Neuro-immune-endocrine functions of the skin: An overview

Expert Review of Dermatology

Volumn 8, Issue 6, 2013, Pages 581-583

  Nejati, Reza ^a   Kovacic, Diane ^a   Slominski, Andrzej ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

cannabinoids; CRH; HPA axis; HPT axis; melatonin; opioids; POMC; serotonin; vitamin D

Indexed keywords

CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; MELATONIN; NEUROHORMONE; OPIATE PEPTIDE; PROOPIOMELANOCORTIN; SECOSTEROID; SEROTONIN;

ANDROGEN SYNTHESIS; CHOLINERGIC SYSTEM; CYTOKINE PRODUCTION; ESTROGEN SYNTHESIS; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NEUROENDOCRINE SYSTEM; NEUROIMMUNOLOGY; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; SKIN FUNCTION; SURVIVAL RATE;

EID: 84887832932     PISSN: 17469872     EISSN: 17469880     Source Type: Journal    
DOI: 10.1586/17469872.2013.856690     Document Type: Review

References (20)

1. Slominskin A, Wortsman J. Neuroendocrinology of the skin. Endocr. Rev. 21(5), 457-487 (2000
2. Slominski AT, Zmijewski MA, Skobowiat C, Zbytek B, Slominski RM, Steketee JD. Sensing the environment: Regulation of local and global homeostasis by the skin's neuroendocrine system. Adv. Anat. Embryol. Cell Biol. 212, v; vii; 1-115 (2012
3. Slominski A, Mihm MC. Potential mechanism of skin response to stress. Int. J. Dermatol 35(12), 849-851 (1996
4. Slominski A, Wortsman J, Luger T, Paus R, Solomon S. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol. Rev. 80(3), 979-1020 (2000
5. Slominski AT, Zmijewski MA, Zbytek B, Tobin DJ, Theoharides TC, Rivier J. Key role of CRF in the skin stress response system. Endocr. Rev. doi:10.1210/er.2012-1092 (2013) (Epub ahead of print
6. Slominski AT, Zmijewski MA, Zbytek B et al. Regulated proenkephalin expression in human skin and cultured skin cells. J. Invest. Dermatol. 131(3), 613-622 (2011
7. Skobowiat C, Dowdy JC, Sayre RM, Tuckey RC, Slominski A. Cutaneous hypothalamic-pituitary-Adrenal axis homolog: Regulation by ultraviolet radiation. Am. J. Physiol. Endocrinol. Metab. 301(3), E484-493 (2011
8. Bĺazquez C, Carracedo A, Barrado L et al. Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J 20(14), 2633-2635 (2006
9. Grando SA, Pittelkow MR, Schallreuter KU. Adrenergic and cholinergic control in the biology of epidermis: Physiological and clinical significance. J. Invest. Dermatol. 126(9), 1948-1965 (2006
10. Slominski A, Tobin DJ, Zmijewski MA, Wortsman J, Paus R. Melatonin in the skin: Synthesis, metabolism and functions. Trends Endocrinol. Metab. 19(1), 17-24 (2008
11. Bodo E, Kany B, Ǵasṕar E et al. Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones. Endocrinology 151(4), 1633-1642 (2010
12. Cianfarani F, Baldini E, Cavalli A et al. TSH receptor and thyroid-specific gene expression in human skin. J. Invest. Dermatol. 130(1), 93-101 (2010
13. Slominski A, Wortsman J, Kohn L et al. Expression of hypothalamic- pituitary-Thyroid axis related genes in the human skin. J. Invest. Dermatol 119(6), 1449-1455 (2002
14. van Beek N, Bodó E, Kromminga A et al. Thyroid hormones directly alter human hair follicle functions: Anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. J. Clin. Endocrinol. Metab. 93(11), 4381-4388 (2008
15. Slominski AT, Kim T-K, Chen JJ et al. Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes. Int. J. Biochem. Cell Biol. 44, 2003-2018 (2012
16. Slominski AT, Kim TK, Shehabi HZ et al. In vivo evidence for a novel pathway of vitamin D(3) metabolism initiated by P450scc and modified by CYP27B1. FASEB J. 26(9), 3901-3915 (2012
17. Bikle DD. Vitamin D metabolism and function in the skin. Mol. Cell Endocrinol. 347(1-2), 80-89 (2011
18. Slominski AT, Zmijewski MA, Semak I et al. Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways. Anticancer Agents Med. Chem. doi:10.2174/ 18715206113139990308 (2013) (Epub ahead of print
19. Slominski A, Zbytek B, Nikolakis G et al. Steroidogenesis in the skin: Implications for local immune functions. J. Steroid Biochem. Mol. Biol. doi:10.1016/j.jsbmb.2013.02.006 (2013) (Epub ahead of print
20. Skobowiat C, Nejati R, Lu L, Williams RW, Slominski AT. Genetic variation of the cutaneous HPA axis: An analysis of UVB-induced differential responses. Gene 530(1), 1-7 (2013