, Schweitzer DH, Langerak AW, Drexhage HA et al. Morbidly obese human subjects have increased peripheral blood CD4 T cells with skewing toward a Treg-and Th2-dominated phenotype. Diabetes 2012; 61: 401-408.
18. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245-252.
19. Breloer M, Fleischer B. CD83 regulates lymphocyte maturation, activation and homeostasis. Trends Immunol 2008; 29: 186-194.
20. Kummer M, Turza NM, Muhl-Zurbes P, Lechmann M, Boutell C, Coffin RS et al. Herpes simplex virus type 1 induces CD83 degradation in mature dendritic cells with immediate-early kinetics via the cellular proteasome. J Virol 2007; 81: 6326-6338.
21. Senechal B, Boruchov AM, Reagan JL, Hart DN, Young JW. Infection of mature monocyte-derived dendritic cells with human cytomegalovirus inhibits stimulation of T-cell proliferation via the release of soluble CD83. Blood 2004; 103: 4207-4215.
22. Smith AG, Sheridan PA, Tseng RJ, Sheridan JF, Beck MA. Selective impairment in dendritic cell function and altered antigen-specific CD8 T-cell responses in diet-induced obese mice infected with influenza virus. Immunology 2009; 126: 268-279.
23. Weber DJ, Rutala WA, Samsa GP, Santimaw JE, Lemon SM. Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine. JAMA 1985; 254: 3187-3189.
24. Eliakim A, Schwindt C, Zaldivar F, Casali P, Cooper DM. Reduced tetanus antibody titers in overweight children. Autoimmunity 2006; 39: 137-141.
25. Karlsson EA, Beck MA. The burden of obesity on infectious disease. Exp Biol Med (Maywood) 2010; 235: 1412-1424.